Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data

(2015) Jörg Rahnenführer et al.   ARCHIVES OF TOXICOLOGY

Developing tools for defining and establishing pathways of toxicity

(2015) Melvin E. Andersen et al.   ARCHIVES OF TOXICOLOGY

MPTP’s Pathway of Toxicity Indicates Central Role of Transcription Factor SP1

(2015) Alexandra Maertens et al.   ARCHIVES OF TOXICOLOGY

TFAP2C expression in breast cancer: correlation with overall survival beyond 10 years of initial diagnosis

(2015) Susan M. Perkins et al.   BREAST CANCER RESEARCH AND TREATMENT

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

Mapping the Human Toxome by Systems Toxicology

(2014) Mounir Bouhifd et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Predictive Endocrine Testing in the 21st Century Using in Vitro Assays of Estrogen Receptor Signaling Responses

(2014) Daniel M. Rotroff et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis

(2014) A R Cyr et al.   ONCOGENE

On mapping the human toxome

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Look back in anger – what clinical studies tell us about preclinical work

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Pathways of Toxicity

(2014) Andre Kleensang et al.   ALTEX-Alternatives to Animal Experimentation

Reprogramming of non-genomic estrogen signaling by the stemness factor SOX2 enhances the tumor-initiating capacity of breast cancer cells

(2013) Alejandro Vazquez-Martin et al.   CELL CYCLE

A map of the PPARα transcription regulatory network for primary human hepatocytes

(2013) Patrick D. McMullen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interaction of E2F7 Transcription Factor with E2F1 and C-terminal-binding Protein (CtBP) Provides a Mechanism for E2F7-dependent Transcription Repression

(2013) Beiyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Estrogen Receptor α Signaling Regulates Breast Tumor-initiating Cells by Down-regulating miR-140 Which Targets the Transcription Factor SOX2

(2012) Yongshu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression

(2012) Laurie E. Littlepage et al.   Cancer Discovery

A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer

(2011) Changyu Shen et al.   BMC Systems Biology

Meta-analysis of estrogen response in MCF-7 distinguishes early target genes involved in signaling and cell proliferation from later target genes involved in cell cycle and DNA repair

(2011) Vidhya Jagannathan et al.   BMC Systems Biology

Prognostic and therapeutic impact of the chromosome 20q13.2 ZNF217 locus amplification in ovarian clear cell carcinoma

(2011) Mohammed Tanjimur Rahman et al.   CANCER

Sox2 expression in breast tumours and activation in breast cancer stem cells

(2011) O Leis et al.   ONCOGENE

E2F1 Regulates Cellular Growth by mTORC1 Signaling

(2011) Sebastian Real et al.   PLoS One

Genome-Wide Mapping of Estrogen Receptor-β–Binding Regions Reveals Extensive Cross-Talk with Transcription Factor Activator Protein-1

(2010) Chunyan Zhao et al.   CANCER RESEARCH

ZNF217 confers resistance to the pro-apoptotic signals of paclitaxel and aberrant expression of Aurora-A in breast cancer cells

(2010) Aurélie Thollet et al.   Molecular Cancer

Transcription factor regulation can be accurately predicted from the presence of target gene signatures in microarray gene expression data

(2010) Ahmed Essaghir et al.   NUCLEIC ACIDS RESEARCH

Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis

(2010) David L. M. van der Meer et al.   NUCLEIC ACIDS RESEARCH

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Repression of ESR1 through Actions of Estrogen Receptor Alpha and Sin3A at the Proximal Promoter

(2009) S. J. Ellison-Zelski et al.   MOLECULAR AND CELLULAR BIOLOGY

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Chemical regulators have overreached

(2009) Thomas Hartung et al.   NATURE

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

GEMS (Gene Expression Metasignatures), a Web Resource for Querying Meta-analysis of Expression Microarray Datasets: 17 -Estradiol in MCF-7 Cells

(2008) S. A. Ochsner et al.   CANCER RESEARCH

Estrogen Receptors α and β as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding

(2008) Edmund C. Chang et al.   MOLECULAR ENDOCRINOLOGY

Toxicity Testing in the 21st Century: Bringing the Vision to Life

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES