Article
Engineering, Biomedical
Maria Vallet-Regi
Summary: This article reports our contributions to mesoporous silica materials in biomedicine, demonstrating their potential in drug delivery with high loading capacity and stimuli-responsive features. The research findings suggest that mesoporous silica nanoparticles have promising applications in drug delivery.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Kyung Oh Jung, Ashok Joseph Theruvath, Hossein Nejadnik, Anna Liu, Lei Xing, Todd Sulchek, Heike E. Daldrup-Link, Guillem Pratx
Summary: Regenerative medicine uses patient own stem cells to regenerate damaged tissues. This study presents a rapid, effective, and straightforward method for cell labeling using mechanoporation. The labeled cells can be monitored post-implantation using PET imaging.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Review
Pharmacology & Pharmacy
Fatemeh Ahmadi, Arezoo Sodagar-Taleghani, Pedram Ebrahimnejad, Seyyed Pouya Hadipour Moghaddam, Farzam Ebrahimnejad, Kofi Asare-Addo, Ali Nokhodchi
Summary: Cancer, the second leading cause of death worldwide, poses challenges for conventional therapies. Nanomaterials, particularly mesoporous silica nanoparticles (MSNs), have been developed to overcome the limitations of conventional cancer treatments. This review highlights the latest progress in using MSNs for cancer diagnosis and treatment, including stimuli-responsive drug delivery, surface modification for targeting, multifunctional MSNs in drug delivery systems, and their potential as imaging platforms. The physicochemical attributes of MSNs and their impact on cancer therapy, as well as challenges and safety concerns, are discussed.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Medicine, Research & Experimental
Saurabh Shah, Paras Famta, Deepkumar Bagasariya, Kondasingh Charankumar, Anupama Sikder, Rama Kashikar, Arun K. Kotha, Mahavir Bhupal Chougule, Dharmendra Kumar Khatri, Amit Asthana, Rajeev Singh Raghuvanshi, Shashi Bala Singh, Saurabh Srivastava
Summary: This review highlights the importance of mesoporous silica nanoparticles (MSN) as delivery vehicles in cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters affecting MSN synthesis, drug loading characteristics, and targeting cancer cells specifically are explained. The applications and potential of MSN in nanotheranostics and imaging are illustrated. The review also discusses the hurdles encountered during the translation process and potential solutions.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Rong-Qin Qi, Wei Liu, Duan-Yu Wang, Fan-Qing Meng, Hong-Ying Wang, Hai-Yan Qi
Summary: The study developed a novel nano scaffold for sustainable distribution and controlled release of local anesthetic drug Ropivacaine, which can be activated by ultrasound for drug release. Results showed that the nanostructure exhibited a more controlled drug release profile. Cell compatibility and animal model studies demonstrated improved neuron cell survival rates and pain relief effects with this nano scaffold.
Review
Chemistry, Multidisciplinary
Xin Ma, Mathilde Lepoitevin, Christian Serre
Summary: This review summarizes the progress of MOFs in biomedical applications, focusing on their advantages, limitations, and future challenges.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Pharmacology & Pharmacy
Nisar Ul Khaliq, Juyeon Lee, Joohyeon Kim, Yejin Kim, Sohyeon Yu, Jisu Kim, Sangwoo Kim, Daekyung Sung, Hyungjun Kim
Summary: Cancer remains a major global health challenge, and traditional chemotherapy often leads to side effects and drug resistance, necessitating the development of alternative treatments like gene therapy. Mesoporous silica nanoparticles (MSNs) offer numerous advantages as gene delivery carriers, including high loading capacity, controlled drug release, and easy surface functionalization. They are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies have reviewed the use of MSNs for delivering therapeutic nucleic acids to cancer cells and discussed their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are also discussed.
