Article
Endocrinology & Metabolism
Anne-Sophie Pepin, Christine Lafleur, Romain Lambrot, Vanessa Dumeaux, Sarah Kimmins
Summary: The study reveals that paternal obesity can impact sperm H3K4me3, which is associated with placental, embryonic, and metabolic outcomes in descendants.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Timofey Lebedev, Rubina Kousar, Bbumba Patrick, Muhammad Usama, Meng-Kuei Lee, Ming Tan, Xing-Guo Li
Summary: Epigenetic remodeling and metabolic reprogramming are two highly intertwined cancer hallmarks. Recent studies have shown that the interplay between epigenetic regulation and metabolic rewiring can be targeted as a potential Achilles' heel in cancer. This review explores the immunomodulatory role of ARID1A and summarizes the advances in targeting ARID1A-deficient cancers to improve patient outcome by harnessing the immune-metabolic vulnerability.
Review
Biochemistry & Molecular Biology
Gioacchino Natoli, Francesco Pileri, Francesco Gualdrini, Serena Ghisletti
Summary: Macrophages respond to microbial and endogenous danger signals by activating various effector and homeostatic responses. This involves rapid changes in gene expression programs and metabolic rewiring, with chromatin modifications integrating transcriptional and metabolic regulation. The mutual influences between signal-induced metabolic changes and gene expression are not fully understood yet, and further research is needed to explore these interactions.
Review
Biochemistry & Molecular Biology
Zhengtao Xiao, Jason W. Locasale
Summary: Chromatin and associated epigenetic marks provide important platforms for gene regulation in response to metabolic changes associated with environmental exposures. Studies have shown that fluctuations of key metabolites can influence chromatin modifications, but their effects on chromatin structure are largely unknown.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
How-Wing Leung, Gabriel Wei Quan Foo, Antonius M. J. VanDongen
Summary: The immediate early gene Arc plays a crucial role in regulating synaptic function and memory consolidation. It interacts with dynamic chromatin and associates with histone markers for active enhancers and transcription in cultured rat hippocampal neurons. Upregulated histone modifications associated with late-onset Alzheimer's disease have been found. Altered expression profiles of over 1900 genes, including those involved in synaptic function, neuronal plasticity, excitability, and signaling pathways, were observed when Arc induction was prevented. About 100 Arc-dependent genes are implicated in the pathophysiology of Alzheimer's disease. The induction of endogenous Arc expression in HEK293T cells increased the transcription of neuronal genes, suggesting that Arc can control gene expression independently of activated signaling pathways. These findings establish Arc as a master regulator of activity-dependent gene expression in neurons and suggest its significance in Alzheimer's disease pathophysiology.
Article
Endocrinology & Metabolism
Sooyeon Lee, Haixia Xu, Aidan Van Vleck, Alex M. Mawla, Albert Mao Li, Jiangbin Ye, Mark O. Huising, Justin P. Annes
Summary: Mitochondrial dysfunction plays a central role in type 2 diabetes, and the pathogenic mechanisms in pancreatic beta-cells are not fully understood. In this study, using samples from diabetic individuals and a mouse model, the authors demonstrate that succinate dehydrogenase (SDH) deficiency drives mitochondrial dysfunction in beta-cell failure and insulinopenic diabetes. SDH deficiency impairs glucose-induced respiratory oxidative phosphorylation and compromises glucose-stimulated ATP production, insulin secretion, and beta-cell growth. The loss of SDH causes excess succinate accumulation, which activates metabolic anabolism and lipid synthesis. This study suggests that SDH deficiency is a contributing mechanism to progressive beta-cell failure in diabetes and identifies mTOR complex 1 inhibition as a potential strategy for mitigation.
