☆ 4.3 Article

ALDH2 Repression Promotes Lung Tumor Progression via Accumulated Acetaldehyde and DNA Damage

NEOPLASIA (2019)

获取全文
添加到收藏夹

期刊

NEOPLASIA
卷 21, 期 6, 页码 602-614

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.neo.2019.03.008

关键词

-

类别

Oncology

资金

  1. National Nature Science Foundation of China [81620108022, 91729302, 81572759, 8147 2758]

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

The major role of aldehyde dehydrogenase 2 family (ALDH2) is to detoxify acetaldehyde (ACE) to non-toxic acetic acid. Many evidences suggest that ALDH2 dysfunction contributes to a variety of human diseases including cancer. However, the biological function and molecular mechanism of ALDH2 in tumor progression remain elusive. In this study, we found that ALDH2 repression was associated with poor prognosis in lung adenocarcinoma. Overexpression of ALDH2 inhibited malignant features of lung adenocarcinoma cells, such as proliferation, stemness and migration, whereas ALDH2 knockdown increased these features. Mechanistically, ALDH2 repression led to accumulation of ACE; whereas ACE enhanced the migration features of lung adenocarcinoma cells, which was associated with increased DNA damage. Importantly, accumulated ACE and increased DNA damage were identified in Aldh2-knockout (KO) mouse lung tissues in vivo. Consistent with this concept, treatment of lung adenocarcinoma cells with ALDH2 agonist Alda-1 suppressed the proliferation, sternness and migration features of lung adenocarcinoma cells. Thus, activating ALDH2, such as via its agonist, may provide a novel strategy for treatment of lung cancer.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Gastroenterology & Hepatology

Ampicillin exacerbates acetaminophen-induced acute liver injury by inducing intestinal microbiota imbalance and butyrate reduction

Zhan-Ming Li, Chao-Yue Kong, Yu-Qin Mao, Jia-Ting Huang, Hui-Ling Chen, Bing Han, Li-Shun Wang

Summary: This study reveals that the antibiotic ampicillin (Amp) may exacerbate acute liver injury (ALI) caused by acetaminophen (APAP) and demonstrates the influence of gut microbiota on this process. The results show that Amp exposure reduces the diversity and alters the composition of gut microbiota, leading to worsened liver damage caused by APAP. This effect is proven to be microbiota-related through fecal microbiota transplantation. Additionally, supplementation of lactobacillus, especially Lactobacillus rhamnosus, can reverse the aggravated liver injury induced by APAP and Amp.

LIVER INTERNATIONAL (2023)

添加到收藏夹
Article Optics

Classification of quantum correlation using deep learning

Shi-Bao Wu, Zhan-Ming LI, Jun Gao, Heng Zhou, Chang-Shun Wang, Xian-Min Jin

Summary: Quantum correlation, an intrinsic property of quantum mechanics, has been widely used in testing physical principles and exploring quantum-enhanced technologies. This study demonstrates the classification of quantum correlation using deep learning in a quantum imaging scheme, addressing the challenge of high levels of loss and noise.

OPTICS EXPRESS (2023)

添加到收藏夹
Article Chemistry, Multidisciplinary

Promotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation

Meng Wu, Jian-Bin Zhang, Yi-Wei Xiong, Yong-Xu Zhao, Meng-Ge Zheng, Xia-Li Huang, Fang Huang, Xing-Xing Wu, Xue Li, Wei-Jiao Fan, Lin Hu, Yuan-Yuan Zeng, Xia-Ju Cheng, Ji-Cheng Yue, Juan-Juan Du, Nan-Nan Chen, Wen-Xiang Wei, Qing-Hua Yao, Xiao-mei Lu, Chao Huang, Jiong Deng, Zhi-Jie Chang, He-Bin Liu, Ting C. Zhao, Y. Eugene Chinn

Summary: By regulating the acetylation of extracellular proteins, eSIRT2 can promote cancer cell metastasis, and the deacetylation mechanism of eSIRT2 in tumor microenvironment has been revealed.

