Article
Oncology
Yangyang Zhang, Lingxiu Zeng, Meng Wang, Zhenwei Yang, Hailin Zhang, Liping Gao, Ranran Zhang, Jialong Liu, Wenqing Shan, Ying Chang, Lan Liu, Qiu Zhao, Yong Li, Jing Liu
Summary: The study found that RIG-I plays an important role in the immunotherapy of colon cancer by maintaining the stability of PD-L1 to promote immune evasion. Silencing RIG-I increases the sensitivity of tumor cells to T cell killing and slows down the growth of colon tumors. High expression of RIG-I promotes tumor progression and enhances the sensitivity to PD-1 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Article
Oncology
Hong Wu, Xuefeng Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang, Chuan Xu
Summary: Analysis of intratumoral microbiota in patients with esophageal cancer reveals a microbiota signature that is associated with chemoimmunotherapy response, showing that Streptococcus stimulates CD8+ T-cell infiltration and induces a favorable response. These findings suggest the potential clinical utility of intratumoral microbiota for cancer immunotherapy.
Article
Medicine, Research & Experimental
Youngran Park, Jin-Gyoung Jung, Zheng-Cheng Yu, Ryoichi Asaka, Wenjing Shen, Yeh Wang, Wei-Hung Jung, Alicja Tomaszewski, Geoff Shimberg, Yun Chen, Vamsi Parimi, Stephanie Gaillard, Ie-Ming Shih, Tian-Li Wang
Summary: The study introduces a new human endometrial epithelial cell line, hEM3, which is non-transformed, capable of stable in vitro growth, and can serve as a model for studying the pathogenesis of endometrium-related diseases.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Minfeng Yang, Arpan Mahanty, Chunjing Jin, Alex Ngai Nick Wong, Jung Sun Yoo
Summary: This study established a label-free metabolic intravital imaging technique using two coenzymes as robust imaging markers to monitor metabolic responses to immunotherapy. The results demonstrated the sensitive monitoring capability of the imaging technique for therapeutic response and the ability to differentiate cancer cells and immunosuppressive cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Yufang Hou, Rixin Zhang, Jinbao Zong, Weiqi Wang, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Min Yang
Summary: In this study, a cancer-immunity cycle-based signature was developed to predict the prognosis and efficacy of immunotherapy for colorectal cancer patients. Low-risk patients showed better prognosis and stronger response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Zuobing Chen, Canping Chen, Lin Li, Tianfang Zhang, Xiaosheng Wang
Summary: Mutations in the E1A binding protein p300 (EP300) are associated with higher tumor mutation burden and antitumor immune activity in various cancer types. This indicates a potential favorable response to immune checkpoint inhibitors in EP300-mutated cancers, making EP300 mutation a potential predictive biomarker for immunotherapy response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Si-Yu Wu, Yi Xiao, Jin-Li Wei, Xiao-En Xu, Xi Jin, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: This study identified two distinct microenvironment phenotypes, 'inflamed' and 'non-inflamed', within the classic basal-like subtype of TNBC, and revealed that MYC amplification and overexpression led to the formation of the non-inflamed TIME. Combination therapy with a DNA methyltransferase inhibitor and immunotherapy reversed T cell exhaustion and improved T cell function, resulting in potent antitumor activity in MYC-overexpressing TNBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemical Research Methods
Mingyi Ju, Jia Bi, Qian Wei, Longyang Jiang, Qiutong Guan, Ming Zhang, Xinyue Song, Ting Chen, Jingyi Fan, Xiaojuan Li, Minjie Wei, Lin Zhao
Summary: This study conducted a pan-cancer analysis of NLRP3-inflammasome-related genes across 24 human cancers, revealing the potential prognostic and therapeutic value of NLRP3 inflammasome in various cancer types. It was found that NLRP3 inflammasome may influence tumor immunity and serve as a stronger predictor for immune signatures compared to tumor mutation burden and glycolytic activity. The study also highlighted the predictive value of NLRP3 inflammasome for cancer immunotherapy response in diverse cancers.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Tong Fu, Lei-Jie Dai, Song-Yang Wu, Yi Xiao, Ding Ma, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: Tumors are not only collections of malignant cells, but also organized complex ecosystems. With the emergence of innovative technologies, researchers can more accurately understand the spatial architecture of the tumor immune microenvironment (TIME), improving our knowledge of tumor biology. The spatial architecture of TIME plays a crucial role in tumor biology and is influenced by the gradient of extracellular nonspecific chemicals (ENSCs).
