Article
Nutrition & Dietetics
Xiang Xu, Gao Zhang, Kun Peng, Yanping Gao, Jinxia Wang, Caiping Gao, Chong He, Fang Lu
Summary: This study found that carnosol (CA) has inhibitory effects on ulcerative colitis. The results showed that CA can alleviate clinical symptoms and tissue damage of colitis, as well as suppress inflammatory cell infiltration and cytokine expression. In addition, CA can restore epithelial barrier functions and maintain the homeostasis of intestinal intraepithelial lymphocytes. Mechanistically, CA exerts its anti-inflammatory effects by inhibiting endoplasmic reticulum stress in epithelial cells.
FRONTIERS IN NUTRITION
(2022)
Article
Engineering, Biomedical
Dong Yu Zhu, Zhi Peng Chen, Zhan Peng Hong, Lanyue Zhang, Xiaoxin Liang, Yuan Li, Xuejuan Duan, Hongsheng Luo, Jinping Peng, Jianwei Guo
Summary: This study describes the design and fabrication of a supramolecular hydrogel dressing based on hydroxypropyl chitosan and poly(N-isopropylacrylamide) that exhibits antimicrobial and anti-inflammatory properties. The hydrogel is injectable, thermosensitive, and self-healable, and its structure and performance can be controlled by adjusting the composition. In vivo wound healing evaluations using a mouse model showed that the hydrogel dressing promoted wound closure and reduced inflammation.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Yalan Dong, Heng Fan, Zhe Zhang, Feng Jiang, Mingyue Li, Haifeng Zhou, Weina Guo, Zili Zhang, Zhenyu Kang, Yang Gui, Zhexing Shou, Junyi Li, Rui Zhu, Yu Fu, Alexey Sarapultsev, Huafang Wang, Shanshan Luo, Ge Zhang, Desheng Hu
Summary: In this study, the therapeutic effect and mechanism of berberine (BBR) in treating DSS-induced colitis were investigated. It was found that BBR can reduce colon inflammation, regulate the abundance and composition of bacteria, restore the broken chemical and epithelial barriers, and modulate the expression of various immune factors. The protective effect of BBR was also observed through the enhancement of the Wnt/beta-catenin pathway. These findings suggest that BBR serves as a potential gut microbiota modulator and mucosal barrier protector for UC prevention and therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yu-Jing Wang, Hong-Yan Wang, Qiang-Ming Li, Xue-Qiang Zha, Jian-Ping Luo
Summary: In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on ulcerative colitis (UC) was confirmed through experiments on mice. The results showed that cDFPW1 significantly alleviated UC symptoms and promoted the proliferation of intestinal epithelial cells. Furthermore, cDFPW1 directly improved intestinal organoid damage and increased the number of epithelial cells, promoting stem cell-mediated intestinal epithelial regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Weijian Cheng, Xiao Wang, Yihan Wu, Wei Li, Chaomei Fu, Liang Zou, Jinming Zhang
Summary: By combining network pharmacology and transcriptomics, this study revealed the potential mechanisms of Huanglian-Houpo Decoction (HLHP) in treating ulcerative colitis (UC) and verified the findings through animal experiments. The 50% ethanol extraction of HL and HP (EHLHP) contained 34 components and showed efficacy against UC through pathways related to calcium signaling, inflammatory signaling, and immune regulation. Animal experiments demonstrated that EHLHP significantly alleviated UC symptoms, enhanced intestinal barrier function, and suppressed immune responses.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Immunology
Yunyun Zou, Aziz Ghaderpour, Bolormaa Munkhbileg, Sang-Uk Seo, Seung-Yong Seong
Summary: Taurodeoxycholate (TDCA) ameliorates DSS-induced colitis in mice by inhibiting both the activation phase and priming phase of N3I signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xiaotian Xu, Ailin Luo, Xi Lu, Meng Liu, Huideng Wang, Hengzhi Song, Chengqiong Wei, Yuhui Wang, Xiaoqun Duan
Summary: The study demonstrates that HA, an active metabolite of HD, can alleviate colitis and promote intestinal mucosal repair by activating the ERB signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Ziping Ye, Yunjuan Zhu, Nana Tang, Xiaojing Zhao, Jingyue Jiang, Jingjing Ma, Hongjie Zhang
Summary: The study found that the alpha 7nAChR agonist GTS-21 can attenuate DSS-induced colitis by increasing the expression of TJ proteins in colon tissues and improving intestinal barrier function.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Chunyan Peng, Chang Zheng, Fan Zhou, Ying Xie, Lei Wang, Deyan Chen, Xiaoqi Zhang
Summary: This study aimed to investigate the effectiveness of Dac51 in DSS-induced colitis and found that Dac51 could improve inflammatory bowel disease by suppressing FTO expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Liang Zhao, Yibing Lv, Xiaoqi Zhou, Zilong Guo, Heli Li, Yanyan Guo, Tao Liu, Lei Tu, Liangru Zhu, Juan Tao, Guanxin Shen, Yong He, Ping Lei
Summary: The secreted form of 78-kDa glucose-regulated protein (sGRP78) has potential in the treatment of colitis. During the resolving phase, sGRP78 levels are reduced but quickly rebound, making it a potential candidate for the treatment of colitis. Administration of sGRP78 improves intestinal symptoms, restores TJ integrity, decreases immune cell infiltration, and impairs production of inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Nutrition & Dietetics
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Xiang-Chen Meng
Summary: This study explores the intestinal barrier repair mechanisms of Bifidobacterium breve (B. breve) strains H4-2 and H9-3 with different exopolysaccharide (EPS) production in mice with colitis. The results demonstrate that both strains of B. breve can regulate cytokine levels and repair intestinal damage caused by colitis. H4-2, with higher EPS output, is more effective at repair than H9-3. These findings are important for clinical applications and the development of probiotic products for colitis treatment.
Article
Food Science & Technology
Haojie Zhang, Yujin Wang, Fengyuan Gao, Rucheng Liu, Wen Chen, Xue Zhao, Qian Sun, Xiaotong Sun, Jingxin Li, Chuanyong Liu, Xuelian Ma
Summary: Gamma-aminobutyric acid (GABA) is a bioactive molecule with potential health benefits, but its involvement in intestinal inflammation is debated. This study found that GABA treatment increases susceptibility to colitis in mice and induces an intestinal barrier defect by inhibiting cell proliferation and promoting apoptosis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biotechnology & Applied Microbiology
Ruihua Ye, Qingyun Guo, Jiaqiang Huang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: Ulcerative colitis (UC) is the most common inflammatory bowel disease (IBD) without a cure. This study focused on the effects of Eucommia ulmoides polysaccharide-modified nano-selenium particles (EUP-SeNP) on DSS-induced colitis. The results showed that EUP-SeNP treatment improved colon histology, intestinal barrier, inflammatory cytokines, and microbiome composition. It also revealed the mechanism of EUP-SeNP in inhibiting the TRL-4/NF-κB signaling pathway in intestinal epithelial cells. This study provides therapeutic potential for IBD.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mingyu Wang, Zequn Fan, Daiwen Chen, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Hui Yan, Ping Zheng
Summary: This study aimed to investigate the alleviated effect of lactate in colitis and provide a nutritional measure to alleviate colitis injury. The results showed that lactate supplementation reduced disease activity index, improved colonic structure, enhanced antioxidant capacity, and increased butyrate levels, ultimately improving growth performance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Salvatore Oliva, Ilaria Laudadio, Valerio Fulci, Danilo Rossetti, Sara Isoldi, Laura Stronati, Claudia Carissimi
DIGESTIVE AND LIVER DISEASE
(2020)
Article
Virology
Sara Isoldi, Saverio Mallardo, Alessia Marcellino, Silvia Bloise, Anna Dilillo, Donatella Iorfida, Alessia Testa, Emanuela Del Giudice, Vanessa Martucci, Mariateresa Sanseviero, Antonio Barberi, Massimo Raponi, Flavia Ventriglia, Riccardo Lubrano
Summary: This study conducted a comprehensive evaluation of children affected by COVID-19, finding the importance of intra-family transmission and the impact of nutritional status on the immune system. Even children with mild cases of the disease may have renal involvement, highlighting the need for prompt evaluation and identification of patients with reduced renal function reserve.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Materials Science, Multidisciplinary
Daniele Valerini, Loredana Tammaro, Roberta Vitali, Gloria Guillot, Antonio Rinaldi
Summary: This study successfully provided strong antibacterial action to electrospun polycaprolactone (PCL) scaffolds by depositing silver (Ag) onto the PCL fibers through sputtering deposition, maintaining the integrity of the fibers' morphology and hydrophobic character. The easy fabrication of these PCL-Ag mats has a wide range of potential applications in biomedical devices, bioremediation, filtration, personal protective equipment, food packaging materials, and more.
Article
Pediatrics
Roberta Vitali, Gianluca Terrin, Francesca Palone, Ilaria Laudadio, Salvatore Cucchiara, Giovanni Boscarino, Maria Di Chiara, Laura Stronati
Summary: This study demonstrated that fecal HMGB1 could be a reliable marker for early identification of necrotizing enterocolitis (NEC) risk in preterm neonates. Further investigation and studies are needed to evaluate the diagnostic accuracy of this marker in managing preterm newborns at risk of NEC, especially in more severe forms of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Gastroenterology & Hepatology
Noemi Fiaschini, Anna Negroni, Francesca Palone, Roberta Vitali, Eleonora Colantoni, Ilaria Laudadio, Mariateresa Mancuso, Salvatore Cucchiara, Laura Stronati
Summary: This study found that inflamed gut contributes to the progression of non-alcoholic fatty liver disease (NAFLD) by impairing gut epithelial and vascular barriers and causing bacterial translocation. The results suggest that dipotassium glycyrrhizate (DPG) can improve liver disease.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Multidisciplinary Sciences
Riccardo Lubrano, Silvia Bloise, Alessia Marcellino, Claudia Proietti Ciolli, Alessia Testa, Enrica De Luca, Anna Dilillo, Saverio Mallardo, Sara Isoldi, Vanessa Martucci, Mariateresa Sanseviero, Emanuela Del Giudice, Concetta Malvaso, Claudio Iacovelli, Rita Leone, Donatella Iorfida, Flavia Ventriglia
Summary: In response to COVID-19 pandemic, universal face masking is important, but there is debate on using masks in children. This study compared the effects on respiratory function in children wearing N95 masks with or without exhalation valve, showing potential impact of masks on children's breathing.
