Article
Urology & Nephrology
Luca Afferi, Chiara Lonati, Francesco Montorsi, Alberto Briganti, Andrea Necchi, Andrea Mari, Andrea Minervini, Riccardo Campi, Ettore di Trapani, Ottavio de Cobelli, R. Jeffrey Karnes, Mohamed Ahmed, M. Carmen Mir, Maria Asuncion Algarra, Michael Rink, Stefania Zamboni, Claudio Simeone, Wojciech Krajewski, Evanguelos Xylinas, Francesco Soria, Kees Hendricksen, Sarah Einerhand, Agostino Mattei, Roberto Carando, Mathieu Roumiguie, Anne Sophie Bajeot, Peter C. Black, Shahrokh F. Shariat, Marco Moschini
Summary: This retrospective study analyzed the clinical data of 1057 patients with pN1-3 cM0 BCa and found that carboplatin-based ACT did not improve overall survival. The results indicate the need for alternative therapies for cisplatin-ineligible patients.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Maheetha Bharadwaj, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: Observational analyses emulating a completed randomized trial suggest that adjuvant chemotherapy following radical cystectomy may improve overall survival in locally advanced bladder cancer patients. The results were consistent across baseline patient and tumor characteristics.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Francesco Soria, Peter C. Black, Adrian S. Fairey, Michael S. Cookson, Evan Y. Yu, Wassim Kassouf, Marc A. Dall'Era, Srikala S. Sridhar, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Siamak Daneshmand, Jeff M. Holzbeierlein, Trinity J. Bivalacqua, Scott North, Daniel A. Barocas, Yair Lotan, Petros Grivas, Andrew J. Stephenson, Jay B. Shah, Bas W. van Rhijn, Philippe E. Spiess, Shahrokh F. Shariat, Paolo Gontero
Summary: In patients with cT2N0 bladder cancer and no preoperative hydronephrosis, neoadjuvant chemotherapy (NAC) increased the rate of pathological complete response and downstaging, showing a positive impact on overall survival.
Article
Oncology
Martin Swinton, Neethu Billy Graham Mariam, Jean Ling Tan, Katherine Murphy, Thiraviyam Elumalai, Manjusha Soni, Alexandra Ferrera, Charlotte Richardson, Richard Walshaw, Hitesh Mistry, Vijay Ramani, Yeepei Song, Alison Birtle, Ann Henry, Joachim Chan, Peter Hoskin, Ananya Choudhury
Summary: This study analyzed the survival outcomes of node-positive bladder cancer patients and found that there was no significant difference in survival rates between surgery and radiation therapy. Bladder-sparing treatment should be considered as an option for patients with poor survival rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Christian Schaufler, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: This study compared the effectiveness of adjuvant radiotherapy (aRT) versus observation in patients with pN1 prostate cancer through a simulated pragmatic trial. The study found that aRT only improved overall survival in patients with Gleason 8-10 disease, >=2 positive lymph nodes, or negative surgical margins.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Joaquim Bellmunt, Maha Hussain, Jurgen E. Gschwend, Peter Albers, Stephane Oudard, Daniel Castellano, Siamak Daneshmand, Hiroyuki Nishiyama, Martin Majchrowicz, Viraj Degaonkar, Yi Shi, Sanjeev Mariathasan, Petros Grivas, Alexandra Drakaki, Peter H. O'Donnell, Jonathan E. Rosenberg, Daniel M. Geynisman, Daniel P. Petrylak, Jean Hoffman-Censits, Jens Bedke, Arash Rezazadeh Kalebasty, Yousef Zakharia, Michiel S. van der Heijden, Cora N. Sternberg, Nicole N. Davarpanah, Thomas Powles
Summary: IMvigor010 is the largest adjuvant study evaluating a checkpoint inhibitor in muscle-invasive urothelial carcinoma. The trial did not show improved disease-free survival with atezolizumab compared to observation. Atezolizumab was generally well tolerated, but higher rates of adverse events leading to discontinuation were reported compared to previous studies on metastatic urothelial carcinoma.
