Article
Biochemistry & Molecular Biology
Yan-Yan Zheng, Ye Wang, Xin Chen, Li-Sha Wei, Han Wang, Tao Tao, Yu-Wei Zhou, Zhi-Hui Jiang, Tian-Tian Qiu, Zhi-Yuan Sun, Jie Sun, Pei Wang, Wei Zhao, Ye-Qiong Li, Hua-Qun Chen, Min-Sheng Zhu, Xue-Na Zhang
Summary: The thymus is essential for skeletal muscle regeneration by promoting satellite cell expansion and may profoundly affect the muscle aging process.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Health Care Sciences & Services
Zhuo Yu, Yan Jiao, Yinhuan Zhao, Weikuan Gu
Summary: Estrogen levels have an impact on women's lifespan, but the management methods vary depending on different life stages. Life quality is related to an individual's health, comfort, and life experiences.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Felicitas Ramirez de Acuna, Francisco Hernandez-Torres, Lara Rodriguez-Outeirino, Jorge N. Dominguez, Lidia Matias-Valiente, Cristina Sanchez-Fernandez, Diego Franco, Amelia E. Aranega
Summary: The transcription factor Pitx2 plays a crucial role in regulating cell proliferation and migration in early myogenic progenitors, contributing to the development and regenerative abilities of skeletal muscle. However, its role in committed myogenic precursors is dispensable for proper muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Salih Tunc Kaya, Kagan Agan, Aydan Fulden-Agan, Pinar Agyar-Yoldas, Talat Ogulcan Ozarslan, Meral Kekecoglu, Adnan Kaya
Summary: This study aimed to investigate the effects of propolis on myocardial ischemia/reperfusion (mI/R) injury in male rats and intact/ovariectomized female rats. Propolis showed a protective effect on the heart by improving antioxidant status and decreasing arrhythmias in male and ovariectomized female rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yusuke Onozato, Yu Sasaki, Yasuhiko Abe, Hidenori Sato, Makoto Yagi, Naoko Mizumoto, Takashi Kon, Takayuki Sakai, Minami Ito, Matsuki Umehara, Ayumi Koseki, Yoshiyuki Ueno
Summary: Alcohol consumption and smoking are significant risk factors for male esophageal squamous cell neoplasia, but the mechanisms behind the development of ESCN in non-drinking and non-smoking females remain unclear. The study found that CDKN2A may play an important role in ESCC development independent of known risk factors, and p14ARF overexpression in the unknown-risk group is noteworthy.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sohyeon Moon, Ok-Hee Lee, Byeongseok Kim, Jinju Park, Semi Hwang, Siyoung Lee, Giwan Lee, Hyukjung Kim, Hyuk Song, Kwonho Hong, Jaejin Cho, Youngsok Choi
Summary: The expression of YAP in the mouse endometrium is periodic and regulated by hormones. YAP plays an important role in the regulation of uterine endometrium dynamics through Hippo signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Koichi Yano, Narantsog Choijookhuu, Makoto Ikenoue, Fidya, Tomohiro Fukaya, Katsuaki Sato, Deokcheol Lee, Noboru Taniguchi, Etsuo Chosa, Atsushi Nanashima, Yoshitaka Hishikawa
Summary: This study investigated the functional role of chromatin protein HMGB2 in liver regeneration. The results showed that the spatiotemporal expression of HMGB2 is closely correlated with hepatocyte proliferation, and HMGB2 knockout leads to delayed cell proliferation and hepatocyte hypertrophy. The experiments also found that cell proliferation is significantly decreased in HMGB2 KO cells and HMGB2 siRNA transfected cells.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Takahiro Masaki, Makoto Habara, Yuki Sato, Takahiro Goshima, Keisuke Maeda, Shunsuke Hanaki, Midori Shimada
Summary: The study reveals that calcineurin regulates the stability and activity of ER-alpha in breast cancer cells by modulating its phosphorylation at Ser 294 and Ser 118 positions. The expression of the calcineurin A-alpha gene (PPP3CA) is associated with poor prognosis in ER-alpha-positive breast cancer patients, suggesting calcineurin as a promising target for therapies in ER-alpha-positive breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Philipp Wartenberg, Imre Farkas, Veronika Csillag, William H. Colledge, Erik Hrabovszky, Ulrich Boehm
Summary: Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain, with a network of aromatase neurons identified in the hypothalamus and amygdala. By birth, this network becomes sexually dimorphic, with aromatase neurons in the arcuate nucleus converting testosterone to estrogen to regulate kisspeptin neuron activity. The study highlights a novel mechanism whereby aromatase neurons regulate the activity of distinct neuronal populations expressing estrogen receptors.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Cell Biology