ADVANCED SCIENCE (2023)

添加到收藏夹
Article Gastroenterology & Hepatology

Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin

Yayun Xu, Jianfa Wang, Xubo Wu, Hui Jing, Shilong Zhang, Zhiqiu Hu, Longhua Rao, Qimeng Chang, Lishun Wang, Ziping Zhang

Summary: Post-cholecystectomy diarrhea (PCD) is a common condition among outpatients who have undergone cholecystectomy, and it is associated with changes in gut microbiota. In this study, a humanized gut microbiome mouse model was used to investigate the effects of altered fecal bacteria on diarrhea. The researchers found that PCD mice transplanted with fecal microbiome from PCD patients had increased gastrointestinal motility and fecal water content compared to mice with fecal microbiome from NonPCD patients and healthy controls. They also identified an enrichment of tryptophan metabolism in the gut microbiota of PCD mice. Additionally, they discovered elevated levels of serotonin and increased expression of 5-HT receptors in the colon of PCD mice, which were associated with diarrhea. The researchers also found that microbial secondary bile acids were responsible for stimulating serotonin levels in the colon and increasing colon motility. Blocking the bile acid-mediated signaling pathway alleviated the symptoms of PCD. These findings suggest that altered gut microbiota and bile acid metabolism play a role in the development of PCD.

GUT MICROBES (2023)

添加到收藏夹
Article Medicine, Research & Experimental

NF-κB represses retinoic acid receptor-mediated GPRC5A transactivation in lung epithelial cells to promote neoplasia

Hongyong Song, Xiaofeng Ye, Yueling Liao, Siwei Zhang, Dongliang Xu, Shuangshuang Zhong, Bo Jing, Tong Wang, Beibei Sun, Jianhua Xu, Wenzheng Guo, Kaimi Li, Min Hu, Yanbin Kuang, Jing Ling, Tuo Zhang, Yadi Wu, Jing Du, Feng Yao, Y. Eugene Chin, Qi Wang, Binhua P. Zhou, Jiong Deng

Summary: Chronic inflammation is closely associated with lung tumorigenesis, and NF-kappa B-mediated epigenetic regulation plays a critical role. NF-kappa B induces transcriptional repression of GPRC5A by forming a complex with retinoic acid receptor alpha/beta, and mediates epigenetic repression through suppression of H3K9ac.

JCI INSIGHT (2023)

添加到收藏夹
Article Energy & Fuels

Short term power load forecasting based on BES-VMD and CNN-Bi-LSTM method with error correction

Nier Wang, Zhanming Li

Summary: This study proposes a short-term power load forecasting method based on bald eagle search (BES) optimization variational mode decomposition (VMD), convolutional bi-directional long short-term memory (CNN-Bi-LSTM) network, and error correction to improve the accuracy of load forecasting. The method decomposes the original load sequence into modal components and establishes prediction models for each component using the CNN-Bi-LSTM network. An error correction model considering short-term factors is also established to reduce the inherent error of the model. The experimental results demonstrate that the proposed method can effectively track load changes and improve the accuracy of short-term power load forecasting.

FRONTIERS IN ENERGY RESEARCH (2023)

添加到收藏夹
Article Food Science & Technology

Analytical method for histamine, urocanic acid isomers, and their precursor histidine in fish sauce based on precolumn dansylation and high-performance liquid chromatography

Jian-Jun Zhong, Liping Xia, Liuru Xue, Boyu Liu, Lingling Zhao, Hua Ye, Zhanming Li

Summary: This work aimed to provide a method for the simultaneous determination of histidine, histamine, and urocanic acid isomers in food. The method was fully validated and successfully applied to several fish sauce samples.

FOOD CONTROL (2023)

添加到收藏夹
Article Microbiology

Fecal microbiome transplant from patients with lactation mastitis promotes mastitis in conventional lactating mice

Chao-Yue Kong, Yi-Qin Yang, Bing Han, Hui-Ling Chen, Yu-Qin Mao, Jia-Ting Huang, Li-Shun Wang, Zhan-Ming Li

Summary: In this study, the role of gut microbiota in lactation mastitis was investigated using a microbiota-humanized mouse model. The results showed that lactation mastitis patients had reduced gut microbiota diversity and dysbiosis. Fecal microbiota transplantation from lactation mastitis patients induced mastitis in antibiotic-treated mice. This study demonstrates that dysbiotic gut microbiota contributes to the pathogenesis of lactation mastitis.

FRONTIERS IN MICROBIOLOGY (2023)

添加到收藏夹
Review Chemistry, Multidisciplinary

Research Progress and Effects of Light on Poultry Circadian Rhythm Regulation Based on CiteSpace

Yue Yu, Zhanming Li

Summary: This study analyzes literature from the Web of Science core database and draws a knowledge graph using CiteSpace to explore the research frontiers between light and circadian rhythm. The study focuses on the regulation of light in the circadian rhythm of poultry, explores the effects of light on poultry growth and immunity, and analyzes the regulatory effect of light on melatonin levels.

