Article
Obstetrics & Gynecology
Donald R. Coustan, Alan R. Dyer, Boyd E. Metzger
Summary: The common approach in the United States for detecting gestational diabetes involves a 2-step protocol, while the International Association of Diabetes and Pregnancy Study Groups recommends a diagnostic test without screening. Both methods have different criteria and implications for identifying gestational diabetes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Nutrition & Dietetics
Chunmei Mi, Hong Liu, Hongying Peng, Chunxia Cheng, Meng Wang, Hua Liu, Guo Feng, Jinru Wu, Hao Nie, Min Liu
Summary: The study revealed a correlation between maternal body mass index and oral glucose tolerance test results, indicating that women who were overweight before pregnancy were more likely to develop hyperglycemia. Additionally, abnormal 2-hour postprandial glucose levels during gestational oral glucose tolerance test may influence postpartum oral glucose tolerance test outcomes.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, General & Internal
Esther Maor-Sagie, Mordechai Hallak, Yoel Toledano, Rinat Gabbay-Benziv
Summary: This study aimed to evaluate the association between oGTT performed after 28 weeks and the risk of T2DM. The results showed that late oGTT had lower rates of GDM and T2DM. However, once GDM was diagnosed, regardless of oGTT timing, the risk of T2DM was increased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hector Gallardo-Rincon, Julieta Lomelin-Gascon, Luis Alberto Martinez-Juarez, Alejandra Montoya, Janinne Ortega-Mont, Victoria Galicia-Hernandez, Diego-Abelardo Alvarez-Hernandez, Rosangela Avila-Dominguez, Enrique Reyes-Munoz, Lucia Marcela Illescas-Correa, Daniel Alberto Diaz Martinez, Francisco Javier Magos Vazquez, Edwin Oswaldo Vargas avila, Alejandro Efrain Benitez-Herrera, Diana Reyes-Gomez, Maria Concepcion Carmona-Ramos, Laura Hernandez-Gonzalez, Oscar Romero-Islas, Ricardo Mujica-Rosales, Roberto Tapia-Conyer
Summary: Capillary OGTT is a valid alternative to the gold standard OGTT for screening of GDM in low-resource situations or in situations where there are other limitations to performing the OGTT as part of primary healthcare services.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGET & THERAPY
(2022)
Article
Obstetrics & Gynecology
Wan-Ju Kung, Hsin-Yi Kuo, Chien-Hung Lee, Yeong-Hwa Zen, Li-Chin Kong, Ching-Chiang Lin
Summary: This study investigated the relationship between abnormal glucose tolerance during pregnancy and maternal-fetal outcomes. The results showed that pregnant women with abnormal glucose tolerance had higher incidences of cesarean section, preterm birth, neonatal macrosomia, and neonatal intensive care unit (NICU) admission.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Nutrition & Dietetics
Farah Yasmin Hasbullah, Barakatun-Nisak Mohd Yusof, Sangeetha Shyam, Rohana Abdul Ghani, Hannah Izzati Mohamed Khir
Summary: This study examined the association between dietary patterns and abnormal glucose tolerance (AGT) in women post-gestational diabetes mellitus. It found that the "cereals-confectionaries" dietary pattern was significantly associated with AGT. Therefore, targeted lifestyle modifications, including dietary interventions, are needed for women post-gestational diabetes to reduce the risk of AGT.
Article
Endocrinology & Metabolism
Yoshifumi Kasuga, Tomoko Kawai, Kei Miyakoshi, Asuka Hori, Masumi Tamagawa, Keita Hasegawa, Satoru Ikenoue, Daigo Ochiai, Yoshifumi Saisho, Mariko Hida, Mamoru Tanaka, Kenichiro Hata
Summary: This study investigated DNA methylation patterns in neonates born to mothers with E-GDM, and found that there were no significant differences in DNA methylation between the E-GDM group and normal OGTT group. Neonates born to mothers with GDM diagnosed based on Japan Society of Obstetrics and Gynecology criteria may not differ in DNA methylation compared to those born to normal OGTT mothers.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Biology
Marek J. Walkowiak, Malgorzata Jamka, Marcin Piotr Walkowiak, Pawel Gutaj, Ewa Wender-Ozegowska
Summary: This study investigated the seasonal variation in gestational diabetes mellitus (GDM) in Central-Eastern Europe and found that the prevalence of GDM was lower in spring compared to other seasons. Mothers who underwent an oral glucose tolerance test in high insolation months had a higher incidence of GDM. Regression analysis showed a significant association between seasonal patterns and GDM prevalence.
