Review
Nutrition & Dietetics
Claudia Infantino, Roberta Francavilla, Adriana Vella, Sabrina Cenni, Nicola Principi, Caterina Strisciuglio, Susanna Esposito
Summary: Vitamin D plays a crucial role in calcium homeostasis and bone health, and it may also modulate the immune system to affect the development of autoimmune diseases such as celiac disease and inflammatory bowel diseases. Research suggests that vitamin D could be involved in the pathogenesis and treatment of these conditions.
Review
Pharmacology & Pharmacy
Andrea Cassinotti, Francesco Passamonti, Sergio Segato
Summary: Cell-based therapies have been explored in immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD). The most studied treatment in IBD involves stem cells, with recent studies also focusing on regulatory cells such as T-reg and Tr1 cells. Preclinical research is also being conducted on induced pluripotent stem cells in animal models related to colitis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Cristiano Pagnini, Maria Carla Di Paolo, Maria Giovanna Graziani, Gianfranco Delle Fave
Summary: Inflammatory bowel diseases (IBD) are chronic conditions with unknown etiology and immunomediated pathogenesis. Research on the intestinal microbiome and the vitamin D/VDR pathway have shown promising potential for novel approaches to diagnosis and treatment of IBD. Probiotic bacteria have shown more exciting results in experimental models than in clinical practice, and understanding their properties and mechanisms of action may lead to new therapeutic applications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Aleksandra Szymczak-Tomczak, Alicja Ewa Ratajczak, Marta Kaczmarek-Rys, Szymon Hryhorowicz, Anna Maria Rychter, Agnieszka Zawada, Ryszard Slomski, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: Vitamin D plays various roles in patients with inflammatory bowel disease (IBD), including regulating bone mineral metabolism, modulating the immune system, and contributing to the pathogenesis of IBD. Vitamin D affects Th1 and Th2 lymphocytes, cytokine release, and the wnt/beta-catenin pathway. IBD is associated with dysbiosis of microbiota, abnormal inflammatory response, and vitamin D deficiency. Therefore, understanding the metabolic pathways, genetic determinants, and environmental factors of vitamin D is crucial for studying vitamin D supplementation in IBD patients, not only for osteoporosis prevention and therapy, but also for modulating the course and pharmacotherapy of IBD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Filippo Vernia, Giorgia Burrelli Scotti, Noemi Sara Bertetti, Giuseppe Donato, Stefano Necozione, Piero Vernia, Nadia Pallotta
Summary: The inadequate intake of Vitamin D and Vitamin K in the diet is a reversible factor for IBD-associated bone loss, but there is a lack of data on Vitamin K. A study found that both IBD patients and control patients had inadequate intake of Vitamin D, while the intake of Vitamin K was inadequate in IBD patients and high in controls. The study suggests that proactive nutritional intervention is needed to address Vitamin K shortages in IBD patients.
Review
Cell Biology
Aicha Kriaa, Vincent Mariaule, Amin Jablaoui, Soufien Rhimi, Hela Mkaouar, Juan Hernandez, Brice Korkmaz, Adam Lesner, Emmanuelle Maguin, Ali Aghdassi, Moez Rhimi
Summary: Inflammatory bowel diseases (IBDs) are a global public health problem with limited effective therapeutic options. Changes in gut microbiota composition and alterations in bile acids (BAs) have been identified as important factors in dysregulated intestinal immunity and the pathogenesis of IBDs. This review explores the interactions between BAs and gut microbiota in IBDs and discusses how the gut microbiota-BA-host axis may influence digestive inflammation.
Review
Cell Biology
Congxin Li, Kaixin Peng, Siqi Xiao, Yuanyuan Long, Qin Yu
Summary: This article discusses the role of Lactobacillus in inflammatory bowel disease and related diseases, including its underlying mechanisms and treatment strategies.
