Article
Infectious Diseases
Emily A. Shephard, Kristin Mondy, Kelly R. Reveles, Theresa Jaso, Dusten T. Rose
Summary: This study does not demonstrate a difference in clinical failure between groups with and without infectious diseases consultation for enterococcal bacteraemia. However, it emphasizes the important benefits of infectious diseases consultation in terms of adherence to treatment bundles and appropriate antibiotic selections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Medicine, General & Internal
Maria Paola Ursi, Lorenzo Bertolino, Roberto Andini, Fabiana D'Amico, Domenico Iossa, Arta Karruli, Eugenio D'Avenia, Sabrina Manduca, Mariano Bernardo, Rosa Zampino, Emanuele Durante-Mangoni
Summary: Research suggests an association between Enterococcal infective endocarditis (EIE) and colorectal diseases such as colorectal neoplasia (CRN) and colorectal cancer (CRC). EIE should be considered a marker of colorectal neoplasia, even in patients with health-care related acquisition. Colonoscopy is generally safe in EIE patients and can help in early diagnosis and treatment of colorectal diseases.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Microbiology
Ingvild Reinseth, Hanne H. Tonnesen, Harald Carlsen, Dzung B. Diep
Summary: The membrane-bound protease Eep is a crucial virulence factor in pathogenic enterococci, involved in stress response and serving as a receptor for bacteriocins. The bacteriocins have potential for treating VRE infections due to their dual function targeting wildtype enterococcal cells and reducing virulence in bacteriocin-resistant mutants.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biology
Sachin Tyagi, Rahul Kunwar Singh, Shree Prakash Tiwari
Summary: Enterococci are opportunistic pathogens causing serious infections, with drug resistance worsening the situation. Antienterococcal compounds with antioxidant activity in food may help prevent foodborne infections. The study tested thermophilic cyanobacteria extracts against drug-resistant Enterococcus faecium, showing promising results.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Infectious Diseases
Malo Penven, Asma Zouari, Sophie Nogues, Anais Collet, Maxime Lecourt, Aurelien Birer, Francois Guerin, Gabriel Auger, Vincent Cattoir
Summary: This study investigated the concordance between WGS-based resistance prediction and phenotypic AST results for enterococcal clinical isolates using online tools and databases. The performances of WGS-based genotype to predict resistant phenotypes were excellent, especially for antibiotics commonly used for treatment of enterococcal infections. However, for some antibiotics, resistance mutations were not included in the databases, making it impossible to predict phenotype from genotype. Improvements should be made by including resistance mutations in the database for these antibiotics.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Natalia Andujar-Tenorio, Antonio Cobo, Ana M. Martinez-Rodriguez, Marina Hidalgo, Isabel Prieto, Antonio Galvez, Magdalena Martinez-Canamero
Summary: A study was conducted on 75 enterococcal strains isolated from mouse feces, fed with a standard diet or high-fat diets enriched with different types of oils, to analyze virulence factors, antibiotic resistance, and biogenic amine production. The results showed that strains isolated from mice fed with extra virgin olive oil displayed less resistance to antibiotics and a more beneficial profile overall, supporting the prebiotic role of polyphenols in modulating gut microbiota.
FRONTIERS IN NUTRITION
(2023)
Review
Infectious Diseases
Eric Jeeho Im, Harry Hyun-Yup Lee, Minzae Kim, Myo-Kyoung Kim
Summary: This article reviewed 23 probiotic products using enterococci found on ten online health product shopping websites in the US, and examined the probiotic potential of enterococcal consumption as well as the mechanism of virulent factors and antibiotic resistance spread. Based on reviewed data, enterococcal probiotic consumption has proven beneficial for symptoms of multiple diseases without any apparent adverse effects, but surveillance monitoring and further studies on enterococcal consumption are necessary due to the gene transfer ability of enterococci.
