Review
Endocrinology & Metabolism
Sarah S. Malik, Diksha Padmanabhan, Rebecca L. Hull-Meichle
Summary: Cystic fibrosis related diabetes is a common complication in patients with cystic fibrosis, but the mechanisms behind its occurrence are not well understood. Cystic fibrosis affects the pancreatic/islet microenvironment, leading to the loss of beta cell function and pathological changes. Further research can help develop better treatment methods.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Soon Kyu Lee, Min-Jung Park, Jeong Won Choi, Jin-Ah Baek, Se-Young Kim, Ho Joong Choi, Young Kyoung You, Jeong Won Jang, Pil Soo Sung, Si Hyun Bae, Seung Kew Yoon, Jong Young Choi, Mi-La Cho
Summary: In this study, a patient-derived avatar model was developed to predict immune homeostasis in liver transplantation patients. The model showed promise in evaluating treatment responses and reducing risks to patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Eleonora Gal, Jurij Dolensek, Andraz Stozer, Laszlo Czako, Attila Ebert, Viktoria Venglovecz
Summary: Anatomical proximity and functional correlations between the exocrine and endocrine pancreas lead to reciprocal effects between the two parts. Inflammatory diseases like pancreatitis and cystic fibrosis disrupt endocrine function, resulting in diabetes of the exocrine pancreas. Despite novel mechanisms being identified, understanding of the intra- and intercellular pathways regulating exocrine-endocrine interactions remains incomplete.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Amir Moheet, Antoinette Moran
Summary: Cystic fibrosis-related diabetes (CFRD) is a common complication of cystic fibrosis (CF) and is associated with poor health outcomes. The pathophysiology of CFRD is complex and not fully understood, but factors such as inflammation, alterations in the hormone axis, insulin resistance, and genetic factors may contribute to its development. Further research is needed to better understand the mechanisms underlying CFRD and the impact of diabetes on clinical outcomes in CF.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Montserrat A. Corbera-Hincapie, Samar E. Atteih, Olivia M. Stransky, Daniel J. Weiner, Iris M. Yann, Traci M. Kazmerski
Summary: This study explores the experiences and perceptions of food insecurity among people with cystic fibrosis. The findings reveal that the rates of food insecurity are higher in this population compared to the general US population. The study highlights the importance of screening and discussing food insecurity in cystic fibrosis care, as well as the need for comprehensive resources in addressing this issue.
Review
Nutrition & Dietetics
Laura Mihaela Trandafir, Otilia Elena Frasinariu, Elena Tarca, Lacramioara Ionela Butnariu, Maria Magdalena Leon Constantin, Mihaela Moscalu, Oana Raluca Temneanu, Alina Sinziana Melinte Popescu, Marian George Melinte Popescu, Iuliana Magdalena Starcea, Elena Cojocaru, Stefana Maria Moisa
Summary: Advances in CF care have improved the quality of life and life expectancy of patients. However, the increased weight of CF patients can have negative cardiovascular effects.
Article
Microbiology
Claudia A. Colque, Andrea G. Albarracin Orio, Pablo E. Tomatis, Gina Dotta, Diego M. Moreno, Laura G. Hedemann, Rachel A. Hickman, Lea M. Sommer, Sofia Feliziani, Alejandro J. Moyano, Robert A. Bonomo, Helle K. Johansen, Soren Molin, Alejandro J. Vila, Andrea M. Smania
Summary: This study provides insights into the long-term adaptive evolution and resistance development of Pseudomonas aeruginosa in the airways of a cystic fibrosis patient. The findings highlight the role of mutations in the chromosomally encoded class C beta-lactamase gene in shaping antibiotic resistance and reveal the impact of prolonged antibiotic treatment on the evolution of multidrug-resistant phenotypes. Understanding the molecular mechanisms of resistance in natural environmental settings is crucial for addressing the challenge of antimicrobial resistance.
Review
Endocrinology & Metabolism
Lise Coderre, Lyna Debieche, Joelle Plourde, Remi Rabasa-Lhoret, Sylvie Lesage
Summary: Cystic fibrosis-related diabetes (CFRD) is a common comorbidity in cystic fibrosis patients, with a prevalence of over 50% in adults. The etiology of CFRD is not fully understood, but research suggests it may result from beta-cell extrinsic factors. Inflammation and ductal cells near beta-cells could play a role in CFRD development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Chemistry, Analytical
Herbert Luke Ogden, Hoyeol Kim, Kathryn A. Wikenheiser-Brokamp, Anjaparavanda P. Naren, Kyu Shik Mun
Summary: Cystic fibrosis is a genetic disease with major clinical features including respiratory failure, pancreatic insufficiency, and intestinal disease. Differences between animal models and human CF patients present limitations to translational research. Organ-on-a-chip technology offers a promising approach to studying CF and may help overcome some of these limitations.
Review
Gastroenterology & Hepatology
Babajide A. Ojo, Kelli L. VanDussen, Michael J. Rosen
Summary: Physiological, molecular, and genetic findings suggest that impaired intestinal epithelial function is a key element in the development of ulcerative colitis (UC). However, the lack of therapies targeting the epithelium is a weakness in UC treatment. The absence of preclinical human models of UC hinders drug discovery.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Anca Daniela Pinzaru, Cristina Maria Mihai, Tatiana Chisnoiu, Alexandru Cosmin Pantazi, Vasile Valeriu Lupu, Mustafa Ali Kassim Kassim, Ancuta Lupu, Elena Grosan, Ahmed Zaki Naji Al Jumaili, Irina Ion, Gabriela Stoleriu, Ileana Ion
Summary: Cystic fibrosis (CF) is the most common inherited condition that leads to death, especially in those of Caucasian heritage. Around 20% of young adults diagnosed with CF will develop hyperglycemia as a complication, which is later classified as a disease associated with CF. Impaired insulin secretion and glucose intolerance are the primary mechanisms associated with diabetes (type 1 or type 2) and CF. Oxidative stress plays a crucial role in triggering other chronic diseases, including CF-related diabetes. Understanding the connection between CF-related diabetes and oxidative stress is essential for individualized therapies.
