Article
Oncology
Jian Huang, Fanglin Tian, Ying Song, Mengru Cao, Shi Yan, Xiuwen Lan, Yimeng Cui, Yaowen Cui, Yue Cui, Dexin Jia, Li Cai, Ying Xing, Xin Wang
Summary: The study demonstrated that EHD1 plays a crucial role in non-small cell lung cancer, regulating the glycolysis pathway through the Wnt/beta-catenin signaling, promoting aerobic glycolysis and proliferation. These findings suggest a potential therapeutic target for NSCLC.
Article
Chemistry, Multidisciplinary
Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Qinong Ye
Summary: Aerobic glycolysis, or the Warburg effect, is a critical process in cancer cell growth and metastasis. This study demonstrates that the transcription factor OVOL2 can directly repress glycolytic gene expression to block the Warburg effect. The activation of OVOL2 by the tumor suppressor p53 through inhibiting MDM2-mediated degradation presents a potential avenue for cancer treatment, particularly in breast cancer.
Article
Oncology
Michele Petruzzelli, Miriam Ferrer, Martijn J. Schuijs, Sam O. Kleeman, Nicholas Mourikis, Zoe Hall, David Perera, Shwethaa Raghunathan, Michele Vacca, Edoardo Gaude, Michael J. Lukey, Duncan I. Jodrell, Christian Frezza, Erwin F. Wagner, Ashok R. Venkitaraman, Timotheus Y. F. Halim, Tobias Janowitz
Summary: In this study, we found that neutrophilia and enhanced aerobic glycolysis occur early in cancer progression. Inhibition of aerobic glycolysis can slow down tumor growth but also leads to cachexia and reduces overall survival. Our findings suggest that neutrophils play an adaptive role in host metabolic homeostasis during cancer progression.
Article
Pharmacology & Pharmacy
Yuxi Zhang, Yi Wang, Yanping Li, Cong Huang, Xiaoqian Xiao, Zhanqiong Zhong, Jingyi Tang, Haolan Lu, Yibei Tang, Jiahui Yang
Summary: In this study, it is shown that dihydroartemisinin (DHA) and artemisinin (AS) inhibit aerobic glycolysis in non-small cell lung cancer (NSCLC) cells through the ERK/c-Myc pathway, leading to the inhibition of tumor growth. This study expands our knowledge of artemisinin derivatives in regulating tumor glucose metabolism and provides a potential strategy for lung cancer therapy.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Cell Biology
Massimo Saini, Laura Schmidleitner, Helena Dominguez Moreno, Elisa Donato, Mattia Falcone, Johanna M. Bartsch, Corinna Klein, Vanessa Vogel, Roberto Wuerth, Nicole Pfarr, Elisa Espinet, Mareike Lehmann, Melanie Koenigshoff, Manuel Reitberger, Simon Haas, Elisabeth Graf, Thomas Schwarzmayr, Tim-Matthia Strom, Saskia Spaich, Marc Suetterlin, Andreas Schneeweiss, Wilko Weichet, Gunnar Schotta, Maximilia Reichert, Nicola Aceto, Martin R. Sprick, Andreas Trumpp, Christina H. Scheel
Summary: The acquisition of mesenchymal traits is a key factor in breast cancer progression. However, the relevance of epithelial-to-mesenchymal transition (EMT) is controversial and depends on the specific context. In this study, researchers isolated epithelial and mesenchymal populations from metastatic breast cancer biopsies and assessed their functional potential in vivo. The results show that decreasing levels of the epithelial cell adhesion molecule (EPCAM) are associated with a decline in disease propagation. Mechanistically, persistent EPCAM expression identifies epithelial clones that resist EMT induction and propagate competitively, while loss of EPCAM defines clones arrested in a mesenchymal state with suppressed tumorigenicity and metastatic potential. These findings highlight the importance of EMT in breast cancer metastasis and suggest potential targets for therapeutic intervention.
