Article
Biochemistry & Molecular Biology
Andrea Sanchez-Navarro, Adrian Rafael Murillo-de-Ozores, Rosalba Perez-Villalva, Nadyeli Linares, Hector Carbajal-Contreras, Maria Elena Flores, Gerardo Gamba, Maria Castaneda-Bueno, Norma A. Bobadilla
Summary: This study demonstrates the relocation of serpinA3c/k to the apical tubular membrane in chronic kidney disease and its increased secretion during cellular stress. Atypical urinary excretion of serpinA3c/k was also observed in acute kidney injury, suggesting its potential as a biomarker for AKI.
Article
Transplantation
Aghiles Hamroun, Luc Frimat, Maurice Laville, Marie Metzger, Christian Combe, Denis Fouque, Christian Jacquelinet, Carole Ayav, Sophie Liabeuf, Celine Lange, Yves-Edouard Herpe, Jarcy Zee, Francois Glowacki, Ziad A. Massy, Bruce Robinson, Benedicte Stengel
Summary: This study reveals the high incidence of hospital-acquired AKI events in patients with CKD and their underreporting at hospital discharge. It also identifies low birth weight and anemia as potential new risk factors in CKD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Takayuki Hamano, Takahiro Imaizumi, Takeshi Hasegawa, Naohiko Fujii, Hirotaka Komaba, Masahiko Ando, Masaomi Nangaku, Kosaku Nitta, Hideki Hirakata, Yoshitaka Isaka, Takashi Wada, Shoichi Maruyama, Masafumi Fukagawa
Summary: The CGA classification is more valuable than the GA classification in predicting kidney disease outcomes, and incorporating a prior biopsy-proven diagnosis significantly improves the accuracy of outcome prediction.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell Biology
Yaochen Cao, Yingquan Xiong, Hongming Sun, Ziqiang Wang
Summary: This study investigates the potential role and underlying mechanisms of Cinacalcet (CIN) in hypercalcemia-driven nerve injury in chronic kidney disease (CKD). The results show that CIN ameliorates hypercalcemia-driven nerve injury in CKD mice by regulating the TRAF2/KLF2/SERPINA3 axis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Urology & Nephrology
Ana Sanchez Horrillo, Laura Salanova Villanueva, Alicia Cabrera Cardenas, Patricia Munoz Ramos, Alberto Ortiz, Borja Quiroga
Summary: The transition from AKI to CKD independently predicts the long-term risk of infection following an episode of AKI.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Article
Biochemistry & Molecular Biology
Shohei Tanaka, Hiromichi Wakui, Kengo Azushima, Shunichiro Tsukamoto, Takahiro Yamaji, Shingo Urate, Toru Suzuki, Eriko Abe, Shinya Taguchi, Takayuki Yamada, Ryu Kobayashi, Tomohiko Kanaoka, Daisuke Kamimura, Sho Kinguchi, Masahito Takiguchi, Kengo Funakoshi, Akio Yamashita, Tomoaki Ishigami, Kouichi Tamura
Summary: Considering the increasing prevalence of obesity and global aging, the consumption of a high-protein diet (HPD) has advantages. However, HPD exacerbates kidney dysfunction in chronic kidney disease (CKD) patients. This study evaluated the effects of an HPD on kidney injury in both CKD and non-CKD conditions. It was found that an HPD does not cause kidney injury in healthy individuals but worsens the condition in CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Mingrui Xiong, Hong Chen, Yu Fan, Muchuan Jin, Dong Yang, Yuchen Chen, Yu Zhang, Robert B. Petersen, Hua Su, Anlin Peng, Congyi Wang, Ling Zheng, Kun Huang
Summary: Ischemia-reperfusion injury is a common cause of acute kidney injury. This study reveals that the endogenous tubular ELA-APJ axis plays a pivotal role in attenuating ischemia-reperfusion-induced AKI. Improving renal blood flow by inhibiting ARG2 and activating PGE2 is an effective treatment for AKI and prevents the subsequent AKI-CKD transition.
Article
Pharmacology & Pharmacy
Sophie Liabeuf, Oriane Lambert, Marie Metzger, Aghiles Hamroun, Maurice Laville, Solene M. Laville, Luc Frimat, Roberto Pecoits-Filho, Denis Fouque, Ziad A. Massy, Christian Jacquelinet, Benedicte Stengel
Summary: Long-term use of proton pump inhibitors is common among chronic kidney disease patients, and it is associated with an increased risk of acute kidney injury, end-stage kidney disease, and all-cause mortality.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kranti A. Mapuskar, Gabriela Vasquez-Martinez, Gabriel Mayoral-Andrade, Ann Tomanek-Chalkley, Diana Zepeda-Orozco, Bryan G. Allen
Summary: Chronic kidney disease (CKD) increases the risk of end-stage renal disease (ESRD) and its associated morbidity and mortality. CKD can lead to metabolic perturbations and oxidative stress, resulting in increased production of reactive oxygen species (ROS) in the kidneys. Mitochondrial oxidative metabolism plays a role in the pathology of CKD, and targeting mitochondria may be a potential treatment approach to delay CKD progression.