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Syrine Abdeljaoued, Sara Arfa, Marie Kroemer, Myriam Ben Khelil, Angelique Vienot, Bruno Heyd, Romain Loyon, Alexandre Doussot, Christophe Borg
Summary: Tissue-resident memory T (T-RM) cells are immune cells that patrol the tissue microenvironment and coordinate anti-tumor immune responses. Recent studies have shown that these cells play a crucial role in cancer immunosurveillance and are associated with positive responses to immunotherapy and better clinical outcomes in cancer patients. This review provides an overview of the advances and recent findings in the phenotype, transcriptional and epigenetic regulation of T-RM cells in cancer, with a focus on gastrointestinal tumors. The clinical implications of T-RM cells in these types of tumors are also highlighted.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Chunhong Zheng, Joseph N. Fass, Yi-Ping Shih, Andrew J. Gunderson, Nelson Sanjuan Silva, Huayu Huang, Brady M. Bernard, Venkatesh Rajamanickam, Joseph Slagel, Carlo B. Bifulco, Brian Piening, Pippa H. A. Newell, Paul D. Hansen, Eric Tran
Summary: In this study, tumor-infiltrating lymphocytes from bile duct and pancreatic cancer patients were examined using immunological screening and single-cell RNA sequencing. The researchers found that neoantigen-reactive T cells infiltrating gastrointestinal cancers exhibited an exhausted state and had distinct transcriptomic signatures, which could potentially be utilized for therapy.
Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Iman M. Talaat, Noha Mousaad Elemam, Maha Saber-Ayad
Summary: Colorectal cancer is the third most common malignant tumor globally, and the complement system of the immune system plays a significant role in combating cancer. This review discusses complement system activation in CRC and its interactions with TME components, providing a framework for further understanding the potential therapies targeting complement activation in solid tumors such as CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Zhuoying Tian, Yue Zeng, Yurong Peng, Junqi Liu, Fang Wu
Summary: Activation of the cGAS-STING pathway by cytoplasmic DNA leads to the production of Type-1 interferons, which play a critical role in cancer-immunity cycle. Research has shown that combination therapy of STING agonists has made progress in preclinical and clinical trials, but selecting appropriate combination therapy regimens remains a challenge.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Mengyuan Li, Zhilan Zhang, Wenxiu Cao, Yijing Liu, Beibei Du, Canping Chen, Qian Liu, Md Nazim Uddin, Shanmei Jiang, Cai Chen, Yue Zhang, Xiaosheng Wang
Summary: The study found that factors such as economic inequality, blood type, disease prevalence, and nutrient intake are closely related to the risk and transmission of COVID-19. High temperature has a more significant effect on reducing COVID-19 transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Virology
Mengyuan Li, Xiaonan Guo, Xiaosheng Wang
Summary: This study used SEIR models to predict the epidemic characteristics of COVID-19 in Wuhan at four different phases, showing that intensive intervention measures can effectively reduce the infection rate and reproduction numbers of the virus, and the predicted trend by the models closely matched the actual epidemic trend.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Letter
Public, Environmental & Occupational Health
W. Cao, C. Chen, M. Li, R. Nie, Q. Lu, D. Song, S. Li, T. Yang, Y. Liu, B. Du, X. Wang
Article
Oncology
Zhixian Liu, Zehang Jiang, Nan Wu, Guoren Zhou, Xiaosheng Wang
Summary: By analyzing immune-related genes, we identified two distinct subtypes of gastric cancer, with differences in immune activity, tumor characteristics, and survival outcomes. This classification may have clinical implications for selecting immunotherapy for gastric cancer patients.
TRANSLATIONAL ONCOLOGY
(2021)
Editorial Material
Oncology
Xiao-Sheng Wang
Summary: ACE2, a host cell receptor for SARS-CoV-2, is associated with cancer and may play a protective role in cancer progression, as well as being correlated with PD-L1 in cancer. Its positive expression is a positive predictor for the response to immune checkpoint inhibitors (ICIs).
