期刊
BIOMOLECULES & THERAPEUTICS
卷 23, 期 1, 页码 90-97出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2014.080
关键词
Trapa japonica Flerov.; Water chestnut; Anti-inflammatory effect; Cytokine; NF-kappa B
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-alpha- and interleukin-6-induced nuclear factor-kappa B activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WOE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WOE may be a promising topical anti-inflammatory agent.
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