APPLIED SCIENCES-BASEL (2023)

添加到收藏夹
Editorial Material Oncology

Editorial: Targeting metabolism of cancer cells and host to overcome drug resistance: Preclinical and clinical studies

Lishun Wang, Hanchen Xu, Yadi Wu

FRONTIERS IN ONCOLOGY (2023)

添加到收藏夹
Article Health Care Sciences & Services

Early Administration of Vancomycin Inhibits Pulmonary Embolism by Remodeling Gut Microbiota

Zhengyan Zhang, Huiling Chen, Jiating Huang, Shilong Zhang, Zhanming Li, Chaoyue Kong, Yuqin Mao, Bing Han

Summary: Pulmonary embolism (PE) is a common and potentially fatal condition in the emergency department. In this study, the role of the gut microbiome in the pathogenesis of PE was explored using antibiotics and fecal microbiota transplantation (FMT) in a mouse model. The results showed that early administration of antibiotics, especially vancomycin, inhibited pulmonary thrombosis and reduced mortality in the mice. FMT with vancomycin-modified gut microbes also suppressed the development of PE. These findings provide new insights into the potential use of vancomycin and gut microbiome manipulation for PE prevention.

JOURNAL OF PERSONALIZED MEDICINE (2023)

添加到收藏夹
Article Chemistry, Applied

Identification of aged-rice adulteration based on near-infrared spectroscopy combined with partial least squares regression and characteristic wavelength variables

Zhanming Li, Jiahui Song, Yinxing Ma, Yue Yu, Xueming He, Yuanxin Guo, Jinxin Dou, Hao Dong

Summary: This study proposed a rapid, simple, and accurate detection method for aged-rice adulteration using near-infrared spectra and partial least squares regression (PLSR) model. The method reduced the number of characteristic variables required by the spectrum and improved the identification accuracy of aged-rice adulteration, providing new clues and alternatives for the quality control of commercial rice.

FOOD CHEMISTRY-X (2023)

添加到收藏夹
Article Endocrinology & Metabolism

The antitumour effects of caloric restriction are mediated by the gut microbiome

Yu-Qin Mao, Jia-Ting Huang, Shi-Long Zhang, Chao Kong, Zhan-Ming Li, Hui Jing, Hui-Ling Chen, Chao-Yue Kong, Sheng-Hui Huang, Pei-Ran Cai, Bing Han, Li-Shun Wang

Summary: The study reveals that caloric restriction increases the presence of Bifidobacterium bifidum in the intestine, which ultimately inhibits tumor development in mice. Caloric restriction and intermittent fasting, without causing malnutrition, have been found to reduce the risk of cancer. Additionally, both caloric restriction and intermittent fasting can alter the composition of the gut microbiota. It is shown in this study that caloric restriction, but not intermittent fasting, protects against subcutaneous MC38 tumor formation in female mice through a mechanism involving the gut microbiota. These findings highlight the oncological significance of modulating the gut taxonomic composition in tumor growth and cancer immunosurveillance.

NATURE METABOLISM (2023)

添加到收藏夹
Article Biochemistry & Molecular Biology

LncRNA MIR31HG fosters stemness malignant features of non-small cell lung cancer via H3K4me1-and H3K27Ace-mediated GLI2 expression

Weiwei Chen, Fei Wang, Xinyuan Yu, Jingjing Qi, Hongliang Dong, Bingjie Cui, Qian Zhang, Yan Wu, Jiajia An, Na Ni, Cuilan Liu, Yuchen Han, Shuo Zhang, Clemens A. Schmitt, Jiong Deng, Yong Yu, Jing Du

Summary: Non-coding RNA plays a crucial role in oncogenesis and stemness development in various cancers, including lung cancer. MIR31HG, a lncRNA, is significantly upregulated in lung cancer tissues and peripheral sera of patients, indicating a poor prognosis. Mechanistically, MIR31HG promotes stemness-associated malignant features of non-small cell lung cancer cells by modulating GLI2 expression via H3K4me and H3K27Ace modifications mediated by the WDR5/MLL3/P300 complex. In vivo studies showed that repression of MIR31HG attenuated tumor growth and distal organ metastasis, while its promotion encouraged cellular invasion in lung and liver tissues. Hence, MIR31HG has the potential to serve as a diagnostic indicator and therapeutic target for lung cancer patients.

ONCOGENE (2023)

添加到收藏夹
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.