Review
Endocrinology & Metabolism
Ziru Li, Clifford J. Rosen
Summary: Bone marrow adipose tissue (BMAT) is a significant component of the bone marrow space in healthy adults, but its expansion is associated with aging, obesity, anorexia nervosa, and irradiation. While traditionally viewed as a negative component, recent studies have revealed that BMAT can serve as an energy reservoir and also plays a role in regulating bone formation and hematopoiesis. This review summarizes the unique characteristics of BMAT and provides an updated understanding of its physiological roles based on a newly established mouse model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Michele Dello Spedale Venti, Biagio Palmisano, Samantha Donsante, Giorgia Farinacci, Flavia Adotti, Ilenia Coletta, Marta Serafini, Alessandro Corsi, Mara Riminucci
Summary: This study analyzed the morphological and immunophenotypic changes of bone marrow adipocytes (BMAds) in different types of bone marrow cancers. The results showed that BMAds were significantly reduced in both bone marrow metastasis and myeloproliferative neoplasia with grade-3 myelofibrosis, along with a decrease in cell diameter and area. Additionally, the expression of certain markers in BMAds differed in these two types of cancers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Parastoo Boroumand, David C. Prescott, Tapas Mukherjee, Philip J. Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y. Zhu, Zhi Liu, Clinton Robbins, Dana J. Philpott, Stephen E. Girardin, Amira Klip
Summary: During obesity and high fat-diet feeding, there is an increase in pro-inflammatory macrophages in adipose tissue as well as invasive Ly6C(high) monocytes produced by the bone marrow. This study explores the relationship between bone marrow adipocytes and Ly6C(high) monocytes, and finds that the whitening of bone marrow adipocytes precedes the rise of adipose tissue macrophages during high fat-diet feeding in mice. Ex vivo treatment of bone marrow cells with conditioned media from bone marrow adipocytes or white adipocytes also favors the presence of Ly6C(high) monocytes. Furthermore, there is a metabolic reprogramming and mitochondrial fission in monocytes before the shift towards Ly6C(high) phenotype.
Article
Cell Biology
Stephanie W. Tobin, Faisal J. Alibhai, Lukasz Wlodarek, Azadeh Yeganeh, Sean Millar, Jun Wu, Shu-hong Li, Richard D. Weisel, Ren-Ke Li
Summary: This study found that aged mice have higher baseline inflammation and fewer satellite cells in muscles compared to young mice. After muscle injury, old mice exhibited a muted inflammatory response but increased recruitment of M2 macrophages and IL-10 expression. Reconstitution with young cells partially restored immune responses of old mice to a more youthful state, leading to increased satellite cell proliferation.
Article
Endocrinology & Metabolism
Jean-Guillaume Letarouilly, Julien Paccou, Sammy Badr, Christophe Chauveau, Odile Broux, Aline Clabaut
Summary: This study found that Tofa has a stimulatory effect on the commitment and differentiation of bone marrow adipocytes, but its effect on bone is not positive.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Lipeng Wang, Hao Zhang, Sicheng Wang, Xiao Chen, Jiacan Su
Summary: BMAs, as a type of bone marrow adipocytes, play significant roles in hematopoiesis, osteogenesis, and immune regulation, and represent a novel target for the treatment of bone marrow-related diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and lower BV/TV. The new BMA parameter Ad.N/BS is correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Vicente F. C. Andrade, Debora Besen, Domingos C. Chula, Victoria Z. C. Borba, David Dempster, Carolina Aguiar Moreira
Summary: This study found that poor glycemic control is associated with hyperplasia and hypertrophy of BMAs and with lower BV/TV. A new BMA parameter, Ad.N/BS, is positively correlated with HbA1c and negatively with O.Th. The use of insulin seems to stimulate the expansion of BMA while that of metformin has the opposite effect.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Jayna J. Mistry, Charlotte Hellmich, Jamie A. Moore, Aisha Jibril, Iain Macaulay, Mar Moreno-Gonzalez, Federica Di Palma, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth
Summary: Infections trigger the rapid expansion of hematopoietic stem cells (HSCs) by promoting the uptake of long-chain free fatty acids via CD36, supporting a metabolic switch from glycolysis to beta-oxidation that is essential for a protective response to bacterial infection.
