Article
Chemistry, Multidisciplinary
Jinzhao Ou, Meng Zhu, Xiaoyan Ju, Dandan Xu, Guojun Lu, Kejia Li, Wei Jiang, Chenxiao Wan, Yuexia Zhao, Yongping Han, Ye Tian, Zhongwei Niu
Summary: The phenotype of tumor-associated macrophages is crucial in regulating the tumor immune microenvironment. Tobacco mosaic virus (TMV), a rod-like plant virus, can polarize macrophages to an M1 phenotype and create a tumor-suppressive microenvironment.
Article
Nanoscience & Nanotechnology
Yun Zhang, Yalan Chen, Jiahao Li, Xueqin Zhu, Yajing Liu, Xiaoxi Wang, Hongfei Wang, Yongjie Yao, Yanfeng Gao, Zhenzhen Chen
Summary: This article discusses the development of M2-like macrophage-targeting nanoparticles (PNP@R@M-T) that can efficiently and selectively deliver drugs to specific types of macrophages and dendritic cells in vivo. The administration of these nanoparticles led to a significant reprogramming of M2-like macrophages, a reduction in tumor size, and prolonged survival, demonstrating its potential as an effective strategy for macrophage-mediated cancer immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yanlin Chen, Siying Zhi, Jiaxin Ou, Junbin Gao, Lu Zheng, Meixin Huang, Shaohua Du, Liu Shi, Yingfeng Tu, Kui Cheng
Summary: Immunotherapy has potential but low clinical response rate, so combined therapy is needed. This study designs cancer cell membrane-coated nanoparticles that combine PDT, TLR7 agonist, and tumor antigen to enhance therapeutic efficacy.
Review
Biochemistry & Molecular Biology
Fernando Torres Andon, Sergio Leon, Aldo Ummarino, Esther Redin, Paola Allavena, Diego Serrano, Clement Anfray, Alfonso Calvo
Summary: TLRs serve as natural initial triggers of immune responses and hold potential in cancer immunotherapy. Intratumoral injection of TLR agonists achieves high local drug exposure and strong antitumor response, potentially leading to cure and antitumor immunological memory.
Article
Medicine, Research & Experimental
Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero-Boix, Aylin Moeckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H. Plate, Yvonne Reiss, Franz Roedel, Lisa Sevenich
Summary: The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer-permissive functions. Radio-immunotherapy resulted in an increase in cytotoxic T-cell numbers and prevented the induction of lymphocyte-mediated immune suppression. However, long-term efficacy was not observed.
EMBO MOLECULAR MEDICINE
(2021)
Article
Fisheries
Raja Aadil Hussain Bhat, Ritesh Shantilal Tandel, Pragyan Dash, Mir Ishfaq Nazir, Dar Jaffer Yousuf, Irfan Ahmad Bhat, Parvaiz Ahmad Ganie, Pankaj Gargotra, C. Siva
Summary: In this study, the full-length TLR4 gene was cloned and characterized in Tor putitora, and its phylogenetic relationship, localization, and binding affinity with ligands were investigated. The results suggest that TpTLR4 plays an important role in sensing pathogen-associated molecular patterns, particularly of viral origin.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuquan Zhang, Yu Liu, Ji Zhou, Jiaxin Wang, Guangyi Jin, Xiaodong Wang
Summary: A novel tumor vaccine containing MUC1 antigen and two adjuvants was developed by the research group, which effectively and safely prevented and treated tumors expressing MUC1 antigen by enhancing specific humoral and cellular immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kuai Yu, Linju Kuang, Tianmei Fu, Congkai Zhang, Yuru Zhou, Chao Zhu, Qian Zhang, Zhanglin Zhang, Aiping Le
Summary: The high expression of CREM is associated with poorer overall survival in gastric adenocarcinoma and is closely related to T-cell exhaustion in the tumor microenvironment. These findings suggest that CREM could serve as a prognostic biomarker in GAC and provide a novel direction for exploring its pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wenjing Shi, Fang Zhang, Xiaozheng Chen, Shuyun Wang, Haiqin Zhang, Zijiang Yang, Guiying Wang, Yan Zheng, Yali Han, Yuping Sun, Aiqin Gao
Summary: Infiltration of immunosuppressive cells in the tumor microenvironment is associated with colorectal cancer progression and resistance to immunotherapy. Immunoglobulin-like transcript 5 (ILT5) is highly expressed in CRC cells and correlates with advanced tumor stages and poor patient survival. ILT5 inhibits T cell infiltration and promotes M2-like polarization of tumor-associated macrophages.
