Article
Nutrition & Dietetics
Laura Danner, Florian Malard, Raquel Valdes, Stephanie Olivier-Van Stichelen
Summary: Non-nutritive sweeteners (NNS) are widely used sugar substitutes, but their effects on physiological processes and detoxification have not been fully understood. This study investigated the impact of two NNS, AceK and Sucr, on P-glycoprotein (PGP) transporter in human cells. It was found that AceK and Sucr acted as PGP inhibitors, potentially posing risks for NNS consumers during medication or exposure to toxins.
Review
Nutrition & Dietetics
Andrea Conz, Mario Salmona, Luisa Diomede
Summary: The human gut microbiota is a complex community of microorganisms in the digestive tract, which plays a vital role in maintaining normal gut health. Factors such as genetics, age, antibiotics, environment, and diet can influence the composition and function of the gut microbiota. With the increasing use of non-nutritive sweeteners (NNS) in diets, their impact on the gut microbiota has become a focus of research. However, conflicting results have been reported in pre-clinical and clinical studies, and a consensus on the effects of NNS on the gut microbiota is yet to be reached.
Article
Biochemistry & Molecular Biology
Jotham Suez, Yotam Cohen, Rafael Valdes-Mas, Uria Mor, Mally Dori-Bachash, Sara Federici, Niv Zmora, Avner Leshem, Melina Heinemann, Raquel Linevsky, Maya Zur, Rotem Ben-Zeev Brik, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Ruthy Fischbein, Olga Sharov, Sergey Malitsky, Maxim Itkin, Noa Stettner, Alon Harmelin, Hagit Shapiro, Christoph K. Stein-Thoeringer, Eran Segal, Eran Elinav
Summary: This study found that the consumption of non-nutritive sweeteners (NNS) may alter the microbiome and glycemic responses in humans. Different NNS had distinct effects on the microbiome and glycemic responses, with saccharin and sucralose significantly impairing glycemic responses. Additionally, when NNS were supplemented to mice, the glycemic responses reflected those in respective human donors and were influenced by microbial signals.
Review
Nutrition & Dietetics
Irene L. L. Richardson, Steven A. A. Frese
Summary: Non-nutritive sweeteners (NNS) are widely used in food and perceived as calorie-free alternatives to sugar-based sweeteners. However, recent research suggests that NNS have an impact on human physiology, particularly on glucose responses, the gastrointestinal epithelium, and the gut microbiome. This raises questions about the interaction between NNS and the gut microbiome, which is increasingly recognized as a significant factor in human health.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Katsumi Iizuka
Summary: Artificial sweeteners may have no effect on body weight and glycemic control, and may even affect glucose absorption, insulin and incretin secretion in the intestine. Intake of artificial sweeteners may also alter the composition of microbiota and worsen glycemic control. Therefore, caution should be exercised when using artificial sweeteners in the treatment of diabetes and obesity.
Article
Biochemistry & Molecular Biology
Ann-Kristin Eriksson Wiklund, Xueli Guo, Elena Gorokhova
Summary: Artificial sweeteners have neurotoxic effects on aquatic life, highlighting the need for risk reassessment and international regulatory standards.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Cheng-Hsin Lin, Hung-Yuan Li, Shu-Huei Wang, Yue-Hwa Chen, Yang-Ching Chen, Hung-Tsung Wu
Summary: The study revealed that non-nutritive sweetener AceK may exacerbate dyslipidemia and atherosclerotic lesion induced by high cholesterol diet, increasing the risk of atherosclerosis.
Article
Obstetrics & Gynecology
Brianna C. Halasa, Allison C. Sylvetsky, Ellen M. Conway, Eileen L. Shouppe, Mary F. Walter, Peter J. Walter, Hongyi Cai, Lisa Hui, Kristina Rother
Summary: This study investigated human fetal exposure to non-nutritive sweeteners (NNS) by analyzing amniotic fluid and umbilical cord blood. Results showed evidence of human transplacental transmission of NNS, suggesting potential adverse effects on metabolic health in offspring. Well-designed, prospective clinical trials are needed to further understand the impact of NNS intake during pregnancy on human development and long-term health.