Ahmed S. Shams, Robert W. Arpke, Micah D. Gearhart, Johannes Weiblen, Ben Mai, David Oyler, Darko Bosnakovski, Omayma M. Mahmoud, Gamal M. Hassan, Michael Kyba
Summary: The CXCR4 signaling is essential for the early activation, proliferation, and self-renewal of satellite cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alice Pierre, Anne Mayeur, Clementine Marie, Victoria Cluzet, Jonathan Chauvin, Nelly Frydman, Michael Grynberg, Joelle Cohen-Tannoudji, Celine J. Guigon, Stephanie Chauvin
Summary: The study revealed that E2 may influence GC fate by specifically regulating the relative abundance of ER beta isoforms mRNA to modulate the balance between pro-apoptotic and non-apoptotic ER beta isoforms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
William Zofkie, Sheryl M. Southard, Thomas Braun, Christoph Lepper
Summary: This study demonstrates the importance of FGF6 in scaling the number of skeletal muscle satellite cells (SCs), and expanding SCs through regulating FGF6 can establish the adult muscle stem cell pool. This could be relevant for designing new strategies to enhance tissue regeneration.
Article
Endocrinology & Metabolism
Meixing Yu, Jia Tang, Yanqing Huang, Chenbing Guo, Peng Du, Ning Li, Qingli Quan
Summary: This study reveals that HOXA10 regulates cholesterol synthesis in endometrial stromal cells by controlling key genes such as HMGCR, MSMO1, ACAT2, HMGCS1, EBP, and SQLE. This finding provides new insights into the metabolic mechanism of cholesterol in cells and suggests a potential treatment strategy for cholesterol synthesis in patients with ovarian endometriosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aoi Ikedo, Yuuki Imai
Summary: Estrogen deficiency impairs fracture healing by affecting the expression ratio of estrogen receptors, especially ERα, in callus during the process. The study clarified the significance of ERs during fracture healing using osteoblast-specific ER knockout mice, showing that ERα in osteocalcin-positive osteoblasts may contribute to the late stage of bone regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Correction
Physiology
Kathryn Vera, Mary McConville, Michael Kyba, Manda Keller-Ross
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Miguel Anselmo, Shandon Coffman, Mia Larson, Kathryn Vera, Emma Lee, Mary McConville, Michael Kyba, Manda L. Keller-Ross
Summary: Facioscapulohumeral muscular dystrophy (FSHD), a common form of muscular dystrophy, is caused by a genetic mutation. This study found that baroreflex sensitivity (BRS) is not reduced in FSHD patients, but an elevated heart rate may be due to low physical activity levels.
PHYSIOLOGICAL REPORTS
(2022)
Article
Physiology
Meiricris Tomaz da Silva, Audrei R. Santos, Tatiana E. Koike, Tabata L. Nascimento, Andrei Rozanski, Darko Bosnakovski, Lygia Pereira, Ashok Kumar, Michael Kyba, Elen H. Miyabara
Summary: It has been found that the proliferation and early differentiation of myoblasts are impaired in Marfan syndrome (MFS) mice during muscle regeneration. The fibrotic niche caused by Fbn1 mutations reduces the myogenic potential of satellite cells, affecting structural and functional muscle regeneration. Treatment with the fibrosis inhibitor Ang-(1-7) partially counteracts satellite cell abnormalities and restores myofiber size and contractile force in regenerating muscles.
Article
Oncology
Tero Sievanen, Tia-Marje Korhonen, Tiina Jokela, Maarit Ahtiainen, Laura Lahtinen, Teijo Kuopio, Anna Lepisto, Elina Sillanpaa, Jukka-Pekka Mecklin, Toni T. Seppala, Eija K. Laakkonen
Summary: Circulating microRNAs (c-miRs) play a significant role in cancer development and LS genetic variation. They have the potential to be used for early cancer detection and LS risk stratification.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Obstetrics & Gynecology
Mari A. Kuutti, Matti Hyvarinen, Markku Kauppinen, Sarianna Sipila, Pauliina Aukee, Eija K. Laakkonen
Summary: This study investigated the associations between early and middle adulthood physical activity (PA) and symptoms of pelvic floor disorders (PFDs) among middle-aged women. The results showed that competitive sports during early adulthood were associated with an increased risk of urge urinary incontinence (UUI) in middle age, while regular PA during early adulthood was associated with an increased risk of fecal incontinence (FI).
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Physiology
Gengyun Le, Cory W. Baumann, Gordon L. Warren, Dawn A. Lowe
Summary: This study developed a novel method to measure muscle strength in female mice, and found that estradiol enhances posttetanic twitch potentiation (PTP) through the G-protein estrogen receptor (GPER) signaling rather than ERa or ERss signaling pathways. These findings indicate the importance of GPER in mediating the effects of estradiol on muscle strength in female mice.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Eero A. Haapala, Earric Lee, Jari Karppinen, Hannamari Skog, Maarit Valtonen, Urho M. Kujala, Jari A. Laukkanen, Johanna K. Ihalainen, Eija K. Laakkonen
Summary: This study investigated the relationship between cardiorespiratory fitness, body composition, and arterial stiffness in women. The results showed that higher cardiorespiratory fitness and lower body fat percentage were associated with lower arterial stiffness, while higher mean arterial pressure was associated with higher arterial stiffness.
SCIENTIFIC REPORTS
(2022)
Correction
Cell & Tissue Engineering
Bayardo I. Garay, Sophie Givens, Phablo Abreu, Man Liu, Dogacan Yucel, June Baik, Noah Stanis, Taylor M. Rothermel, Alessandro Magli, Juan E. Abrahante, Natalya A. Goloviznina, Hossam A. N. Soliman, Neha R. Dhoke, Michael Kyba, Patrick W. Alford, Samuel C. Dudley, Jop H. van Berlo, Brenda Ogle, Rita R. C. Perlingeiro
Article
Cell Biology
Sira Karvinen, Tia-Marje Korhonen, Tero Sievanen, Jari E. Karppinen, Hanna-Kaarina Juppi, Veera Jakoaho, Urho M. Kujala, Jari A. Laukkanen, Maarit Lehti, Eija K. Laakkonen
Summary: Decreased systemic oestrogen levels have an impact on metabolic health, and the mechanisms behind this process are not fully understood. Both oestrogens and exercise have been shown to improve metabolic health, potentially through circulating microRNA signalling. Extracellular vesicles (EV) have gained attention in the field of tissue crosstalk, but the co-isolation of high-density lipoprotein (HDL) particles with EVs has been overlooked in many studies, which may influence the results.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Review
Cardiac & Cardiovascular Systems
Bhairab N. Singh, Dogacan Yucel, Bayardo I. Garay, Elena G. Tolkacheva, Michael Kyba, Rita C. R. Perlingeiro, Jop H. Berlo, Brenda M. Ogle
Summary: During cardiac development and morphogenesis, the differentiation of cardiac progenitor cells into mature cardiomyocytes is regulated by factors that also influence proliferation. Understanding the interaction between proliferation and maturation could enhance the use of human induced pluripotent stem cell-derived cardiomyocytes for modeling adult-level cardiac function in engineered cardiac tissues.
CIRCULATION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jari E. Karppinen, Petri Wiklund, Johanna K. Ihalainen, Hanna-Kaarina Juppi, Ville Isola, Matti Hyvarinen, Essi K. Ahokas, Urho M. Kujala, Jari Laukkanen, Juha J. Hulmi, Juha P. Ahtiainen, Sulin Cheng, Eija K. Laakkonen
Summary: It is uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass-adjusted resting energy expenditure (REEadj). This study found that there is a significant difference in REEadj between middle-aged and younger women, as well as between middle-aged women with different menopausal statuses. The study also demonstrated that menopause may not contribute to the decline in REEadj in women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Geriatrics & Gerontology
Matti Hyvarinen, Juha Karvanen, Hanna-Kaarina Juppi, Jari E. Karppinen, Tuija H. Tammelin, Vuokko Kovanen, Pauliina Aukee, Sarianna Sipila, Timo Rantalainen, Eija K. Laakkonen
Summary: The objective of this study was to examine the associations between menopausal symptoms and cardiometabolic risk factors. The authors conducted a cross-sectional and longitudinal study on a representative population sample of women aged 47-55 years. The results showed modest positive associations between menopausal symptoms and cholesterol and fat mass measures, but these associations disappeared after adjusting for confounders. Menopausal symptoms did not predict changes in risk factors during the follow-up period.