Article
Pediatrics
Li Hua, Qian Chen, Quan-Hua Liu, Yi-Feng Guo, Ru-Hong Cheng, Jun Zhang, Jian-Hua Zhang, Li-Wei Wang, Ruo-Xu Ji
Summary: The study found that a polymorphism in the MS4A2 gene and antibiotic use were independently associated with childhood eczema development, and they interacted to increase the risk of the disease in Chinese Han toddlers.
Article
Immunology
S. Scott Sutton, Joseph Magagnoli, Tammy Cummings, James Hardin
Summary: This study explored the association between antibiotics, antivirals, and hospitalization among influenza patients. The results showed that patients treated with antivirals, antibiotics, or both had a lower risk of hospitalization within 30 days compared to those without treatment. Additionally, patients treated with both antibiotics and antivirals had a lower risk of respiratory hospitalization within 30 days compared to those with antivirals alone.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
C. Mary Schooling, Shiu Lun Au Yeung, Man Ki Kwok, Gabriel M. M. Leung
Summary: This study assessed the association between breastfeeding and late adolescent lipid sub-fractions. Exclusive breastfeeding was found to be associated with lower lipid levels, suggesting its potential role in cardiovascular disease prevention.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Microbiology
Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves
Summary: The emergence of antimicrobial resistance poses a significant healthcare challenge in the twenty-first century. Antibody-antibiotic conjugates (AACs) provide an alternative to conventional antibiotics, utilizing the selectivity and safety of antibodies to deliver more potent antibiotics with fewer off-target effects. Despite the complexity of developing AACs, some successful examples are currently undergoing clinical studies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Construction & Building Technology
Xi Chen, Li Huang, Qian Li, Meng Wu, Lixia Lin, Miao Hong, Huanzhuo Wang, Xuefeng Yang, Liping Hao, Nianhong Yang
Summary: Exposure to environmental tobacco smoke (ETS) during pregnancy and infancy is associated with an increased risk of upper respiratory tract infections (URTI) in infants, particularly continued ETS exposure during pregnancy. Infants breastfed for less than 12 months are more susceptible to developing URTI when exposed to ETS during infancy.
Article
Medicine, General & Internal
Thitipong Sirilak, Penkarn Kanjanarat, Surapon Nochaiwong, Wasan Katip
Summary: Antibiotic consumption accounted for 15-20% of drug costs in Thailand, with a higher than recommended rate of antibiotic prophylaxis for postpartum infection. This study aimed to determine the incidence of postpartum infections and factors associated with antibiotic prophylaxis. The results showed no significant difference in postpartum infection between patients who received antibiotics and those who didn't, but there was a significant association between third to fourth degree tear and episiotomy and antibiotic prophylaxis.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Teresa M. Graus, Susanne Brandstetter, Birgit Seelbach-Gobel, Michael Melter, Michael Kabesch, Christian Apfelbacher, Sara Fill Malfertheiner, A. Ambrosch, P. Arndt, A. Baessler, M. Berneburg, St. Bose-O'Reilly, R. Brunner, Wolfgang Buchalla, A. Franke, S. Hausler, I. Heid, C. Herr, W. Hogler, S. Kerzel, M. Koller, M. Leitzmann, D. Rothfuss, W. Rosch, B. Schaub, B. H. F. Weber, St. Weidinger, S. Wellmann
Summary: In Germany, less than 50% of mothers practice full breastfeeding for at least 4 months after childbirth, despite its health benefits. A study found no significant association between maternal health literacy and breastfeeding behavior.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Review
Infectious Diseases
Julie Gorham, Fabio S. Taccone, Maya Hites
Summary: Difficult-to-treat pulmonary infections caused by multidrug-resistant pathogens are a major concern and nebulized antibiotics are increasingly being used to treat these infections. Nebulized antibiotics have the advantage of delivering high drug concentrations to the site of infection while minimizing systemic adverse effects. However, there is still a lack of clinical studies confirming their efficacy and safety.
Article
Nutrition & Dietetics
Carlos Alberto Feldens, Laura Boianovsky Petracco, Gustavo G. Nascimento, Huihua Li, Marcia Regina Vitolo, Karen Glazer Peres
Summary: Increased dental overjet in adolescence is a clinically relevant outcome associated with the complexity and high cost of treatment. Breastfeeding has a protective effect on dental overjet, with 63.1% of the effect mediated by pacifier use. However, the direct effect of breastfeeding alone on dental overjet was not statistically significant.