AMERICAN JOURNAL OF PERINATOLOGY
(2021)
Article
Environmental Sciences
Edrick Ramos, Diego Padilla-Reyes, Abrahan Mora, Hector Barrios-Pina, Shashi Kant, Jurgen Mahlknecht
Summary: Contamination from wastewater infiltration poses a threat to urban groundwater resources. Artificial sweeteners are used as tracers to determine wastewater sources. The occurrence of artificial sweeteners in an urban groundwater system in Mexico was investigated for the first time, revealing that most of these compounds are discharged directly into sewer systems.
Article
Food Science & Technology
Meztli Ramos-Garcia, Jorge Luis Ble-Castillo, Carlos Garcia-Vazquez, Carlos Alfonso Tovilla-Zarate, Isela Esther Juarez-Rojop, Viridiana Olvera-Hernandez, Alma Delia Genis-Mendoza, Ruben Cordova-Uscanga, Carlos Alfonso Alvarez-Gonzalez, Juan Cuauhtemoc Diaz-Zagoya
Summary: According to this study, recommended doses of NNS do not alter feeding behavior, body weight, or glycemic tolerance in healthy and with altered glycemic rats.
Article
Nutrition & Dietetics
Weilan Wang, Jodi E. Nettleton, Michael G. Gaenzle, Raylene A. Reimer
Summary: Maternal consumption of non-nutritive sweeteners can alter the composition and metabolism of the cecal microbiome in offspring, which is associated with increased body weight and body fat. The changes in microbial composition and metabolism may be responsible for the increased obesity risk in offspring.
FRONTIERS IN NUTRITION
(2022)
Review
Pediatrics
Francisca Concha, Veronica Sambra, Paola Caceres, Sandra Lopez-Arana, Bielka Carvajal, Martin Gotteland
Summary: The rapid increase in the use of non-nutritive sweeteners (NNSs) instead of sugar in foods and beverages is a global concern. Limited studies have been conducted on the consumption of NNSs by pregnant or lactating women and infants, but evidence suggests potential negative impacts on birth outcomes and infant weight gain. Further research is needed, especially in Latin America and Asia, to evaluate the effects of chronic exposure to NNSs in at-risk groups and update recommendations.
FRONTIERS IN PEDIATRICS
(2023)
Article
Environmental Sciences
Tamanna Sultana, Chris D. Metcalfe
Summary: This study provides key data on the sampling rates and concentrations of artificial sweeteners using polar organic chemical integrative samplers (POCIS) for the first time.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Article
Nutrition & Dietetics
Grace Farhat, Fleur Dewison, Leo Stevenson
Summary: Most UK adults have a high-risk perception of NNS and lack knowledge of related regulations. Risk perception is influenced by multiple factors, and information dissemination can significantly reduce it.
Article
Medicine, General & Internal
Brian M. Cavagnari, Georgina Gomez, Irina Kovalskys, Dayana Quesada, Juan Carlos Brenes, E. N. REPRESENTACIoN D. E. L. G. R. U. P. O. E. L. A. N. S. EN REPRESENTAC DEL GRP ELANS
Summary: This study investigates the consumption of non-caloric sweeteners (NCS) in the adult population of Argentina and finds that the average intake of saccharin, aspartame, acesulfame-K, and sucralose is well below their respective acceptable daily intake (ADI). Women and older individuals are more likely to consume NCS, while the Northeast and South regions have lower proportions of NCS consumers. Beverages are the main source of NCS consumption.
MEDICINA-BUENOS AIRES
(2022)
Article
Obstetrics & Gynecology
Anna Palatnik, Andrea Moosreiner, Stephanie Olivier-Van Stichelen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Eugenia Wulff, Jeffrey Boakye, Rex Berendt, John Hanover, Stephanie Olivier-van Stichelen
Letter
Obstetrics & Gynecology
Anna Palatnik, Andrea Moosreiner, Stephanie Olivier-Van Stichelen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Letter
Obstetrics & Gynecology
Anna Palatnik, Andrea Moosreiner, Stephanie Olivier-Van Stichelen
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Multidisciplinary Sciences
Eugenia Wulff-Fuentes, Rex R. Berendt, Logan Massman, Laura Danner, Florian Malard, Jeet Vora, Robel Kahsay, Stephanie Olivier-Van Stichelen
Summary: Over the past 35 years, extensive research has been conducted on protein O-GlcNAcylation, resulting in the establishment of a database of human O-GlcNAcylated proteins and the acquisition of a more robust semi-consensus sequence through analysis. Additionally, a comprehensive meta-analysis of human O-GlcNAcylated proteins has revealed that O-GlcNAcylation is a master regulator of cell signaling.