CELL DEATH DISCOVERY
(2023)
Review
Cell Biology
Zhilin Zhang, Huan Zhang, Tian Chen, Lin Shi, Daorong Wang, Dong Tang
Summary: This article discusses the association between inflammatory bowel disease (IBD) and dysbiosis of the gut microbiota, which leads to persistent immune response and inflammation. Short-chain fatty acids (SCFAs) derived from fiber-rich diet produced by probiotic gut bacteria have shown anti-inflammatory effects and can delay the progression of IBD. The modulation of innate immune recognition and cytokine production by SCFAs may intervene in the progression of IBD. More studies are needed to investigate the clinical impact of SCFA.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Saifullah Afridi, Musarrat Adnan, Muhammad Waqar Hameed, Abdul Wajid Khalil, Zafar Iqbal, Daniel C. Hoessli, Muhammad Shahid, Shafi Ullah Khan, Jamshed Iqbal, Xiaoming Zhang, Zhiyuan Wu
Summary: TRP-1 was found to strongly accelerate the proliferation of regulatory T cells in vitro in a concentration-dependent manner. This small molecule increased T-reg cell numbers and improved the expression of CD4 + CD25 + FOXP3 +, with low cytotoxicity, suggesting a potential mechanism for TCR-based T-reg cell activation.
BIOORGANIC CHEMISTRY
(2021)
Review
Microbiology
Valerio Baldelli, Franco Scaldaferri, Lorenza Putignani, Federica Del Chierico
Summary: This article discusses the significant contribution of Enterobacteriaceae to the pathogenesis of inflammatory bowel diseases (IBDs), particularly their role in exacerbating and progressing IBD. Despite the unclear mechanism, their expansion is associated with inflammatory responses, increased levels of nitrate and oxygen, and bile acid dysmetabolism.
Review
Pathology
Ioanna Aggeletopoulou, Markos Marangos, Stelios F. Assimakopoulos, Athanasia Mouzaki, Konstantinos Thomopoulos, Christos Triantos
Summary: Studies show that there are characteristic microbial patterns in various systemic autoimmune diseases, including inflammatory bowel disease (IBD). Vitamin D deficiency, which predisposes to autoimmune diseases and IBD, can lead to changes in the gut microbiome and disruption of intestinal epithelial barrier integrity. This review explores the role of the gut microbiome in IBD and discusses how vitamin D and vitamin D receptor (VDR)-associated signaling pathways contribute to the development and progression of IBD by affecting gut barrier function, microbial community, and immune system function. Understanding the cellular functions of vitamin D-VDR signaling in intestinal epithelial cells may lead to the development of new treatment strategies for IBD in the future.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Review
Nutrition & Dietetics
Dominika Glabska, Aleksandra Kolota, Katarzyna Lachowicz, Dominika Skolmowska, Malgorzata Stachon, Dominika Guzek
Summary: Inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) are associated with decreased quality of life and mental health problems. Vitamin D supplementation is considered to be effective in improving mental health in affected individuals. Studies have shown a positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but further research is needed for confirmation.
Article
Food Science & Technology
Van-Long Truong, Woo-Sik Jeong
Summary: Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea polyphenols have established antioxidant and anti-inflammatory properties, and their supplementation can prevent inflammatory conditions and improve the outcome of patients with inflammatory bowel diseases (IBD).
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Endocrinology & Metabolism
Daniela Gallo, Antonino Bruno, Matteo Gallazzi, Simona Antonia Maria Cattaneo, Giovanni Veronesi, Angelo Genoni, Maria Laura Tanda, Luigi Bartalena, Alberto Passi, Eliana Piantanida, Lorenzo Mortara
Summary: This study suggests that supplementation with vitamin D and selenium in patients with Graves' disease receiving MMI treatment can modulate the frequency of Treg and NK cells, leading to better control of hyperthyroidism symptoms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Adrian Boicean, Victoria Birlutiu, Cristian Ichim, Paula Anderco, Sabrina Birsan
Summary: Inflammatory bowel diseases (IBD) are complex diseases characterized by chronic inflammation in the gastrointestinal tract. Fecal microbiota transplantation (FMT) has shown increasing effectiveness and safety in treating recurrent Clostridium difficile infection (CDI) and co-infection of SARS-CoV-2 and CDI. By modifying the gut microbiota, FMT offers an alternative approach to indirectly influence the host's immune system in a safe way, improving clinical symptoms and endoscopic findings in IBD patients. Further validation is needed to establish a clinical protocol for FMT in IBD.
