Endogenous IQGAP1 and IQGAP3 do not functionally interact with Ras

Issues with data and analyses: Errors, underlying themes, and potential solutions

(2018) Andrew W. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identifying and Overcoming Threats to Reproducibility, Replicability, Robustness, and Generalizability in Microbiome Research

(2018) Patrick D. Schloss   mBio

On the low reproducibility of cancer studies

(2018) Haijun Wen et al.   National Science Review

Clinical update on K-Ras targeted therapy in gastrointestinal cancers

(2018) Shubham Pant et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

PDGFR-modulated miR-23b cluster and miR-125a-5p suppress lung tumorigenesis by targeting multiple components of KRAS and NF-kB pathways

(2017) Srivatsava Naidu et al.   Scientific Reports

Efforts to Develop KRAS Inhibitors

(2017) Matthew Holderfield   Cold Spring Harbor Perspectives in Medicine

Expression and diagnostic value of CCT3 and IQGAP3 in hepatocellular carcinoma

(2016) E-Na Qian et al.   Cancer Cell International

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

(2016) Shaoyong Lu et al.   CHEMICAL SOCIETY REVIEWS

Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases

(2016) Suyong Choi et al.   NATURE CELL BIOLOGY

Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles

(2016) Anja E. Eisenhardt et al.   Oncotarget

Cdc42 and k-Ras Control Endothelial Tubulogenesis through Apical Membrane and Cytoskeletal Polarization: Novel Stimulatory Roles for GTPase Effectors, the Small GTPases, Rac2 and Rap1b, and Inhibitory Influence of Arhgap31 and Rasa1

(2016) Pieter R. Norden et al.   PLoS One

IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development

(2015) Xiaolan Fang et al.   Cytoskeleton

The biology of IQGAP proteins: beyond the cytoskeleton

(2015) A. C. Hedman et al.   EMBO REPORTS

IQGAPs choreograph cellular signaling from the membrane to the nucleus

(2015) Jessica M. Smith et al.   TRENDS IN CELL BIOLOGY

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas

(2015) Kui Wu et al.   Nature Communications

IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function

(2014) Hironori Matsunaga et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts

(2014) Charlotte Steenblock et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction

(2014) Mallar Bhattacharya et al.   JOURNAL OF CLINICAL INVESTIGATION

IQGAP3 Promotes EGFR-ERK Signaling and the Growth and Metastasis of Lung Cancer Cells

(2014) Ying Yang et al.   PLoS One

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

An open investigation of the reproducibility of cancer biology research

(2014) Timothy M Errington et al.   eLife

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase–driven tumors

(2013) Katherine L Jameson et al.   NATURE MEDICINE

Rho Isoform-specific Interaction with IQGAP1 Promotes Breast Cancer Cell Proliferation and Migration

(2012) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

PrePPI: a structure-informed database of protein–protein interactions

(2012) Qiangfeng Cliff Zhang et al.   NUCLEIC ACIDS RESEARCH

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload

(2011) Mauro Sbroggiò et al.   CARDIOVASCULAR RESEARCH

MAPK Scaffold IQGAP1 Binds the EGF Receptor and Modulates Its Activation

(2011) Dean E. McNulty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

(2009) Colin D. White et al.   FEBS LETTERS

Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phoxTranslocation and Reactive Oxygen Species Generation in Lung Endothelial Cells

(2009) Peter V. Usatyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway

(2009) J.-B. Wang et al.   JOURNAL OF CELL SCIENCE

Involvement of IQGAP3, a regulator of Ras/ERK-related cascade, in hepatocyte proliferation in mouse liver regeneration and development

(2009) Koshi Kunimoto et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Development of Hepatocellular Carcinoma in Iqgap2-Deficient Mice Is IQGAP1 Dependent

(2008) V. A. Schmidt et al.   MOLECULAR AND CELLULAR BIOLOGY

IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade

(2008) Hisashi Nojima et al.   NATURE CELL BIOLOGY