Article
Endocrinology & Metabolism
Logan J. Massman, Michael Pereckas, Nathan T. Zwagerman, Stephanie Olivier-Van Stichelen
Summary: This study highlights the significant role of O-GlcNAcylation in the pathophysiology of ACTH-secreting adenomas, including cellular proliferation and hypersecretion. O-GlcNAc enzymes were found to be upregulated in aggressive tumors, indicating a potential link between O-GlcNAcylation and pituitary adenoma etiology. Additionally, O-GlcNAcylation was shown to play a crucial role in the endocrine function of pituitary adenomas, particularly in corticotropic tumors.
Article
Computer Science, Software Engineering
Florian Malard, Laura Danner, Emilie Rouzies, Jesse G. Meyer, Ewen Lescop, Stephanie Olivier-Van Stichelen
Summary: This article introduces EpyNN, an educational Python resource designed to help the public understand key concepts and practical implementation of scalable artificial neural network (ANN) architectures. EpyNN includes an educational API and workflows, as well as a documentation website that provides learning materials with code, mathematics, graphical representation, and text side-by-side.
Editorial Material
Biochemistry & Molecular Biology
M. Osman Sheikh, Chantelle J. Capicciotti, Stephanie Olivier-Van Stichelen
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dawn M. Wenzel, Stephanie Olivier-Van Stichelen
Summary: Proper neuronal development is crucial for growth and adult brain function, with genetic mutations or environmental factors potentially leading to brain malformations and diseases like epilepsy and intellectual disabilities. The role of glycosylation in neuronal development is significant, as genetic defects in this pathway are often associated with severe neurological abnormalities. O-GlcNAcylation plays an essential role in neuronal development and signaling, with mutations in O-GlcNAc transferase (OGT) linked to X-linked intellectual disabilities (XLID).
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Developmental Biology
Yiwen Cui, Meredith Cruz, Anna Palatnik, Stephanie Olivier-Van Stichelen
Summary: Gestational diabetes mellitus (GDM) can be influenced by fetal sex, in addition to placental endocrine dysregulation. This study investigated the role of the O-GlcNAc pathway in mediating sex-specific placenta dysfunction in GDM. The expression of O-GlcNAc enzymes, specifically OGT, was found to be significantly reduced in male placentas from GDM mothers. In vitro studies further demonstrated the impact of OGT downregulation on hormonal production in trophoblast cells and primary syncytiotrophoblasts (SCTs) derived from male placentas.
Article
Nutrition & Dietetics
Laura Danner, Florian Malard, Raquel Valdes, Stephanie Olivier-Van Stichelen
Summary: Non-nutritive sweeteners (NNS) are widely used sugar substitutes, but their effects on physiological processes and detoxification have not been fully understood. This study investigated the impact of two NNS, AceK and Sucr, on P-glycoprotein (PGP) transporter in human cells. It was found that AceK and Sucr acted as PGP inhibitors, potentially posing risks for NNS consumers during medication or exposure to toxins.
Article
Mathematical & Computational Biology
Florian Malard, Eugenia Wulff-Fuentes, Rex R. Berendt, Guillaume Didier, Stephanie Olivier-Van Stichelen
Summary: Post-translational modifications are crucial for protein function and signaling, with O-GlcNAcylation being a highly conserved case in point. The development of the O-GlcNAc Database v1.2, with data from 42 organisms and over 14,500 O-GlcNAcylated proteins, marks a significant advancement in consolidating information on O-GlcNAcylation. The database system, emphasizing user-friendliness and automation, showcases a sustainable and cost-efficient model for creating scientific online databases beyond the O-GlcNAc research community.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Florian Malard, Eugenia Wulff-Fuentes, Rex Berendt, Stephanie Olivier-Van Stichelen
Meeting Abstract
Biochemistry & Molecular Biology
Laura Danner, Stephanie Olivier-Van Stichelen
Meeting Abstract
Biochemistry & Molecular Biology
Eugenia A. Wulff, Rex Berendt, John A. Hanover, Stephanie Olivier-Van Stichelen