Article
Infectious Diseases
Yankun Lu, Yichao Wang, Jing Wang, Adrian J. J. Lowe, Luke E. E. Grzeskowiak, Yanhong J. J. Hu
Summary: Early-life antibiotic exposure is common and can affect the development of the child's microbiome and immune system. This study investigated the impact of early-life antibiotics exposure on childhood asthma development using data from the Australian Longitudinal Study of Australian Children. The results showed that any early-life antibiotic exposure increased the risk of early-persistent asthma among all children by 2.3-fold.
Article
Infectious Diseases
Meiyan Chu, Jing Lin, Mingjie Wang, Zhengchang Liao, Chuanding Cao, Ming Hu, Ying Ding, Yang Liu, Shaojie Yue
Summary: The implementation of an antibiotic stewardship program in a neonatal intensive care unit (NICU) led to significant reductions in the duration of initial antibiotic courses and total days of antibiotic usage during NICU stays. The study also showed that limiting antibiotic use in very low birth weight (VLBW) infants is beneficial and can be safely and effectively achieved in China.
Article
Obstetrics & Gynecology
Ellen Margrethe Mikkelsen, Sinna Pilgaard Ulrichsen, Benjamin Randeris Johannesen, Anne Sofie Dam Laursen, Lauren Anne Wise, Elizabeth Elliott Hatch, Kenneth Jay Rothman, Amelia Kent Wesselink, Holly Crowe, Henrik Toft Sorensen
Summary: This study assessed the association between preconception antibiotic use and fecundability. The results showed that the use of antibiotics, especially sulfonamides and macrolides, was associated with decreased fecundability.
FERTILITY AND STERILITY
(2023)
Article
Gastroenterology & Hepatology
Sonia Friedman, Olav Sivertsen Garvik, Jan Nielsen, Bente Mertz Norgard
Summary: The use of anti-inflammatory/immunosuppressive medications by fathers before conception is not significantly associated with childhood infections, according to this study. These results address an important research gap regarding paternal medication safety.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Infectious Diseases
Fredman Gonzalez, Marta Diez-Valcarce, Yaoska Reyes, Nadja A. Vielot, Christian Toval-Ruiz, Lester Gutierrez, Omar Zepeda, Edwing Centeno Cuadra, Patricia Blandon, Hannah Browne, Natalie M. Bowman, Samuel Vilchez, Jan Vinje, Sylvia Becker-Dreps, Filemon Bucardo
Summary: This study aimed to characterize the timing and genotype distribution of symptomatic and asymptomatic sapovirus infections and re-infections in a Nicaraguan birth cohort. The results showed that most sapovirus infections occurred after 5 months of age and during the second year of life, and re-infections with the same genotype were rare. The study provides insights into the natural history and epidemiology of sapovirus infections in young children.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Public, Environmental & Occupational Health
T. Sevin, C. Daniau, S. Alfandari, E. Piednoir, C. Dumartin, H. Blanchard, L. Simon, A. Berger-Carbonne, S. Le Vu
Summary: This study analyzed antimicrobial prescription patterns for various healthcare-associated infections (HAIs) in France based on 2017 data, highlighting the importance of tailoring treatments to specific pathogens and their resistance profiles. The findings underscore the need for personalized antimicrobial stewardship efforts in combating HAIs.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Psychology, Developmental
Flore Moulin, Marion Bailhache, Maeva Monnier, Xavier Thierry, Stephanie Vandentorren, Sylvana M. Cote, Bruno Falissard, Thierry Simeon, Bertrand Geay, Laeticia Marchand, Marie-Noelle Dufourg, Pierre-Yves Ancel, Marie-Aline Charles, Alexandra Rouquette, Maria Melchior, Cedric Galera
Summary: Emerging research suggests that the prevalence of child and adolescent mental health problems has increased considerably during the COVID-19 crisis. Factors such as family socioeconomic status (SES) and financial difficulties during the crisis have been found to negatively impact children's mental health, particularly in deprived children.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Ninoshka J. D'Souza, Miaobing Zheng, Gavin Abbott, Sandrine Lioret, Kylie D. Hesketh
Summary: This study compared the associations between behavioural patterns derived from three different methods and three childhood outcomes. The results showed discrepancies in associations across pattern derivation methods, which has implications for comparing studies that have used different methods.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Alexandra Descarpentrie, Jonathan Y. Bernard, Stephanie Vandentorren, Maria Melchior, Cedric Galera, Airu Chia, Mary F-F Chong, Marie-Aline Charles, Barbara Heude, Sandrine Lioret
Summary: This study found that preschoolers' lifestyle patterns were associated with their socio-emotional, behavioural, and BMI outcomes at 8 years old. Boys' healthy lifestyle pattern (nutrient-dense diet and limited screen time) was positively associated with prosocial behaviours and inversely related to hyperactivity-inattention symptoms at 8 years old. Girls' mixed lifestyle pattern (sugar or artificially sweetened beverages, high screen time, physical activity, and low sleep times) was associated with prosocial behaviours.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Claire Guivarch, Aminata Hallimat Cisse, Marie-Aline Charles, Barbara Heude, Blandine de Lauzon-Guillain
Summary: This study examines the impact of early parental feeding practices on children's growth. It shows that parental restriction for weight at 2 years is positively associated with child BMI z-scores from 4 to 8 years. Additionally, high use of food as a reward is positively associated with later BMI z-scores among boys. Parental feeding practices mediate the relationship between early and later growth.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Endocrinology & Metabolism
Sandrine Lioret, Faryal Harrar, Delia Boccia, Kylie D. Hesketh, Konsita Kuswara, Celine Van Baaren, Silvia Maritano, Marie-Aline Charles, Barbara Heude, Rachel Laws
Summary: This narrative systematic review examined the effectiveness of interventions during pregnancy and early childhood in improving energy balance-related behaviors and preventing obesity in children from disadvantaged families. The review found that interventions targeting breastfeeding initiation and multi-behavioral interventions were most effective in reducing obesity risk. Interventions involving first-time mothers, professional delivery agents, multidisciplinary teams, and peer groups were also more likely to be effective. The review highlighted the importance of co-creation with stakeholders and adherence to theoretical frameworks for developing inclusive and effective programs.
