Article
Nutrition & Dietetics
Juan C. Pardo, Vicenc Ruiz de Porras, Joan Gil, Albert Font, Manel Puig-Domingo, Mireia Jorda
Summary: Prostate cancer is the most commonly diagnosed male malignancy in the Western world. Metabolic reprogramming and epigenetic remodeling play important roles in the progression and therapy resistance of prostate cancer, and there is crosstalk between metabolism and epigenetics. A high-fat diet has been associated with prostate cancer progression. Understanding these alterations and mechanisms can help identify prognostic and predictive biomarkers, as well as targetable vulnerabilities.
Review
Cell Biology
Dipanwita Das, Nandini Karthik, Reshma Taneja
Summary: Inflammation is a crucial immune response against infection and tissue damage, but chronic inflammation is linked to cancer development. Immune cells produce inflammatory mediators to facilitate tumor growth, while aberrant expression of inflammatory factors by tumor cells recruits immune cells for mutual crosstalk, creating a conducive environment for tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Tongxin Ge, Xiang Gu, Renbing Jia, Shengfang Ge, Peiwei Chai, Ai Zhuang, Xianqun Fan
Summary: Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic homeostasis are prominent hallmarks of carcinogenesis. This review summarizes the interplay between metabolism and epigenetics in cancer, highlighting their reciprocal modulation and potential therapeutic opportunities.
CANCER COMMUNICATIONS
(2022)
Review
Cell Biology
Yu'e Liu, Chao Chen, Xinye Wang, Yihong Sun, Jin Zhang, Juxiang Chen, Yufeng Shi
Summary: Mitochondria play a crucial role in both energy supply and regulation of key metabolites involved in epigenetic regulation. Tumorigenesis is influenced by gene mutations and the tumor microenvironment, with mitochondria and epigenetics being essential for tumor initiation, evolution, metastasis, and recurrence. Targeting mitochondrial metabolism and epigenetics holds promise for cancer treatment.
Review
Pharmacology & Pharmacy
Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Summary: Colorectal cancer is characterized by metabolic reprogramming, which plays a crucial role in promoting tumor progression by modulating core metabolic pathways. Activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming, with protein kinases serving as integral components in facilitating interactions between signaling pathways and metabolic pathways in CRC.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Hera Wong, Ryohichi Sugimura
Summary: Haematological malignancies are a diverse group of cancers that can occur at any stage of hematopoiesis. Chronic inflammation induced by inflammatory cytokines activates signaling pathways in malignant cells, leading to cancer stem cell phenotypes and disease progression. Studying the molecular mechanisms of immune cell interaction with malignant cells could provide new avenues for targeted therapies for haematological malignancies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Review
Oncology
Zhi-Man Zhu, Fu-Chun Huo, Jian Zhang, Hong-Jian Shan, Dong-Sheng Pei
Summary: The crosstalk between m6A modification and alternative splicing plays crucial biological roles in tumorigenesis. Understanding the regulation of alternative splicing by m6A modification contributes to the development of tumor therapy strategies.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Zhi-Man Zhu, Fu-Chun Huo, Jian Zhang, Hong-Jian Shan, Dong-Sheng Pei
Summary: N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes, and it significantly influences various aspects of RNA metabolism. Pre-mRNA alternative splicing, a process that generates multiple splice isoforms, contributes to protein diversity in mammals. There is crosstalk between m6A modification and alternative splicing, where m6A modifications on pre-mRNAs regulate alternative splicing patterns by recruiting specific RNA-binding proteins or directly influencing the interaction between proteins and RNAs. Alternative splicing can also impact the deposition or recognition of m6A modification on mRNAs.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yuan Wu, Xu Li, Qiong Li, Chienshan Cheng, Lan Zheng
Summary: The review examines mechanistic evidence for the connection between obesity and breast cancer, exploring the factors that promote tumor development or metastasis. It highlights the role of adipokines, metabolic pathways, inflammatory microenvironment, adipose stem cells, and miRNAs in breast cancer progression. The review also discusses possible therapeutic directions and the risks associated with autologous breast remodeling and fat transplantation. Furthermore, it explores the causes of the obesity paradox and the impact of enhanced immunity. Evaluating the balance between inflammation and immunity in obesity-induced breast cancer warrants further investigation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Oncology
Teresa Gagliano, Claudio Brancolini
Summary: This review article delves into the communication between cancer cells and non-cancerous cells, focusing on the role of epigenetics in cell-cell interactions. Studies suggest that epigenetic regulations are closely linked to tumor-stroma interactions, which could be crucial for future cancer therapy design.
