Article
Chemistry, Multidisciplinary
Andrea Urru, Ayako Nakaki, Oualid Benkarim, Francesca Crovetto, Laura Segales, Valentin Comte, Nadine Hahner, Elisenda Eixarch, Eduard Gratacos, Fatima Crispi, Gemma Piella, Miguel A. Gonzalez Ballester
Summary: In this study, a new pipeline for fetal and neonatal segmentation has been developed, along with the creation of two new fetal atlases. The results show that the use of the new templates and segmentation strategy leads to accurate results, outperforming a reference pipeline in early and late-onset fetal brain segmentation.
Article
Neurosciences
Raul R. Cruces, Jessica Royer, Peer Herholz, Sara Lariviere, Reinder Vos De Wael, Casey Paquola, Oualid Benkarim, Bo-yong Park, Janie Degre-Pelletier, Mark C. Nelson, Jordan DeKraker, Ilana R. Leppert, Christine Tardif, Jean -Baptiste Poline, Luis Concha, Boris C. Bernhardt
Summary: Multimodal MRI has advanced human neuroscience, but demands processing methods to integrate information. Micapipe is an open processing pipeline for multimodal MRI datasets, generating various connectomes and matrices across different spatial scales for easy replication of findings.
Review
Clinical Neurology
Amy A. Jolly, Adriana Zainurin, Gillian Mead, Hugh S. Markus
Summary: Fatigue is a common symptom following stroke, but its underlying mechanisms are still unknown. This study aimed to assess the association between neuroimaging parameters and post-stroke fatigue (PSF). The results showed little evidence for a significant association between any neuroimaging parameters and PSF. Further research is needed to investigate the role of lesion location and altered brain networks in mediating PSF.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Biology
Ross D. Markello, Aurina Arnatkeviciute, Jean-Baptiste Poline, Ben D. Fulcher, Alex Fornito, Bratislav Misic
Summary: The study developed the abagen toolbox for analyzing transcriptomic data and found that the choice of processing pipeline significantly influences research outcomes when using the Allen Human Brain Atlas. The results show that processing steps affecting gene normalization have the greatest impact on downstream statistical inferences and conclusions.
Article
Clinical Neurology
Shijing Wang, Francesco Leri, Sakina J. Rizvi
Summary: Anhedonia, a core symptom of major depressive disorder, extends beyond impaired consummatory pleasure to deficits in various functions, with dopamine and other neurotransmitters playing key roles. While extensive research has explored reward anticipation and outcome, there are translational gaps in understanding reward motivation, effort, valuation, and learning.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Astronomy & Astrophysics
Stefan Meingast, Herve Bouy, Verena Fuernkranz, David Hernandez, Alena Rottensteiner, Erik Braendli
Summary: The VISIONS public survey provides large-scale, multi-epoch imaging of nearby star-forming regions at high resolution in the near-infrared. The data is processed using a custom pipeline infrastructure to minimize astrometric and photometric biases and produce science-ready images and source catalogs. The pipeline modules, written in Python, ensure accessibility, robustness, and high performance while achieving accurate calibration and compliance with ESO Phase 3 regulations.
