Article
Cell Biology
Shuwei Xie, Carter Dierlam, Ellie Smith, Ramon Duran, Allana Williams, Angelina Davis, Danita Mathew, Naava Naslavsky, Jyoti Iyer, Steve Caplan
Summary: Through studying worms and mammalian cells, we have discovered that retromer plays a crucial role in development and ciliogenesis, particularly in the removal of CP110.
JOURNAL OF CELL SCIENCE
(2022)
Article
Cell Biology
Julian M. Carosi, Leanne K. Hein, Jarrod J. Sandow, Linh V. P. Dang, Kathryn Hattersley, Donna Denton, Sharad Kumar, Timothy J. Sargeant
Summary: The study reveals that the abundance of retromer+ endosomes is controlled by MTORC1 through autophagy inhibition. Activation of autophagy does not affect retromer assembly or interaction with TBC1D5, but targets these endosomes for bulk destruction following their capture by phagophores. TBC1D5's binding ability to retromer is critical for its capture by autophagosomes following MTOR inhibition.
Article
Biochemistry & Molecular Biology
Yang Zhao, Fulei Tang, Daehoon Lee, Wen-Cheng Xiong
Summary: The study demonstrates that low levels of VPS35-mCherry fusion protein expression in neonatal mice can alleviate neurodegenerative phenotypes and restore the quantity of other retromer components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Junxian Yu, Haoran Feng, Qingqing Sang, Fangyuan Li, Mengdi Chen, Beiqin Yu, Zhuoqing Xu, Tao Pan, Xiongyan Wu, Junyi Hou, Zhenggang Zhu, Chao Yan, Liping Su, Jianfang Li, Bingya Liu
Summary: The expression of VPS35 is upregulated in gastric cancer patients and is correlated with tumor invasion and poor prognosis. VPS35 promotes cell proliferation by recycling EGFR to the cell surface and increases tumor growth. High expression of VPS35 also increases the sensitivity of gastric cancer to EGFR inhibitors.
Article
Biochemistry & Molecular Biology
Julian M. Carosi, Donna Denton, Sharad Kumar, Timothy J. Sargeant
Summary: The retromer complex regulates the fate of receptors in the endolysosomal system and plays a central role in metabolic processes. This review focuses on the assembly of retromer components and how it interacts with endosomal membranes to sort cargo receptors. The article also explores the regulation of retromer in different metabolic states and its involvement in various diseases and microbial infections.
MOLECULAR AND CELLULAR BIOLOGY
(2023)
Article
Immunology
Xiao Ren, Lingling Yao, YongGang Wang, Lin Mei, Wen-Cheng Xiong
Summary: This study found that microglial VPS35 deficiency contributes to the development of Alzheimer's disease in a mouse model. The deficiency leads to decreased learning and memory function, increased deposition of A-beta and activation of astrocytes. The study also revealed the importance of microglial VPS35 in the development of disease-associated microglia (DAM) and the uptake of A-beta.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Lisa Marquardt, Matthew Taylor, Florian Kramer, Kerstin Schmitt, Gerhard H. Braus, Oliver Valerius, Michael Thumm
Summary: The yeast PROPPIN Atg18 is a beta-propeller protein that binds to both phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P-2. It can induce membrane tubulation and fission through membrane insertion. Atg18 interacts with Vps35, a component of the retromer complex, and competes with sorting nexin proteins Vps5 and Vps17. Atg18-retromer is involved in vacuolar fragmentation during hyperosmotic stress.
