被撤回的出版物: MiR-29a inhibits the progression of oral squamous cell carcinoma by targeting Wnt/β-catenin signalling pathway (Retracted article. See vol. 50, pg. 85, 2022)

Aim: The study aimed to investigate the role of miR-29a in the progression of oral squamous cell carcinoma (OSCC), as well as its molecular mechanism. Methods: Tissue samples were collected from 103 OSCC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the relative expression of miR-29a in OSCC tissues and cell line. Cell proliferation, motility and apoptosis were detected using MTT, transwell and flow cytometry methods, respectively. Western blot was used to measure the protein expression. Results: The expression of miR-29a was decreased in OSCC tissue and cells (p < .05 for both), and its down-regulation was negatively associated with the lymph node metastasis (p = .017) and TNM stage (p = .007). Enforcing miR-29a expression in OSCC cells using mimic transfection could significantly inhibit the proliferation, migration and invasion, and promote cells apoptosis. Furthermore, miR-29a over-expression could suppress Wnt/beta-catenin pathway activity. Meanwhile, LiCl, the activator of Wnt/beta-catenin pathway, could reverse the anti-tumour action induced by miR-29a over-expression. Conclusions: MiR-29a may inhibit the malignant progression of OSCC by suppressing Wnt/beta-catenin signalling pathway.