Article
Obstetrics & Gynecology
Xiaoxiao Peng, Mingyi Liu, Jun Gang, Ying Wang, Xiuhua Ma
Summary: The study aimed to predict gestational diabetes mellitus (GDM) in high-risk pregnant women by testing fasting blood glucose, 1h and 2h plasma glucose, and HbA1c in early pregnancy. The results showed that 1h plasma glucose had the highest predictive value for GDM among these factors.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medical Laboratory Technology
Wenlin Bai, Hui Wang, Ruiling Fang, Mengwen Lin, Yao Qin, Hongjuan Han, Jing Cui, Rong Zhang, Yifei Ma, Durong Chen, Wenping Zhang, Li Wang, Hongmei Yu
Summary: The effect of abnormal OGTT0h+1h+2h on macrosomia was significantly greater than other OGTT characteristics, especially for those with pre-pregnancy BMI >= 24 kg/m2.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Nana Liu, Yin Sun, Yaxin Wang, Liangkun Ma, Suhan Zhang, Hang Lin
Summary: This study aimed to investigate the composition of intestinal microbiota and its longitudinal variation between the second trimester (T2) and the third trimester (T3) in women with gestational diabetes mellitus (GDM) and pregnant women with normal glucose tolerance. Fecal samples were collected from both groups, and the results showed that the dominant phyla did not significantly change between T2 and T3 in both groups. However, there were significant differences in the relative abundances of certain genera and phyla between the GDM group and the control group. The study concluded that while the composition of intestinal microbiota was stable over time, it differed between women with GDM and those with normal glucose tolerance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Vanessa Guerreiro, Isabel Maia, Joao Sergio Neves, Daniela Salazar, Maria Joao Ferreira, Fernando Mendonca, Maria Manuel Silva, Marta Borges-Canha, Sara Viana, Claudia Costa, Jorge Pedro, Ana Varela, Eva Lau, Paula Freitas, Davide Carvalho
Summary: The 1-hour plasma glucose concentration may be a useful indicator of beta-cell dysfunction and insulin resistance in patients with morbid obesity, showing strong correlations with other glucose parameters.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Obstetrics & Gynecology
Yanhui Hao, Lei Qu, Yuna Guo, Liying Ma, Muhe Guo, Yiqing Zhu, Yan Jin, Qin Gu, Yue Zhang, Wenguang Sun
Summary: This study found a correlation between pre-pregnancy low-carbohydrate diet and detrimental OGTT values in patients with gestational diabetes mellitus.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Medical Laboratory Technology
Emma L. Jamieson, Goce Dimeski, Robert Flatman, Peter E. Hickman, Graham Ross Dallas Jones, Julia Marley, H. David McIntyre, Alan R. McNeil, Christopher J. Nolan, Julia M. Potter, Arianne Sweeting, Peter Ward, Andrea Rita Horvath, Paul Williams, Greg Brown
Summary: To improve birth outcomes, all pregnant women without known diabetes are recommended for an oral glucose tolerance test (OGTT) to screen for hyperglycaemia in pregnancy (diabetes in pregnancy or gestational diabetes mellitus (GDM)). This review presents contemporary approaches to minimize preanalytical glycolysis in OGTT samples, with a focus on GDM diagnosis using criteria from the HAPO study. The challenges of implementing these approaches in diverse Australian healthcare settings were explored.
CLINICAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Endocrinology & Metabolism
Sura M. Alwash, H. David McIntyre, Jake Najman, Abdullah Mamun
Summary: Higher triceps skinfold thickness at age 5 is associated with increased risk of gestational diabetes mellitus, independent of BMI.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Obstetrics & Gynecology
George Mnatzaganian, Mark Woodward, H. David McIntyre, Liangkun Ma, Nicola Yuen, Fan He, Helen Nightingale, Tingting Xu, Rachel R. Huxley
Summary: This study suggests that besides the increasing prevalence of obesity, other risk factors for gestational diabetes mellitus (GDM) are also on the rise over time.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Pediatrics
Danielle K. Longmore, Angela Titmuss, Elizabeth Barr, Federica Barzi, Alison Simmonds, I-Lynn Lee, Eyvette Hawthorne, Ruth Derkenne, Christine Connors, Jacqueline Boyle, Paul Zimmet, Kerin O'Dea, Jeremy Oats, Harold D. McIntyre, Alex Brown, Jonathan Shaw, Louise J. Maple-Brown
Summary: This study assessed the growth trajectories of infants born to mothers with gestational diabetes mellitus (GDM) according to breastfeeding and maternal hyperglycemia in pregnancy. The results showed that predominantly breastfed infants had lower BMI trajectories, and among GDM offspring, predominant breastfeeding was associated with lower weight-for-age at 14 months.