Article
Oncology
M. . Carmen Mir, Riccardo Campi, Yohann Loriot, Javier Puente, Gianluca Giannarini, Andrea Necchi, Morgan Roupret
Summary: This case study discusses the treatment of a 71-year-old woman with locally advanced bladder cancer and chronic kidney disease. The patient underwent neoadjuvant immunotherapy and radical cystectomy, and the role of adjuvant chemotherapy and immunotherapy in high-risk bladder cancer patients is explored.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Oncology
Luca Afferi, Chiara Lonati, Francesco Montorsi, Alberto Briganti, Andrea Necchi, Andrea Mari, Andrea Minervini, Riccardo Tellini, Riccardo Campi, Gerald Bastian Schulz, Peter C. Black, Ettore di Trapani, Ottavio de Cobelli, R. Jeffrey Karnes, Mohamed Ahmed, M. Carmen Mir, Maria Asuncion Algarra, Michael Rink, Stefania Zamboni, Francesca Mondini, Claudio Simeone, Alessandro Antonelli, Alessandro Tafuri, Wojciech Krajewski, Bartosz MaAAlkiewicz, Evanguelos Xylinas, Francesco Soria, Rafael Sanchez Salas, Amandeep Arora, Xavier Cathelineau, Kees Hendricksen, Maida Ammiwala, Marco Borghesi, Francesco Chierigo, Jeremy Yuen-Chun Teoh, Agostino Mattei, Simone Albisinni, Florian Roghmann, Mathieu Roumiguie, Anne Sophie Bajeot, Elisabeth Maier, Atiqullah Aziz, Rodolfo Hurle, Roberto Contieri, Benjamin Pradere, Roberto Carando, Cedric Poyet, Mario Alvarez-Maestro, David D'Andrea, Shahrokh F. Shariat, Marco Moschini
Summary: A trend towards greater benefit from adjuvant chemotherapy (ACT) in pN+ bladder cancer (BCa) has been observed, particularly in patients with a higher number of positive lymph nodes and advanced cancer stage.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hyehyun Jeong, Kyu-pyo Kim, Jae Ho Jeong, Dae Wook Hwang, Jae Hoon Lee, Ki-Hun Kim, Deok-Bog Moon, Myung Ah Lee, Se Jun Park, Hong Jae Chon, Jin-hong Park, Ji Sung Lee, Baek-Yeol Ryoo, Changhoon Yoo
Summary: The effectiveness of adjuvant gemcitabine plus cisplatin (GemCis) therapy was evaluated in a homogeneous group of high-risk patients with resected, lymph node-positive extrahepatic cholangiocarcinoma. The study found that adjuvant GemCis did not improve survival outcomes compared with capecitabine in this patient population.
Review
Oncology
Shane Kronstedt, Sai Krishnaraya Doppalapudi, Joseph Boyle, Kevin Chua, Thomas L. Jang, Giovanni E. Cacciamani, Saum Ghodoussipour
Summary: This study aimed to assess the survival benefit for different times to adjuvant chemotherapy after radical cystectomy. Four selected studies showed that an earlier administration of adjuvant chemotherapy could provide a survival benefit.
Article
Oncology
John Ernandez, Sumedh Kaul, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Simon Kim, Joaquim Bellmunt, Irving Kaplan, Aria F. Olumi, Boris Gershman
Summary: Although radiotherapy combined with adjuvant chemotherapy is seldom used, it does not improve overall survival in locally advanced bladder cancer (LABC). These results emphasize the need for prospective trials to better define the potential benefits of post-operative radiotherapy with regard to symptomatic progression and oncologic outcomes.