ASTRONOMY & ASTROPHYSICS
(2023)
Review
Clinical Neurology
Emily L. Ball, Mahnoor Shah, Eilidh Ross, Rachel Sutherland, Charlotte Squires, Gillian E. Mead, Joanna M. Wardlaw, Terence J. Quinn, Dorota Religa, Erik Lundstrom, Joshua Cheyne, Susan D. Shenkin
Summary: This systematic review investigates the associations between magnetic resonance imaging (MRI) features performed at stroke diagnosis and post-stroke cognitive impairment in stroke survivors. The findings suggest that cerebral atrophy, microbleeds, and severity of white matter hyperintensities are associated with cognitive outcomes, while the association between increasing cerebral small vessel disease score and cognitive outcomes is inconclusive. These findings can help identify stroke patients at risk of cognitive problems, but the clinical utility of acute MRI in predicting cognitive problems remains uncertain.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Geriatrics & Gerontology
Marte Stine Einstad, Till Schellhorn, Pernille Thingstad, Stian Lydersen, Eva Birgitte Aamodt, Mona Kristiansen Beyer, Ingvild Saltvedt, Torunn Askim
Summary: Cognitive decline and decline in physical performance are common after stroke, with stroke lesion volume being a key factor in dual impairment early after stroke.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Ji-Hun Yoo, Benjamin Chong, Peter Alan Barber, Cathy Stinear, Alan Wang
Summary: This review examines the methodologies currently used in motor outcome prediction studies using atlas-based voxel neuroimaging features. The study found that there are various limitations in the current methods, such as a lack of detailed reporting on image acquisition and a lack of consensus on the use of a single sensorimotor atlas for prediction. Therefore, there is a need for further validation and improvement in neuroimaging feature development for motor outcome prediction.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Anatomy & Morphology
Mohammad Seyyed Mohammadi, Alexia Planty-Bonjour, Fabrice Poupon, Ivy Uszynski, Cyril Poupon, Christophe Destrieux, Frederic Andersson
Summary: The brainstem is crucial for various important functions and the need for atlases describing its structure and connectivity is evident. This paper presents a method to create a high-resolution multisubject atlas of the human brainstem and reveals higher variability than previously assumed. The atlas, based on four specimens, can be easily expanded.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biochemical Research Methods
Li Wang, Zhengwang Wu, Liangjun Chen, Yue Sun, Weili Lin, Gang Li
Summary: The human cerebral cortex goes through significant development during early postnatal stages. However, it is challenging to accurately process and quantify infant brain development due to low tissue contrast and inter-site data heterogeneity in infant brain MRI scans. To address these challenges, we propose a robust computational pipeline that utilizes deep learning techniques. The pipeline can handle different imaging protocols and scanners and has demonstrated superior effectiveness and accuracy compared to existing methods.
Article
Neurosciences
Oscar Ferrante, Ling Liu, Tamas Minarik, Urszula Gorska, Tara Ghafari, Huan Luo, Ole Jensen
Summary: Magnetoencephalography (MEG) allows for quantifying and locating human neuronal activity with high temporal resolution. However, the abundance of options in open-source toolboxes makes reproducible research and newcomers to the field face challenges. The FLUX pipeline provides standardized analysis steps in cognitive neuroscience with a focus on quantifying and localizing oscillatory brain activity, aiming to promote standardization and support education in the field.
Article
Neurosciences
Yang Hu, Qingfeng Li, Kaini Qiao, Xiaochen Zhang, Bing Chen, Zhi Yang
Summary: Magnetic resonance imaging (MRI) is a non-invasive tool widely used for measuring human brain properties. However, there is a lack of processing pipelines for multi-modal MRI data, and the reliability and validity measures are inadequate. To address this, PhiPipe, a multi-modal MRI processing pipeline, was developed and evaluated. PhiPipe showed comparable or better reliability and validity compared to two popular single-modality pipelines. It provides a user-friendly solution for multi-modal MRI data processing and includes reliability and validity assessments to aid researchers in experimental design and statistical analysis. This study also presents a framework for evaluating the reliability and validity of image processing pipelines.
HUMAN BRAIN MAPPING
(2023)
Article
Anatomy & Morphology
Artur Agaronyan, Raeyan Syed, Ryan Kim, Chao-Hsiung Hsu, Scott A. Love, Jacob M. Hooker, Alicia E. Reid, Paul C. Wang, Nobuyuki Ishibashi, Yeona Kang, Tsang-Wei Tu
Summary: The study on the olive baboon brain provides insights into the human brain and neurological disorders. PET and MRI are used for non-invasive brain imaging, and a three-dimensional atlas of the olive baboon brain is developed for multimodal imaging analysis.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Sport Sciences
Stanley Hughwa Hung, Mohamed Salah Khlif, Sharon Kramer, Emilio Werden, Laura J. Bird, Bruce C. V. Campbell, Amy Brodtmann
Summary: This study aimed to examine the association between poststroke physical activity (PA) and white matter hyperintensities (WMH) volume. The results showed that meeting PA guidelines was associated with lower WMH volume in univariable analysis. However, in multivariable analysis, meeting PA guidelines was not associated with WMH volume, while older age was associated with greater WMH volume.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Clinical Neurology
Alina Sprenger-Svacina, Johannes Haensch, Kilian Weiss, Nils Grosse Hokamp, David Maintz, Marc Schlamann, Gereon R. Fink, Natalie Schloss, Kai Laukamp, Gilbert Wunderlich, Helmar C. Lehmann, Thorsten Lichtenstein
Summary: This study evaluated the utility of a multi-parametric MRI protocol to detect loss of spinal motor neurons and subsequent muscle damage in adult SMA patients. The results showed that water T-2 mapping and Dixon-based PDFF estimation can distinguish between SMA patients and controls.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Melanie Filser, Axel Buchner, Gereon Rudolf Fink, Stefan M. Gold, Iris-Katharina Penner
Summary: Patients with multiple sclerosis (MS) are at increased risk of experiencing mental health problems, including depression and anxiety. However, there is limited knowledge about the assessment and association of these affective symptoms in MS. Further research is needed to improve diagnosis and care.
