Article
Chemistry, Analytical
Maria Carcelen, Veronica Vidal, Alfredo Franco, Marcos Gomez, Fernando Moreno, Jose L. Fernandez-Luna
Summary: This article introduces a simple, fast and label-free method based on a gold nanohole array biosensor to detect the spectral response and changes in cell-matrix adhesion of cancer cells. The experimental results show that this biosensor can effectively distinguish different cell populations in the cell cycle and detect changes in cell-matrix interaction in real time.
Article
Chemistry, Multidisciplinary
Ajay Kumar Agrawal, Akanksha Ninawe, Anuj Dhawan
Summary: A theoretical analysis is presented for nanostructured plasmonic sensor chips, using plasmonic nanostructures on thin films for highly sensitive localized sensing. Different nanostructures are compared in terms of sensitivity and performance, with the potential for detecting multiple biomolecules simultaneously. The proposed sensors exhibit high surface sensitivity and differential reflectance for detecting thin layers of biomolecules.
Article
Chemistry, Multidisciplinary
Jin Wang, Chen Wang, Jing-Juan Xu, Xing-Hua Xia, Hong-Yuan Chen
Summary: Integrating discrete plasmonic nanoparticles into assemblies can induce plasmonic coupling, leading to stronger electromagnetic field enhancement effects. This enables better performance in plasmon-based applications, such as enhanced fluorescence and Raman effects, holding great potential for trace analyte detection and nanomedicine. The recent advances in various plasmonic nanoassemblies and their applications in biosensing and cell imaging are discussed, along with the fabrication strategies for self-assembled plasmonic nanostructures.
CHINESE CHEMICAL LETTERS
(2023)
Article
Materials Science, Multidisciplinary
S. Shukla, P. Arora
Summary: In this study, Aluminum-based plasmonic devices with MXene nanosheet were engineered to achieve high sensitivities and Figure of Merit simultaneously in the optical communication band. The effect of various 2D nanomaterials on the sensitivity and Figure of Merit was investigated, and promising applications in bio-sensing were demonstrated.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2022)
Article
Physics, Fluids & Plasmas
C. Alex Safsten, Volodmyr Rybalko, Leonid Berlyand
Summary: This study focuses on the onset of motion of a living cell driven by myosin contraction. The results show that stable asymmetric moving states bifurcate from unstable radial stationary states, and these moving states have nonlinear asymptotic stability in modeling observable steady cell motion.
Article
Engineering, Industrial
Giuseppe Ingarao, Massimiliano Amato, Abdul Latif, Angela Daniela La Rosa, Rosa Di Lorenzo, Livan Fratini
Summary: Manufacturing scientists are searching for new processes to achieve energy and resource efficient circular economy strategies. Solid state recycling processes, specifically Friction Stir Consolidation (FSC), have been found to be environmentally friendly alternatives for recycling aluminum alloy scraps. This paper presents an environmental characterization of FSC and provides a comparative analysis with traditional remelting routes, assessing the environmental performance and providing guidelines for implementation. Results show that FSC is an environmentally friendly solution, especially when combined with renewable energy sources.
JOURNAL OF MANUFACTURING SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Caroline McCue, Adel Atari, Sean Parks, Yuen-Yi Tseng, Kripa K. K. Varanasi
Summary: Trypsin has been the primary method of cell dissociation for a century, but there has been little change to the process. Enzymatic cell detachment strategies can be labor-intensive and generate waste, so researchers have developed microtextured polystyrene surfaces to lower cell adhesion strength. These surfaces enable decreased cell adhesion strength while maintaining cell viability and proliferation.
Article
Chemistry, Physical
Mateusz Niedzwiedz, Marek Bara, Adrian Barylski
Summary: The article examines the relationship between the morphology, micromechanical and sclerometric properties of Al2O3 layers and the parameters of anodizing of aluminum alloys. The study finds that the produced layers have high hardness and a suitable range of porosity.
Article
Engineering, Mechanical
Sevval Kaya, Oguz Yunus Saribiyik
Summary: Coating of metal surfaces is important for improving material quality in different fields such as corrosion resistance, hydrophobicity, and conductivity. Understanding the effects of surface properties on bacterial adhesion at the atomic level offers new perspectives. This study investigated the influence of different current densities on the morphology, microhardness, and bacterial attachment behavior of a protective aluminum oxide layer. Results showed changes in crystal morphology, microhardness, and bacterial adhesion depending on the applied current density. Higher current densities led to increased microhardness, surface roughness, and bacterial attachment.
SURFACE TOPOGRAPHY-METROLOGY AND PROPERTIES
(2023)
Article
Chemistry, Physical
Sonja Jozic, Branimir Lela, Jure Krolo, Suzana Jakovljevic
Summary: This paper presents an innovative sustainable method of producing metal foams. Aluminum alloy waste in the form of chips obtained by machining process is used as the base material. Natrium chloride is used as the leachable agent to create pores in the metal foams, which are later removed by leaching, resulting in metal foams with open cells. Compression tests were conducted on the obtained samples to analyze the influence of input factors on the desired performance of the metal foams, such as relative density and energy absorption. The optimal values of the input parameters were determined to be a 61.44% volume percentage of natrium chloride, a compaction temperature of 300°C, and a compaction force of 495 kN.