Article
Pharmacology & Pharmacy
Mingjun Gao, Jin Yang, Hailong Gong, Yuancai Lin, Jing Liu
Summary: Trametinib has the potential to inhibit glioma cell proliferation, migration, and invasion, induce apoptosis, and target the PKM2/c-myc pathway. The inhibitory effects on glycolytic metabolism may hold promise for the treatment of gliomas.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jinming Zhang, Weimou Chen, Jiangzhou Du, Lanhe Chu, Zili Zhou, Wenshan Zhong, Dongyu Liu, Haohua Huang, Yi Huang, Yujie Qiao, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Summary: In this study, it was found that RNF130 is down-regulated in pulmonary fibrosis and inhibits the transition of fibroblast to myofibroblast through suppressing aerobic glycolysis. Furthermore, it was demonstrated that targeting the RNF130-c-myc axis could be a promising strategy to alleviate the progression of idiopathic pulmonary fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huinan Qu, Da Qi, Xinqi Wang, Yuan Dong, Qiu Jin, Junyuan Wei, Chengshi Quan
Summary: CLDN6 is a breast cancer suppressor gene that inhibits breast cancer proliferation by suppressing c-MYC-mediated aerobic glycolysis, reducing glucose uptake and lactate production. This study provides insights into the molecular mechanisms of CLDN6 in breast cancer inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ti-Chun Chan, Yi-Ting Chen, Kien Thiam Tan, Chia-Ling Wu, Wen-Jeng Wu, Wei-Ming Li, Ju-Ming Wang, Yow-Ling Shiue, Chien-Feng Li
Summary: This study reveals that CEBPD plays an oncogenic role in UC by activating AKT signaling and initiating metabolic reprogramming from mitochondrial oxidative phosphorylation to glycolysis to satisfy glucose addiction, thus promoting cancer growth. The positive feedback loops involving CEBPD and MYC enhance cancer growth and may complement theranostic approaches.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chenchen Hu, Tianyue Liu, Wenxin Zhang, Yuanjie Sun, Dongbo Jiang, Xiyang Zhang, Yang Liu, Siyi Mao, Yiming Xu, Jingyu Pan, Jing Wang, Yinan Huang, Shuya Yang, Kun Yang
Summary: In this study, it was found that miR-145 negatively correlated with metabolic reprogramming-related genes and inhibited the proliferation and metastasis of cervical cancer cell lines by impeding aerobic glycolysis. The research also showed that miR-145 affected glycolysis through its binding to the 3' UTR of MYC and suppressed tumor growth in mice.
Article
Cell Biology
Zhengwei Yan, Minzhang Cheng, Guohui Hu, Yao Wang, Shaopeng Zeng, Aidi Huang, Linlin Xu, Yuan Liu, Chao Shi, Libin Deng, Quqin Lu, Hai Rao, Hua Lu, Ye-Guang Chen, Shiwen Luo
Summary: The study identified SuFu Negating Protein 1 (SNEP1) as a novel target in the Hedgehog (Hh) signaling pathway, promoting colorectal cancer cell proliferation and tumor growth, as well as reducing sensitivity to anti-Hh inhibitors. SNEP1 destabilizes SuFu to regulate Hh signaling, playing a critical role in tumor growth and anti-Hh resistance.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Lu Bai, Zhao-Xu Yang, Peng-Fei Ma, Jian-Shan Liu, De-Sheng Wang, Heng-Chao Yu
Summary: SLC25A51 is overexpressed in hepatocellular carcinoma (HCC) and correlates with clinicopathological characteristics and poor survival in HCC patients. Its overexpression promotes the growth and metastasis of HCC cells through reprogramming glucose metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Hongcheng Wang, Jianfa Wang, Jiazhe Liu, Yiwei Wang, Guanggai Xia, Xinyu Huang
Summary: This study reveals the association between JMJD5 expression and cell proliferation and metabolic shift in pancreatic cancer cells. Decreased JMJD5 expression promotes pancreatic cancer cell proliferation and induces a metabolic shift from oxidative phosphorylation to glycolysis. Furthermore, JMJD5 negatively regulates c-Myc expression, leading to decreased expression of c-Myc-targeted metabolic genes.
