Loss of USP18 in microglia induces white matter pathology

Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

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Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa

(2018) Thomas Blank et al.   Frontiers in Immunology

Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize

(2017) Sonya Bells et al.   JOURNAL OF NEUROSCIENCE

Improvement of olfactory function after sinus surgery correlates with white matter properties measured by diffusion tensor imaging

(2017) Daniel Güllmar et al.   NEUROSCIENCE

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature

(2016) D. Kavanagh et al.   BLOOD

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

(2016) Marije E.C. Meuwissen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

White matter and cognition: making the connection

(2016) Christopher M. Filley et al.   JOURNAL OF NEUROPHYSIOLOGY

Multiple functions of USP18

(2016) Nadine Honke et al.   Cell Death & Disease

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi–Goutières syndrome

(2013) Eloy Cuadrado et al.   BRAIN

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids

(2011) Rosa Rademakers et al.   NATURE GENETICS