Article
Biotechnology & Applied Microbiology
Yuxiang Ge, Yixuan Li, Zixu Wang, Lan Li, Huajian Teng, Qing Jiang
Summary: The study found that early application of dynamic compression had a suppressive effect on the expression of chondrocyte-specific markers, while late application of dynamic compression promoted cartilage matrix gene expression and suppressed hypertrophic development. Dynamic mechanical compression loading not only promotes chondrogenic differentiation of SMSCs, but also plays a vital role in maintaining the cartilage phenotype.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xiaoen Shi, Haizhen Guo, Xinlu Zhang, Xu Zhang, Chen Cao, Huan Li, Shutong Chen, Lei Han, Sheng Wang
Summary: Photodynamic therapy (PDT) is limited by tumor oxygen heterogeneity, but a novel oxygen level-responsive nanomedicine is reported here. This nanomedicine consists of a hypoxia-responsive molecule (Cy-NO2), a radical generator (ADVN), and a pH-responsive polymer. Under normoxic conditions, Cy-NO2 acts as a photosensitizer for effective PDT, while under hypoxic conditions, it transforms into a photothermal agent to generate toxic free radicals for thermodynamic therapy. This study offers a promising strategy for smart cancer therapy by overcoming oxygen heterogeneity.
ACS MATERIALS LETTERS
(2023)
Article
Engineering, Biomedical
Jinrui Zhang, Bo Li, Jianlin Zuo, Rui Gu, Bin Liu, Chao Ma, Jingjing Li, Kai Liu
Summary: The development of a novel protein adhesive with strong tissue adhesion and chondrogenic capabilities for cartilage repair has been reported in this study. This adhesive, fabricated by the electrostatic combination of chondroitin sulfate (CS) and positively charged elastin-like protein, showed robust adhesion properties on different tissue substrates and promoted cartilage tissue integration. It exhibited beneficial healing effects in a rat model of cartilage defect, making it a promising candidate for translational application in the field of cartilage repair.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan, Hengfeng Yuan
Summary: This study designed a nanocarrier that can regulate the delivery of therapeutic agents into chondrocytes using ROS responsiveness, and confirmed the exact biological mechanisms of this strategy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Shichen Zhang, Zhengqiang Li, Zhimin Xu, Yixin Tang, Congcong Duan, Huanyan Dai, Xinyu Dai, Xin Wei, Yan Liu, Caina Xu, Bing Han
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common type of head and neck cancer. Traditional treatments can have negative effects on physiological functions and appearance. This article discusses the use of reactive oxygen species (ROS)-based cancer therapy and summarizes various nanotherapeutics for HNSCC, including photodynamic therapy, sonodynamic therapy, radiation therapy, and chemodynamic therapy. The challenges and future directions for these treatments are also discussed.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Zhongrun Yuan, Sa Liu, Wenjing Song, Ying Liu, Gangyuan Bi, Renjian Xie, Li Ren
Summary: Galactose has been found to promote chondrogenesis and cartilage matrix formation, which suggests its potential for cartilage repair and regeneration.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Claudio Intini, Tom Hodgkinson, Sarah M. Casey, John P. Gleeson, Fergal J. O'Brien
Summary: CI/II-HyA scaffolds were able to enhance and prolong cartilage repair while reducing hypertrophic cartilage formation, as evidenced by improved cartilage-like formation and consistent responses in protein expression analysis. The study also highlighted the variable chondrogenic abilities of human MSCs from different donors.