Review
Microbiology
Stephanie L. Collins, Jonathan C. Stine, Jordan E. Bisanz, C. Denise Okafor, Andrew D. Patterson
Summary: This Review discusses host-microbiota interactions and their impact on bile acid metabolism and composition. The gut microbiota plays a crucial role in bile acid metabolism, with diverse biological roles for bile acids being discovered. External factors such as antibiotics and diet also influence bile acid composition. Understanding the impact of bile acid signaling networks in different organs is increasingly important for the development of targeted therapeutics.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoliang Zhou, Debopriya Chakraborty, Iain A. Murray, Denise Coslo, Zoe Kehs, Anitha Vijay, Carolyn Ton, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Gary H. Perdew
Summary: Intestinal homeostasis is maintained through balanced cellular turnover, proliferation, differentiation, and self-renewal, but can be influenced by the aryl hydrocarbon receptor (AHR). The AHR plays a role in small intestinal gene expression and cellular repertoire remodeling, promoting intestinal resilience. Genetic ablation of Ahr impairs lineage commitment and differentiation, while exposure to AHR ligands reverses these effects.
LABORATORY INVESTIGATION
(2023)
Article
Immunology
Wei-Bei Wang, Yang-Ding Lin, Luming Zhao, Chang Liao, Yang Zhang, Micha Davila, Jasmine Sun, Yidong Chen, Na Xiong
Summary: Skin undergoes morphological changes immediately after birth and is exposed to various environmental assaults. Proper localization and function of immune cells, specifically invariant natural killer T (iNKT) cells, in the skin is critical for protection and establishment of skin tissue homeostasis. This study reveals a developmentally programmed process that directs preferential localization of iNKT cells to the skin for early local homeostatic regulation. The skin iNKT cells not only play a role in proper commensal bacterial colonization and tissue development, but also provide a local source of transferrin that regulates iron metabolism in hair follicle progenitor cells and helps hair follicle development.
Article
Biochemistry & Molecular Biology
Sougat Misra, Tai-Jung Lee, Aswathy Sebastian, John McGuigan, Chang Liao, Imhoi Koo, Andrew D. Patterson, Randall M. Rossi, Molly A. Hall, Istvan Albert, K. Sandeep Prabhu
Summary: Macrophages play a crucial role in inflammation and its resolution. Selenium and selenoproteins, which contain the amino acid selenocysteine, are essential for the functions of macrophages. In this study, the researchers investigated the role of SELENOW, a highly expressed selenoprotein, in inflammation using Selenow knock-out macrophages. The results suggest that SELENOW is involved in redox processes and bioenergetics during inflammation and its resolution.
Article
Biochemistry & Molecular Biology
Jonathan A. A. Young, Silvana Duran-Ortiz, Stephen Bell, Kevin Funk, Yuan Tian, Qing Liu, Andrew D. D. Patterson, Edward O. O. List, Darlene E. E. Berryman, John J. J. Kopchick
Summary: Growth hormone (GH) affects protein metabolism and alters circulating levels of glycine and hydroxyproline. GH abnormality, such as increased GH action or GH resistance, leads to changes in amino acid concentrations in plasma and feces. Acute GH treatment decreases liver gene expression of glycine metabolism genes and serum glycine in mice.
Article
Toxicology
Anitha Vijay, Nina R. Boyle, Supriya M. Kumar, Gary H. Perdew, Shanthi Srinivasan, Andrew D. Patterson
Summary: This study investigates the effects of a persistent organic pollutant on the enteric nervous system, finding that it leads to delayed intestinal motility and neuronal damage, thereby affecting gastrointestinal function.
TOXICOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Lulu Sun, Yi Zhang, Jie Cai, Bipin Rimal, Edson R. Rocha, James P. Coleman, Chenran Zhang, Robert G. Nichols, Yuhong Luo, Bora Kim, Yaozong Chen, Kristopher W. Krausz, Curtis C. Harris, Andrew D. Patterson, Zhipeng Zhang, Shogo Takahashi, Frank J. Gonzalez
Summary: Bile salt hydrolase (BSH) in Bacteroides is associated with the development of colorectal cancer (CRC) by activating the beta-catenin/CCL28 pathway and promoting the generation of immunosuppressive T-reg cells. Inhibition of BSH activity could slow down CRC progression and serve as a potential target for CRC prevention and treatment.