Article
Gastroenterology & Hepatology
Noga Korenfeld, Maya Finkel, Nufar Buchshtab, Meirav Bar-Shimon, Meital Charni-Natan, Ido Goldstein
Summary: The study reveals that glucagon and glucocorticoids play a role in the transcriptional regulation of amino acid catabolism genes, and their synergistic effect can enhance gluconeogenesis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dong Kyu Kim, Hyobin Jeong, Jingi Bae, Moon-Yong Cha, Moonkyung Kang, Dongjin Shin, Shinwon Ha, Seung Jae Hyeon, Hokeun Kim, Kyujin Suh, Mi-Sun Choi, Hoon Ryu, Seong-Woon Yu, Jong-Il Kim, Yeon-Soo Kim, Sang-Won Lee, Daehee Hwang, Inhee Mook-Jung
Summary: This study reveals the crucial role of mitochondria in neural progenitors and their association with the protein amyloid-beta, which is linked to Alzheimer's disease. Mitochondrial dysfunction inhibits neuronal differentiation, leading to deficits in adult hippocampal neurogenesis and cognitive function. The research suggests that lysine demethylase 5A epigenetically suppresses differentiation in response to mitochondrial damage.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Immunology
Phillip Ssekamatte, Obondo James Sande, Reinout van Crevel, Irene Andia Biraro
Summary: Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance. The review discusses the epidemiological aspects of DM and TB, and explores the mechanisms of susceptibility to TB in T2DM patients. Understanding these mechanisms can help develop practical treatment plans to lessen the burden of the diseases in rampant areas.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
David Pladevall-Morera, Jan J. Zylicz
Summary: Cellular metabolism and epigenetics play crucial roles in early mammalian embryo development, interacting with each other to influence cell fate and the epigenome. Recent studies have revealed the non-canonical functions of metabolism when re-localized to the nucleus, along with the challenges and future prospects in advancing the field of epi-metabolomics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Yang Zhao, Yuhao Liu, Guizhen Zhao, Haocheng Lu, Yaozhong Liu, Chao Xue, Ziyi Chang, Hongyu Liu, Yongjie Deng, Wenying Liang, Huilun Wang, Oren Rom, Minerva T. Garcia-Barrio, Tianqing Zhu, Yanhong Guo, Lin Chang, Jiandie Lin, Y. Eugene Chen, Jifeng Zhang
Summary: This study reveals the role of BAF60a-NRF1 axis as a modulator of mitochondrial function in atherosclerosis. Macrophages in advanced plaques show reduced expression of Baf60a, leading to compromised mitochondrial integrity and increased adhesion, apoptosis, and plaque development. Over expression of BAF60a rescues mitochondrial dysfunction in an NRF1-dependent manner.
Article
Plant Sciences
Yue Lu, Qing Bu, Mingli Chuan, Xiaoyun Cui, Yu Zhao, Dao-Xiu Zhou
Summary: Chromatin modifications play a crucial role in shaping the epigenome and regulating gene expression during plant development and adaptation to environmental changes. The activities of chromatin modification enzymes are influenced by cellular metabolites, such as S-adenosyl-methionine, acetyl-CoA, alpha-ketoglutarate, and NAD(+). On the other hand, changes in the plant epigenome and activity of epigenetic regulators can impact cellular metabolism through regulation of metabolic enzymes. This review highlights recent advances in understanding the metabolic control of plant chromatin regulators and epigenomes, which contribute to plant adaptation to environmental stresses.
Article
Oncology
Parmanand Malvi, Vipin Rawat, Romi Gupta, Narendra Wajapeyee
Summary: Metabolic reprogramming, characterized by the overexpression of metabolic enzymes, is a key feature of cancer cells. This study focuses on lactate dehydrogenase (LDHA) as an overexpressed enzyme in various cancer types, including pancreatic ductal adenocarcinoma (PDAC), and its role in promoting cancer growth. The study models the adaptation of cancer cells to LDHA inhibition, specifically using the competitive LDHA inhibitor sodium oxamate. Through various molecular analyses, the study identifies significant differences in mRNA expression, chromatin accessibility, and metabolite levels between oxamate-resistant PDAC cells and parental cells. Furthermore, integrated analysis reveals changes in metabolic enzymes that contribute to the observed alterations in metabolites. This study provides insights into the transcriptional, chromatin, and metabolic landscapes of LDHA inhibitor resistance in PDAC cells, and highlights the need for further functional studies to understand the mechanisms underlying this resistance and optimize the use of LDHA inhibitors in cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
C. Megan Young, Laurent Beziaud, Pierre Dessen, Angela Madurga Alonso, Albert Santamaria-Martinez, Joerg Huelsken
Summary: This study examines the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic phenotype. The findings demonstrate that MICs specifically alter their metabolism to efficiently colonize distant organs, and understanding these mechanisms may help control cancer progression.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Youbao Zhao, Xiaorong Lin
Summary: The transcription factor Pas2 was found to be a key regulator in metabolic response to hypoxia in the human fungal pathogen Cryptococcus neoformans, interacting with another transcription factor Rds2. The Pas2/Rds2 complex plays a critical role in rewiring metabolism between respiration and fermentation, shedding light on the adaptation mechanisms of lower eukaryotes like C. neoformans to low oxygen levels.