Article
Medicine, General & Internal
Iga Wawrzyk-Bochenek, Mansur Rahnama, Slawomir Wilczynski, Anna Wawrzyk
Summary: The study aimed to quantitatively assess the effectiveness of microneedle mesotherapy in reducing skin discoloration using the gray-level co-occurrence matrix (GLCM) method. The skin of 12 women aged 29 to 68 was examined, and microneedle mesotherapy using a preparation containing 12% ascorbic acid was performed. The effectiveness of the treatment was quantified using image analysis and processing methods.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yong Chool Boo
Summary: Arbutin, a compound of hydroquinone and D-glucose, has been studied for over 30 years for its skin lightening action. Research has focused on its mechanism of action, efficacy, safety, and potential synergies with other compounds. Studies also suggest that arbutin's antioxidant properties may contribute to its skin depigmenting effects. Future research may lead to advanced skin lightening and protecting cosmetic products.
Article
Chemistry, Physical
Md. Zahirul Kabir, Hafsa Tayyab, Cem Erkmen, Saharuddin B. Mohamad, Bengi Uslu
Summary: In this study, the combination process of BEX with HSA was investigated to understand the transport of the anticancer agent in the circulatory system. The fluorescence spectrum of HSA was found to be quenched by BEX, suggesting the involvement of static quenching process and the formation of the BEX-HSA complex. The binding affinity between BEX and HSA was moderate, and the stabilizing intermolecular forces involved hydrophobic interactions and hydrogen bonds.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Food Science & Technology
Ju-Huei Chien, Xiao-Fan Huang, Wen-Lin Lai, Kai-Fu Chang, Chia-Yu Li, Szu-Yin Chen, Chun-Yu Wu, Kuan-Ying Li, Nu-Man Tsai
Summary: This study revealed the anticancer potential of PPa extract in HL-60 cells by inhibiting cell proliferation through affecting cell cycle and inducing apoptosis. Moreover, PPa extract could modulate the expression of cell cycle-related proteins and activate apoptosis pathways, leading to cell death.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Katarzyna Michalak-Micka, Dominic Rutsche, Luca Mazzone, Vanessa L. Buchler, Ueli Moehrlen, Agnes S. Klar, Thomas Biedermann
Summary: This study provides an in-depth analysis of Merkel cells in human fetal skin. It confirms the phenotypical features of these cells and demonstrates their persistence after isolation, in culture, and in skin substitutes. The findings are important for the future application of fetal tissue-engineered skin in clinical settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Dinesh S. Reddy, Manasa Kongot, Vishal Singh, Md. Abrar Siddiquee, Rajan Patel, Nitin K. Singhal, Fernando Avecilla, Amit Kumar
Summary: A series of new C4-C4' biscoumarin-pyrimidine conjugates were synthesized and tested for their anticancer activity, with compound 1c showing the best antiproliferative effect. All compounds exhibited no toxicity towards healthy cells and displayed strong binding interactions with the drug carrier protein.
ARCHIV DER PHARMAZIE
(2021)
Article
Medicine, Research & Experimental
Natasha Tatiana Sobol, Luisina Maria Solerno, Brady Beltran, Liliana Vasquez, Giselle Vanina Ripoll, Juan Garona, Daniel Fernando Alonso
Summary: Osteosarcoma, the most common primary bone malignancy, requires novel treatment strategies for improved patient survival. Repurposed agent dDAVP shows potential anti-tumor activity in osteosarcoma by inhibiting AVPR2-expressing cell growth and raising cAMP levels, suggesting a promising therapeutic tool for managing this aggressive cancer. Further preclinical exploration on orthotopic or metastatic models is warranted to confirm its efficacy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Engineering, Electrical & Electronic
Lin Ju, Zhigang Fan, Bo Liu, Yue Ming, Xiaotian Shi, Xueshen Li
Summary: In this study, the time characteristics of image quality degradation caused by aero-optical effects in time-varying hypersonic conditions were investigated. A time-accurate imaging scheme based on time discretization was used to predict the imaging quality of the infrared detection system affected by aero-optical effects. Wave aberration, point spread function, and peak signal-to-noise ratio were used as evaluation indicators. The results showed that the degradation of image quality caused by aero-optical transmission effect is not significant during the working process, while the aero-thermal radiation effect rapidly degrades the image quality, predominantly determining the image deterioration.
IEEE PHOTONICS JOURNAL
(2022)
Article
Spectroscopy
Ali Saber Abdelhameed, Ahmed H. Bakheit, Eman S. Hassan, Amer M. Alanazi, Ahmed M. Naglah, Haitham AlRabiah
Summary: This study aimed to characterize the binding mechanism between Enasidenib and human serum albumin (HSA) using experimental and theoretical approaches. The results demonstrated that the binding of Enasidenib and HSA is a spontaneous process driven by electrostatic forces.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Medicine, General & Internal
Juemin Zhao, Yanjun Dan, Ziqi Liu, Qianqian Wang, Min Jiang, Chengfeng Zhang, Hamm-Ming Sheu, Chrang-Shi Lin, Leihong Xiang
Summary: Post-inflammatory hyperpigmentation (PIH) is a common pigmentary disorder that occurs after skin inflammation or injury. Ultraviolet B (UVB) radiation can worsen PIH by promoting inflammation and melanogenesis in skin cells. Solamargine (SM), a compound extracted from Solanum undatum, has anti-inflammatory and whitening effects on skin cells, making it a potential treatment for PIH.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
F. Kaya, E. Tugcugil
Summary: Polymyxin B is commonly used to treat drug-resistant gram-negative bacteria, but it can cause side effects such as hyperpigmentation. This case report describes a 68-year-old male patient who developed hyperpigmentation after being treated with polymyxin B for a chest infection. The patient had underlying chronic kidney disease and chronic obstructive pulmonary disease.
NIGERIAN JOURNAL OF CLINICAL PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Anil Kumar, Biswajit Mohanty, Parthapratim Munshi
Summary: This study investigates the changes that may occur in the binding process of polymorphic drugs to a target, and probes the root of the diversity in binding affinities using both experimental and computational methods, including the analysis of electron density topological properties and noncovalent interactions.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Ai Hasegawa, Yoshie Tsujiya, Ayaka Ueda, Motohiro Yamamori, Noboru Okamura
Summary: This study aimed to clarify the mechanisms of drug-drug interactions between warfarin and 5-fluorouracil (5-FU) or capecitabine. The results showed that the combination of 5-FU or capecitabine with warfarin enhanced its anticoagulant effects, indicating a pharmacological interaction rather than a pharmacokinetic interaction.
Article
Chemistry, Multidisciplinary
Maria Varaka, Martha Z. Vardaki, Georgios Gaitanis, Ioannis D. Bassukas, Nikolaos Kourkoumelis
Summary: This study evaluated the impact of different optical clearing agents (OCAs) on enhancing skin optical permeability in optical coherence tomography (OCT) images. Results showed that the application of OCAs induced significant changes in both the OCT signal decay rate and epidermal thickness.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Eun-Soo Lee, Suho Kim, Sang-Won Lee, Jinsang Jung, Sung Hoon Lee, Hye-Won Na, Hyoung-June Kim, Yong Deog Hong, Won Seok Park, Tae Geol Lee, Dong-Gyu Jo, Se-Hwa Kim
Summary: The study found that deposition of PM particles increases and penetrates deeper into the skin after disrupting the skin barrier. These results suggest that MNLO imaging could be used for visualizing and quantifying the spatial distribution of PM in ex vivo human skin tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