Article
Immunology
Ruchi Yadav, Quan-Zhen Li, Hanwen Huang, S. Louis Bridges, J. Michelle Kahlenberg, Arlene A. Stecenko, Balazs Rada
Summary: This study identified several new autoantibodies in the blood of CF patients and found associations with neutrophil components, diabetes, lung disease severity, and P. aeruginosa infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kavisha Arora, Fanmuyi Yang, John Brewington, Gary McPhail, Alexander R. Cortez, Nambirajan Sundaram, Yashaswini Ramananda, Herbert Ogden, Michael Helmrath, John P. Clancy, Anjaparavanda P. Naren
Summary: Cystic fibrosis is a deadly multiorgan disorder caused by gene mutations, with patients exhibiting large phenotypic variation. Clinical trials are difficult due to limited patient pools, and this study aims to use in vitro patient enteroids and in vivo mice implanted human intestinal organoids to test treatment responses for rare CF mutations.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Katherine N. Gibson-Corley, John F. Engelhardt
Summary: The life expectancy of cystic fibrosis (CF) patients has significantly increased over the past decade, and the growth in CF animal models has enhanced our understanding of this complex multisystemic disease, particularly in terms of gastrointestinal pathologies.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Editorial Material
Hematology
Yunjie Huang, Sidney W. Whiteheart
Article
Hematology
Madhu M. Ouseph, Yunjie Huang, Meenakshi Banerjee, Smita Joshi, Laura MacDonald, Yu Zhong, Huijuan Liu, Xianting Li, Binggang Xiang, Guoying Zhang, Massaki Komatsu, Zhenyu Yue, Zhenyu Li, Brian Storrie, Sidney W. Whiteheart, Qing Jun Wang
Review
Physiology
Misak Harutyunyan, Yunjie Huang, Kyu-Shik Mun, Fanmuyi Yang, Kavisha Arora, Anjaparavanda P. Naren
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jinchao Zhang, Yunjie Huang, Jing Chen, Haining Zhu, Sidney W. Whiteheart
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Priyanka Nair-Gupta, Alessia Baccarini, Navpreet Tung, Fabian Seyffer, Oliver Florey, Yunjie Huang, Meenakshi Banerjee, Michael Overholtzer, Paul A. Roche, Robert Tampe, Brian D. Brown, Derk Amsen, Sidney W. Whiteheart, J. Magarian Blander
Article
Medicine, Research & Experimental
Shaojing Ye, Yunjie Huang, Smita Joshi, Jinchao Zhang, Fanmuyi Yang, Guoying Zhang, Susan S. Smyth, Zhenyu Li, Yoshimi Takai, Sidney W. Whiteheart
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Multidisciplinary Sciences
Yunjie Huang, Kavisha Arora, Kyu Shik Mun, Fanmuyi Yang, ChangSuk Moon, Sunitha Yarlagadda, Anil Jegga, Timothy Weaver, Anjaparavanda P. Naren
SCIENTIFIC REPORTS
(2019)
Article
Hematology
Meenakshi Banerjee, Yunjie Huang, Smita Joshi, Gabriel J. Popa, Michael D. Mendenhall, Qing Jun Wang, Beth A. Garvy, Thein Myint, Sidney W. Whiteheart
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Eva Kocar, Tea Lenarcic, Vesna Hodnik, Anastasija Panevska, Yunjie Huang, Gregor Bajc, Rok Kostanjsek, Anjaparavanda P. Naren, Peter Macek, Gregor Anderluh, Kristina Sepcic, Marjetka Podobnik, Matej Butala
Summary: Aegerolysins, proteins produced by various organisms including bacteria, fungi, plants, and protozoa, interact with membranes enriched with cholesterol and specific sphingolipids. While fungal aegerolysins are well-studied for their interaction with sphingolipids, bacterial aegerolysins, particularly from pathogenic genera such as Pseudomonas and Vibrio, remain poorly understood. This study focuses on the interaction between the Pseudomonas aeruginosa aegerolysin RahU and ceramide phosphorylethanolamine (CPE), shedding light on the importance of the ligand cavity in RahU membrane interaction.
SCIENTIFIC REPORTS
(2021)
Letter
Critical Care Medicine
Yunjie Huang, Grace Paul, Jesun Lee, Karen Mccoy, Anjaparavanda P. Naren
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Kavisha Arora, Yunjie Huang, Kyushik Mun, Sunitha Yarlagadda, Nambirajan Sundaram, Marco M. Kessler, Gerhard Hannig, Caroline B. Kurtz, Inmaculada Silos-Santiago, Michael Helmrath, Joseph J. Palermo, John P. Clancy, Kris A. Steinbrecher, Anjaparavanda P. Naren
Article
Hematology
Yunjie Huang, Smita Joshi, Binggang Xiang, Yasunori Kanaho, Zhenyu Li, Beth A. Bouchard, Carole L. Moncman, Sidney W. Whiteheart