Article
Biochemistry & Molecular Biology
Carlos Palma, H. David McIntyre, Carlos Salomon
Summary: Research on extracellular vesicles (EVs) has provided insights into physiological and pathophysiological conditions, particularly during pregnancy. Gestational diabetes mellitus (GDM) is a common and influential complication that affects the miRNAs and proteins within EVs, leading to metabolic changes.
Article
Public, Environmental & Occupational Health
Angela Titmuss, Anita D'Aprano, Federica Barzi, Alex D. H. Brown, Anna Wood, Christine Connors, Jacqueline A. Boyle, Elizabeth Moore, Kerin O'Dea, Jeremy Oats, H. David McIntyre, Paul Zimmet, Jonathan E. Shaw, Maria E. Craig, Louise J. Maple-Brown
Summary: This study found that hyperglycemia in pregnancy is associated with increased developmental risk in children, particularly in the areas of fine motor skills and problem-solving. The findings suggest that interventions targeting maternal hyperglycemia may help optimize developmental trajectories in children.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Nutrition & Dietetics
Faisal Altemani, Helen L. Barrett, Leonie K. Callaway, H. David McIntyre, Marloes Dekker Nitert
Summary: The abundance of nitrate-reducing bacteria in the oral microbiota is reduced in women who develop preeclampsia, indicating a potential pathway for prevention.
Article
Pediatrics
Angela Titmuss, Danielle K. Longmore, Federica Barzi, Elizabeth L. M. Barr, Vanya Webster, Anna Wood, Alison Simmonds, Alex D. H. Brown, Christine Connors, Jacqueline A. Boyle, Jeremy Oats, H. David McIntyre, Jonathan E. Shaw, Maria E. Craig, Louise J. Maple-Brown
Summary: This study found that children exposed to in utero hyperglycaemia have different growth trajectories in infancy compared to unexposed children, but similar weight and BMI by the end of follow-up. Children exposed to T2D had lower mean peak BMI in infancy.
Article
Obstetrics & Gynecology
Nina Meloncelli, Emma Shipton, Jenny Doust, Michael D'Emden, Harold David McIntyre, Leonie Callaway, Susan de Jersey
Summary: This study investigated the perceptions and use of COVID-19 changes to gestational diabetes mellitus (GDM) screening and diagnostic recommendations among healthcare professionals in Queensland. The findings revealed that clinicians had diverse opinions on the rapid changes, with some questioning the underlying evidence base while others continued to support the changes. Clinicians in areas with higher prevalence of GDM were more concerned about missed diagnoses.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna J. Wood, I-Lynn Lee, Elizabeth L. M. Barr, Federica Barzi, Jacqueline A. Boyle, Christine Connors, Elizabeth Moore, Jeremy J. N. Oats, Harold D. McIntyre, Angela Titmuss, Alison Simmonds, Paul Z. Zimmet, Alex D. H. Brown, Sumaria Corpus, Jonathan E. Shaw, Louise J. Maple-Brown
Summary: This study aimed to determine the rates and predictors of postpartum diabetes screening among Aboriginal and/or Torres Strait Islander and non-Indigenous women with gestational diabetes mellitus (GDM). The study found that postpartum screening rates were lower among Aboriginal and/or Torres Strait Islander women compared to non-Indigenous women. Early postpartum screening should be prioritized to detect prediabetes and diabetes among high-risk populations.