Article
Neurosciences
Alessia Filippone, Jian-Guo Li, Domenico Pratico
Summary: This study demonstrates that genetic manipulation of VPS35 affects intracellular degradation pathways, with downregulation of VPS35 leading to alterations in autophagy flux and intracellular accumulation of aggregates. Besides cargo sorting and trafficking, VPS35 plays a critical role as a regulator of intracellular degradation pathways by supporting the function of the retromer complex system.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Cell Biology
Jenny Sassone, Chiara Reale, Giovanna Dati, Maria Regoni, Maria Teresa Pellecchia, Barbara Garavaglia
Summary: Mutations in the VPS35 gene have been linked to late-onset familial Parkinson's disease, potentially affecting lysosomal and autophagy function, mitochondrial homeostasis, neurotransmission, and interacting with other genes associated with PD such as alpha-SYNUCLEIN, PARKIN, and LRRK2.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Sarah D. Neuman, Erica L. Terry, Jane E. Selegue, Amy T. Cavanagh, Arash Bashirullah
Summary: The research identifies the crucial role of the retromer complex in recycling secretory granule membrane proteins in Drosophila larval salivary glands, shedding light on secretory granule maturation and neurodegenerative diseases. This study provides new insights into the function of the retromer complex in secretory cells and suggests that missorting of secretory cargo might contribute to the progression of neurodegenerative diseases.
DISEASE MODELS & MECHANISMS
(2021)
Article
Neurosciences
Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore
Summary: The VPS35 gene mutation is associated with Parkinson's disease, but it is not related to α-synuclein. Overexpression of VPS35 does not protect against α-synuclein-induced neurodegeneration in mice models. The study suggests a limited interaction between VPS35 and α-synuclein in the pathogenesis of Parkinson's disease.
MOLECULAR NEURODEGENERATION
(2023)
Article
Virology
Puxian Fang, Huichang Zhang, Ting Cheng, Tong Ding, Sijin Xia, Wenwen Xiao, Zhuang Li, Shaobo Xiao, Liurong Fang
Summary: This study reveals the interaction between accessory protein NS6 of Porcine deltacoronavirus (PDCoV) and VPS35, a subunit of the retromer complex, which is critical for PDCoV infection and replication. Knockdown of VPS35 inhibits wild-type PDCoV infection, demonstrating the proviral function of VPS35. Depletion of VPS35 prevents retrograde transport of PDCoV NS6, leading to lysosomal degradation and inhibition of viral production.
JOURNAL OF VIROLOGY
(2023)
Article
Neurosciences
Erin T. Williams, Xi Chen, P. Anthony Otero, Darren J. Moore
Summary: Perturbations of the endolysosomal pathway, specifically involving VPS35 and the retromer complex, play an important role in the pathogenesis of Parkinson's disease and Alzheimer's disease. This review focuses on the impact of the PD-linked D620N mutation in causing retromer dysfunction and its implications in neurodegeneration. The association of VPS35 and the retromer with other neurodegenerative diseases is also discussed.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Alana N. Vagnozzi, Jian-Guo Li, Jin Chiu, Roshanak Razmpour, Rebecca Warfield, Servio H. Ramirez, Domenico Pratico
Summary: VPS35 plays a crucial role in tau metabolism and neuropathology, with its overexpression reducing pathological tau in neuronal cells while genetic silencing leads to accumulation. The availability of active cathepsin D mediates the effect of VPS35 on pathological tau accumulation, making it a potential therapeutic target for human tauopathies.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yi Liu, Haijun Deng, Li Liang, Guiji Zhang, Jie Xia, Keyue Ding, Ni Tang, Kai Wang
Summary: VPS35 enhances HCC metastasis by activating the Wnt/PCP signaling pathway and regulates the membrane sorting and trafficking of FZD2 and ROR1 in hepatoma cells to facilitate PCP pathway activation.
