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Infratentorial Supracerebellar Approach for Resection of Midbrain Cavernous Malformation: 3-Dimensional Operative Video

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OPERATIVE NEUROSURGERY
卷 18, 期 2, 页码 E44-E44

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OXFORD UNIV PRESS INC
DOI: 10.1093/ons/opz114

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Brainstem cavernoma; Midbrain cavernoma; Supratentorial infracerebellar; Brainstem cavernous malformation

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Cavernous malformations (cavernomas) of the brain stem with recurrent hemorrhage may be amenable to microsurgical resection if they are present close to the surface. The risks of surgery need to be balanced with the natural history of the lesion and the accumulation of neurological deficits and risk to life with multiple hemorrhages. In this 3D operative video, we illustrate the technique for the resection of a dorsally located midbrain cavernous malformation. Informed consent was obtained for this procedure. The cavernoma is accessed with the use of a supracerebellar infratentorial approach. The infratentorial craniotomy and coagulation of the superior vermian veins is shown. A description is provided of the use of hemosiderin staining and the intercollicular relative safe zone(1) as landmarks for the neurotomy. The technique of cavernoma dissection from the surrounding gliotic plane is shown and described. In this case, the patient required prolonged rehabilitation but fully recovered without residual deficit 1 yr following surgery.

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Sileri, A. Vignali, A. Belvedere, P. Bernante, P. Bertoglio, S. Boussedra, E. Brunocilla, M. Cervellera, M. Cescon, R. Cipriani, G. Cisternino, E. De Crescenzo, P. De Iaco, M. Del Gaudio, G. Dondi, M. Droghetti, G. Germinario, A. Gori, F. Frio, E. Jovine, Bianchi F. Mineo, D. Morezzi, J. Neri, D. Parlanti, A. M. Perrone, A. P. Pezzuto, M. Pignatti, V Pinto, G. Poggioli, M. Ravaioli, M. Rottoli, I. S. Russo, L. Sartarelli, R. Schiavina, M. Serenari, M. Serra, P. Solli, V Tonini, M. Taffurelli, M. Tanzanu, M. Tesei, T. Violante, S. Zanotti, F. Borghi, D. Cianflocca, Grimaldi S. Di Maria, D. Donati, E. Gelarda, P. Geretto, G. Giraudo, M. C. Giuffrida, F. Maione, A. Marano, S. Palagi, L. Pellegrino, C. Peluso, S. Giaccardi, V Testa, F. Agresta, D. Prando, M. Zese, F. Aquila, C. Gambacciani, L. Lippa, F. Pieri, O. S. Santonocito, G. Armatura, G. Bertelli, A. Frena, P. Marinello, F. Notte, S. Patauner, G. Scotton, S. Fulginiti, G. Gallo, G. Sammarco, G. Vescio, P. Balercia, L. Catarzi, G. Consorti, E. L. G. Asti, D. Bernardi, L. Bonavina, A. Lovece, F. Di Marzo, H. Fujiwara, D. Hashimoto, S. Yamaki, T. Yamamoto, H. Daiko, M. Ishikawa, K. Ishiyama, S. Iwata, K. Kanematsu, Y. Kanemitsu, T. Kato, A. Kawai, E. Kobayashi, Kato M. Kobayashi, K. Moritani, M. Nakagawa, F. Nakatani, J. Oguma, Y. Tanase, M. Uno, T. Hada, H. Iwahashi, M. Miyamoto, J. Suminokura, M. Takano, K. Fujiwara, N. Fujiwara, A. Kurosaki, H. Ababneh, M. Al Abdallah, F. Ayasra, Y. Ayasra, F. Hammad, A. Qasem, F. J. Abu Za'nouneh, A. A. Al-Shraideh, T. Fahmawee, A. Hmedat, A. Ibrahim, K. Obeidat, Al S. Abdel, R. Abdel Jalil, M. K. Abou Chaar, M. Al-Masri, H. Al-Najjar, F. Alawneh, O. Alsaraireh, M. Elayyan, R. Ghanem, I Lataifeh, I Fakhradiyev, T. Saliev, S. Tanabayeva, H. Almahmeed, S. Almazeedi, S. Alsabah, M. Jamal, N. Aldokali, O. Senossi, M. T. Subhi, M. Algallai, S. Alwarfly, S. Alzaede, M. Gahwagi, M. Moftah, M. Abusannoga, A. Alawami, M. Alawami, M. Albashri, A. Malek, D. Burgan, E. Kamoka, A. Kilani, A. Salamah, M. Salem, A. Shuwayyah, M. Abdelkabir, I Altomi, M. Altoumi, A. Bouhuwaish, A. Elmabri, M. Omar, A. S. Taher, E. Abdulwahed, E. Alshareea, N. Aribi, S. Aribi, M. Biala, R. Ghamgh, M. Morgom, S. A. A. Alansari, Z. Aldayri, A. Alsoufi, A. Elhadi, F. Elhajdawe, I Ellojli, A. A. D. Ergebi, A. Kredan, A. Msherghi, T. Nagib, A. Abudher, K. Alshareef, F. Elamin, S. Bradulskis, E. Dainius, E. Kubiliute, J. Kutkevicius, A. Parseliunas, A. Subocius, D. Venskutonis, F. Rasoaherinomenjanahary, J. B. Razafindrahita, L. H. Samison, E. C. Ong, Maei N. Abdul, C. W. Ngo, S. Ramasamy, K. H. Hamdan, M. R. Ibrahim, J. A. Tan, M. R. Thanapal, E. Choong, R. Z. M. Lim, Sahid N. Amin, F. Hayati, J. Jayasilan, R. K. Sriram, S. Subramaniam, A. F. Ibrahim, Jusoh A. Che, A. H. Hussain, Sidek A. S. Mohamed, Yunus M. F. Mohd, J. Y. Soh, ,

