Review
Microbiology
Tielong Xu, Long-xue Li, Yao Jia, Qingni Wu, Weifeng Zhu, Zhou Xu, Bin Zheng, Xuexin Lu
Summary: This paper systematically reviews the action modes of miRNAs-HCoVs by considering both the modes of action of miRNAs and the molecular biology of viruses. It was found that miRNAs have tremendous antiviral effects against HCoVs, but the regulatory effects of miRNAs with targets within the shared ORFs are complex and need further confirmation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Lu Li, Peike Sheng, Tianqi Li, Christopher J. Fields, Nicholas M. Hiers, Yuzhi Wang, Jianping Li, Casey M. Guardia, Jonathan D. Licht, Mingyi Xie
Summary: Li et al. systematically analyzed Argonaute-CLASH data to identify candidate target RNA-directed miRNA degradation (TDMD) triggers that induce nontemplated nucleotide addition at the miRNA 3' end. They found widespread TDMD triggers in target RNAs that can cooperate with encoded proteins to induce miRNA degradation.
GENES & DEVELOPMENT
(2021)
Article
Biochemistry & Molecular Biology
Matjaz Rokavec, Zekai Huang, Heiko Hermeking
Summary: This study conducted a comprehensive integrative meta-analysis of multiple computational and experimental miR-34 related datasets, and developed tools to identify and characterize novel miR-34 targets. The meta-analysis results were integrated into a user-friendly website, METAmiR34TARGET, which allows for the prediction of relevant miR-34 targets using expression data obtained from cell lines and tumors/tissues. The website also includes information on more than 200 experimentally validated miR-34 target mRNAs. This research is important for further understanding the role of the p53/miR-34 connection in tumor suppression and for identifying potential cancer drug targets.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Zhiwen Fu, Liu Wang, Shijun Li, Fen Chen, Kathy Ka-Wai Au-Yeung, Chen Shi
Summary: miRNAs play a crucial role in cancer treatment by regulating gene expression and influencing the growth and survival of cancer cells. They are considered an attractive target for anticancer drug development and have shown promising results in research and therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xibi Fang, Lihong Qin, Haibin Yu, Ping Jiang, Lixin Xia, Zhen Gao, Runjun Yang, Yumin Zhao, Xianzhong Yu, Zhihui Zhao
Summary: This study conducted a genome-wide analysis of microRNAs and mRNAs in immature and mature testes of Chinese Red Steppes, identifying novel candidate microRNAs and functional genes associated with bull reproduction traits. The intricate regulating networks between microRNAs and genes were explored, providing valuable insights into the molecular mechanisms of male fertility and spermatogenesis in cattle. Real-time PCR was used to verify the expression levels of differentially expressed genes and microRNAs, contributing to future genetic and epigenetic studies of sperm development and maturity.
Article
Oncology
Kevin Y. Du, Javeria Qadir, Burton B. Yang, Albert J. Yee, Weining Yang
Summary: miR-17-5p, a member of miR-17-92 cluster, plays important roles in tumorigenesis and cancer progression. Tissue-specific expression complexity of targeted transcripts seems to contribute to the differential functions of miR-17-5p in different types of cancers. In this study, the positive correlation between miR-17-5p expression levels and the selected miR-17-5p targeted transcripts in different tissues was observed. Overexpression of specific miR-17-5p targeted genes' 3'-UTRs promoted miR-17-5p expression in cancer cell lines.
Article
Biochemistry & Molecular Biology
Sandra Schreiber, Patrick Daum, Heike Danzer, Manuela Hauke, Hans-Martin Jaeck, Juergen Wittmann
Summary: This study provides new insights into the expression and function of miR-128 by validating novel target mRNAs expressed in B cells and identifying additional pathways likely controlled by this miRNA in the immune system.
Article
Oncology
Max Enwald, Terho Lehtimaki, Pashupati P. Mishra, Nina Mononen, Teemu J. Murtola, Emma Raitoharju
Summary: This study provides new evidence on the expression of prostate tissue microRNAs and related pathways that may link risk factors to prostate cancer and pinpoint new therapeutic possibilities.
Article
Genetics & Heredity
Xiaoyan He, Zhen Han, Huayan Yin, Fan Chen, Yihuan Dong, Lufei Zhang, Xiaoqing Lu, Jianbin Zeng, Wujun Ma, Ping Mu
Summary: This study identified salt-tolerance-related miRNAs and their target mRNAs in a salt-tolerant wheat variety, QM6, under salt stress conditions. It was found that QM6 enhances salt tolerance by increasing the expression of genes related to stress resistance, antioxidation, nutrient absorption, and lipid metabolism balance, which are regulated by the identified miRNAs. This data provides a theoretical basis for future research on miRNAs and novel genes related to salt tolerance in wheat for the development of genetically improved salt-tolerant wheat varieties.