NATURE COMMUNICATIONS
(2021)
Review
Endocrinology & Metabolism
Meshail Okla, Moustapha Kassem
Summary: Bone marrow adipose tissue (MAT) is a unique fat depot near bone surfaces that regulates skeletal function. Recent studies show that MAT responds to changes in energy metabolism, leading to potential detrimental effects on bone health. Understanding the thermogenic potential of MAT could improve bone health and overall energy metabolism.
Article
Hematology
Clinton C. Mason, Carme R. Fiol, Monika J. Baker, Elisabet Nadal-Melsio, Eva Yebra-Fernandez, Luciana Bicalho, Avirup Chowdhury, Michael Albert, Alistair G. Reid, Simone Claudiani, Jane F. Apperley, Jamshid S. Khorashad
Summary: The study identified genes in the NOX family as potential candidates for therapeutic development in AML, with NOX1 showing consistent knockdown effectiveness impacting leukemia cell survival, and further investigation highlighting NOX2 as another member with clear knockdown efficacy.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Ji Yeon Lee, Jae-Yeon Yang, Sang Wan Kim
Summary: Lineage-tracing studies have shown that parathyroid hormone and anti-sclerostin antibody can convert bone lining cells into active osteoblasts, while these cells may also differentiate into bone marrow adipocytes. Rosiglitazone can stimulate this differentiation process, but Scl-Ab administration may suppress it, contributing to anabolic effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yegor E. Yegorov, Anastasia Poznyak, Evgeny E. Bezsonov, Alexander D. Zhuravlev, Nikita G. Nikiforov, Khava S. Vishnyakova, Alexander N. Orekhov
Summary: The development of chronic inflammation is associated with aging, and senescent cells contribute to maintaining inflammation. Anti-aging drugs can improve inflammation and promote rejuvenation. The immune system cells play a role in inflammation, and mutations in these cells accumulate with age. These mutations may lead to the appearance of naive cells with a pro-inflammatory phenotype, contributing to chronic inflammation. Monocytes carrying mitochondrial mutations may be responsible for comorbidity and worsening prognosis in aging-related pathologies.
Review
Endocrinology & Metabolism
F. Salamanna, D. Contartese, C. Errani, M. Sartori, V. Borsari, G. Giavaresi
Summary: This review systematically evaluates the role of bone marrow adipocytes (BMAs) in the development and progression of bone metastasis. Preclinical studies suggest that BMAs may play a crucial role in bone metastasis in prostate, breast, and malignant melanoma cancers. However, further preclinical and clinical studies are needed to better understand the role of BMAs.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Luca Pangrazzi, Juergen Reidla, Jose Antonio Carmona Arana, Erin Naismith, Carina Miggitsch, Andreas Meryk, Michael Keller, Adelheid Alma Nora Krause, Franz Leonard Melzer, Klemens Trieb, Michael Schirmer, Beatrix Grubeck-Loebenstein, Birgit Weinberger
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Oncology
Finn Mildner, Sieghart Sopper, Arno Amann, Andreas Pircher, Georg Pall, Stefan Koeck, Erin Naismith, Dominik Wolf, Gabriele Gamerith
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Luca Pangrazzi, Luigi Balasco, Yuri Bozzi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Geriatrics & Gerontology
Markus Mandl, Sonja A. Wagner, Florian M. Hatzmann, Asim Ejaz, Heike Ritthammer, Saphira Baumgarten, Hans P. Viertler, Jochen Springer, Marit E. Zwierzina, Monika Mattesich, Camille Brucker, Petra Waldegger, Gerhard Pierer, Werner Zwerschke
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Luca Pangrazzi, Erin Naismith, Carina Miggitsch, Jose' Antonio Carmona Arana, Michael Keller, Beatrix Grubeck-Loebenstein, Birgit Weinberger
Review
Geriatrics & Gerontology
Luca Pangrazzi, Birgit Weinberger
EXPERIMENTAL GERONTOLOGY
(2020)
Editorial Material
Geriatrics & Gerontology
Werner Zwerschke