JOURNAL OF NEUROLOGY
(2023)
Article
Oncology
Michael M. Wollring, Jan-Michael Werner, Elena K. Bauer, Caroline Tscherpel, Garry S. Ceccon, Philipp Lohmann, Gabriele Stoffels, Christoph Kabbasch, Roland Goldbrunner, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: This study evaluated the use of FET PET and MRI for early response assessment in recurrent glioma patients treated with lomustine-based chemotherapy. The results suggest that FET PET provides complementary information to RANO criteria for response evaluation early after treatment initiation.
Article
Clinical Neurology
Martin K. R. Svacina, Alina Sprenger-Svacina, Anastasia Tsakmaklis, Alina M. Rueb, Ines Klein, Hauke Wuestenberg, Gereon R. Fink, Helmar C. Lehmann, Maria J. G. T. Vehreschild, Fedja Farowski
Summary: This study found that the gut microbiome of CIDP patients has increased diversity and enrichment of Firmicutes, which produce short-chain fatty acids. However, intravenous immunoglobulin (IVIg) administration did not have a short-term impact on the gut microbiome in CIDP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neuroimaging
Nina N. Kleineberg, Claudia C. Schmidt, Monika K. Richter, Katharina Bolte, Natalie Schloss, Gereon R. Fink, Peter H. Weiss
Summary: Previous studies on left hemisphere stroke patients found effector-specific differences in imitation performance and differences between meaningless and meaningful gestures. The current study investigated the impact of gesture meaning on lesion correlates of effector-specific imitation deficits in a large sample of sub-acute left hemisphere stroke patients. The results revealed significant interactions between the effector used for imitation and the meaning of the imitated gesture. Lesion-symptom mapping analyses identified brain regions associated with impaired imitation, regardless of the effector or gesture meaning. The findings highlight the importance of considering gesture meaning in assessments of apraxia.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Anja Schaffrath, Sophia Schleyken, Aline Seger, Hannah Jergas, Pelin Ozduzenciler, Marlene Pils, Lara Bloemeke, Anneliese Cousin, Johannes Willbold, Tuyen Bujnicki, Oliver Bannach, Gereon R. Fink, Dieter Willbold, Michael Sommerauer, Michael T. Barbe, Gultekin Tamguney
Summary: This study used surface-based fluorescence intensity distribution analysis (sFIDA) to detect and quantify single particles of alpha-synuclein aggregates in stool samples of 94 PD patients, 72 isolated rapid eye movement sleep behavior disorder (iRBD) patients, and 51 healthy controls. The results showed significantly elevated concentrations of alpha-synuclein aggregates in stool samples of iRBD patients compared to controls (p = 0.024) or PD patients (p < 0.001). The study suggests that measuring alpha-synuclein aggregates in stool using the sFIDA assay could support the diagnosis of prodromal synucleinopathies.