FRONTIERS IN GENETICS
(2021)
Article
Clinical Neurology
Jiahuan Wu, Ying Meng, Fei Xu, Qian Wu, Cheng Wang
Summary: This study investigated the genome-wide biological significance of circulating miRNA markers in adult epileptic seizures patients. The results identified potential biomarkers for adult epilepsy and revealed their functions in cell regulating pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Amanda E. Bries, Joe L. Webb, Brooke Vogel, Claudia Carrillo, Timothy A. Day, Michael J. Kimber, Rudy J. Valentine, Matthew J. Rowling, Stephanie Clark, Kevin L. Schalinske, Elizabeth M. McNeill
Summary: Consumption of whole eggs for 2 weeks alters gene expression in the prefrontal cortex, visceral adipose tissue, and liver of rats, affecting pathways related to glutathione metabolism and cholesterol biosynthesis. These findings suggest that acute consumption of a diet containing whole eggs can impact key pathways involved in disease development.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karimi
Summary: This manuscript reviews the regulation of the PI3K/Akt/p53 and the Sirt1/Nrf2 pathways by miRNAs in DOX-induced cardiotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Maija Puhka, Lisse Thierens, Daniel Nicorici, Tarja Forsman, Tuomas Mirtti, Taija af Haellstroem, Elina Serkkola, Antti Rannikko
Summary: Prostate cancer lacks non-invasive specific biomarkers for aggressive disease. This study focuses on urinary extracellular vesicles (uEV) as potential biomarkers. The results show that uEV carry a comprehensive presentation of differentially expressed miRNAs, target mRNAs, and pathogenesis pathways associated with prostate cancer status and progression.
Article
Biochemistry & Molecular Biology
Sigmund Ramberg, Aleksei Krasnov, Duncan Colquhoun, Christian Wallace, Rune Andreassen
Summary: By investigating miRNA expression in the head-kidney and lesion sites, this study successfully identified miRNAs responding to Moritella viscosa in salmon. These miRNAs may regulate host response to bacterial infection by targeting genes involved in immune response, metabolism, and cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yiming Su, Qiyi Li, Zhiyong Zheng, Xiaomin Wei, Peiyong Hou
Summary: Venous thromboembolism (VTE) is a complex and life-threatening disease involving vascular endothelial cell (VEC) dysfunction. This study aimed to identify core genes and pathways in VECs related to the development of unprovoked VTE, showing that genes such as CREB1, HIF1 alpha, and ESM1 are up-regulated in VTE patients. Further analysis revealed potential mechanistic roles of ESM1, HIF1 alpha, and the CREB1-miRNA-target genes axis in the development of uVTE.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Laura Kananen, Mikko Hurme, Alexander Buerkle, Maria Moreno-Villanueva, Jurgen Bernhardt, Florence Debacq-Chainiaux, Beatrix Grubeck-Loebenstein, Marco Malavolta, Andrea Basso, Francesco Piacenza, Sebastiano Collino, Efstathios S. Gonos, Ewa Sikora, Daniela Gradinaru, Eugene H. J. M. Jansen, Martijn E. T. Dolle, Michel Salmon, Wolfgang Stuetz, Daniela Weber, Tilman Grune, Nicolle Breusing, Andreas Simm, Miriam Capri, Claudio Franceschi, Eline Slagboom, Duncan Talbot, Claude Libert, Jani Raitanen, Seppo Koskinen, Tommi Harkanen, Sari Stenholm, Mika Ala-Korpela, Terho Lehtimaki, Olli T. Raitakari, Olavi Ukkola, Mika Kahonen, Marja Jylha, Juulia Jylhava
Summary: Circulating cell-free DNA (cf-DNA) levels are associated with age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes, and various biomarkers. Higher cf-DNA levels were found in men, especially middle-aged men and women who smoke, and older frail individuals. Inflammatory markers, metabolites, and antioxidant levels were correlated with cf-DNA levels. These findings have implications for future studies on the epidemiology and biological mechanisms of cf-DNA and its potential as a clinical marker.
Article
Psychology, Clinical
Amanda Nurmi, Laura Pulkki-Raback, Pia Salo, Katja Pahkala, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Terho Lehtimaki, Eero Jokinen, Liisa Keltikangas-Jarvinen, Tomi P. Laitinen, Paivi Tossavainen, Leena Taittonen, Jorma S. A. Viikari, Olli T. Raitakari, Suvi P. Rovio
Summary: The study found that adverse childhood psychosocial factors are associated with midlife learning ability and memory. Specifically, poor self-regulatory behavior and social adjustment in childhood are related to poorer learning ability and memory 30 years later.