Article
Biochemistry & Molecular Biology
Jingwen Jiang, Liyuan Peng, Kui Wang, Canhua Huang
Summary: Metabolic reprogramming in cancer cells leads to altered functions of metabolic enzymes, including the regulation of epigenetic modifications, gene transcription, post-translational modifications, and cellular antioxidant capacity. Understanding the noncanonical functions of metabolic enzymes, especially in response to redox manipulation, is crucial for clarifying the connection between metabolism and redox processes, and exploring novel therapeutic strategies for cancer treatment.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Oncology
Suman Mohajan, Praveen Kumar Jaiswal, Mousa Vatanmakarian, Hassan Yousefi, Saikolappan Sankaralingam, Suresh K. Alahari, Sweaty Koul, Hari K. Koul
Summary: The Hippo pathway serves as a master regulator of various cellular processes and its deregulation is associated with cancer. Despite the importance, the detailed functions of the components of the mammalian Hippo pathway in tumor biology are still unclear.
Article
Cell Biology
Olivia A. Maguire, Sarah E. Ackerman, Sarah K. Szwed, Aarthi V. Maganti, Francois Marchildon, Xiaojing Huang, Daniel J. Kramer, Adriana Rosas-Villegas, Rebecca G. Gelfer, Lauren E. Turner, Victor Ceballos, Asal Hejazi, Bozena Samborska, Janane F. Rahbani, Christien B. Dykstra, Matthew G. Annis, Ji-Dung Luo, Thomas S. Carroll, Caroline S. Jiang, Andrew J. Dannenberg, Peter M. Siegel, Sarah A. Tersey, Raghavendra G. Mirmira, Lawrence Kazak, Paul Cohen
Summary: The study identified the key role of crosstalk between mammary adipocytes and neoplastic cells in promoting obesity-driven breast cancer progression. Glycine amidinotransferase (Gatm) in adipocytes and Acsbg1 in cancer cells were found to be crucial for this process.
Review
Biochemistry & Molecular Biology
Emanuela Di Gregorio, Gianmaria Miolo, Asia Saorin, Agostino Steffan, Giuseppe Corona
Summary: Cancer metabolism research has regained prominence, challenging the role of genetics in understanding cancer development; the discovery of oncometabolites has brought about a new paradigm of viewing cancer as a metabolic disease; the study of oncometabolites is pivotal in the development of new targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Andrea Palicelli, Martina Bonacini, Stefania Croci, Cristina Magi-Galluzzi, Sofia Canete-Portillo, Alcides Chaux, Alessandra Bisagni, Eleonora Zanetti, Dario De Biase, Beatrice Melli, Francesca Sanguedolce, Moira Ragazzi, Maria Paola Bonasoni, Alessandra Soriano, Stefano Ascani, Maurizio Zizzo, Carolina Castro Ruiz, Antonio De Leo, Guido Giordano, Matteo Landriscina, Giuseppe Carrieri, Luigi Cormio, Daniel M. Berney, Daniel Athanazio, Jatin Gandhi, Alberto Cavazza, Giacomo Santandrea, Alessandro Tafuni, Magda Zanelli
Summary: Immune checkpoint therapy targeting the PD-1-PD-L1 axis has shown promising results in treating immunologically ''hot'' tumors, with pembrolizumab demonstrating good therapeutic activity in selected prostate cancer patients. Analysis of PD-L1 expression in human prostate cancer samples revealed varying positivity rates across different histological subtypes, with different PD-L1 antibody clones showing differential expression patterns in tumor cells. Tumor heterogeneity, inter-institutional preanalytics, and variability in interpretation may lead to biases in results.
