期刊
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
卷 6, 期 -, 页码 177-197出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-092818-015550
关键词
virus entry and uncoating; trafficking; mechanics; antigen-presenting cells; gene therapy
类别
More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular, or gastrointestinal tracts. They cause acute clinical manifestations or persist under humoral and cell-based immunity. Immunosuppressed individuals are at risk of death from an AdV infection. Concepts about cell entry of AdV build on strong foundations from molecular and cellular biology-and increasingly physical virology. Here, we discuss how virions enter and deliver their genome into the nucleus of epithelial cells. This process breaks open the virion at distinct sites because the particle has nonisometric mechanical strength and reacts to specific host factors along the entry pathway. We further describe how macrophages and dendritic cells resist AdV infection yet enhance productive entry into polarized epithelial cells. A deep understanding of the viral mechanisms and cell biological and biophysical principles will continue to unravel how epithelial and antigen-presenting cells respond to AdVs and control inflammation and persistence in pathology and therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据