Review
Urology & Nephrology
Fang Wang, Jie Ding
Summary: The use of consensus AKI criteria has improved our understanding of pediatric AKI epidemiology, and an association between AKI and CKD in pediatric populations has been endorsed. However, further studies are needed to better answer a definitive causal relationship between pediatric AKI and the subsequent development of CKD.
Article
Pharmacology & Pharmacy
Huapan Shu, Yumei Wang, Hui Zhang, Qingqing Dong, Lulu Sun, Yuchi Tu, Qianqian Liao, Li Feng, Lijun Yao
Summary: The profibrotic phenotype of renal tubular epithelial cells (TECs) and the accumulation of CD206(+) M2 macrophages play important roles in the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). However, the mechanisms underlying this transition are not well understood. In this study, the researchers investigated the role of serum and glucocorticoid-inducible kinase (SGK) and T-LAK-cell-originated protein kinase (TOPK) in the AKI-CKD transition. They found that SGK3 inhibited epithelial to mesenchymal transition (EMT) in TECs while promoting M2 macrophage polarization, and TOPK phosphorylation mediated the crosstalk between TECs and macrophages during the transition.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Taisei Nagasaki, Hitoshi Maeda, Kazuaki Taguchi, Hiroki Yanagisawa, Kento Nishida, Kazuki Kobayashi, Naoki Wada, Isamu Noguchi, Ryota Murata, Hiromi Sakai, Hiroaki Kitagishi, Junji Saruwatari, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama
Summary: Renal ischemia-reperfusion can cause tubular cell damage, leading to acute kidney injury and chronic kidney disease. This study explores the potential of three molecules, HIF-1 alpha, AMPK, and Nrf2, to protect tubular cells from these disorders. The researchers found that CO-enriched red blood cell therapy can effectively prevent the pathological conditions of AKI and AKI to CKD by ameliorating hypoxia inducible tubular cell damage.
Review
Physiology
Fengyun Wang, Lixin Zhou, Amity Eliaz, Chang Hu, Xinhua Qiang, Li Ke, Glenn Chertow, Isaac Eliaz, Zhiyong Peng
Summary: Acute kidney injury (AKI) and chronic kidney disease (CKD) are associated with high morbidity and mortality. Galectin-3 (Gal3), a protein with proinflammatory and profibrotic properties, has been implicated in the development and progression of both AKI and CKD. Elevated Gal3 levels in the serum of AKI and CKD patients and its association with CKD progression have been observed. Gal3 is also associated with AKI incidence in critically ill patients, and blocking Gal3 has shown promising results in reducing AKI incidence and mortality in animal models.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gang Zhang, Xiaofeng Sun, Dongying Zhang, Xiwen Zhang, Kun Yu
Summary: This study investigated the role and molecular mechanism of nuclear factor kappa B (NFκB) and serine protease inhibitor A3 (SerpinA3) interaction in myocardial ischemia-reperfusion (IR) injury. The results demonstrated that increased expression of SerpinA3 activates NFκB and contributes to myocardial infarction. Silencing of SerpinA3 reduces inflammation, oxidative stress, and apoptosis, thus protecting the myocardium.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andrea Sanchez-Navarro, Adrian Rafael Murillo-de-Ozores, Rosalba Perez-Villalva, Nadyeli Linares, Hector Carbajal-Contreras, Maria Elena Flores, Gerardo Gamba, Maria Castaneda-Bueno, Norma A. Bobadilla
Summary: This study demonstrates the relocation of serpinA3c/k to the apical tubular membrane in chronic kidney disease and its increased secretion during cellular stress. Atypical urinary excretion of serpinA3c/k was also observed in acute kidney injury, suggesting its potential as a biomarker for AKI.
Review
Immunology
David Faz-Munoz, Andrea Hinojosa-Azaola, Juan M. Mejia-Vilet, Norma O. Uribe-Uribe, Marina Rull-Gabayet, Wallace Rafael Munoz-Castaneda, Nancy Janeth Vargas-Parra, Eduardo Martin-Nares
Summary: Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitides and IgG4-related disease are two distinct autoimmune diseases that share similarities in clinical, serological, radiological, and histopathological features, and can coexist in the same patient.
IMMUNOLOGIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Andrea Sanchez-Navarro, Miguel Angel Martinez-Rojas, Adrian Albarran-Godinez, Rosalba Perez-Villalva, Johan Auwerx, Abigail de la Cruz, Lilia G. Noriega, Florencia Rosetti, Norma A. Bobadilla
Summary: Sirt7 deficiency protects mice from acute kidney injury by reducing albuminuria and tubular damage markers, as well as decreasing inflammation. This suggests that Sirt7 plays a critical role in promoting renal damage and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Maria Fernanda Zavala-Miranda, Abril Alicia Perez-Arias, Sofia E. Marquez-Macedo, Roque A. Comunidad-Bonilla, Juanita Romero-Diaz, Luis E. Morales-Buenrostro, Juan M. Mejia-Vilet
Summary: This study characterizes the clinical presentation and outcomes of LN in a Hispanic cohort from Mexico. The results show that, although the response to treatment and patient survival are comparable to other regions, there is still a high rate of renal relapses and progression to decline in kidney function.
Article
Rheumatology
Abril A. Perez-Arias, R. Angelica Mendez-Perez, Cristino Cruz, Maria Fernanda Zavala-Miranda, Juanita Romero-Diaz, Sofia E. Marquez-Macedo, Roque A. Comunidad-Bonilla, C. Carolina Garcia-Rueda, Juan M. Mejia-Vilet
Summary: This study aimed to assess the performance of uMCP-1 and its association with response to therapy and kidney function in LN patients. The results showed that urine MCP-1 levels were significantly higher in patients with active LN compared to those with chronic LN. Additionally, uMCP-1 played an important role in predicting treatment response and kidney function loss.
CLINICAL RHEUMATOLOGY
(2023)
Article
Transplantation
Abril A. Perez-Arias, Sofia Marquez-Macedo, Oscar R. Pena-Vizcarra, Maria Fernanda Zavala-Miranda, Juanita Romero-Diaz, Luis E. Morales-Buenrostro, Juan M. Mejia-Vilet
Summary: This study found that repeated renal flares in lupus nephritis are associated with a lower response to therapy and an adverse prognosis for kidney function and patient survival.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Juan Antonio Ortega-Trejo, Rosalba Perez-Villalva, Andrea Sanchez-Navarro, Brenda Marquina, Bernardo Rodriguez-Iturbe, Norma A. Bobadilla
Summary: After preconditioning with multiple episodes of mild or severe ischemia/reperfusion in experimental rats, it was found that the acute kidney injury caused by three episodes of IR had less long-term adverse effects on the kidneys, alleviating the progression to chronic kidney disease. This renal protection was associated with changes in molecular and cellular levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Sofia E. Marquez-Macedo, Abril A. Perez-Arias, Oscar R. Pena-Vizcarra, Maria Fernanda Zavala-Miranda, Bernardo Juarez-Cuevas, Megan A. Navarro-Gerrard, Luis E. Morales-Buenrostro, Juan M. Mejia-Vilet
Summary: This study evaluated the rates and factors associated with kidney function recovery and reinitiation of kidney replacement therapy (KRT) in lupus nephritis (LN) patients. Approximately 50% of patients recovered kidney function within 6 months, but around 50% of those who recovered kidney function reinitiated dialysis in the long term.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Isaac Gonzalez-Soria, Axel D. D. Soto-Valadez, Miguel Angel Martinez-Rojas, Juan Antonio Ortega-Trejo, Rosalba Perez-Villalva, Gerardo Gamba, Andrea Sanchez-Navarro, Norma A. A. Bobadilla
Summary: We found that SerpinA3K is present in urine from rats and humans with acute kidney injury (AKI) and chronic kidney disease (CKD). To understand its role in AKI, we studied SerpinA3K-deficient mice after inducing ischemia/reperfusion (I/R). The KOSA3+IR group showed ameliorated renal dysfunction, preserved antioxidant enzyme levels, and better cellular responses to hypoxic injury compared to the WT group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Juan Antonio Ortega-Trejo, Norma A. A. Bobadilla
Summary: Acute kidney injury (AKI) is a global health problem and has recently been recognized as a risk factor for developing chronic kidney disease (CKD). Ischemic preconditioning (IPC) has emerged as a promising strategy to prevent renal tissue damage from AKI. Several studies have shown the effectiveness of IPC in reducing renal damage and efforts are being made to find the best strategy to activate reparative mechanisms. Remote IPC, inducing ischemia in distant tissues before renal ischemia-reperfusion, is also being studied. This review provides a comprehensive overview of existing studies on IPC strategies for AKI and their impact on renal function and structure in animal models and humans, as well as the prospects and challenges for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Miguel Angel Martinez-Rojas, Andrea Sanchez-Navarro, Juan Manuel Mejia-Vilet, Rosalba Perez-Villalva, Norma Uribe, Norma A. Bobadilla
Summary: In patients with proliferative lupus nephritis (LN), urinary excretion of serpin-A3 (uSerpA3) is higher than before the flare, which can predict clinical response to therapy, and the decline of uSerpA3 levels can predict treatment response at early stages.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)