Review
Chemistry, Multidisciplinary
Neeraj Kumar, Pankaj Chamoli, Mrinmoy Misra, M. K. Manoj, Ashutosh Sharma
Summary: This review article provides an overview of various types of metal nanoparticles (NPs) and magnetic nanoparticles (MNPs), as well as carbon nanostructures, in the fields of drug delivery and bio-imaging. It discusses their applications in phototherapy, radio-therapeutics, gene-delivery, and biotherapeutics, highlighting their potential in medicine. The article also examines the challenges and future perspectives of using NPs as biomaterials in biomedicine.
Review
Pharmacology & Pharmacy
Pankaj Bhatt, Vipin Kumar, Vetriselvan Subramaniyan, Kandasamy Nagarajan, Mahendran Sekar, Suresh Chinni, Gobinath Ramachawolran
Summary: Natural polymers have gained attention in drug delivery due to their biocompatibility and biodegradability. However, their surface properties often limit their use. Plasma treatment can overcome these limitations by improving the properties of natural polymers. This review provides an overview of recent advances in plasma modification of natural polymer-based drug delivery systems.
Article
Pharmacology & Pharmacy
Puneet Tyagi
Summary: The interaction of conventional drug delivery systems with the in vivo environment and surface modification may lead to immune activation and manufacturing challenges, while biomimetic delivery systems combine the advantages of cell surface composition and synthetic nanoparticles.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Jack Boylan, Rajat Chauhan, Kavya Koneru, Meenakshi Bansal, Theodore Kalbfleisch, Chinmay S. Potnis, Kendall Hartline, Robert S. Keynton, Gautam Gupta
Summary: Room temperature storage of biospecimens is crucial to eliminate energy consumption and reduce costs associated with cold-chain logistics. The introduction of aqueous capture and release gels offers an innovative solution for preservation and recovery at optimized conditions, surpassing traditional methods in efficiency and integrity maintenance.
Review
Nanoscience & Nanotechnology
Ziyuan Li, Yingwen Mu, Cheng Peng, Martin F. Lavin, Hua Shao, Zhongjun Du
Summary: Nanomedicine, a rapidly emerging discipline in biology, medicine, and pharmacology, utilizes silica nanoparticles (SNPs) for drug delivery and biomedical imaging due to their unique properties and biocompatibility. Adverse effects of SNPs in nanomedicine applications are reviewed, along with potential opportunities and challenges for future use.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Catherine Gomez, Gauthier Hallot, Sophie Laurent, Marc Port
Summary: Recent reviews have highlighted the efficient syntheses of metallic bismuth nanoparticles, but there is limited research on their medical applications compared to the well-documented clinical use of bismuth(III) complexes. Analysis of the literature reveals significant potential for metallic bismuth nanoparticles in theranostic applications, including imaging and therapy. While preclinical studies have shown promise, more data on the toxic effects are needed before immediate clinical use.
Article
Chemistry, Applied
Iris Garrido-Cano, Vicente Candela-Noguera, Guadalupe Herrera, Juan Miguel Cejalvo, Ana Lluch, M. Dolores Marcos, Felix Sancenon, Pilar Eroles, Ramon Martinez-Manez
Summary: Mesoporous silica nanoparticles (MSNs) are efficiently internalized by human cells, with uptake mechanisms differing among cell types and particles. These biocompatible materials do not induce ROS/RNS production, nor affect mitochondrial membrane potential or cell cycle within cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Food Science & Technology
Janani Muthukumar, Ramalingam Chidambaram, Sivaramakrishnan Sukumaran
Summary: This article explores the potential value of polysaccharides from marine seaweeds in food applications, focusing on their types and biological properties.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Chemistry, Physical
Jeelani Gh Peerzada, Ramalingam Chidambaram
Summary: This study used groundnut shell, banana peel, coconut husk, orange peel, and walnut shell as raw materials to extract biogenic nano-silica through an alkali leaching extraction method. The silica nanostructures extracted were tested for entomotoxic activity against Sitophilus oryzae, and SEM and TEM images showed agglomerated nano-sized particles. Characterization of the extracted powder was done using XRD and FTIR to confirm the transformation of amorphous silica, while SEM, TEM, and EDAX were used to study morphology and elemental composition. Optimization of the synthesis process was carried out using response surface methodology to maximize production.
