Review
Cell Biology
Yue Li, Wanqing Zheng, Yangyang Lu, Yanrong Zheng, Ling Pan, Xiaoli Wu, Yang Yuan, Zhe Shen, Shijia Ma, Xingxian Zhang, Jiaying Wu, Zhong Chen, Xiangnan Zhang
Summary: Mitophagy is an essential cellular process that regulates mitochondrial quantity through autophagy, with BNIP3L/Nix serving as a receptor. BNIP3L is involved in various physiological and pathological processes and is crucial in the induction of mitophagy. This review provides an overview of BNIP3L-mediated mitophagy, its molecular regulation, and its potential role in human diseases such as cancer and neurological disorders.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Yilun Zhang, Zhenzhen Jia, Xianlei Gao, Juan Zhao, Hongyan Zhang
Summary: The study found that nanoplastics can be internalized by cells and disrupt mitochondrial functionality, leading to aberrations in energy metabolism. Accumulation of nanoplastics in alimentary sources poses a significant hazard to the mammalian gastrointestinal system. The study also revealed that high concentrations of nanoplastics hinder the process of mitophagy, leading to pathological consequences and influencing gut microbiota composition and nutritional metabolism.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Plant Sciences
Shuna Cui, Tingting Chen, Mengmeng Wang, Yuanyuan Chen, Qi Zheng, Xinyi Feng, Shihua Li, Junsong Wang
Summary: The study found that Tanshinone I can inhibit the growth and migration of cervical cancer cells, induce apoptosis and cell cycle arrest. It also induces autophagy and mitophagy in cervical cancer cells by affecting mitochondrial function and metabolism, thus inhibiting metastasis.
Article
Environmental Sciences
Shuangquan Wen, Li Wang, Tao Wang, Mingchang Xu, Wenhua Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Liu
Summary: This study found that cadmium induces mitochondrial mass decrease by activating PINK1-Parkin and Nix pathways. Puerarin improved the decrease in mitochondrial membrane potential induced by Cd, and blocked mitophagy mediated by PINK1-Parkin and Nix, inhibiting Cd-induced mitochondrial mass decrease in rat cortical neurons both in vitro and in vivo.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Xiaohui Jin, Leilei Zhu, Shuaifei Lu, Caiyin Li, Ming Bai, Erping Xu, Jiduo Shen, Yucheng Li
Summary: This study investigated the effect of baicalin on mitophagy in the hippocampus of mice exposed to chronic unpredictable mild stress (CUMS) and explored its potential mechanism. The results showed that baicalin improved depressive-like behaviors in CUMS mice and ameliorated mitochondrial structural impairment in the hippocampus neuron. Baicalin increased NIX and AMPK, and improved mitophagy level and mitochondrial function in HT22 cells by directly binding to AMPK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mija Marinkovic, Ivana Novak
Summary: Mitophagy is a specialized form of autophagy that selectively removes mitochondria. BNIP3L/NIX, a well-studied mitophagy receptor, plays a crucial role in the programmed removal of healthy mitochondria across various cell types, but questions remain regarding its regulation and balancing between cellular life and death decisions.
Article
Biochemistry & Molecular Biology
Chang-Yong Choi, Mai Tram Vo, John Nicholas, Young Bong Choi
Summary: Our study reveals that the mitochondrial translation elongation factor Tu located on the outer membrane of mitochondria can inhibit altered mitochondria-induced apoptosis through its autophagic function. The autophagy-competent TUFM is required for self-dimerization and mitophagy, and its stabilization upon autophagy activation could inhibit caspase-8 activation, providing insights into the regulation of apoptosis by mitophagy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Medicine, Research & Experimental
Bang-Chuan Hu, Jing-Wen Zhu, Guo-Hua Wu, Juan-Juan Cai, Xue Yang, Zi-Qiang Shao, Yang Zheng, Jun-Mei Lai, Ye Shen, Xiang-Hong Yang, Jing-Quan Liu, Ren-Hua Sun, Hai -Ping Zhu, Xiang-Ming Ye, Shi-Jing Mo
Summary: In this study, the researchers investigated the role of insulin-like growth factor-binding protein 7 (IGFBP-7) in inflammation-coupling tubular damage (ICTD) and its potential as a therapeutic target for septic acute kidney injury (AKI).
Article
Cell Biology
Chien-Feng Huang, Yi-Hsien Hsieh, Shun-Fa Yang, Chao-Hung Kuo, Pei-Han Wang, Chung-Jung Liu, Renn-Chia Lin
Summary: In this study, PD was found to inhibit the growth of human OS cells by upregulating apoptotic-related proteins and mitophagy-related proteins. The inhibition of LC3 or NIX decreased apoptosis and mitophagy in PD-treated cells. Knockdown of p38MAPK decreased mitochondrial dysfunction, autophagy, mitophagy, and NIX/LC3B expression in PD-treated cells. Binding affinity analysis revealed a strong binding affinity in the PD-NIX and PD-LC3 complexes. These findings suggest that PD-induced mitophagy inhibition may represent a novel therapeutic strategy for human OS by targeting the NIX/LC3 pathways.
Article
Biochemistry & Molecular Biology
Yuan Jiang, Yan-Yi Jiang, De-Chen Lin
Summary: This review summarizes the methods for identifying super-enhancers and core regulatory circuits in cancer cells, as well as the mechanisms by which master transcription factors and super-enhancers cooperatively regulate cancer-specific expression programs. It also discusses the cancer type and subtype specificity of core regulatory circuits and their significance in cancer biology.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Cell Biology
Jin Lei, Ming-Hui Zhou, Fu-Chi Zhang, Kang Wu, Sheng-Wen Liu, Hong-Quan Niu
Summary: Members of the IRF gene family, including IRF1, IRF2, IRF5, IRF8, and IRF9, are significantly upregulated in glioma and associated with advanced tumor grades and poorer outcomes. Low mutation rates but genetic alterations in IRFs are linked to more favorable patient survival. Functional analysis reveals IRFs involvement in glioma pathology mainly through inflammation- and immunity-related pathways, with correlations identified between IRFs and immune cell infiltration in glioma tissues. These findings suggest that IRF family members may serve as prognostic biomarkers and indicators of immune status in glioma patients.
Article
Medicine, Research & Experimental
Xi-Chun Pan, Ya-Lan Xiong, Jia-Hui Hong, Ya Liu, Yan-Yan Cen, Tao Liu, Qun-Fang Yang, Hui Tao, Yu-Nong Li, Hai-Gang Zhang
Summary: Cardiomyocytic FoxP3 can participate in cardiac remodeling by negatively regulating Parkin-mediated mitophagy, and restoring the activity of cardiomyocytic FoxP3 can provide a cardioprotective strategy by inhibiting excessive cardiac mitophagy.
Article
Biochemistry & Molecular Biology
Jia-Jing Lu, Peng-Fei Wu, Jin-Gang He, Yu-Ke Li, Li-Hong Long, Xia-Ping Yao, Jia-Hao Yang, Hong-Sheng Chen, Xiang-Nan Zhang, Zhuang-Li Hu, Zhong Chen, Fang Wang, Jian-Guo Chen
Summary: Recent studies suggest that mitophagy, a selective autophagy process that removes damaged mitochondria, may be involved in various neurological disorders. This study found that the inflammation cytokine TNF-alpha impaired mitophagy in the prefrontal cortex, leading to the accumulation of damaged mitochondria and resulting in synaptic defects and behavioral abnormalities. The downregulation of the mitophagy protein NIX was observed in both patients with major depressive disorder and animal models, and restoring NIX levels alleviated behavioral abnormalities.
MOLECULAR PSYCHIATRY
(2023)
Article
Immunology
Ranjeet Singh Mahla, Akhilesh Kumar, Helena J. Tutill, Sreevidhya Tarakkad Krishnaji, Bharathwaj Sathyamoorthy, Mahdad Noursadeghi, Judith Breuer, Amit Kumar Pandey, Himanshu Kumar
Summary: Analysis of RNASeq data from PBMCs of treatment naive TB patients and healthy controls showed dysregulation of metabolic pathways and upregulation of mitophagy due to M. tuberculosis (Mtb) infection. Transcriptomic data from NCBI-GEO database indicated that M. bovis (BCG) infection also induces similar metabolic rewiring and mitophagy pathways. Chronic Mtb infection and BCG in-vitro infection downregulated oxidative phosphorylation while upregulating glycolysis and mitophagy, suggesting non-pathogenic mycobacterial species BCG can be used as a model for studying Mtb infection outcomes.
Article
Biochemistry & Molecular Biology
Xinyuan Yu, Xiaojun Liu, Xiujuan Mi, Xiaoqiong Luo, Zhiyun Lian, Jun Tang, Guixue Wang
Summary: Jionoside A1, a substance found in Rehmannia glutinosa, may have protective effects against ischemic stroke by reducing the consequences of ischemia-reperfusion injury and promoting neurological recovery. These findings provide theoretical justification for the application of Jionoside A1 in the treatment of ischemic stroke.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Virology
Keun Young Hwang, Young Bong Choi
JOURNAL OF VIROLOGY
(2016)
Article
Biochemistry & Molecular Biology
Young Bong Choi, Noula Shembade, Kislay Parvatiyar, Siddharth Balachandran, Edward William Harhaj
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Virology
Jennifer C. Chmura, Kevin Herold, Ayana Ruffin, Trudymae Atuobi, Yetunde Fabiyi, Ashley E. Mitchell, Young Bong Choi, Elana S. Ehrlich
Article
Virology
Qiwang Xiang, Hyunwoo Ju, Qian Li, Szu-Chieh Mei, Daming Chen, Young Bong Choi, John Nicholas
JOURNAL OF VIROLOGY
(2018)
Article
Microbiology
Young Bong Choi, Yeeun Choi, Edward William Harhaj
Article
Biochemistry & Molecular Biology
Jeongho Kwon, Eunhye Han, Chi-Bao Bui, Woochul Shin, Junho Lee, Sejeong Lee, Young-Bong Choi, Ann-Hwee Lee, Kyong-Hoon Lee, Chankyu Park, Martin S. Obin, Sung Kyu Park, Yun Jeong Seo, Goo Taeg Oh, Han-Woong Lee, Jaekyoon Shin
Article
Virology
Young Bong Choi, John Nicholas
Article
Microbiology
Young Bong Choi, Gordon Sandford, John Nicholas
Article
Microbiology
Young Bong Choi, Edward William Harhaj
Article
Microbiology
Suchitra Mohanty, Teng Han, Young Bong Choi, Alfonso Lavorgna, Jiawen Zhang, Edward William Harhaj
Review
Virology
Mai Tram Vo, Young Bong Choi
Summary: Selective autophagy is a key mechanism for the degradation of specific subcellular organelles and materials, as well as a defense mechanism against invading pathogens such as viruses. However, viruses have evolved strategies to counteract host antiviral defenses and manipulate selective autophagy for their successful infection. This review focuses on the regulation of selective autophagy by human herpesviruses.
Article
Biochemistry & Molecular Biology
Chang-Yong Choi, Mai Tram Vo, John Nicholas, Young Bong Choi
Summary: Our study reveals that the mitochondrial translation elongation factor Tu located on the outer membrane of mitochondria can inhibit altered mitochondria-induced apoptosis through its autophagic function. The autophagy-competent TUFM is required for self-dimerization and mitophagy, and its stabilization upon autophagy activation could inhibit caspase-8 activation, providing insights into the regulation of apoptosis by mitophagy.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Microbiology
Mai Tram Vo, Chang-Yong Choi, Young Bong Choi
Summary: Recently, it has been discovered that viruses can regulate selective autophagy to facilitate productive infections. Specifically, the human herpesvirus 8 (HHV-8) activates selective autophagy of mitochondria, called mitophagy, to inhibit antiviral immune responses during lytic infection in host cells. The viral interferon regulatory factor 1 (vIRF-1) of HHV-8 plays a crucial role in mitophagy activation by directly binding to mammalian autophagy-related gene 8 (ATG8) proteins, particularly GABARAPL1. The mitophagy receptor NIX promotes the interaction between vIRF-1 and GABARAPL1, and this interaction is essential for mitophagy activation and productive replication of HHV-8.