Article
Genetics & Heredity
Tiit Ord, Tapio Lonnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen, Miika Kiema, Kadri Ounap, Maleeha Maria, Pierre R. Moreau, Pashupati P. Mishra, Senthil Palani, Jenni Virta, Heidi Liljenback, Einari Aavik, Anne Roivainen, Seppo Yla-Herttuala, Johanna P. Laakkonen, Terho Lehtimaki, Minna U. Kaikkonen
Summary: Coronary artery disease (CAD) is a global disease with significant genetic factors. By using single-cell and bulk RNA sequencing, this study explores the biological diversity of atherosclerosis-associated cell states and their contribution to CAD risk. The researchers identified disease-associated cell states, with Vcam1 thorn smooth muscle cells showing the highest contribution to CAD heritability. The findings provide insights into CAD risk mechanisms and have implications for precision medicine and tailored therapeutic interventions.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Peripheral Vascular Disease
Erika Kahonen, Satu Korpimaki, Markus Juonala, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Olli T. Raitakari, Mika Kivimaki, Jussi Vahtera
Summary: Limited data is available on the association between neighbourhood deprivation and arterial stiffening. This study found that neighbourhood deprivation in childhood and adulthood predicts arterial stiffness indicated by pulse wave velocity (PWV). These findings suggest that neighbourhood deprivation and low adulthood socioeconomic status are independent risk factors for increased arterial stiffness in adulthood.
Article
Peripheral Vascular Disease
Emmi Vaerri, Lauri Suojanen, Jenni K. Koskela, Manoj K. Choudhary, Antti Tikkakoski, Mika Kahonen, Pasi I. Nevalainen, Jukka Mustonen, Ilkka Porsti
Summary: This study aims to compare tonometric radial artery blood pressure (BP) measurements during passive head-up tilt with ambulatory BP recordings and evaluate possible laboratory cutoff values for hypertension. The results showed that laboratory BP measurements had slightly higher systolic pressure and lower diastolic pressure compared to ambulatory BP. The laboratory cutoff of 136/82 mmHg classified 76% of subjects correctly as normotensive or hypertensive. The remaining 24% of discordant results may be attributed to white-coat or masked hypertension, or higher physical activity during out-of-office recordings.
BLOOD PRESSURE MONITORING
(2023)
Article
Nutrition & Dietetics
Christoph Saner, Alistair M. Senior, Hanyue Zhang, Aino-Maija Eloranta, Costan G. Magnussen, Matthew A. Sabin, Markus Juonala, Marco Janner, David P. Burgner, Ursula Schwab, Eero A. Haapala, Berit L. Heitmann, Stephen J. Simpson, David Raubenheimer, Timo A. Lakka
Summary: This study tested for protein leverage and the protein leverage hypothesis in children and adolescents. The results showed that proportional energy intake of proteins was inversely associated with energy intake, and increased energy intake on diets with lower protein content was counterbalanced by increased energy expenditure and did not lead to increased adiposity.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Miikael Lehtimaki, Binisha H. H. Mishra, Coral Del-Val, Leo-Pekka Lyytikainen, Mika Kahonen, C. Robert Cloninger, Olli T. T. Raitakari, Reijo Laaksonen, Igor Zwir, Terho Lehtimaki, Pashupati P. P. Mishra
Summary: This study used an unsupervised machine learning method called PGMRA to discover the genotype-lipidome relations in a Finnish population. The researchers found 93 statistically significant lipidome-genotype relations, which contained a total of 5977 SNPs across 3164 genes. Twenty nine of these relations represented distinct subgroups with unique SNPs and participants. Pathway enrichment analysis identified 30 significantly enriched biological processes related to plasma lipid metabolism. These findings have implications for precision medicine research.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Juhani S. Koskinen, Ville Kyto, Markus Juonala, Jorma S. A. Viikari, Jaakko Nevalainen, Mika Kahonen, Terho Lehtimaki, Nina Hutri-Kahonen, Tomi P. Laitinen, Paivi Tossavainen, Eero Jokinen, Costan G. Magnussen, Olli T. Raitakari
Summary: This study examines the association between childhood and adult dyslipidemia and adult carotid atherosclerotic plaques, and found that childhood dyslipidemia, even if resolved by adulthood, is still a risk factor for adult carotid plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Simo-Pekko Salminen, Anssi Solismaa, Leo-Pekka Lyytikainen, Vesa Paavonen, Nina Mononen, Terho Lehtimaki, Esa Leinonen, Olli Kampman
Summary: This study examined the clustering of Cloninger's temperament dimensions and their association with single nucleotide polymorphisms (SNPs). The results showed that multiple SNPs from different genes were associated with different temperament clusters. Genetic risk scores (GRSs) were also found to be associated with individuals' temperament profiles. However, further research is needed to explore the clinical applicability of these clusters.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Pashupati P. Mishra, Binisha H. Mishra, Emma Raitoharju, Nina Mononen, Jorma Viikari, Markus Juonala, Nina Hutri-Kahonen, Mika Kahonen, Olli T. Raitakari, Terho Lehtimaki
Summary: Advanced integrative analysis of DNA methylation and transcriptomics data reveals the effects of smoke-induced epigenetic alterations on gene expression and biological processes, linking smoking and related diseases.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)