Summary: During the COVID-19 pandemic, lockdown measures have led to a portion of cancer patients not being able to receive planned surgery. In regions with full lockdowns, one in seven patients did not undergo surgery and experienced longer waiting times. Although short-term oncological outcomes were not greatly affected, delayed surgeries might result in long-term reduction in survival.

LANCET ONCOLOGY (2021)

Article Neurosciences

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing-Olesen, Timothy R. Hammond, T. Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles Vanderburg, Soyon Hong, Harry Bulstrode, Peter J. Hutchinson, Daniel J. Gaffney, David A. Hafler, Robin J. M. Franklin, Evan Z. Macosko, Beth Stevens

Summary: Enzymatic dissociation during single-cell sequencing experiments can lead to aberrant gene expression, especially in microglia. A validated protocol is presented to preserve in vivo transcriptional profiles and cell-type diversity and yield. Similar gene expression changes are observed in postmortem human brain tissue, and these changes can be induced by exposure to elevated temperatures ex vivo.

NATURE NEUROSCIENCE (2022)

Article Neurosciences

Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and human neural cells

Harry Bulstrode, Gemma C. Girdler, Tannia Gracia, Alexander Aivazidis, Ilias Moutsopoulos, Adam M. H. Young, John Hancock, Xiaoling He, Katherine Ridley, Zhaoyang Xu, John H. Stockley, John Finlay, Clement Hallou, Teodoro Fajardo, Daniel M. Fountain, Stijn van Dongen, Alexis Joannides, Robert Morris, Richard Mair, Colin Watts, Thomas Santarius, Stephen J. Price, Peter J. A. Hutchinson, Emma J. Hodson, Steven M. Pollard, Irina Mohorianu, Roger A. Barker, Trevor R. Sweeney, Omer Bayraktar, Fanni Gergely, David H. Rowitch

Summary: Zika virus can infect human developing brain progenitors, leading to epidemic microcephaly, but it has limited infectivity for adult brain cancer glioblastoma. CD11b+ microglia/macrophages derived from glioblastoma are able to protect progenitors against Zika virus infection in a non-cell autonomous manner. Treatment with interferon beta and inhibition of JAK1/2 signaling can enhance the resistance of progenitors to Zika virus. These findings have important implications for neuroprotection and improved treatment of brain cancer.

NEURON (2022)

Article Clinical Neurology

Memory recovery in relation to default mode network impairment and neurite density during brain tumor treatment

Rafael Romero-Garcia, John Suckling, Mallory Owen, Moataz Assem, Rohitashwa Sinha, Pedro Coelho, Emma Woodberry, Stephen J. Price, Amos Burke, Thomas Santarius, Yaara Erez, Michael G. Hart

Summary: The objective of this study is to explore the interactions between brain tumors and brain networks, and identify protective features and risk factors for memory recovery after surgery. Using NODDI and resting-state networks, imaging biomarkers of cognitive recovery and decline can be identified. Brain tumors and their corresponding treatment can have a major impact on patients' memory recovery.

JOURNAL OF NEUROSURGERY (2022)

Article Health Care Sciences & Services

Can compliment and complaint data inform the care of individuals with chronic subdural haematoma (cSDH)?

Katherine Jones, Benjamin Davies, Daniel J. Stubbs, Alexander Komashie, Rowan M. Burnstein, Peter Hutchinson, Thomas Santarius, Alexis J. Joannides

Summary: The study explored complaints and compliments reported to Patient Advice and Liaison (PALS) by individuals undergoing surgery for chronic subdural haematoma (cSDH). Complaints mostly involved relationship and management problems, while compliments were related to good clinical quality. Patients were more likely to register compliments, while family members were more likely to register complaints.

BMJ OPEN QUALITY (2021)

Article Biochemical Research Methods

On-chip perivascular niche supporting stemness of patient-derived glioma cells in a serum-free, flowable culture

Magda Gerigk, Harry Bulstrode, HaoTian Harvey Shi, Felix Tonisen, Camilla Cerutti, Gillian Morrison, David Rowitch, Yan Yan Shery Huang

Summary: The development of an in vitro model for studying the migration of glioblastoma stem-like cells (GSCs) and their interactions with perivascular niches in the tumor microenvironment was demonstrated in this study. The model showed maintenance of stemness of patient-derived GSCs and fetal neural stem cells, as well as upregulation of neovascularization-related genes in endothelial cells co-cultured with GSCs. The on-chip platform enabled live-cell imaging of GSC-microvessel interaction and quantitative analysis of GSC polarization and migration, showing a different interaction pattern compared to non-tissue specific vascular niches of human origin.

LAB ON A CHIP (2021)

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