Article
Oncology
Huan Chen, Min Qu, Haoqing Shi, Zhenyang Dong, Yan Wang, Xu Gao
Summary: The purpose of this study was to determine whether immediate androgen deprivation therapy (ADT) plus radiotherapy (RT) extends survival in men with node-positive prostate cancer after radical prostatectomy compared with those who received ADT alone. The results showed that the addition of RT to ADT did not significantly improve castration-resistant prostate cancer (CRPC)-free and distant metastasis-free survival. However, patients with positive lymph nodes < 4 may benefit from ADT plus RT.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Stefania Zamboni, Luca Afferi, Francesco Soria, Atiqullah Aziz, Mohammad Abufaraj, Cedric Poyet, Andrea Necchi, David D'Andrea, Giuseppe Simone, Mariaconsiglia Ferriero, Ettore Di Trapani, Claudio Simeone, Alessandro Antonelli, Andrea Gallina, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Giorgio Gandaglia, Agostino Mattei, Philipp Baumeister, Livio Mordasini, Kees Hendricksen, Charlotte S. Voskuilen, Michael Rink, Shahrokh F. Shariat, Evanguelous Xylinas, Marco Moschini
Summary: In this study, ACT was found to be significantly associated with reduced risk of recurrence and CSM in PUC patients only, while no significant benefit was observed in other histological subtypes. Limitations include the retrospective design, lack of central pathology review, and inadequate number of ACT cycles.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G. Schultz, Chiara Lonati, Agostino Mattei, R. Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F. Shariat, Marco Moschini
Summary: The study found that patients with variant histology bladder cancer have a higher risk of recurrence, requiring extended surveillance time, and different histological types have different risks of recurrence and metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Johan Abrahamsson, Petter Kollberg, Helen Almquist, Mats Blackberg, Johan Brandstedt, Kerstin Lyttkens, Athanasios Simoulis, Gottfrid Sjodahl, Anne Sorenby, Elin Tragardh, Fredrik Liedberg
Summary: This study demonstrates that complete metabolic response with FDG-PET-CT predicts improved progression-free and cancer-specific survival in patients with LN-positive bladder cancer undergoing induction chemotherapy followed by radical cystectomy.
Article
Oncology
Bumjin Lim, Wonchul Lee, Yoon Soo Kyung, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
Summary: A Gleason grade of 5 and bone metastasis lesion count >= 4 were found to be significantly associated with CRPC-free survival and overall survival in patients with metastatic hormone-sensitive prostate cancer (mHSPC). Gleason grade 5 is a new prognostic indicator for mHSPC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jongpil Lee, Jungyo Suh, Cheryn Song, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Choung Soo Kim, Hanjong Ahn
Summary: Preoperative sarcopenia in patients with organ-confined renal cell carcinoma undergoing radical nephrectomy is associated with poorer overall and cancer-specific survival rates, making it an independent risk factor for all-cause and cancer-specific mortality.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Andrology
Seul Gi Kim, Dalsan You, Kyung Kim, Joomin Aum, Yu Seon Kim, Myoung Jin Jang, Kyung Hyun Moon, Hyun-Wook Kang
Summary: The study investigated the potential of human mesenchymal stem cell-derived conditioned medium (MSC-CM) for the treatment of erectile dysfunction (ED). Through biochemical analysis and animal studies, the therapeutic effects of MSC-CM in healing damaged cavernosal tissue and restoring erectile function were confirmed, demonstrating significant potential for the treatment of ED.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Urology & Nephrology
Sahyun Pak, Kyu-Won Jung, Eun-Hye Park, Young Hwii Ko, Young-Joo Won, Jae Young Joung
Summary: The incidence and mortality of prostate cancer in Korean men are expected to increase significantly by 2034, particularly in older men. Concerted efforts in screening, diagnosis, and treatment strategies should be considered by healthcare planners and providers.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Multidisciplinary Sciences
Sang Eun Park, Wonju Kim, Ji-Ye Hong, Dayeon Kang, Seulki Park, Jungyo Suh, Dalsan You, Yun-Yong Park, Nayoung Suh, Jung Jin Hwang, Choung-Soo Kim
Summary: This study identified miR-96-5p as a key regulator in sunitinib resistance in CCRCC by direct suppression of PTEN, leading to poor prognosis in patients with high miR-96-5p and low PTEN levels.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Dong Hyeon An, Jae Hyeon Han, Myoung Jin Jang, Joomin Aum, Yu Seon Kim, In Gab Jeong, Bumsik Hong, Dalsan You
Summary: This study evaluated the feasibility and safety of solo-surgeon pure laparoscopic donor nephrectomy. The results showed that it is technically feasible, but the scope of surgery performed alone needs to be adjusted. Most postoperative complications were unrelated to solo-surgery.