Article
Biochemical Research Methods
Sumana Srivatsa, Jack Kuipers, Fabian Schmich, Simone Eicher, Mario Emmenlauer, Christoph Dehio, Niko Beerenwinkel
Article
Cell Biology
Jaroslaw Sedzicki, Therese Tschon, Shyan Huey Low, Kevin Willemart, Kenneth N. Goldie, Jean-Jacques Letesson, Henning Stahlberg, Christoph Dehio
JOURNAL OF CELL SCIENCE
(2018)
Article
Multidisciplinary Sciences
Elodie Lobet, Kevin Willemart, Noelle Ninane, Catherine Demazy, Jaroslaw Sedzicki, Christophe Lelubre, Xavier De Bolle, Patricia Renard, Martine Raes, Christoph Dehio, Jean-Jacques Letesson, Thierry Arnould
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Neha Daga, Simone Eicher, Abhilash Kannan, Alain Casanova, Shyan H. Low, Saskia Kreibich, Daniel Andritschke, Mario Emmenlauer, Jeremy L. Jenkins, Wolf-Dietrich Hardt, Urs F. Greber, Christoph Dehio, Christian von Mering
NUCLEIC ACIDS RESEARCH
(2018)
Review
Cell Biology
Alexander Wagner, Christoph Dehio
CELLULAR MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Yansheng Liu, Yang Mi, Torsten Mueller, Saskia Kreibich, Evan G. Williams, Audrey Van Drogen, Christelle Borel, Max Franks, Pierre-Luc Germain, Isabell Bludau, Martin Mehnert, Michael Seifert, Mario Emmenlauer, Isabel Sorg, Fedor Bezrukov, Frederique Sloan Bena, Hu Zhou, Christoph Dehio, Giuseppe Testa, Julio Saez-Rodriguez, Stylianos E. Antonarakis, Wolf-Dietrich Hardt, Ruedi Aebersold
NATURE BIOTECHNOLOGY
(2019)
Article
Medicine, General & Internal
Olivier Cunrath, Dominik M. Meinel, Pauline Maturana, Joseph Fanous, Julien M. Buyck, Pamela Saint Auguste, Helena M. B. Seth-Smith, Jonas Koerner, Christoph Dehio, Vincent Trebosc, Christian Kemmer, Richard Neher, Adrian Egli, Dirk Bumann
Correction
Microbiology
Nathalie Q. Balaban, Sophie Helaine, Kim Lewis, Martin Ackermann, Bree Aldridge, Dan I. Andersson, Mark P. Brynildsen, Dirk Bumann, Andrew Camilli, James J. Collins, Christoph Dehio, Sarah Fortune, Jean-Marc Ghigo, Wolf-Dietrich Hardt, Alexander Harms, Matthias Heinemann, Deborah T. Hung, Urs Jenal, Bruce R. Levin, Jan Michiels, Gisela Storz, Man-Wah Tan, Tanel Tenson, Laurence Van Melderen, Annelies Zinkernagel
NATURE REVIEWS MICROBIOLOGY
(2019)
Review
Microbiology
Nathalie Q. Balaban, Sophie Helaine, Kim Lewis, Martin Ackermann, Bree Aldridge, Dan I. Andersson, Mark P. Brynildsen, Dirk Bumann, Andrew Camilli, James J. Collins, Christoph Dehio, Sarah Fortune, Jean-Marc Ghigo, Wolf-Dietrich Hardt, Alexander Harms, Matthias Heinemann, Deborah T. Hung, Urs Jenal, Bruce R. Levin, Jan Michiels, Gisela Storz, Man-Wah Tan, Tanel Tenson, Laurence Van Melderen, Annelies Zinkernagel
NATURE REVIEWS MICROBIOLOGY
(2019)
Review
Microbiology
Alexander Wagner, Colin Tittes, Christoph Dehio
FRONTIERS IN MICROBIOLOGY
(2019)
Review
Cell Biology
Maxime Quebatte, Christoph Dehio
CELLULAR MICROBIOLOGY
(2019)
Article
Biochemical Research Methods
Simon Dirmeier, Mario Emmenlauer, Christoph Dehio, Niko Beerenwinkel
BMC BIOINFORMATICS
(2019)
Article
Microbiology
Isabel Sorg, Christoph Schmutz, Yun-Yueh Lu, Katja Fromm, Lena K. Siewert, Alexandra Bogli, Kathrin Strack, Alexander Harms, Christoph Dehio
CELL HOST & MICROBE
(2020)
Review
Microbiology
Maxime Quebatte, Christoph Dehio
CURRENT OPINION IN MICROBIOLOGY
(2017)