Article
Gastroenterology & Hepatology
Kathleen Yan, Adelina Hung, Caitlin Parmer, Hui Yang, Dhanpat Jain, Bentley Lim, Andrew L. Goodman, Guadalupe Garcia-Tsao
Summary: In an experimental model, treatment with semisynthetic bile acid obeticholic acid significantly reduced the abundance of Enterococcus in the gut, leading to improvements in liver function. This suggests that OCA may have potential therapeutic effects for certain liver diseases.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
D. Widmer, A. F. Widmer, R. Jeger, M. Dangel, S. Stortecky, R. Frei, A. Conen
Summary: This study investigated the prevalence of enterococci in the groins of cardiological patients receiving transfemoral interventions. The results showed that enterococcal colonization in the groin is common and there is frequent isolation of enterococci from patients with TAVR-associated infective endocarditis, indicating the need to change the current recommendation for antimicrobial prophylaxis before TAVR to include coverage against enterococci.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Infectious Diseases
Jamil Muqtadir Bhatti, Syed Ali Raza, Ayesha Farooq Alam, Yameena Noman Khan, Ali Mala, Irshad Batool, F. N. U. Sameeullah
Summary: Enterococcal bacteremia has become prevalent in hospitalized patients, with increasing resistance to antibiotics. Inappropriate antibiotic use contributes to mortality, while targeted therapy and appropriate antibiotic use can reduce the risk of death.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Abeer Khaled Mokhtar Abu-El-Azayem, Maha Mahmoud Kotb, Heba Hamed Arnaout, Noha Samir Abdel Latif, Mai S. Soliman, Marwa Salah Mostafa
Summary: The study showed that diclofenac can inhibit the growth and biofilm formation of enterococcal isolates, reduce the expression of efflux pump genes, but does not significantly affect ciprofloxacin resistance rates. Diclofenac may provide a promising preventive and therapeutic alternative for medical and dental prosthesis-associated enterococcal infections.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Microbiology
Zheren Huang, Yilin Bai, Qin Wang, Xue Yang, Tiejun Zhang, Xuan Chen, Hongning Wang
Summary: This study identifies the presence of transferable oxazolidinone resistance genes in enterococcal isolates from different production stages in a pig farm in China. The dissemination of these genes poses a major challenge to public health and environmental safety, emphasizing the need for continuous monitoring and research.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Yusibeska Ramos, Stephanie Sansone, Sung-Min Hwang, Tito A. Sandoval, Mengmeng Zhu, Guoan Zhang, Juan R. Cubillos-Ruiz, Diana K. Morales
Summary: During the process of surface penetration, Enterococcus faecalis undergoes distinct transcriptional, metabolic, and ultrastructural changes, allowing it to resist external stressors and thrive in its surrounding environment.
Article
Biochemistry & Molecular Biology
Carme Grau-Bove, Carlos Gonzalez-Quilen, Giulia Cantini, Patrizia Nardini, Beatriz Espina, Daniele Bani, Ximena Terra, MTeresa Blay, Esther Rodriguez-Gallego, Michaela Luconi, Anna Ardevol, Montserrat Pinent
Summary: This study investigated the secretion mechanisms of GLP1 and PYY in the human colon and discovered a potential direct paracrine function of GLP1 through the expression of its receptors in the colon epithelium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Tai-Chung Tseng, Yu-Chung Chuang, Jia-Ling Yang, Chi-Ying Lin, Sung-Hsi Huang, Jann-Tay Wang, Yee-Chun Chen, Shan-Chwen Chang
Summary: In this study, combination therapy with high-dose daptomycin and fosfomycin was found to improve the survival rate of patients with vancomycin-resistant enterococcus bloodstream infection compared to daptomycin monotherapy. The survival benefit was most pronounced for patients with fosfomycin MIC ≤64 mg/L and a low Pitt bacteremia score.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Gastroenterology & Hepatology
Rita Pombinho, Ana Vieira, Ana Camejo, Cristel Archambaud, Pascale Cossart, Sandra Sousa, Didier Cabanes
Article
Nutrition & Dietetics
Camille Martin-Gallausiaux, Ludovica Marinelli, Herve M. Blottiere, Pierre Larraufie, Nicolas Lapaque
Summary: This article discusses the mechanisms and impact of short-chain fatty acids (SCFA) on gut functions, host immunity, and human health. SCFA, derived from bacterial fermentation of dietary fibers, serve as important fuels for intestinal epithelial cells and modulate various functions to impact intestinal homeostasis.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2021)
Article
Microbiology
Josie F. Gibson, Grace R. Pidwill, Oliver T. Carnell, Bas G. J. Surewaard, Daria Shamarina, Joshua A. F. Sutton, Charlotte Jeffery, Aurelie Derre-Bobillot, Cristel Archambaud, Matthew K. Siggins, Eric J. G. Pollitt, Simon A. Johnston, Pascale Serror, Shiranee Sriskandan, Stephen A. Renshaw, Simon J. Foster, Alice Prince, Michael Otto, Alice Prince, Michael Otto, Alice Prince, Michael Otto
Summary: Staphylococcus aureus is a commensal inhabitant of the human skin and nares, but can cause serious diseases if able to breach protective barriers. Previous research has found that non-pathogenic microflora members can enhance the pathogenicity of S. aureus leading to serious diseases.