Article
Multidisciplinary Sciences
Eleonora Colantoni, Francesca Palone, Vincenzo Cesi, Beatrice Leter, Giulia Sugoni, Ilaria Laudadio, Anna Negroni, Roberta Vitali, Laura Stronati
Summary: This study demonstrated for the first time that the microalgae I. galbana is an excellent culture medium for the probiotic L. reuteri. The fermented compound derived from the growth of L. reuteri in I. galbana was shown to significantly reduce the adhesiveness and invasiveness of harmful Escherichia coli. These findings open up new possibilities for the use of microalgae as growth media for probiotics and the production of biofunctional compounds.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Laudadio, Alex Bastianelli, Valerio Fulci, Claudia Carissimi, Eleonora Colantoni, Francesca Palone, Roberta Vitali, Elisa Lorefice, Salvatore Cucchiara, Anna Negroni, Laura Stronati
Summary: This study investigated the role of ZNF281 in intestinal fibrosis, revealing its significant involvement in fibrogenesis by controlling gene expression that affects fibroblast activation and differentiation into myofibroblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Noemi Fiaschini, Mariateresa Mancuso, Mirella Tanori, Eleonora Colantoni, Roberta Vitali, Gianfranco Diretto, Laura Lorenzo Rebenaque, Laura Stronati, Anna Negroni
Summary: A close relationship between gut-liver diseases and brain functions has been discovered. Bile acid receptors, bacterial-derived molecules, and the blood-brain barrier all play important roles in this association. This study found that non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) can impact the expression of bile acid receptors in the brain, as well as circulating bile acid composition, blood-brain barrier integrity, and neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Roberta Vitali, Anna Barbara Mancuso, Francesca Palone, Claudio Pioli, Vincenzo Cesi, Anna Negroni, Salvatore Cucchiara, Salvatore Oliva, Claudia Carissimi, Ilaria Laudadio, Laura Stronati
Summary: It has been found that extracellular HMGB1 has a role in inflammatory disorders, including IBD. This study explored the relationship between HMGB1 and PARP1 in controlling intestinal inflammation. The results show that PARP1 promotes HMGB1 secretion in intestinal inflammation, and inhibiting PARP1 may be a new approach to manage IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Roberta Vitali, Francesca Palone, Ilaria De Stefano, Chiara Fiorente, Flavia Novelli, Emanuela Pasquali, Emiliano Fratini, Mirella Tanori, Simona Leonardi, Barbara Tanno, Eleonora Colantoni, Sara Soldi, Serena Galletti, Maria Grimaldi, Alessio Giuseppe Morganti, Lorenzo Fuccio, Simonetta Pazzaglia, Claudio Pioli, Mariateresa Mancuso, Loredana Vesci
Summary: Pelvic radiation disease (PRD) is a common side effect in patients with abdominal/pelvic cancers treated with radiotherapy, but current preclinical models have limited applications for studying its pathogenesis and possible therapeutic strategies. In this study, we evaluated the efficacy of three different locally and fractionated X-ray exposures to select the most effective irradiation protocol for PRD induction in mice. Using the selected protocol, we found that PRD resulted in impaired cell crypts differentiation and proliferation, local inflammation, bacterial translocation, and dysbiosis. We also identified lactoferrin and elastase as useful non-invasive markers to monitor disease progression. Therefore, our preclinical model may be helpful in developing new therapeutic strategies for PRD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Sara Isoldi, Franca Viola, Salvatore Cucchiara, Anna Dilillo, Donatella Iorfida, Anna Maria Testi, Francesco Fiorentino, Saverio Mallardo
Summary: This study retrospectively reviewed cases of collagenous gastritis in pediatric patients and described the management experience and literature review. The patients in the cases were not responsive to oral iron supplements but had good clinical and laboratory response with ferric carboxymaltose (FCM) infusion.
INDIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Anna Barbara Mancuso, Roberta Vitali, Francesca Palone, Noemi Fiaschini, Eleonora Colantoni, Salvatore Cucchiara, Sara Isoldi, Danilo Rossetti, Laura Stronati
Meeting Abstract
Gastroenterology & Hepatology
Noemi Fiaschini, Anna Negroni, Vincenzo Cesi, Francesca Palone, Salvatore Cucchiara, Marina Aloi, Danilo Rossetti, Laura Stronati