Article
Biochemical Research Methods
Peerzada Gh Jeelani, C. Ramalingam
Summary: Biogenic silica from rice husk was used as a controlled release system for a biocide derived from Justicia adhatoda extract. The study showed successful bonding and high loading of the extract in the silica support, resulting in improved mortality rate against rice weevil.
IET NANOBIOTECHNOLOGY
(2021)
Letter
Engineering, Chemical
Ramalingam Chidambaram
JOURNAL OF FOOD ENGINEERING
(2022)
Review
Food Science & Technology
Cheryl Joseph, Rishika Batra, Pavidharshini Selvasekaran, Ramalingam Chidambaram
Summary: This review discusses the effects of sugar and fat substitution on the textural and rheological properties, sensory acceptance, and calorific value of the end cocoa-based products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Food Science & Technology
Pavidharshini Selvasekaran, Ramalingam Chidambaram
Summary: This study highlights the influence of production conditions on the structural properties of food-grade aerogels and emphasizes the importance of impregnation methods, efficiency, and controlled release properties for functional ingredients. Food-grade aerogels act as carriers to protect and control the release of micronutrients, healthy oils, and bioactive compounds, but challenges remain in incorporating them into real food systems.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Pavidharshini Selvasekaran, Ramalingam Chidambaram
Summary: The article discusses the development of low/no fat and low/no sucrose chocolate formulations, emphasizing the differences in flow properties, texture, melting properties, and sensory aspects compared to traditional formulations.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Melvin S. Samuel, E. Selvarajan, Ramalingam Chidambaram, Himanshu Patel, Kathirvel Brindhadevi
Summary: Chromium, a valuable but toxic ecological pollutant, needs to be reduced in marine systems to lower toxicity levels. Various adsorbents have been found effective in decreasing chromium concentrations, addressing the issue of chromium contamination.
Review
Food Science & Technology
Jeelani Peerzada Gh, Bruce Joshua Sinclair, Gopi Krishna Perinbarajan, Ragini Dutta, Rajnandini Shekhawat, Natasha Saikia, Ramalingam Chidambaram, Abdel-Tawab Mossa
Summary: Edible coatings are thin layers of natural and active ingredients applied to food surfaces, either solid or liquid, to enhance shelf life and quality by factors like mass transfer, diffusivity, permeability, and attribute losses. Made from biopolymers and food grade additives, these environmentally safe and biodegradable coatings exhibit strong mechanical and rheological characteristics. With various properties like antifouling, antimicrobial, conductive, super hydrophobic, and self-healing, edible coatings have the potential to replace epoxy based resins in food packaging industries. This review focuses on different types of smart and edible coatings in post-harvest stages and their effects on food products, as well as their application and future prospects in food industries, along with safety, legal, and environmental concerns.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Review
Polymer Science
Jeelani Gh Peerzada, Nupur Ojha, M. S. Mohamed Jaabir, Bharathi Lakshmi, Shirley Hannah, Ramalingam Chidambaram, Bruce Joshua Sinclair, Gopi Krishna, Pandiyan Muthuramalingam, Abdel-Tawab Mossa
Summary: The food industry's demand for sustainable food packaging material has increased, and biobased polymers, which are degradable, offer various benefits with the advancement of nanotechnology, making them a suitable solution to the challenges faced by the industry.
Article
Nanoscience & Nanotechnology
Peerzada Gh Jeelani, P. Swetha, Shanmuga Priya, C. Ramalingam
Summary: The study found that using biogenically produced nano silica to fabricate controlled release fertilizers can enhance nitrogen assimilation, thus improving the efficiency of nitrogen utilization by plants. These fertilizers were demonstrated to have controlled and prolonged release effects in both soil and water, with minimal impact on the soil microbial ecosystem.
INTERNATIONAL JOURNAL OF NANOTECHNOLOGY
(2021)
