A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

(2019) Marcelo M. Samsa et al.   MOLECULAR THERAPY

Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH

(2019) Khalid A. Hajj et al.   Small

RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial

(2019) Fatma Doener et al.   VACCINE

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model

(2018) Alex Allen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials

(2018) Martin R Gaudinski et al.   LANCET

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity

(2018) Shinu John et al.   VACCINE

Engineering circular RNA for potent and stable translation in eukaryotic cells

(2018) R. Alexander Wesselhoeft et al.   Nature Communications

The Potential Role of circRNA in Tumor Immunity Regulation and Immunotherapy

(2018) Zihao Xu et al.   Frontiers in Immunology

Targeting gp100 and TRP-2 with a DNA vaccine: Incorporating T cell epitopes with a human IgG1 antibody induces potent T cell responses that are associated with favourable clinical outcome in a phase I/II trial

(2018) Poulam M. Patel et al.   OncoImmunology

New Vaccine Technologies to Combat Outbreak Situations

(2018) Susanne Rauch et al.   Frontiers in Immunology

Phase I clinical trial of an intranodally administered mRNA based therapeutic vaccine against HIV-1 infection

(2018) Lorna Leal et al.   AIDS

mRNA as novel technology for passive immunotherapy

(2018) Thomas Schlake et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Circular RNAs as Therapeutic Agents and Targets

(2018) Lesca M. Holdt et al.   Frontiers in Physiology

Mechanism of action of mRNA-based vaccines

(2017) Carlo Iavarone et al.   Expert Review of Vaccines

Plasmid DNA Manufacturing for Indirect and Direct Clinical Applications

(2017) Marco Schmeer et al.   HUMAN GENE THERAPY

RNA sensors of the innate immune system and their detection of pathogens

(2017) Nanhua Chen et al.   IUBMB LIFE

DNA vaccines for fish: Review and perspectives on correlates of protection

(2017) R A Dalmo   JOURNAL OF FISH DISEASES

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

(2017) Darin K. Edwards et al.   Journal of Translational Medicine

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

A thermostable messenger RNA based vaccine against rabies

(2017) Lothar Stitz et al.   PLoS Neglected Tropical Diseases

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes

(2016) K. J. McCann et al.   CLINICAL CANCER RESEARCH

The notorious R.N.A. in the spotlight - drug or target for the treatment of disease

(2016) Philipp Reautschnig et al.   RNA Biology

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

(2015) Hubert Kübler et al.   Journal for ImmunoTherapy of Cancer

Self-replicating alphavirus RNA vaccines

(2014) Karl Ljungberg et al.   Expert Review of Vaccines

Safety and Immunogenicity of DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild-Type Glycoproteins in a Phase I Clinical Trial

(2014) U. N. Sarwar et al.   JOURNAL OF INFECTIOUS DISEASES

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer

(2014) Steffen Rausch et al.   Human Vaccines & Immunotherapeutics

Clinical optimization of antigen specific modulation of type 1 diabetes with the plasmid DNA platform

(2013) Peter Gottlieb et al.   CLINICAL IMMUNOLOGY

Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity

(2013) K. M. Quinn et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor ligands enhance the protective effects of vaccination against porcine reproductive and respiratory syndrome virus in swine

(2013) Lili Zhang et al.   VETERINARY MICROBIOLOGY

DNA vaccines

(2013) Cevayir Coban et al.   Human Vaccines & Immunotherapeutics

DNA fusion-gene vaccination in patients with prostate cancer induces high-frequency CD8+ T-cell responses and increases PSA doubling time

(2012) Lindsey Chudley et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice

(2012) S Domingos-Pereira et al.   Mucosal Immunology

Novel Strategies to Improve DNA Vaccine Immunogenicity

(2011) Cevayir Coban et al.   CURRENT GENE THERAPY

A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial

(2011) Julie E. Ledgerwood et al.   JOURNAL OF INFECTIOUS DISEASES

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Efficacy of Three Vaccines in Protecting Western Scrub-Jays (Aphelocoma californica) from Experimental Infection with West Nile Virus: Implications for Vaccination of Island Scrub-Jays (Aphelocoma insularis)

(2011) Sarah S. Wheeler et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

DNA vaccines: an historical perspective and view to the future

(2010) Margaret A. Liu   IMMUNOLOGICAL REVIEWS

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

DNA Vaccination of American Robins (Turdus migratorius) Against West Nile Virus

(2009) A. Marm Kilpatrick et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY