Article
Pharmacology & Pharmacy
Maria C. Lobita, Nesma El-Sayed, Joao F. Pinto, Helder A. Santos
Summary: Delivery of cancer cell membranes (CM) is a new approach for cancer immunotherapy. In this study, fast dissolving microneedles (MNs) loaded with melanoma CM were developed and evaluated using two different polymers. The results show that the HA-MN system is a promising device for melanoma immunotherapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Medicine, Research & Experimental
Mayuri Dalvi, Pratik Kharat, Pradip Thakor, Valamla Bhavana, Shashi Bala Singh, Neelesh Kumar Mehra
Summary: The article discusses the application of microfabrication technology in enhancing the permeability of drugs for transdermal delivery, with a focus on the composition, fabrication techniques, and applications of microneedles. Microneedles can be classified into different types and are primarily used for delivering low molecular weight drugs, peptides, enzymes, vaccines, and bio-therapeutics.
Article
Chemistry, Multidisciplinary
Geonwoo Kang, Minkyung Kim, Huisuk Yang, Jiwoo Shin, Jeeho Sim, Hyeri Ahn, Mingyu Jang, Youseong Kim, Hye Su Min, Hyungil Jung
Summary: A latch applicator, consisting of simple plastic parts and operated by thumb force, was developed for efficient and cost-effective administration of dissolving microneedles (DMN). The optimized latch applicator demonstrated successful insertion of the drug-loaded DMN into the skin and showed higher antibody production compared to intramuscular injection in an immunization test. This latch applicator has the potential to greatly improve drug delivery, including vaccines, with its effective DMN insertion and competitive price.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Keegan Braz Gomes, Bernadette D'Souza, Sharon Vijayanand, Ipshita Menon, Martin J. D'Souza
Summary: Effective vaccines delivered via painless methods would revolutionize vaccination. This study developed fast-dissolving microneedles to deliver antigen-loaded polymeric nanoparticles, achieving a dual-delivery platform for transdermal vaccination. The study demonstrated the feasibility of this approach and its potential for transdermal vaccine administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Tomas Bauleth-Ramos, Nesma El-Sayed, Flavia Fontana, Maria Lobita, Mohammad-Ali Shahbazi, Helder A. Santos
Summary: Dissolving microneedles (dMNs) are water-soluble polymer drug delivery systems that have become popular for transdermal drug delivery. They offer advantages such as fast dissolution, short application time, and no biohazard risk, making them suitable for various biomedical and pharmaceutical applications. The formulation of successful dMNs requires careful consideration of patch design, needles geometry, polymer composition, method of formation, and payloads, as these factors directly affect the mechanical properties and efficacy of the microneedles. This review serves as a guide for dMN formulation, discussing the challenges at each step and strategies to optimize their administration and drug release.
Article
Pharmacology & Pharmacy
Na Zhang, Xinxin Zhou, Libo Liu, Lini Zhao, Hui Xie, Zhihang Yang
Summary: This study developed insulin-loaded dissolving microneedles that can efficiently deliver insulin to the skin to treat diabetes. The fabrication process of microneedles is uniform, controllable, and has the potential for mass production and practical application in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Geonwoo Kang, Minkyung Kim, Huisuk Yang, Jiwoo Shin, Jeeho Sim, Hyeri Ahn, Mingyu Jang, Youseong Kim, Hye Su Min, Hyungil Jung
Summary: In this article, a novel applicator is developed to efficiently insert dissolving microneedle patches into the skin with optimized force and velocity. This applicator is cost-competitive and easy to use with thumb-force operation. The study shows that the microneedle and applicator system can generate significantly higher antibody levels compared to intramuscular injection when using a model antigen.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Hua Wang, Yangxue Fu, Pei Liu, Fei Qu, Shuo Du, Yan Li, Hongyao Du, Lianbin Zhang, Juan Tao, Jintao Zhu
Summary: A mechanically robust supramolecular dissolving microneedle (DMN) patch loaded with triamcinolone acetonide (TA) has been developed for efficient treatment of psoriasis. This innovative approach shows promising applications in transdermal drug delivery and expands the range of drugs in DMNs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Paper & Wood
Jin Ah Kim, Soo Chan Park, Seung-Jun Lee, Jin-Chul Kim
Summary: The addition of cellulose nanofibers to dissolving microneedle arrays increases needle stiffness and enhances skin-piercing capability. However, it also decreases the dissolution rate and transdermal delivery rate of water-soluble cargo loaded in the microneedles.
Article
Pharmacology & Pharmacy
Xiumei Jiang, Pu Chen, Wenxin Niu, Renhua Fang, Hang Chen, Yue An, Weiqing Wang, Changzhao Jiang, Jincui Ye
Summary: This study evaluated the efficacy of Tofacitinib citrate microneedles in arthritis treatment, assessed the dose-effect relationship, and determined the cumulative penetration during percutaneous injection. The results showed that Tofacitinib microneedles effectively inhibited joint swelling in rats, demonstrating potential for Rheumatoid arthritis treatment.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Instruments & Instrumentation
Muhammad Iqbal Nasiri, Lalitkumar K. Vora, Juhaina Abu Ershaid, Ke Peng, Ismaiel A. Tekko, Ryan F. Donnelly
Summary: The development of dissolving microneedles loaded with nanoemulsion shows promising results in intradermal and transdermal drug delivery. The efficient delivery of drugs into the skin and the enhanced antifungal activity against Candida albicans indicate the potential of this technology in drug delivery applications.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Miao Yu, Zhe Lu, Yan Shi, Yutang Du, Xiguang Chen, Ming Kong
Summary: Hyaluronic acid swelling microneedles (HA SMNs) show enhanced mechanical strength and swelling performance, allowing transdermal drug delivery through the diffusing path mediated by swollen needles to overcome the limitations of poor drug condensation in hyaluronic acid dissolving microneedles (HA DMNs), resulting in higher relative bioavailability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Pharmacology & Pharmacy
Sakshi Priya, Yashika Tomar, Vaibhavi Meghraj Desai, Gautam Singhvi
Summary: For decades, scientists have been focusing on finding effective long-term or disease-modifying treatments for skin disorders. Conventional drug delivery systems have shown poor efficacy and associated side effects, leading to challenges in patient adherence. Dissolving microneedles have gained attention for their advantages in breaching skin barriers with minimal discomfort and easy application, making them a potential novel drug delivery strategy for the long-term treatment of skin disorders.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Materials Science, Multidisciplinary
Chi Huang, Kaijun Gou, Xuan Yue, Shiyi Zhao, Rui Zeng, Yan Qu, Chen Zhang
Summary: This study developed a novel liposome-in-microneedles (MNs) based transdermal drug delivery system for the treatment of psoriasis. The system provides efficient drug delivery and stable drug release, improving the clinical symptoms of psoriasis. The efficacy of the system was demonstrated through in vivo experiments in mice, showing significant reduction in inflammatory response and severity of psoriatic lesions.