Article
Biophysics
Zhijun Lin, Mengyao Liu, Wei Xing, Fenghua Wang, Hongxia Zhang, Xiaoli Wei, Hans Schmitthenner, Xi Xie, Xiaojun Xia, Jiang Yang
Summary: This study reports a multiplexed enhanced fluorescence microarray immunoassay based on a nanostructured gold nanoisland substrate, which can simultaneously and semi-quantitatively detect multiple biomarkers in cancer cells. Compared to other conventional assay methods, this method exhibits higher sensitivity and lower detection limits.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Physical
Sambhavi Shukla, Pankaj Arora
Summary: This study utilizes a modified ATR configuration to detect minute refractive index changes near the sensing surface. The presence of graphene and silicon layers enhances sensitivity, while aluminum serves as a plasmonic metal for economical value and compatibility. Geometrical parameters are engineered for maximum sensitivity and narrow linewidth using the transfer matrix method.
Article
Chemistry, Multidisciplinary
Pengfei Zhang, Xinyu Zhou, Jiapei Jiang, Jayeeta Kolay, Rui Wang, Guangzhong Ma, Zijian Wan, Shaopeng Wang
Summary: Plasmonic scattering microscopy (PSM) adds a dry objective to a surface plasmon resonance (SPR) system, providing higher spatial resolution and larger field of view. PSM allows studying multiple cells simultaneously and quantifying the mechanical properties of cell-substrate contacts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Optics
Sambhavi Shukla, Pankaj Arora
Summary: The study focused on aluminum-MoS2 plasmonic structures in the near-infrared region for biosensing applications. By optimizing the intermediate layers and exploring different heterostructures with Al as the plasmonic metal layer, enhanced interaction with the sensing medium was achieved. An analysis of sensor performance based on sensitivity and Figure of Merit (FOM) showed promising results for potential biomedical applications.
Article
Biotechnology & Applied Microbiology
N. Novosel, T. Misic Radic, J. Zemla, M. Lekka, A. Cackovic, D. Kasum, T. Legovic, P. Zutinic, M. Gligora Udovic, N. Ivosevic DeNardis
Summary: This study investigates the impact of temperature on three algal species, revealing species-specific responses due to structural features of the cell envelope. Temperature-induced changes in surface properties and physiological activity highlight the importance of cell-substrate interactions and molecular modifications for understanding algal behavior under stress.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Article
Biophysics
Han-Yun Hsieh, Ray Chang, Yung-Yu Huang, Po-Han Juan, Hidetoshi Tahara, Kuan-Yi Lee, Di Ngoc Kha Vo, Ming-Han Tsai, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This study successfully detected the DNA sequence of LMP1 using a combination of microfluidic PCR and gold nanoslit-based SPR sensor, achieving rapid and accurate analytical procedures, as well as enhancing the detection efficiency of DNA extracted from EBV-positive cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biotechnology & Applied Microbiology
Sheng-Hann Wang, Chia-Wen Kuo, Shu-Cheng Lo, Wing Kiu Yeung, Ting-Wei Chang, Pei-Kuen Wei
Summary: In this study, a spectral image contrast-based flow digital nanoplasmon-metry method was developed to amplify and quickly detect the peak shift signal of gold nanoparticles (AuNPs) by comparing the scattering image brightness in two neighboring wavelength bands near the local surface plasmon resonance (LSPR) peak. The method provides an ultrahigh signal-to-noise ratio and has a lower sample volume requirement compared to conventional LSPR immunoassays. It demonstrates high sensitivity, selectivity, and a broad dynamic detection range.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cheng-Chuan Chen, Shu-Cheng Lo, Pei-Kuen Wei
Summary: Label-free detection of mercuric ions in aqueous solutions was achieved using capped gold nanoslit arrays combined with electrochemical sensing technique. The system showed high sensitivity and selectivity towards Hg2+ ions, with a detection range from 100 μM to 10 nM and a detection limit of 1 μM. The developed system has the potential to be applied in detecting various chemicals and biomolecules.
Article
Nanoscience & Nanotechnology
Chia-Wen Kuo, Sheng-Hann Wang, Shu-Cheng Lo, Wei-Han Yong, Ya-Lun Ho, Jean-Jacques Delaunay, Wan-Shao Tsai, Pei-Kuen Wei
Summary: The study proposes a method for sensitive detection of small molecules by coupling image dipoles of gold nanoparticles with Fano resonance of capped gold nanoslits. The coupling mechanism was verified through calculations and experiments, showing potential for detecting low concentrations of small molecules. This resonant coupling significantly pushes the sensitivity boundary, with the detection limit reported to be 3 orders of magnitude lower than prism-based SPR.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Prakhar Dutta, Ting-Yu Su, An-Ying Fu, Mei-Chi Chang, Yu-Jie Guo, I-Jung Tsai, Pei-Kuen Wei, Yu-Sheng Chang, Ching-Yu Lin, Yu-Jui Fan
Summary: In this study, a portable solar-powered centrifuge was developed to provide access to centrifugation in remote areas. The device showed high yield and plasma purity in a short time, and can be used for various purposes. The integration of smartphone reader and nanoplamonic chip allows for evaluation of autoantibodies through image analysis. The device can operate under different conditions with minimal energy requirement, making it suitable for areas without electricity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Optics
Yi-Ru Li, Kuang-Li Lee, Kuan-Ming Chen, Yun Cheng Lu, Pin Chieh Wu, Sy-Hann Chen, Jiun-Haw Lee, Pei-Kuen Wei
Summary: This paper proposes a measurement method for sensitive and label-free detection of virus-like particles (VLPs) using color images of nanoplasmonic sensing chips. The experimental results show that the image contrast method has good linearity and can achieve direct detection of SARS-CoV-2 VLPs in a short period of time.