Review
Biochemistry & Molecular Biology
Andrea Palicelli, Stefania Croci, Alessandra Bisagni, Eleonora Zanetti, Dario De Biase, Beatrice Melli, Francesca Sanguedolce, Moira Ragazzi, Magda Zanelli, Alcides Chaux, Sofia Canete-Portillo, Maria Paola Bonasoni, Stefano Ascani, Antonio De Leo, Guido Giordano, Matteo Landriscina, Giuseppe Carrieri, Luigi Cormio, Jatin Gandhi, Davide Nicoli, Enrico Farnetti, Simonetta Piana, Alessandro Tafuni, Martina Bonacini
Summary: This study reviewed the potential correlations between PD-L1 and MMR/MSI/BRCA/PTEN statuses in prostate cancer and discussed several other relevant genes. The results showed that some patients can be treated with specific antibody drugs. Further research is needed to verify the efficacy of these treatment methods and the relationship with the related factors.
Article
Oncology
Giuseppina Bruno, Valeria Li Bergolis, Annamaria Piscazzi, Fabiana Crispo, Valentina Condelli, Pietro Zoppoli, Francesca Maddalena, Michele Pietrafesa, Guido Giordano, Danilo Swann Matassa, Franca Esposito, Matteo Landriscina
Summary: The study reveals the role of the TRAP1 gene in the adaptive response of human colorectal cancer cells to hypoxia. TRAP1 is involved in regulating HIF-1α stabilization, glycolytic metabolism, and gene expression reprogramming. It also affects glucose uptake, lactate production, and ribosome biogenesis through the mTOR pathway.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Annamaria Piscazzi, Valentina Condelli, Fabiana Crispo, Anna Rita Daniela Coda, Giovanni Calice, Giuseppina Bruno, Santina Venuto, Daniele Tibullo, Guido Giordano, Michele Pietrafesa, Arcangelo Liso, Matteo Landriscina
Summary: IGFBP6 downregulation is associated with the progression of ovarian cancer and the development of platinum resistance.
Article
Oncology
Francesca Pia Caruso, Mario Rosario D'Andrea, Luigi Coppola, Matteo Landriscina, Valentina Condelli, Luigi Cerulo, Guido Giordano, Almudena Porras, Massimo Pancione
Summary: This study found that the regulation mechanism of the Lymphocyte antigen-6 (Ly6) gene family is associated with the development and prognosis of colorectal cancer. Specifically, the expression of Ly6G6D is correlated with tumor differentiation and DNA methylation levels, with p38 alpha MAPK and DNMT1 playing important roles. These findings provide potential clinical applications for the diagnosis and treatment of colorectal cancer.
CANCER CELL INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Francesca Sanguedolce, Magda Zanelli, Andrea Palicelli, Stefano Ascani, Maurizio Zizzo, Giorgia Cocco, Lars Bjornebo, Anna Lantz, Matteo Landriscina, Vincenza Conteduca, Ugo Giovanni Falagario, Luigi Cormio, Giuseppe Carrieri
Summary: A consensus classification has been developed for molecular stratification of bladder cancer (BC), which includes a six-cluster scheme. Immunohistochemistry (IHC) has been explored as a potential method for risk stratification and has shown promising results in different clinical settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Francesca Sanguedolce, Magda Zanelli, Andrea Palicelli, Alberto Cavazza, Loredana DE Marco, Maurizio Zizzo, Stefano Ascani, Matteo Landriscina, Guido Giordano, Francesco Sollitto, Domenico Loizzi
Summary: This review analyzes the main features and issues of the latest WHO classifications of NENs of the lung and the digestive system in order to point out the strengths and limitations of our current understanding of these complex diseases.