NATURE COMMUNICATIONS
(2023)
Article
Food Science & Technology
Xiaoling Chen, Andrew D. Patterson, Gary H. Perdew, Iain A. Murray, Joshua J. Kellogg
Summary: A novel AHR modulator, 2-amino-4-methyl-benzothiazole, was predicted, identified, and characterized in white button mushrooms using a molecular networking approach. Cell-based assays showed that this compound has agonistic activity and upregulates CYP1A1 expression. These findings demonstrate the potential of molecular networking in identifying novel receptor modulators from natural products.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters
Summary: Long-term ligand activation of PPARa in mice causes hepatocarcinogenesis, while hepatocarcinogenesis is diminished in Ppara-null and PPARA-humanized mice. Lipidomic analyses showed elevated levels of hepatic linoleic acid and overall fatty liver in Ppara-null and PPARA-humanized mice. The accumulation of linoleic acid and loss of CD4+ T cells suggest a new role for PPARa in age-associated hepatocarcinogenesis.
Article
Oncology
Sangshan Tian, Devendra Paudel, Fuhua Hao, Rabin Neupane, Rita Castro, Andrew D. Patterson, Amit K. Tiwari, K. Sandeep Prabhu, Vishal Singh
Summary: This study reveals that supplementation of diet with refined inulin leads to abnormal succinate accumulation in the intestinal lumen, which contributes to promoting colon inflammation and tumorigenesis.
Article
Cell Biology
Beng San Yeoh, Rachel M. Golonka, Piu Saha, Mrunmayee R. Kandalgaonkar, Yuan Tian, Islam Osman, Andrew D. Patterson, Andrew T. Gewirtz, Bina Joe, Matam Vijay-Kumar
Summary: Congenital portosystemic shunt (PSS) occurs sporadically in C57BL/6 J mice, leading to abnormal serologic, metabolic, and physiologic parameters. To reliably and efficiently identify PSS mice, we explored simple, inexpensive, and noninvasive urine-based screening tests. Metabolome profiling revealed elevated levels of Krebs cycle intermediates in the urine of PSS mice, which we utilized to develop three colorimetric assays: urinary iron-chelation, pH strip, and phenol red assays. These assays provide a feasible and noninvasive method for diagnosing PSS in mice, aiding biomedical research by stratifying PSS mice and minimizing confounding factors.
Article
Neurosciences
Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Yuan Tian, Craig B. Marcus, Andrew D. Patterson, Gary H. Perdew
Summary: The aryl hydrocarbon receptor (AHR) plays important roles in xenobiotic metabolism, immune function, and tissue homeostasis. The regulation of AHR activity by endogenous ligands is still poorly understood. In this study, we identified and quantified 6 tryptophan metabolites that individually activate AHR in mouse and human serum. These metabolites are not significantly metabolized by CYP1A1/1B1, unlike the potent endogenous AHR ligand 6-formylindolo[3,2b]carbazole. Our results suggest that these tryptophan metabolites may contribute to constitutive but low level systemic AHR activity in humans.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)
Article
Neurosciences
Ethan W. Morgan, Fangcong Dong, Andrew J. Annalora, Iain A. Murray, Trenton Wolfe, Reece Erickson, Krishne Gowda, Shantu G. Amin, Kristina S. Petersen, Penny M. Kris-Etherton, Craig B. Marcus, Seth T. Walk, Andrew D. Patterson, Gary H. Perdew
Summary: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that regulates various cellular functions. Tryptophan metabolites derived from host and bacterial metabolism act as AHR activators. This study investigates the presence and metabolic source of these metabolites and examines the biological relevance of circulating tryptophan metabolites. The results improve our understanding of homeostatic AHR activity and related diseases.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Alexis Bretin, Jun Zou, Beng San Yeoh, Vu L. Ngo, Shawn Winer, Daniel A. Winer, Lavanya Reddivari, Michael Pellizzon, William A. Walters, Andrew D. Patterson, Ruth Ley, Benoit Chassaing, Matam Vijay-Kumar, Andrew T. Gewirtz
Summary: Psyllium protects against experimental colitis by altering bile acid metabolism and activating FXR, which suppresses pro-inflammatory signaling.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gary H. Perdew, Charlotte Esser, Megan Snyder, David H. Sherr, Ellen H. van den Bogaard, Karen McGovern, Pedro M. Fernandez-Salguero, Xavier Coumoul, Andrew D. Patterson
Summary: The aryl hydrocarbon receptor (AHR) senses low-molecular-weight molecule signals from environmental exposures, the microbiome, and host metabolism. It plays important roles in host homeostasis, chronic disease development, and responses to toxic insults. Recent research has shown that AHR is a promising target for cancer, metabolic diseases, skin conditions, and autoimmune disease. This meeting aimed to explore the potential therapeutic applications based on our understanding of this receptor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