Article
Urology & Nephrology
Jong Keun Kim, Bosik Kang, Yu Seon Kim, Yujin Yun, Myoung Jin Jang, Donghwan Bae, Dalsan You
Summary: This study evaluated the performance of a new multi-degree-of-freedom articulating laparoscopic instrument, ArtiSential, in renal surgery and compared it with a straight-shaped instrument and the da Vinci surgical system. The results showed that ArtiSential had shorter operative times for renal pedicle clamping and ureter dissection compared to the robotic system, but longer operative time for bladder repair. There were no significant differences among the groups in terms of blood loss or intraoperative complications.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Yunlim Kim, Sangjun Yoo, Bumjin Lim, Cheol Kwak, Dalsan You, Jung Jin Hwang, Choung-Soo Kim
Summary: This study compared the anti-prostate cancer effects of the novel biguanide derivative IM176 with those of metformin and phenformin. The results showed that IM176 effectively reduced the viability of prostate cancer cells and induced apoptosis, demonstrating comparable anti-tumor effects to other biguanides. Therefore, IM176 may be a new candidate for the treatment of patients with prostate cancer.
PROSTATE INTERNATIONAL
(2023)
Article
Oncology
Jungyo Suh, Teak Jun Shin, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim, Hanjong Ahn
Summary: This study aims to evaluate the association between serum lipid profile and prostate cancer (PC) risk and aggressiveness. The results showed that increased serum triglyceride level is associated with higher risk and aggressiveness of PC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Dongsu Kim, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Bumsik Hong
Summary: This study compares the oncological outcomes of radical nephroureterectomy (RNU) and kidney-sparing surgery (KSS) to explore the indications of KSS for ureteral cancer. The results show that there is no significant difference in overall survival (OS) and cancer-specific survival (CSS) between RNU and KSS for patients with unifocal ureteral urothelial carcinoma (UC).
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Urology & Nephrology
Dongsu Kim, Wook Nam, Yoon Soo Kyung, Dalsan You, In Gab Jeong, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn, Bumjin Lim
Summary: This study aims to evaluate the impact of preoperative renal impairment on the oncological outcomes of patients with urothelial carcinoma who underwent radical cystectomy. Patients were divided into two groups based on glomerular filtration rates (GFR) and compared for clinicopathological characteristics and oncological outcomes. The results show that GFR values in the range of 60<_GFR<90 mL/min/1.73 m2 are independent prognostic factors for poor recurrence-free survival, cancer-specific survival, and overall survival in patients after radical cystectomy compared to GFR values of >_90 mL/min/1.73 m2.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Cell & Tissue Engineering
Yu Seon Kim, Joomin Aum, Bo Hyun Kim, Myoung Jin Jang, Jungyo Suh, Nayoung Suh, Dalsan You
Summary: This study evaluated the effect of adipose-derived stem cell-derived conditioned medium (ADSC-CM) on renal function in rats with acute kidney injury induced by renal ischemia-reperfusion injury (IRI). The results showed that renal parenchymal injection of ADSC-CM improved renal function, reduced kidney damage, and promoted kidney tissue repair.
INTERNATIONAL JOURNAL OF STEM CELLS
(2022)
Meeting Abstract
Urology & Nephrology
Jong Keun Kim, Bosik Kang, Yu Seon Kim, Yujin Yun, Myoung Jin Jang, Donghwan Bae, Dalsan You
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Shinje Moon, Yoon Jung Kim, Hye Soo Chung, Jae Myung Yu, Il In Park, Sung Gon Park, Sahyun Pak, Ohseong Kwon, Young Goo Lee, Sung Tae Cho
Summary: This study found a significant association between nocturia and mortality risk in both men and women. The severity of nocturia was positively correlated with mortality risk.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2022)
Article
Cell & Tissue Engineering
Han Kyu Chae, Nayoung Suh, Myong Jin Jang, Yu Seon Kim, Bo Hyun Kim, Joomin Aum, Ha Chul Shin, Dalsan You, Bumsik Hong, Hyung Keun Park, Choung-Soo Kim
Summary: In an animal model of chronic kidney disease, the efficacy and safety of high dose injection of human bone marrow-derived mesenchymal stem cells (hBMSC) via the tail vein were confirmed to improve renal function in rats without significant adverse effects.
INTERNATIONAL JOURNAL OF STEM CELLS
(2022)