CELLULAR SIGNALLING
(2022)
Article
Gastroenterology & Hepatology
Lishuang Ding, Xuezheng Liang
Summary: The study demonstrates the regulatory role of RRAGD in human hepatocellular carcinoma cells, with knockdown of RRAGD inhibiting cancer progression and aerobic glycolysis. RRAGD expression is upregulated by oncogene MYC and represents a potential therapeutic target for HCC intervention.
ANNALS OF HEPATOLOGY
(2021)
Article
Cell Biology
Ruimin Chang, Xiaoxiong Xiao, Yao Fu, Chunfang Zhang, Xiaoyan Zhu, Yang Gao
Summary: In this study, ITGB1-DT was identified as a prognosis-related and oncogenic lncRNA in LUAD through activating the ITGB1-DT/ITGB1/Wnt/beta-catenin/MYC positive feedback loop, implicating it as a potential prognostic biomarker and therapeutic target for LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M. Parker, Donald A. R. Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J. Vocadlo, Esther M. Verheyen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Prince Kumar Lat, Kun Liu, Dev N. Kumar, Kenneth K. L. Wong, Esther M. Verheyen, Dipankar Sen
NUCLEIC ACIDS RESEARCH
(2020)
Article
Multidisciplinary Sciences
Simon J. H. Wang, Donald A. R. Sinclair, Hae-Yoon Kim, Stephen D. Kinsey, Byoungjoo Yoo, Claire R. Y. Shih, Kenneth K. L. Wong, Charles Krieger, Nicholas Harden, Esther M. Verheyen
Editorial Material
Biochemistry & Molecular Biology
Kenneth Kin Lam Wong, Esther M. Verheyen
Article
Cell Biology
Kenneth Kin Lam Wong, Jenny Zhe Liao, Claire R. Y. Shih, Nicholas Harden, Esther M. Verheyen
JOURNAL OF CELL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Tongchao Li, Tian-Ming Fu, Kenneth Kin Lam Wong, Hongjie Li, Qijing Xie, David J. Luginbuhl, Mark J. Wagner, Eric Betzig, Liqun Luo
Summary: The study investigates the dynamic cellular processes by which olfactory receptor neurons target axons to specific glomeruli in the olfactory circuit of Drosophila. Through time-lapse imaging and fast imaging techniques, the researchers identified the mechanisms involved in ipsilateral targeting and revealed the dynamics of axon branching upon approaching the target. These observations provide insights into the cellular basis of wiring specificity establishment.
Review
Cell Biology
Kenneth Kin Lam Wong, Esther M. Verheyen
Summary: Research in fruit fly models has shown that fly tumors can utilize various strategies to acquire and consolidate different metabolic profiles, providing new insights into the reasons and functional importance of metabolic reprogramming. Additionally, these studies identify metabolic vulnerabilities as potential targets for cancer therapy.
DISEASE MODELS & MECHANISMS
(2021)
Article
Genetics & Heredity
Payel W. Ganguly, Landiso Madonsela, Jesse t J. Chao, Christopher J. R. Loewen, Timothy P. J. O'Connor, Esther M. Verheyen, Douglas W. J. Allan
Summary: DNA sequencing is widely used in clinical practice, and the fruit fly Drosophila melanogaster has been proven to be a valuable tool for testing the function of hundreds of human gene variants. Experimental assessments of variant function are becoming more common, and Drosophila offers a powerful platform for clinical variant interpretation.
Editorial Material
Cell Biology
Esther M. Verheyen
Summary: This article introduces the launch of the Drosophila as a Disease Model subject collection and highlights the importance of Drosophila research in human disease modeling and translational medicine.
DISEASE MODELS & MECHANISMS
(2022)
Article
Cell Biology
Sarah J. Gignac, Katja R. MacCharles, Katherine Fu, Kywana Bonaparte, Gamze Akarsu, Thalia W. Barrett, Esther M. Verheyen, Joy M. Richman
Summary: The study of rare genetic diseases provides valuable insights into human gene function. In Robinow syndrome, mutations in genes in Wnt signaling pathways cause distinct skeletal phenotypes. By expressing mutant DVL1 proteins in chicken and Drosophila, researchers found that these variants disrupt cartilage and wing morphology and affect Wnt signaling. These findings have implications for future therapies to improve skeletal growth.
DISEASE MODELS & MECHANISMS
(2023)