Article
Obstetrics & Gynecology
Sumaiya Adam, Harold David McIntyre, Kit Ying Tsoi, Anil Kapur, Ronald C. Ma, Stephanie Dias, Pius Okong, Moshe Hod, Liona C. Poon, Graeme N. Smith, Lina Bergman, Esraa Algurjia, Patrick O'Brien, Virna P. Medina, Cynthia Maxwell, Lesley Regan, Mary L. Rosser, Bo Jacobsson, Mark A. Hanson, Sharleen L. O'Reilly, Fionnuala M. McAuliffe
Summary: Gestational diabetes (GDM) affects approximately 17 million pregnancies worldwide. Women with a history of GDM are at a significantly higher risk of developing type 2 diabetes and cardiovascular disease compared to those without prior GDM. Although prevention and delayed progression of GDM to type 2 diabetes is possible, it is not widely practiced. Considering the increasing rates of type 2 diabetes and CVD in women globally, it is crucial to utilize pregnancy as an opportunity for early identification and preventive intervention.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Cynthia Maxwell, Rachelle Shirley, Amy C. O'Higgins, Mary L. Rosser, Patrick O'Brien, Moshe Hod, Sharleen L. O'Reilly, Virna P. Medina, Graeme N. Smith, Mark A. Hanson, Sumaiya Adam, Ronald C. Ma, Anil Kapur, Harold David McIntyre, Bo Jacobsson, Liona C. Poon, Lina Bergman, Lesley Regan, Esraa Algurjia, Fionnuala M. McAuliffe
Summary: Obesity is a chronic, progressive, relapsing, and treatable neurobehavioral disease that affects women's health and requires a focus on optimizing health outcomes rather than weight loss. Appropriate and sensitive language, as well as trauma-informed care, is necessary when discussing obesity.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Liona C. Poon, Long Nguyen-Hoang, Graeme N. Smith, Lina Bergman, Patrick O'Brien, Moshe Hod, Pius Okong, Anil Kapur, Cynthia Maxwell, Harold David McIntyre, Bo Jacobsson, Esraa Algurjia, Mark A. Hanson, Mary L. Rosser, Ronald C. Ma, Sharleen L. O'Reilly, Lesley Regan, Sumaiya Adam, Virna P. Medina, Fionnuala M. McAuliffe
Summary: Hypertensive disorders of pregnancy (HDP) are the leading cause of maternal and perinatal morbidity and mortality, accounting for 16% of maternal deaths in high-income countries and approximately 25% in low- and middle-income countries. HDP increases the risk of future cardiovascular disease. Failure to achieve normal cardiovascular adaptation during pregnancy is associated with the development of HDP. Women with a history of HDP may experience long-term hemodynamic alterations, predisposing them to cardiovascular morbidity and mortality. Therefore, it is crucial to identify underlying cardiovascular risk factors during pregnancy and the postpartum period and develop strategies for lifestyle and therapeutic interventions to reduce the risk of future cardiovascular disease in women with a history of HDP.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Obstetrics & Gynecology
Sarah Louise Killeen, Niamh Donnellan, Sharleen L. O'Reilly, Mark A. Hanson, Mary L. Rosser, Virna P. Medina, Chandni Maria Jacob, Hema Divakar, Moshe Hod, Liona C. Poon, Lina Bergman, Patrick O'Brien, Anil Kapur, Bo Jacobsson, Cynthia Maxwell, Harold David McIntyre, Lesley Regan, Esraa Algurjia, Ronald C. Ma, Sumaiya Adam, Fionnuala M. McAuliffe
Summary: The period before and during pregnancy is crucial for addressing malnutrition and reducing noncommunicable disease risks. The FIGO Nutrition Checklist is a tool designed to address these issues by assessing dietary requirements, body mass index, diet quality, and micronutrients. It generates awareness, identifies risks, and collects information for health-promoting conversations between women and healthcare professionals.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Josephine G. Laurie, Shelley A. Wilkinson, Harold D. Mcintyre, Centaine Snoswell
Summary: This study conducted a cost-minimisation analysis comparing a novel, digital-based model for gestational diabetes mellitus (GDM) management with conventional care. The results showed that the intervention group using the digital model achieved a modest health service cost saving of approximately AU$17,441.78 (US$12,158.92) over a 12-month period, while patients saved approximately $566.56 (US$394.96) per patient. Overall, the introduction of the digital-based model resulted in a total saving of $679,872 (US$473,948.82) for the cohort of 1200 women.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Josephine G. Laurie, Shelley A. Wilkinson, Alison Griffin, Harold D. McIntyre
Summary: This study implemented a novel digital model of care for gestational diabetes mellitus (GDM) and found that it provided similar clinical outcomes to traditional care, while also improving efficiency. The digital model of care has the potential for generalizability to culturally diverse GDM patients and offers important insights for service redesign in the digital era.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)