Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

(2019) Farah H. Siddiqi et al.   Nature Communications

Structural Basis of Smoothened Activation in Hedgehog Signaling

(2018) Pengxiang Huang et al.   CELL

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin

(2018) Sarah D. Ackerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

(2018) Jason J Early et al.   eLife

The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell–Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth

(2018) Michelle W. Millar et al.   Frontiers in Oncology

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis

(2017) Andrea Schampel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization

(2017) Andrea Vettori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule screen in embryonic zebrafish using modular variations to target segmentation

(2017) Sandra Richter et al.   Nature Communications

Zebrafish neurobehavioral phenomics for aquatic neuropharmacology and toxicology research

(2016) Allan V. Kalueff et al.   AQUATIC TOXICOLOGY

Pharmacological treatment and BBB-targeted genetic therapy for MCT8-dependent hypomyelination in zebrafish

(2016) David Zada et al.   Disease Models & Mechanisms

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

σ1 receptor ligands control a switch between passive and active threat responses

(2016) Andrew J Rennekamp et al.   Nature Chemical Biology

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

(2016) Giancarlo Bruni et al.   Nature Chemical Biology

Adhesion G protein-coupled receptors in nervous system development and disease

(2016) Tobias Langenhan et al.   NATURE REVIEWS NEUROSCIENCE

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway

(2016) Ramadevi Subramani et al.   Oncotarget

Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression

(2016) Hsin-Lin Cheng et al.   Oncotarget

Cholesterol-dependent Conformational Plasticity in GPCR Dimers

(2016) Xavier Prasanna et al.   Scientific Reports

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Prostaglandin signaling regulates nephron segment patterning of renal progenitors during zebrafish kidney development

(2016) Shahram Jevin Poureetezadi et al.   eLife

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

(2015) Gianina Ravenscroft et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes

(2015) Seong-Il Kang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gpr126/Adgrg6deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice

(2015) Courtney M. Karner et al.   HUMAN MOLECULAR GENETICS

Nimodipine-mediated re-myelination after facial nerve crush injury in rats

(2015) Yin-da Tang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents

(2015) Shuke Nie et al.   NEUROPHARMACOLOGY

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

(2015) Sarah D. Ackerman et al.   Nature Communications

InChI, the IUPAC International Chemical Identifier

(2015) Stephen R Heller et al.   Journal of Cheminformatics

Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells

(2015) Wenzhe Ma et al.   Scientific Reports

Versican in inflammation and tissue remodeling: The impact on lung disorders

(2014) A. Andersson-Sjoland et al.   GLYCOBIOLOGY

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases

(2013) Rasheduzzaman Chowdhury et al.   ACS Chemical Biology

Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin

(2013) T. D. Glenn et al.   DEVELOPMENT

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene

(2013) F.-S. Geng et al.   DEVELOPMENT

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

(2013) A. Hruscha et al.   DEVELOPMENT

Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ

(2013) James C. Pendleton et al.   EXPERIMENTAL NEUROLOGY

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

(2013) C. Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves

(2013) A. W. English et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures

(2012) S. Baxendale et al.   Disease Models & Mechanisms

An L-Type Calcium Channel Agonist, Bay K8644, Extends the Window of Intervention Against Ischemic Neuronal Injury

(2012) Hong-hai Hu et al.   MOLECULAR NEUROBIOLOGY

Gpr126 is essential for peripheral nerve development and myelination in mammals

(2011) K. R. Monk et al.   DEVELOPMENT

Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish

(2011) Lauren M.J. Buck et al.   HEARING RESEARCH

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(2011) Daniel Paris et al.   MOLECULAR MEDICINE

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects

(2010) Clare E. Buckley et al.   NEUROPHARMACOLOGY

Deoxygedunin, a Natural Product with Potent Neurotrophic Activity in Mice

(2010) Sung-Wuk Jang et al.   PLoS One

The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse

(2010) Helen Waller-Evans et al.   PLoS One

The biological role and regulation of versican levels in cancer

(2009) Carmela Ricciardelli et al.   CANCER AND METASTASIS REVIEWS

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

(2008) Kelly N. Owens et al.   PLoS Genetics

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols