IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Replication confers β cell immaturity

(2018) Sapna Puri et al.   Nature Communications

Modeling human pancreatic beta cell dedifferentiation

(2018) Marc Diedisheim et al.   Molecular Metabolism

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

(2017) Luisa Iommarini et al.   Frontiers in Oncology

Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand

(2017) Michael Coronado et al.   CIRCULATION RESEARCH

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

(2016) A R Hall et al.   Cell Death & Disease

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

(2016) Ksenia Kurbatskaya et al.   Acta Neuropathologica Communications

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

(2015) Guy A. Rutter et al.   BIOCHEMICAL JOURNAL

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

(2015) James Cantley et al.   BMC BIOLOGY

A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia

(2015) Adrian L. Harris   Cell Metabolism

How Mitochondrial Dynamism Orchestrates Mitophagy

(2015) O. S. Shirihai et al.   CIRCULATION RESEARCH

Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption

(2015) Natalie C. Kegulian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells

(2015) Asish Dasgupta et al.   JOURNAL OF IMMUNOLOGY

Hypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?

(2015) Hemant Kumar et al.   MEDIATORS OF INFLAMMATION

Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells

(2015) Q Lu et al.   Cell Death & Disease

HIF-1 reduces ischaemia–reperfusion injury in the heart by targeting the mitochondrial permeability transition pore

(2014) Sang-Ging Ong et al.   CARDIOVASCULAR RESEARCH

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

(2014) A Yalcin et al.   Cell Death & Disease

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease

(2013) Joe Atherton et al.   AGING CELL

Sweet and Sour  -Cells: ROS and Hif1  Induce Warburg-Like Lactate Production During Type 2 Diabetes

(2013) J. Cantley et al.   DIABETES

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

(2013) Sadhana A. Samant et al.   MOLECULAR AND CELLULAR BIOLOGY

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease

(2013) Laura Dunn et al.   NEUROBIOLOGY OF AGING

Ion channels and regulation of insulin secretion in human β-cells

(2013) Leonid E. Fridlyand et al.   Islets

Disruption of Protein Quality Control in Parkinson's Disease

(2013) C. Cook et al.   Cold Spring Harbor Perspectives in Medicine

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Mechanisms of Control of the Free Ca2+ Concentration in the Endoplasmic Reticulum of Mouse Pancreatic  -Cells: Interplay With Cell Metabolism and [Ca2+]c and Role of SERCA2b and SERCA3

(2011) M. A. Ravier et al.   DIABETES

Cardiac ATP-sensitive K+ channel associates with the glycolytic enzyme complex

(2011) Miyoun Hong et al.   FASEB JOURNAL

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)- -TrCP, sequentially regulate glycolysis during the cell cycle

(2011) S. Tudzarova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

(2010) J F Rivera et al.   CELL DEATH AND DIFFERENTIATION

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity

(2010) Robert A. Ritzel et al.   REGULATORY PEPTIDES

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Identification of a Novel Small Molecule HIF-1  Translation Inhibitor

(2009) T. Narita et al.   CLINICAL CANCER RESEARCH

Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes

(2009) Chang-jiang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave

(2009) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase

(2009) K. Mitra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic β-cells

(2008) Catherine Arden et al.   BIOCHEMICAL JOURNAL

Why expression of some genes is disallowed in β-cells

(2008) Roel Quintens et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Role for von Hippel-Lindau Protein in Pancreatic  -Cell Function

(2008) S. Puri et al.   DIABETES