NPJ PARKINSONS DISEASE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Stetter, Jan-Michael Werner, Michael Schroeter, Claudia Baumann, Janina Neuneier, Marc Schlamann, Matthias Schmidt, Alexander Drzezga, Gereon R. Fink, Norbert Galldiks
Summary: Differentiating brain tumors from nonneoplastic lesions using conventional MRI may be challenging. Clinical symptoms often remain unspecific, and imaging findings from MRI may be inconclusive. PET with the radiolabeled somatostatin receptor ligand DOTATATE was performed, and it facilitated the diagnosis of a falcine meningioma consistent with its value for the differential diagnosis of meningioma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Felix Kohle, Marie Madlener, Emanuel F. Bruno, Gereon R. Fink, Volker Limmroth, Lothar Burghaus, Michael P. Malter
Summary: This study revealed that most patients with status epilepticus (SE) were not effectively treated with benzodiazepines (BZDs) according to current guidelines. Sufficient dosing of BZDs was found to be beneficial for patients with generalised convulsive SE, but not for other types of SE. Treatment decisions guided by the semiology of SE are crucial, and further evidence is urgently needed for the management of non-generalised convulsive SE.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Correction
Health Policy & Services
Kim Dillen, Yasemin Goereci, Veronika Dunkl, Anne Muller, Gereon R. Fink, Raymond Voltz, Mevhibe Hocaoglu, Clemens Warnke, Heidrun Golla
PALLIATIVE & SUPPORTIVE CARE
(2023)
Article
Health Policy & Services
Kim Dillen, Yasemin Goereci, Veronika Dunkl, Anne Mueller, Gereon R. Fink, Raymond Voltz, Mevhibe Hocaoglu, Clemens Warnke, Heidrun Golla
Summary: This study culturally adapted and translated the IPOS Neuro-S8 into German and evaluated its face and content validity. The results showed that the German version of the IPOS Neuro-S8 has demonstrated face and content validity and captures relevant symptoms of neurological patients needing palliative care. The next step is to investigate its psychometric properties, including construct and criterion validity.
PALLIATIVE & SUPPORTIVE CARE
(2023)
Article
Oncology
Norbert Galldiks, Nathalie L. Albert, Michael Wollring, Jan-Michael Werner, Philipp Lohmann, Javier E. Villanueva-Meyer, Gereon R. Fink, Karl-Josef Langen, Joerg-Christian Tonn
Summary: In patients with meningioma, anatomical imaging using MRI or CT is the main method for diagnosis and treatment planning. However, these imaging modalities have limitations in accurately delineating meningioma, especially in cases of trans-osseus growth and tumors with complex geometry, as well as differentiating post-therapeutic changes from relapse. PET imaging, which provides metabolic and cellular information, is being increasingly used to complement anatomical imaging and improve the clinical management of meningioma patients.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
Theresa Paul, Valerie M. Wiemer, Lukas Hensel, Matthew Cieslak, Caroline Tscherpel, Christian Grefkes, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
Summary: This study used diffusion spectrum imaging (DSI) and a novel compartment-wise analysis approach to investigate the structural connectivity between bilateral cortical core motor regions in chronic stroke patients. The results showed that the structural connectivity between these regions is associated with both basal and complex motor control. Specifically, the recovery of basal motor control may be supported by an alternative pathway through the contralesional primary motor cortex (M1) and non-crossing fibers of the contralesional corticospinal tract (CST). These findings help explain conflicting interpretations of the functional role of the contralesional M1 and suggest the potential of cortico-cortical structural connectivity as a biomarker for motor recovery post-stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Joshua N. Strelow, Till A. Dembek, Juan C. Baldermann, Pablo Andrade, Gereon R. Fink, Veerle Visser-Vandewalle, Michael T. Barbe
Summary: This study aimed to assess the utility of low beta-band suppression as a tool for contact selection in STN-DBS for PD. The results showed that the degree of low beta-band suppression correlated with the clinical efficacy of the respective stimulation contact, indicating its potential as a reliable tool for contact selection in STN-DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Lukas Hensel, Aline Seger, Ezequiel Farrher, Anna K. Bonkhoff, N. Jon Shah, Gereon R. Fink, Christian Grefkes, Michael Sommerauer, Christopher E. J. Doppler
Summary: This study found that the motor response in Parkinson's disease patients is related to the temporal dynamics of corticostriatal functional connectivity. Patients with high response spent more time in a regionally integrated state, while low responders showed lower functional connectivity between the anterior midcingulate cortex/dorsal anterior cingulate cortex and putamen during a more segregated state, which was correlated with the motor response.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Ji-Won Kim, Henning R. Stetefeld, Gereon R. Fink, Michael P. Malter
Summary: This study reports on the clinical practice in managing stroke patients with seizures at onset (SaO) from a large tertiary stroke center in Germany. The data show that SaO is rare in stroke patients but associated with more extensive strokes and increased in-hospital mortality.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