Article
Public, Environmental & Occupational Health
Johanna L. Nader, Monica Lopez-Vicente, Jordi Julvez, Monica Guxens, Tim Cadman, Ahmed Elhakeem, Marjo-Riitta Jarvelin, Nina Rautio, Jouko Miettunen, Hanan El Marroun, Maria Melchior, Barbara Heude, Marie-Aline Charles, Tiffany C. Yang, Rosemary R. C. McEachan, John Wright, Kinga Polanska, Jennie Carson, Ashleigh Lin, Sebastian Rauschert, Rae-Chi Huang, Maja Popovic, Lorenzo Richiardi, Eva Corpeleijn, Marloes Cardol, Tuija M. Mikkola, Johan G. Eriksson, Theodosia Salika, Hazel Inskip, Johan Lerbech Vinther, Katrine Strandberg-Larsen, Kathrin Guerlich, Veit Grote, Berthold Koletzko, Marina Vafeiadi, Jordi Sunyer, Vincent W. V. Jaddoe, Jennifer R. Harris
Summary: The EU LifeCycle Project aims to combine and analyze data from over 250,000 participants in Europe and Australia. This study provides an overview of the available mental health measures in 17 European and Australian cohorts participating in the project.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maeva Monnier, Flore Moulin, Marion Bailhache, Xavier Thierry, Stephanie Vandentorren, Sylvana Cote, Bruno Falissard, Thierry Simeon, Bertrand Geay, Laetitia Marchand-Martin, Marie-Noelle Dufourg, Marie-Aline Charles, Pierre-Yves Ancel, Maria Melchior, Alexandra Rouquette, Cedric Galera, Nathalie Bajos, Fabrice Carrat, Pierre-Yves Ancel, Marie-Aline Charles, Florence Jusot, Claude Martin, Laurence Meyer, Ariane Pailhe, Alexandra Rouquette, Gianluca Severi, Alexis Spire, Mathilde Touvier, Marie Zins, Xavier Thierry, Thierry Simeon, Bertrand Geay, Laetitia Marie-Noelle Dufourg, Marie-Aline Charles
Summary: This study aims to fill the knowledge gap regarding the association between parents' and children's mental health issues during the COVID-19 school closure in France. The study found that parental anxiety and depression symptoms were associated with children's hyperactivity/inattention and emotional symptoms during the pandemic.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Sandra Florian, Mathieu Ichou, Lidia Panico, Stephanie Pinel-Jacquemin, Tanja G. M. Vrijkotte, Margreet W. Harskamp-van Ginkel, Rae-Chi Huang, Jennie Carson, Loreto Santa Marina Rodriguez, Mikel Subiza-Perez, Martine Vrijheid, Silvia Fernandez-Barres, Tiffany C. Yang, John Wright, Eva Corpeleijn, Marloes Cardol, Elena Isaevska, Chiara Moccia, Marjolein N. Kooijman, Ellis Voerman, Vincent Jaddoe, Marieke Welten, Elena Spada, Marisa Rebagliato, Andrea Beneito, Luca Ronfani, Marie-Aline Charles
Summary: Research shows that immigrants have better health outcomes than natives, known as the 'immigrant health paradox'. However, this advantage does not necessarily transfer to their children in the form of higher birth weight. The study found that children of immigrants in France and Australia had higher birth weight, while children of immigrants in the UK and the Netherlands had lower birth weight compared to native children.