BIOENGINEERING-BASEL
(2022)
Review
Chemistry, Multidisciplinary
Yujie Dai, Yiming Ding, Linlin Li
Summary: Nanozymes possess high catalytic activity and stability, making them advantageous in generating or eliminating reactive oxygen species (ROS) for potential applications in disease therapy. Researchers are exploring catalytic mechanisms and strategies to design nanozyme-based platforms for cancer therapy, pathogen infection, neurodegenerative diseases, and more. Challenges and future opportunities for the development and application of nanozymes are also being discussed.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Seong-Won Yang, Young-Il Jeong, Min-Suk Kook, Byung-Hoon Kim
Summary: Folic acid-conjugated nanophotosensitizers showed ROS-sensitive properties and could be delivered to cancer cells via a folate receptor-mediated pathway, making them promising candidates for targeted photodynamic therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Analytical
Hao Yu, Binjie Chen, Huiming Huang, Zhentao He, Jiangman Sun, Guan Wang, Xinggui Gu, Ben Zhong Tang
Summary: Photodynamic therapy is a non-invasive approach for tumor elimination that is gaining increasing attention. The development of aggregation-induced emission (AIE) active photosensitizers has opened up new possibilities for overcoming the limitations of traditional photodynamic therapy.
Article
Critical Care Medicine
Jose Marchan, Olga Wittig, Dylana Diaz-Solano, Marcos Gomez, Jose E. Cardier
Summary: This study investigated the capacity of mesenchymal stromal cells (MSCs) to promote chondrogenesis from chondrocytes or chondrons in 2D and 3D coculture systems. The results demonstrated that MSCs can promote the proliferation of functional chondrocytes, enhance the expression of cartilage genes, and increase GAG production. These findings provide a potential treatment approach for cartilage repair using chondrogenic constructs based on MSCs and chondrocytes.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Biochemistry & Molecular Biology
Nicholas J. Lyons, Rabina Giri, Jakob Begun, David Clark, David Proud, Yaowu He, John D. Hooper, Thomas Kryza
Summary: This article discusses the role of reactive oxygen species (ROS) in normal and malignant colonic cell biology and explores how existing and emerging therapies can utilize ROS for therapeutic benefit. Recent research has shed light on the contribution of ROS to the cytotoxicity of conventional chemotherapy, as well as the generation of ROS in response to excitatory stimuli in emerging therapies such as photodynamic therapy, sonodynamic therapy, and radiodynamic therapy. However, the poor prognosis and resistance associated with metastatic colorectal cancer necessitate the development of new and more effective treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Orthopedics
Ashok Joseph Theruvath, Elhussein Elbadry Mahmoud, Wei Wu, Hossein Nejadnik, Louise Kiru, Tie Liang, Stephen Felt, Heike Elisabeth Daldrup-Link
Summary: Combining ascorbic acid and an FDA-approved iron supplement for pretreating MSCs improved their chondrogenic differentiation and led to hyaline-like cartilage regeneration in the knee joints of mature Gottingen minipigs.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Feng Han, Zhengdong Tu, Zhuang Zhu, Dachuan Liu, Qingchen Meng, Qifan Yu, Ying Wang, Jianquan Chen, Tao Liu, Fengxuan Han, Bin Li
Summary: Excessive ROS level, inflammation, and weak tissue regeneration ability hinder annulus fibrosus (AF) repair, but a composite hydrogel incorporating antioxidant, anti-inflammatory, and AF cell recruitment properties has been developed. This hydrogel eliminates ROS, induces anti-inflammatory response, and promotes extracellular matrix secretion. It can effectively repair AF in rats and has potential applications in AF repair and intervertebral disc herniation prevention.
Article
Engineering, Biomedical
Yunxiu Zhang, Qingyan Jia, Fuchun Nan, Jian Wang, Ke Liang, Jian Li, Xiaokuang Xue, Haohui Ren, Weimin Liu, Jiechao Ge, Pengfei Wang
Summary: In this study, three types of red-emissive carbon dots (RCDs) were successfully prepared with maximum emission at approximately 680 nm. The RCDs exhibited adjustable generation of reactive oxygen species (ROS) through type I and type II photodynamic therapy (PDT). The unique ROS formation of RCDs was determined by their core sizes and surface states, and they were able to induce cell programmed death via activating mitochondrion-mediated apoptotic pathways. This work provides a new prospect for RCDs as nanophotosensitizers to overcome the limitations of single type PDT.