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Biochemical Research Methods
Lin Li, Canping Chen, Xiaosheng Wang
Summary: The DITHER algorithm defines intratumor heterogeneity (ITH) levels by evaluating entropy values within tumors, showing strong correlations with tumor progression, unfavorable phenotype, genomic instability, and immune evasion. Compared to other ITH evaluation methods, DITHER has more prominent characteristics and its scores are positively correlated with tumor purity.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Virology
Jiali Lei, Mengyuan Li, Xiaosheng Wang
Summary: This study predicted the development trend of the second wave of COVID-19 in five European countries, including peak times and numbers of cases and deaths. The results showed that the second wave of COVID-19 is expected to have more cases and deaths, last longer, but with a lower mortality rate.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xuan Han, Qin Wei, Yan Lv, Ling Weng, Haoying Huang, Qingyun Wei, Mengyuan Li, Yujie Mao, Di Hua, Xueting Cai, Meng Cao, Peng Cao
Summary: This study explores a combinatorial strategy using GDNPs and PD-1 mAb to improve the efficacy of immune checkpoint inhibitor therapy by altering the cold tumor microenvironment and inducing anti-tumor immune responses.
Article
Oncology
Lin Li, Xiaosheng Wang
Summary: Gastric cancer is highly heterogeneous, and researchers identified three subtypes (ImD, StE, and ImE) based on immune infiltration, DNA repair activity, genomic stability, and other factors. A prognostic model (IDOScore) was developed, which showed correlation with immunotherapy response and could potentially impact the management of GC.
NPJ PRECISION ONCOLOGY
(2021)
Article
Immunology
Yili Zhang, Xinyi Huang, Kai Sun, Mengyuan Li, Xu Wang, Tao Han, Hao Shen, Baoyu Qi, Yanming Xie, Xu Wei
Summary: This study investigated the differences of several serum markers among populations with different bone mass and found that IGF-1 and leptin may be key biomarkers associated with postmenopausal osteoporosis (PMOP). The findings suggest that these cytokines have the potential to be useful screening tests for PMOP diagnosis and clinical follow-up.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Correction
Biology
Mengyuan Li, Zhilan Zhang, Lin Li, Xiaosheng Wang
COMMUNICATIONS BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen, Peng Cao
Summary: A novel therapy for EGFR-mutant NSCLC, using kiwi-derived extracellular vesicles (KEVs) loaded with STAT3 interfering RNA (siSTAT3), has been developed. These KEVs showed enhanced safety compared to cationic liposomes and displayed excellent stability, high specificity, and good cytotoxicity towards EGFR over-expressing and mutant cancer cells. Systemic administration of these KEVs significantly suppressed tumor growth in mice.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Chunwang Zhou, Mengyuan Li, Yingxin Chu, Liyan Zheng, Shubo Zhang, Xiujiang Gao, Ping Gao
Summary: This study aimed to investigate the effects of stellate ganglion block (SGB) on cerebral ischemia-reperfusion (I/R) injury. The results showed that SGB inhibited ferroptosis of hippocampal neurons via activating the Hippo pathway, thereby alleviating I/R injury. These findings provide a new insight into the treatment of ischemic stroke and other ischemic encephalopathies.
METABOLIC BRAIN DISEASE
(2023)
Article
Immunology
Mengyuan Li, Xuejiao Gao, Xiaosheng Wang
Summary: By analyzing multi-omics datasets, we identified molecular and clinical features associated with tumor mutation burden (TMB), which could serve as valuable predictors for TMB and immunotherapy response, with potential clinical implications for cancer management.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Mengyuan Li, Haipeng Huang, Lin Yao, Hongmei Yang, Shiqi Ma, Haizhu Zheng, Zhen Zhong, Shuo Yu, Bin Yu, Hongfeng Wang
Summary: This study analyzed and summarized the effects of acupuncture on the modulation of specific patterns of brain region activity changes in migraine patients, providing a mechanism for treating migraine by acupuncture. The results showed that acupuncture treatment helps improve pain symptoms in patients with migraine, with hyperactivation in the left angular gyrus and hypoactivation in the left superior frontal gyrus and right superior frontal gyrus. The migraine group also showed hyperactivation in the corpus callosum compared to healthy controls.
FRONTIERS IN NEUROLOGY
(2023)