Article
Medicine, General & Internal
Camille Davisse-Paturet, Massimiliano Orri, Stephane Legleye, Aline-Marie Florence, Jean-Baptiste Hazo, Josiane Warszawski, Bruno Falissard, Marie-Claude Geoffroy, Maria Melchior, Alexandra Rouquette
Summary: This study found that self-reported COVID-19-like symptoms in 2020 were associated with a higher risk of suicidal ideation in 2021. However, serology-confirmed SARS-CoV-2 infection in 2020 did not show a significant association with suicidal ideation in 2021. Further research is needed to clarify the role of the virus in relation to suicide risk.
Correction
Medicine, General & Internal
Johan L. Vinther, Tim Cadman, Demetris Avraam, Claus T. Ekstrom, Thorkild I. A. Sorensen, Ahmed Elhakeem, Ana C. Santos, Angela Pinot de Moira, Barbara Heude, Carmen Iniguez, Costanza Pizzi, Elinor Simons, Ellis Voerman, Eva Corpeleijn, Faryal Zariouh, Gilian Santorelli, Hazel M. Inskip, Henrique Barros, Jennie Carson, Jennifer R. Harris, Johanna L. Nader, Justiina Ronkainen, Katrine Strandberg-Larsen, Loreto Santa-Marina, Lucinda Calas, Luise Cederkvist, Maja Popovic, Marie-Aline Charles, Marieke Welten, Martine Vrijheid, Meghan Azad, Padmaja Subbarao, Paul Burton, Puishkumar J. Mandhane, Rae-Chi Huang, Rebecca C. Wilson, Sido Haakma, Silvia Fernandez-Barres, Stuart Turvey, Susana Santos, Suzanne C. Tough, Sylvain Sebert, Theo J. Moraes, Theodosia Salika, Vincent W. V. Jaddoe, Deborah A. Lawlor, Anne-Marie Nybo Andersen
Article
Pediatrics
Karen Milcent, Malamine Gassama, Marie-Noelle Dufourg, Xavier Thierry, Marie-Aline Charles, Corinne Bois
Summary: This study examines the routine health screening conducted in French nursery schools for children aged 3-4 years and measures the extent of early socioeconomic health disparities. The results show that disparities exist in vision, hearing, overweight, dental health, language, and psychomotor development among different socioeconomic groups. Children in disadvantaged areas have higher rates of visual disorders, while children with unemployed parents are more likely to have untreated caries, language impairments, and psychomotor impairments. Except for children in disadvantaged areas, vaccine coverage is lower among disadvantaged groups.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Sadia Khan, El Hassane Ouaalaya, Amandine Divaret Chauveau, Emeline Scherer, Gabriel Reboux, Laurence Millon, Antoine Deschildre, Christophe Marguet, Marie-Noelle Dufourg, Marie -Aline Charles, Chantal Raherison Semjen
Summary: This study aimed to identify and characterize early life wheeze profiles and asthma phenotypes in the general population of France. By analyzing data from 18,329 newborns, four wheeze profiles and four asthma phenotypes were identified. This study is of great significance for the early identification and classification of pediatric asthma.
RESPIRATORY MEDICINE
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Marion Lecorguille, Mireille Schipper, Aisling O'Donnell, Adrien M. Aubert, Muriel Tafflet, Malamine Gassama, Alexander Douglass, James R. Hebert, Cecily Kelleher, Marie-Aline Charles, Catherine M. Phillips, Romy Gaillard, Sandrine Lioret, Barbara Heude
LANCET GLOBAL HEALTH
(2023)
Article
Pediatrics
Marianne Jacques, Fleur Lorton, Marie-Noelle Dufourg, Corinne Bois, Elise Launay, Thierry Simeon, Jocelyn Raude, Christele Gras-Le Guen, Daniel Levy-Bruhl, Marie-Aline Charles, Martin Chalumeau, Pauline Scherdel
Summary: Incomplete vaccination is a growing problem among pediatric population in high-income countries, but the factors influencing it are not well understood. Identifying these factors is crucial for developing targeted interventions to improve vaccination uptake.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Gael Toubon, Marie-Jose Butel, Jean-Christophe Roze, Johanne Delannoy, Pierre-Yves Ancel, Julio Aires, Marie-Aline Charles
Summary: This study investigates the association between gut microbiota at 3.5 years of age and later BMI during childhood. The results show that the Firmicutes to Bacteroidetes ratio at 3.5 years is positively associated with BMI z-score at 5 years. Certain genera of gut microbiota are also found to be positively or negatively associated with BMI z-scores at 5 years. Predicted metabolic functions are associated with lower or higher BMI z-scores at 5 years.
INTERNATIONAL JOURNAL OF OBESITY
(2023)