Article
Biotechnology & Applied Microbiology
Jiajia Zhang, Mengdie Yang, Xin Fan, Mengqin Zhu, Yuzhen Yin, Hongyan Li, Jie Chen, Shanshan Qin, Han Zhang, Kun Zhang, Fei Yu
Summary: By designing Mn-based IRT radiosensitizers, local interstitial radiotherapy can be enhanced to address the insufficient systematic immune responses and inhibit tumor metastasis by remodeling the tumor microenvironment and activating immune responses.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Zeng Zeng, Huali Gao, CongXian Chen, Lianbo Xiao, Kun Zhang
Summary: Cancer is a significant health problem worldwide, and the use of bioresponsive nanomaterials shows great potential in cancer diagnosis and therapy.
FRONTIERS IN CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Qiuxia Peng, Zhangbo Qian, Huali Gao, Kun Zhang
Summary: This article mainly reviews the applications of transition-metal based nanomaterials in tumor thermal ablation and diagnosis. Transition-metal based nanomaterials have high conversion efficiency of light energy into heat energy and the ability to targetedly deliver drugs, which are significant for improving therapeutic effects and reducing damage to healthy tissues.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Rui Cui, Luo Wang, Dongyun Zhang, Kun Zhang, Jianping Dou, Linan Dong, Yixuan Zhang, Jiapeng Wu, Longfei Tan, Jie Yu, Ping Liang
Summary: The study developed D-mannose-chelated iron oxide nanoparticles (man-IONPs) to polarize macrophages into an antitumor phenotype, effectively inhibiting the progression of hepatocellular carcinoma.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Chemistry, Multidisciplinary
Jingping Zhong, Xin Yang, Shangzhi Gao, Ji Luo, Jianhui Xiang, Guanhua Li, Yanling Liang, Lijuan Tang, Cheng Qian, Jing Zhou, Li Zheng, Kun Zhang, Jinmin Zhao
Summary: This article introduces a highly active and catalytic single-atom nanoenzyme. By manipulating the geometric and electronic structures, a SAzyme with superoxide dismutase-like activity is designed. This SAzyme exhibits excellent catalytic activity, degrading oxygen free radicals and displaying catalase-like activity, with potential therapeutic applications in osteoarthritis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Duo Wang, Mengqi Zhang, Guanhua Qiu, Chao Rong, Xiaoqi Zhu, Guchun Qin, Cunqing Kong, Jing Zhou, Xiayi Liang, Zhaoting Bu, Junjie Liu, Tao Luo, Jianjun Yang, Kun Zhang
Summary: By constructing an intratumorally synthesized Au bioreactor, heat diffusion in thermally sensitive hydrogel-filled tumors was dispersed, improving energy utilization efficiency and expanding the effective ablation zone. This approach reversed the immunosuppressive tumor microenvironment, enhanced microwavegenetics, and identified extracellular matrix viscosity as a general immune escape target. By remodeling ECM and blocking viscosity reprogramming, immune cell recruitment and activation were enhanced, leading to improved CAR-T immunotherapy against tumor recurrence after incomplete microwave ablation.
Review
Chemistry, Inorganic & Nuclear
Xueni Zhang, Qing Zhao, Jianjun Yang, Taixia Wang, Fubo Chen, Kun Zhang
Summary: Conventional chemotherapeutic drugs have severe side effects and low bioavailability, which hinders current clinical cancer treatments. Tumor microenvironment (TME)-responsive nanomedicine has emerged as a safe and effective approach for cancer diagnosis and therapy. In this review, the intratumoral biosynthesis of inorganic nanomaterials for cancer diagnosis and treatment, triggered by specific TME conditions, is systematically summarized. The review also discusses unresolved issues, potential solutions, perspectives, and future directions in this field.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Zhaoting Bu, Jianjun Yang, Yan Zhang, Tao Luo, Chao Fang, Xiayi Liang, Qiuxia Peng, Duo Wang, Ningjing Lin, Kun Zhang, Weizhong Tang
Summary: Researchers have developed a sequential ubiquitination and phosphorylation epigenetics modulation strategy using Fe-metal-organic framework (Fe-MOF) as a nanoplatform for chemodynamic therapy (CDT). This strategy can block ubiquitination and phosphorylation, leading to increased sensitivity to reactive oxygen species (ROS) and activation of acute immune responses. The Fe-MOF-based CDT nanoplatform also shows potential for inhibiting metastatic colorectal cancer (mCRC) and enhancing other ROS-based anti-tumor methods.