Article
Chemistry, Analytical
Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan, Pei-Kuen Wei, Horn-Jiunn Sheen
Summary: This study developed a rapid and highly sensitive EBV screening method using a nanofluidic preconcentrator integrated with a nanoslit Fano resonance biosensor to detect latent membrane protein 1 (LMP1) for EBV diagnosis. Through nanoimprinting and aluminum deposition, a low-cost nanoslit plasmonic sensing chip was mass-produced, achieving a limit of detection of 100 pg/ml and a sensing range of 100 pg/ml to 10 μg/ml.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Wei-Che Huang, Chin-Dian Wei, Shimshon Belkin, Tung-Han Hsieh, Ji-Yen Cheng
Summary: With the widespread use of antibiotics, the detection and categorization of compounds with antibiotic activity has become increasingly important. Researchers have developed a new platform, BacSPA, which uses genetically modified Escherichia coli sensor strains to monitor the responses to different antibiotics. By using timelapse photography and a machine learning algorithm, the method can accurately identify and categorize antibiotics within three hours.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Multidisciplinary Sciences
Wei-Ru Lu, Wen-Tse Yang, Justin Chu, Tung-Han Hsieh, Fu-Liang Yang
Summary: Through innovative deduction learning, the efficiency of personalized blood glucose modeling has been improved with limited data, and outlier predictions have been eliminated using an automatic screening algorithm. The DL model achieved significant improvements with limited training data, leading to precise noninvasive blood glucose measurements.
SCIENTIFIC REPORTS
(2022)
Article
Optics
Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, Pei-kuen Wei
Summary: In this work, high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures are presented. The hybrid Tamm-plasmon mode, resulting from the Fano coupling between higher order Tatum plasmon states and Bloch-wave surface plasmon polariton on the gold nanoslit array, demonstrates high surface sensitivity and resonant quality. The experimental results show that the hybrid mode has significantly higher sensitivity and better signal-to-noise ratios in biomolecular interaction measurement.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Chemistry, Analytical
Shu-Cheng Lo, Shao-Sian Li, Wen-Fai Yang, Kuang-Chong Wu, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This paper presents a new micro/nanostructure co-hot embossing technique for the integration of gold-capped nanostructures as localized surface plasmon resonance (SPR) sensors into a microfluidic channel. The advantage of this technique is that it eliminates the need for alignment between the SPR sensors and the microfluidic channel during bonding. The integrated SPR sensor and microfluidic channel were characterized, and the sensitivity of the SPR sensor to refractive index was determined using different concentrations of glycerol solutions. The SPR sensor was also used for quantifying latent membrane protein (LMP-1) by modifying anti-LMP-1 on its surface, and a calibration curve was created using different concentrations of LMP-1 samples.
Article
Astronomy & Astrophysics
Yu-Chih Chen, Ting-Wai Chiu, Tung -Han Hsieh
Summary: In this study, we perform hybrid Monte-Carlo simulation of lattice QCD with Nf = 2 + 1 + 1 domain-wall quarks at the physical point. The results provide a basis for studying finite temperature QCD with Nf = 2 + 1 + 1 domain-wall quarks. By measuring the topological charge and determining the topological susceptibility at different lattice spacings and temperatures, we are able to extract the topological susceptibility in the continuum limit.
Article
Nanoscience & Nanotechnology
Wu-Jhang Chen, Kuo-Chin Hsu, Te-Hua Fang, Chun- Lee, Tao-Hsing Chen, Tung-Han Hsieh
Summary: Ag-doped TiO2 nanofibers were successfully prepared using electrospinning technology and exhibited higher photocatalytic activity under both visible and UV light, improving degradation efficiency. The best performing sample, with 5% Ag doping, achieved complete degradation of MB in 90 minutes under UV light and 70% degradation in 240 minutes under visible light.
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES
(2021)
Article
Computer Science, Information Systems
Tung-Han Hsieh, Chao-Lung Chou, Yu-Pin Lan, Pin-Hsuan Ting, Chun-Ting Lin
Summary: This paper proposes a fast and robust single-frame IR small target detection algorithm with a low computational cost based on a layered gradient kernel, which shows excellent performance in small target detection and is suitable for real-time applications according to experimental results.