Article
Neurosciences
Zehra Esra Ilhan, Vincent Brochard, Nicolas Lapaque, Stephane Auvin, Patricia Lepage
Summary: Anti-seizure medications can affect the gut microbiota and have different impacts on the growth of gut bacterial strains. The toxicity of medication ingredients varies and can also affect gut epithelial cells. Gut microbial metabolites may play a role in mediating the interaction between medications and epithelial cells.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Immunology
Natalie Descoeudres, Luc Jouneau, Celine Henry, Kevin Gorrichon, Aurelie Derre-Bobillot, Pascale Serror, Laura Lee Gillespie, Cristel Archambaud, Alessandro Pagliuso, Helene Bierne
Summary: Listeria monocytogenes may enter a persistence phase in hepatocytes, altering their immune functions and creating an environment favorable for persistent infection. This long-term infection results in an overexpression of genes related to antiviral immunity and a decrease in acute phase protein genes, as well as changes in cholesterol metabolism-associated genes in infected cells. These findings suggest that Listeria profoundly deregulates innate immune functions of hepatocytes during persistent infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Xufei Zhang, Magali Monnoye, Mahendra Mariadassou, Fabienne Beguet-Crespel, Nicolas Lapaque, Christine Heberden, Veronique Douard
Summary: The study revealed different impacts of fructose and glucose intake on mice, with glucose leading to increased adiposity, glucose intolerance, and intestinal permeability, while fructose resulted in elevated IL6 levels. The research also identified the potential roles of microbiota composition and inflammatory factors in gut barrier function and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Rozenn Souillard, Jeanne Laurentie, Isabelle Kempf, Virginie Le Caer, Sophie Le Bouquin, Pascale Serror, Virginie Allain
Summary: This study assesses the occurrence of enterococci in poultry in France based on veterinary laboratory data. The results show the emergence of enterococcal diseases in poultry over the past 15 years, particularly in broilers, and emphasize the importance of maintaining a surveillance system.
VETERINARY MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
F. Repoila, F. Le Bohec, C. Guerin, C. Lacoux, S. Tiwari, A. K. Jaiswal, M. Passos Santana, S. P. Kennedy, B. Quinquis, D. Rainteau, V Juillard, S. Furlan, P. Bouloc, P. Nicolas, A. Miyoshi, V Azevedo, P. Serror
Summary: Enterococcus faecalis, a natural inhabitant of the human gastrointestinal tract, can become dominant and cause infections when the intestinal homeostasis is disrupted. The concentrations of bile acids deoxycholate and taurocholate could potentially impact the growth and population of E. faecalis.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Natalia Nunez, Aurelie Derre-Bobillot, Nicolas Trainel, Goran Lakisic, Alexandre Lecomte, Francoise Mercier-Nome, Anne-Marie Cassard, Helene Bierne, Pascale Serror, Cristel Archambaud
Summary: This study reveals the ability of Enterococcus faecalis to survive and proliferate in hepatocytes and exhibit similar behaviors in kidney cells. This finding is of great significance for understanding pathobiont-driven diseases.
Article
Gastroenterology & Hepatology
Camille Martin-Gallausiaux, Diego Garcia-Weber, Amandine Lashermes, Pierre Larraufie, Ludovica Marinelli, Veronica Teixeira, Alice Rolland, Fabienne Beguet-Crespel, Vincent Brochard, Timothe Quatremare, Alexandre Jamet, Joel Dore, Scott D. Gray-Owen, Herve M. Blottiere, Cecile Arrieumerlou, Nicolas Lapaque
Summary: The gut microbiota has an impact on the health of the host through interactions with intestinal epithelial cells. It has been found that the commensal bacterium A. muciniphila promotes intestinal homeostasis by activating the ALPK1/TIFA/TRAF6 axis, a pathway associated with innate immunity.
Article
Microbiology
Jeanne Laurentie, Gwenaelle Mourand, Pauline Grippon, Sylviane Furlan, Claire Chauvin, Eric Jouy, Pascale Serror, Isabelle Kempf
Summary: Enterococcus cecorum, a commensal bacterium in the chicken gut, is causing worldwide lameness in broilers. It leads to various infections and necrosis, resulting in animal suffering and antimicrobial use. This study aimed to determine ECOFF values for E. cecorum and investigate the antimicrobial resistance patterns of isolates from French broilers.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Microbiology
Jeanne Laurentie, Valentin Loux, Christelle Hennequet-Antier, Emilie Chambellon, Julien Deschamps, Angelina Trotereau, Sylviane Furlan, Claire Darrigo, Florent Kempf, Julie Lao, Marine Milhes, Celine Roques, Benoit Quinquis, Celine Vandecasteele, Roxane Boyer, Olivier Bouchez, Francis Repoila, Jean Le Guennec, Helene Chiapello, Romain Briandet, Emmanuelle Helloin, Catherine Schouler, Isabelle Kempf, Pascale Serror
Summary: Enterococcus cecorum is an important pathogen of poultry, particularly causing locomotor disorders and septicemia in fast-growing broilers. Despite its common presence in the intestinal microbiota of chickens, the genetic and phenotypic relatedness of disease-associated isolates remains little investigated. By analyzing the genomes of more than 100 isolates, a few genes associated with disease and the phylogenetic clustering of multidrug-resistant clones were identified. These findings contribute to a better understanding of E. cecorum-related diseases and provide insights for preventive strategies.