EXPERIMENTAL GERONTOLOGY
(2020)
Review
Cell Biology
Sophia Daum, Hannes Hagen, Erin Naismith, Dominik Wolf, Andreas Pircher
Summary: Tumor progression relies heavily on vascular supply, with inhibition of angiogenesis being a promising therapeutic strategy. Recent advancements in single cell RNA sequencing and preclinical observations allow for detailed characterization of the tumor microenvironment in NSCLC, leading to the identification of new aspects for personalized inhibition of angiogenesis. The tumor vasculature consists of various cellular subtypes that interact closely with other components of the tumor microenvironment, providing insight for the development of more targeted combinational therapies in NSCLC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andreas Meryk, Marco Grasse, Luigi Balasco, Werner Kapferer, Beatrix Grubeck-Loebenstein, Luca Pangrazzi
Review
Biochemistry & Molecular Biology
Luca Pangrazzi, Luigi Balasco, Yuri Bozzi
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Alessandra Georgette Ciancone Chama, Evgenia Shlosman, Lorenzo Mattioni, Alberto Galbusera, Giuliano Iurilli, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Abnormal tactile response is a common feature in Autism Spectrum Disorders (ASDs), and patients with Phelan-McDermid syndrome (PMS) also exhibit similar tactile response abnormalities. This study investigated the neural substrates involved in whisker-guided behaviors in Shank3b(-/-) mice, which showed deficits in texture discrimination and low responsiveness to repetitive whisker stimulation. Reduced activation in the primary somatosensory cortex (S1) and hippocampus was observed, suggesting impaired sensory processing. Resting-state fMRI further revealed decreased connectivity between S1 and the hippocampus, potentially impairing whisker-dependent cues recognition.
Article
Immunology
Luca Pangrazzi, Sacha Genovesi, Luigi Balasco, Enrica Cerilli, Camilla Robol, Giulia Zunino, Silvano Piazza, Giovanni Provenzano, Yuri Bozzi
Summary: This study investigates the association between immune dysfunction and cerebellar defects in autism spectrum disorder. The cerebellar transcriptome of En2(-/-) mice shows over-representation of biological processes related to immune function, while pro-inflammatory molecules are reduced in the cerebellum and increased in the peripheral blood of mutant mice.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Neurosciences
Gabriele Chelini, Luca Pangrazzi, Yuri Bozzi
Summary: Postnatal development of the brain is characterized by sensitive periods during which life experiences reshape local circuitry. These periods provide an opportunity for adaptive fine-tuning, but also increase vulnerability for the development of disorders. Adverse childhood experiences are recognized as a major risk factor for various medical conditions. Research on rodents has revealed the interaction between critical periods and early-life experiences, offering insights into brain disorders.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Luigi Balasco, Marco Pagani, Luca Pangrazzi, Gabriele Chelini, Francesca Viscido, Alessandra Georgette Ciancone Chama, Alberto Galbusera, Giovanni Provenzano, Alessandro Gozzi, Yuri Bozzi
Summary: Sensory abnormalities are common in individuals with autism spectrum disorders (ASDs). A study found that mice lacking the ASD-associated gene Cntnap2 display altered somatosensory processing and deficits related to core symptoms of ASDs. The study suggests that these mice can serve as a reliable model to study sensory abnormalities in ASDs.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Endocrinology & Metabolism
Markus Mandl, Heike Ritthammer, Asim Ejaz, Sonja A. Wagner, Florian M. Hatzmann, Saphira Baumgarten, Hans P. Viertler, Marit E. Zwierzina, Monika Mattesich, Valerie Schiller, Tina Rauchenwald, Christian Ploner, Petra Waldegger, Gerhard Pierer, Werner Zwerschke