MATERIALS & DESIGN
(2022)
Review
Pharmacology & Pharmacy
Lijing Zhang, Ranran Guo, Siqi Wang, Xiaotong Yang, Guixia Ling, Peng Zhang
Summary: Transdermal preparations, especially dissolving microneedles, have gained significant attention in recent years due to their painless, safe, efficient delivery and easy operation. This article reviews the preparation methods, matrix polymer materials, performance testing, and applications of dissolving microneedles, aiming to provide a solid knowledge foundation for further research in this field.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Suyong Kim, Manita Dangol, Geonwoo Kang, Shayan F. Lahiji, Huisuk Yang, Mingyu Jang, Yonghao Ma, Chengguo Li, Sang Gon Lee, Chang Hyun Kim, Young Wook Choi, So Jeong Kim, Ja Hyun Ryu, Ji Hwoon Baek, Jaesuk Koh, Hyungil Jung
MOLECULAR PHARMACEUTICS
(2017)
Article
Engineering, Biomedical
Huisuk Yang, Suyong Kim, Geonwoo Kang, Shayan F. Lahiji, Mingyu Jang, Young Mi Kim, Jae-Myung Kim, Sang-Nae Cho, Hyungil Jung
ADVANCED HEALTHCARE MATERIALS
(2017)
Article
Engineering, Biomedical
Shayan Fakhraei Lahiji, Seol Hwa Seo, Suyong Kim, Manita Dangol, Jiyong Shim, Cheng Guo Li, Yonghao Ma, Chisong Lee, Geonwoo Kang, Huisuk Yang, Kang-Yell Choi, Hyungil Jung
Article
Chemistry, Applied
Suyong Kim, Jeongwon Lee, F. Lahiji Shayan, Seohyun Kim, Inyoung Huh, Yonghao Ma, Huisuk Yang, Geonwoo Kang, Hyungil Jung
CARBOHYDRATE POLYMERS
(2018)
Article
Pharmacology & Pharmacy
Inyoung Huh, Suyong Kim, Huisuk Yang, Mingyu Jang, Geonwoo Kang, Hyungil Jung
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2018)
Article
Engineering, Biomedical
Chisong Lee, Hongil Kim, Suyong Kim, Shayan F. Lahiji, Na-Young Ha, Huisuk Yang, Geonwoo Kang, Hai Yen Thi Nguyen, Yuri Kim, Myung-Sik Choi, Nam-Hyuk Cho, Hyungil Jung
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Chemistry, Applied
G. Kang, T. N. T. Tu, S. Kim, H. Yang, M. Jang, D. Jo, J. Ryu, J. Baek, H. Jung
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2018)
Article
Dermatology
Huisuk Yang, Suyong Kim, Mingyu Jang, Hyeonjun Kim, Seunghee Lee, Youseong Kim, Younghyon Andrew Eom, Geonwoo Kang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Ye Eun Lee, Jaesuk Koh, Hyungil Jung
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Dermatology
Geonwoo Kang, Suyong Kim, Huisuk Yang, Mingyu Jang, Liching Chiang, Ji Hwoon Baek, Ja Hyun Ryu, Go Woon Choi, Hyungil Jung
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Chemistry, Applied
M. Jang, S. Baek, G. Kang, H. Yang, S. Kim, H. Jung
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Geonwoo Kang, Minkyung Kim, Huisuk Yang, Jiwoo Shin, Jeeho Sim, Hyeri Ahn, Mingyu Jang, Youseong Kim, Hye Su Min, Hyungil Jung
Summary: A latch applicator, consisting of simple plastic parts and operated by thumb force, was developed for efficient and cost-effective administration of dissolving microneedles (DMN). The optimized latch applicator demonstrated successful insertion of the drug-loaded DMN into the skin and showed higher antibody production compared to intramuscular injection in an immunization test. This latch applicator has the potential to greatly improve drug delivery, including vaccines, with its effective DMN insertion and competitive price.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Jeeho Sim, SeongDae Gong, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Jaesung Park, Youngchan Kim, Hyunkyu Lee, Hyunji Jung, Youseong Kim, Chansol Jeon, Hyeri Ahn, Minkyung Kim, Jaibyung Choi, Ho Lee, Hyungil Jung
Summary: This study used a dissolvable micro-channeling system (DMCS) to enhance the delivery of serum through micro-channels embedded with dissolving microneedles (DMNs). The results showed that this combinatorial serum application method significantly improved the transdermal delivery of active compounds and had better skincare efficacy compared to only using serum application.