Article
Oncology
Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Qin Wang, Chunyan Zhu, Chao Fang, Junjie Liu, Kun Zhang, Yan Liu
Summary: In this study, exosomes derived from M1 macrophages were engineered to deliver RSL3 and induce ferroptosis in tumor cells, activating immune responses and mitigating the immunosuppressive tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Materials Science, Multidisciplinary
Tong Xu, Jingwei Hu, Chao Fang, Tao Luo, Junjie Liu, Kun Zhang
Summary: Researchers have developed a composite zeolite-based hemostat spray consisting of Ag-doped beta zeolite and coupled fibrinogen/thrombin. This composite hemostat exhibits the most robust hemostasis ability with the least bleeding amount and shortest hemostasis time. It can also kill bacteria, ameliorate bacteria-aroused inflammation, and promote wound healing.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Duo Wang, Xiaoqi Zhu, Xiaobo Wang, Qin Wang, Kangning Yan, Guichun Zeng, Guanhua Qiu, Rong Jiao, Xia Lin, Jie Chen, Qiaoling Yang, Wen Qin, Junjie Liu, Kun Zhang, Yan Liu
Summary: The multichannel sonocatalysis amplifier attenuates IDH1-mutated cholangiocarcinoma plasticity and tolerance to ROS therapy by blocking Nrf2 to inhibit glutathione biosynthesis, disrupting redox homeostasis, and enhancing sonocatalytic ROS production. It also disrupts Ca2+ homeostasis, reprograms mitochondrial energy and substance metabolism, hinders DNA self-repair, and impairs IDH1-mutation-induced tolerance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Multidisciplinary Sciences
Chao Fang, Gaozhe Xiao, Taixia Wang, Li Song, Bo Peng, Bin Xu, Kun Zhang
Summary: This review provides a detailed overview of oncolytic viruses (OVs) as a promising antitumor method in tumor immunotherapy, focusing on their mechanisms, current research, clinical applications, and future perspectives. OVs have the potential to directly kill tumor cells and activate the immune system for enhanced antitumor responses. The review also highlights the challenges and opportunities in the clinical translation of OVs.
Article
Chemistry, Multidisciplinary
Jianchao Ge, Chao Fang, Haisong Tan, Ming Zhan, Meng Gu, Jianshu Ni, Guangcan Yang, Haipeng Zhang, Jinliang Ni, Kun Zhang, Bin Xu
Summary: In the treatment of BPH, an injectable SAGA hydrogel, featuring Zn2+-triggered in situ gelation, has been developed to reprogram the prostate microenvironment and treat BPH. The hydrogel can alleviate Zn2+-induced inflammation and glycolysis, and the glycyrrhizic acid in the hydrogel can also regulate the immune response and scavenge reactive oxygen species (ROS).
ADVANCED MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Xiulin Dong, Qiaoling Yang, Hai Wang, Chunyan Zhu, Taixia Wang, Chao Fang, Yan Zhang, Jianjun Yang, Kun Zhang, Qing Zhao
Summary: A fusion strategy based on cancer stem cell (CSC) membrane is proposed to target and attenuate the properties and plasticity of cancer stem cells. The engineered biomimetic nanoeffectors coated with fusion membrane can disrupt energy metabolism, trigger mitochondrial apoptosis, and inhibit tumor proliferation. This strategy has been shown to hinder the progression of breast cancer in experimental models.
Review
Materials Science, Multidisciplinary
Yan Zhang, Chao Fang, Wei Zhang, Kun Zhang
Summary: This review highlights the importance of pyroptosis in tumors and inflammatory diseases and the potential of nanobiotechnology in treating pyroptosis-related diseases. It summarizes the pyroptosis pathways, inducers, and inhibitors, and explores the role of nanotechnology in regulating pyroptosis and treating cancer and inflammation-associated diseases.