A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

A decade of Genome Medicine: toward precision medicine

(2019) Rabia Begum   Genome Medicine

Comparative effectiveness of rituximab, abatacept, and tocilizumab in adults with rheumatoid arthritis and inadequate response to TNF inhibitors: prospective cohort study

(2019) Jacques-Eric Gottenberg et al.   BMJ-British Medical Journal

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

(2018) Mariella G. Filbin et al.   SCIENCE

Enhancer Logic and Mechanics in Development and Disease

(2018) Ryan Rickels et al.   TRENDS IN CELL BIOLOGY

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

CD4+ T cells in obesity and obesity-associated diseases

(2018) Yueshui Zhao et al.   CELLULAR IMMUNOLOGY

Allergic inflammatory memory in human respiratory epithelial progenitor cells

(2018) Jose Ordovas-Montanes et al.   NATURE

Genetics of rheumatoid arthritis: 2018 status

(2018) Yukinori Okada et al.   ANNALS OF THE RHEUMATIC DISEASES

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Author Correction: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2018) Huipeng Li et al.   NATURE GENETICS

Medicine in the digital age

(2018)   NATURE MEDICINE

Systems biology–based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma

(2018) Lei Huang et al.   Science Translational Medicine

A wellness study of 108 individuals using personal, dense, dynamic data clouds

(2017) Nathan D Price et al.   NATURE BIOTECHNOLOGY

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Seq-Well: portable, low-cost RNA sequencing of single cells at high throughput

(2017) Todd M Gierahn et al.   NATURE METHODS

Putting the Patient Back Together — Social Medicine, Network Medicine, and the Limits of Reductionism

(2017) Jeremy A. Greene et al.   NEW ENGLAND JOURNAL OF MEDICINE

Single-cell analyses to tailor treatments

(2017) Alex K. Shalek et al.   Science Translational Medicine

Drug Target Protein-Protein Interaction Networks: A Systematic Perspective

(2017) Yanghe Feng et al.   Biomed Research International

Bezafibrate for the treatment of dyslipidemia in patients with coronary artery disease: 20-year mortality follow-up of the BIP randomized control trial

(2016) Yaron Arbel et al.   Cardiovascular Diabetology

Realizing the Full Potential of Precision Medicine in Health and Health Care

(2016) Victor J. Dzau et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

(2016) Daniel Marbach et al.   NATURE METHODS

Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Network-based in silico drug efficacy screening

(2016) Emre Guney et al.   Nature Communications

Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis

(2016) Sandra Hellberg et al.   Cell Reports

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

A validated gene regulatory network and GWAS identifies early regulators of T cell–associated diseases

(2015) Mika Gustafsson et al.   Science Translational Medicine

Ranking in interconnected multilayer networks reveals versatile nodes

(2015) Manlio De Domenico et al.   Nature Communications

Genome-Wide Detection and Analysis of Multifunctional Genes

(2015) Yuri Pritykin et al.   PLoS Computational Biology

Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis

(2015) Sudeep Chenna Narendra et al.   PLoS One

An atlas of active enhancers across human cell types and tissues

(2014) Robin Andersson et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

A Generally Applicable Translational Strategy Identifies S100A4 as a Candidate Gene in Allergy

(2014) S. Bruhn et al.   Science Translational Medicine

Modules, networks and systems medicine for understanding disease and aiding diagnosis

(2014) Mika Gustafsson et al.   Genome Medicine

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Peroxisome proliferator-activated receptor γ agonist effect on rheumatoid arthritis: a randomized controlled trial

(2013) Michelle J Ormseth et al.   ARTHRITIS RESEARCH & THERAPY

The Peroxisome Proliferator Activated Receptor‐γ Pioglitazone Improves Vascular Function and Decreases Disease Activity in Patients With Rheumatoid Arthritis

(2013) Wendy Marder et al.   Journal of the American Heart Association

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Ensembl BioMarts: a hub for data retrieval across taxonomic space

(2011) R. J. Kinsella et al.   Database-The Journal of Biological Databases and Curation

Stability selection

(2010) Nicolai Meinshausen et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Proliferation Signal Inhibitors for the Treatment of Refractory Autoimmune Rheumatic Diseases

(2009) Kam Hon Yoon   Annals of the New York Academy of Sciences

Communicability in complex networks

(2008) Ernesto Estrada et al.   PHYSICAL REVIEW E