Article
Oncology
Alessandro Parisi, Riccardo Giampieri, Alex Mammarella, Cristiano Felicetti, Lisa Salvatore, Maria Bensi, Maria Grazia Maratta, Antonia Strippoli, Roberto Filippi, Maria Antonietta Satolli, Angelica Petrillo, Bruno Daniele, Michele De Tursi, Pietro Di Marino, Guido Giordano, Matteo Landriscina, Pasquale Vitale, Ina Valeria Zurlo, Emanuela Dell'Aquila, Silverio Tomao, Ilaria Depetris, Francesca Romana Di Pietro, Federica Zoratto, Davide Ciardiello, Maria Vittoria Pensieri, Ornella Garrone, Barbara Galassi, Claudio Ferri, Rossana Berardi, Michele Ghidini
Summary: This study aimed to investigate the impact of primary and secondary chemotherapy-induced nausea and vomiting (CINV) prophylaxis with NK1 receptor antagonists (NK1-RA) in patients with gastrointestinal malignancies. The results showed that primary NK1-RA use reduced nausea and the need for rescue antiemetic therapy, and increased the rates of complete antiemetic response and complete antiemetic protection during chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Criscuolo, Rosario Avolio, Matteo Parri, Simona Romano, Paola Chiarugi, Danilo Swann Matassa, Franca Esposito
Summary: The study found that cisplatin treatment may cause metabolic remodeling in ovarian cancer cells, leading to reduced levels of reduced glutathione (GSH) and decreased sensitivity to oxidative stress. Additionally, levels of enzymes involved in GSH synthesis were reduced, while expression of thioredoxin reductase increased. In patients with HGSOC, the expression of the cysteine-glutamate antiporter xCT, which is crucial for GSH synthesis, directly correlated with post-progression survival and was significantly reduced in patients not responding to platinum-based therapy.
Review
Biochemistry & Molecular Biology
Augusto Leone, Antonio Colamaria, Nicola Pio Fochi, Matteo Sacco, Matteo Landriscina, Giovanni Parbonetti, Matteo de Notaris, Giulia Coppola, Elena De Santis, Guido Giordano, Francesco Carbone
Summary: The current treatment guidelines for recurrent glioblastoma are still uncertain, and further research and clinical trials are needed to provide better treatment strategies. For patients who fail initial treatment and show signs of disease progression, clinicians need to consider the patient's medical history and molecular characteristics to develop personalized treatment plans.
Article
Oncology
Danilo Swann Matassa, Daniela Criscuolo, Rosario Avolio, Ilenia Agliarulo, Daniela Sarnataro, Consiglia Pacelli, Rosella Scrima, Alessandra Colamatteo, Giuseppe Matarese, Nazzareno Capitanio, Matteo Landriscina, Franca Esposito
Summary: This study investigates the role of TRAP1 in cancer cell metabolism and reveals that TRAP1 regulates the activity of complex III, thereby affecting oxidative phosphorylation in cancer cells. Additionally, the components of complex III are found to be correlated with the response to cancer therapy and survival rates, implying the potential of complex III as a therapeutic target.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Giuseppe Bronte, Vincenza Conteduca, Matteo Landriscina, Antonio Domenico Procopio
Summary: This meta-analysis demonstrates that high levels of circulating MDSCs are associated with worse overall survival in prostate cancer patients, supporting the importance of MDSC detection and targeting in this population.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Chemistry, Medicinal
Carmela Mazzoccoli, Fabiana Crispo, Ilaria Laurenzana, Michele Pietrafesa, Lorenza Sisinni, Rosa Lerose, Donatella Telesca, Maria R. Milella, Te Liu, Gerardo Della Sala, Jessica Sebastiani, Romano Silvestri, Giuseppe La Regina
Summary: This study investigates the molecular mechanisms of a new tubulin inhibitor, ARDAP, and finds that it can effectively treat solid tumors by inhibiting cell proliferation and metastasis, as well as promoting cell differentiation. ARDAP exhibits low toxicity towards breast cancer cells and no significant harm to healthy cells, making it a promising candidate for chemotherapy or adjuvant therapy.
ARCHIV DER PHARMAZIE
(2023)