Article
Immunology
Divanshu Shukla, Ashok Patidar, Uddipan Sarma, Prashant Chauhan, Surya Prakash Pandey, Himanshu Singh Chandel, Neelam Bodhale, Soumya Kanti Ghosh, Carlos Alberto Guzman, Thomas Ebensen, Ricardo Silvestre, Arup Sarkar, Bhaskar Saha, Surajit Bhattacharjee
Summary: TLRs on host cells recognize PAMPs on pathogens and trigger immune responses. Leishmania infection alters TLR interdependency, revealing a unique immune evasive mechanism. Targeting TLR interdependency can induce a host-protective immune response against intracellular pathogens.
Article
Oncology
Donghwan Jeon, Douglas G. McNeel
Summary: The presence of specific Toll-like receptor (TLR) agonists can attenuate the expression of PD-1 in activated CD8(+) T-cells, leading to an improvement in anti-tumor activity. Different TLR agonists have distinct effects on the gene expression profiles of T-cells, especially in combination with TLR1/2, TLR3, and TLR9. Combining TLR3 and TLR9 agonists for tumor vaccination can effectively suppress tumor growth.
Article
Biology
Vadim Mett, Oleg V. Kurnasov, Ivan A. Bespalov, Ivan Molodtsov, Craig M. Brackett, Lyudmila G. Burdelya, Andrei A. Purmal, Anatoli S. Gleiberman, Ilia A. Toshkov, Catherine A. Burkhart, Yakov N. Kogan, Ekaterina L. Andrianova, Andrei V. Gudkov, Andrei L. Osterman
Summary: GP532, a substantially deimmunized derivative of the TLR5 agonist entolimod, retains potent NF-kappa B activation while eliminating key B- and T-cell epitopes and an inflammasome-activating domain. It is suitable for multi-dose therapies and patients with high titers of preexisting flagellin-neutralizing antibodies.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tongyi Shang, Xinying Yu, Yuan Gu, Rong Du, Yanjun Cai, Yuwei Li, Guodong Zheng, Chaoqun Wang, Jian Zhang, Jifang Liu, Shisong Han, Bin Yang
Summary: Cancer immunotherapy, specifically targeting macrophages, is a promising method for tumor therapy. However, tumor-associated macrophages usually have a tumor-promoting phenotype and the over-expression of CD47 inhibits their function. A nano-assembly system was constructed to re-educate macrophages to have an anti-tumoral phenotype and enhance their phagocytosis of cancer cells. This dual regulation of macrophages resulted in a synergistic immunotherapy effect and inhibited tumor growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Anthony Ambesi, Pranav Maddali, Paula J. McKeown-Longo
Summary: The structural changes in the fibronectin matrix in the tumor microenvironment promote tumor progression by inducing the pro-tumorigenic cytokine IL-8 through activation of TLRs, resulting in the formation of an inflammatory microenvironment conducive to metastatic progression.
Review
Cell Biology
Valentino Le Noci, Giancarla Bernardo, Francesca Bianchi, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini
Summary: The microbiota is a complex ecosystem of active microorganisms in mammals, playing critical roles in maintaining health, symbiosis with the immune system, pathogen defense, and tolerance to commensal microbes. Toll-like receptors (TLRs) are key in sensing the microbiota, associated with cancer development, and potentially disrupting TLR tolerance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Yingrui Deng, Xiaoting Zhang, Rui Li, Zhuo Li, Boguang Yang, Peng Shi, Honglu Zhang, Chunming Wang, Chunyi Wen, Gang Li, Liming Bian
Summary: This study investigates the efficacy of biofunctionalizing a hyaluronic acid hydrogel with a synthetic Wnt5a mimetic ligand (Foxy5 peptide) to promote the chondrogenesis of human mesenchymal stem cells (hMSCs). The conjugation of Foxy5 peptide in the hydrogels activates non-canonical Wnt signaling, leading to enhanced expression of chondrogenic markers and metabolic activities of encapsulated hMSCs. Furthermore, Foxy5 peptide inhibits hypertrophy of chondrogenically induced hMSCs through multiple signaling pathways. These findings provide valuable insights for the rational design of bio-inductive scaffolds in regenerative medicine.
Article
Gastroenterology & Hepatology
Chunyan Liu, Lintao Wang, Mengzhen Xu, Yajie Sun, Zhen Xing, Junfeng Zhang, Chunming Wang, Lei Dong
Summary: This study successfully transformed the spleen into a liver-like organ by directly reprogramming the splenic fibroblasts into hepatocytes. This method, which does not require cell or tissue transplantation, provides a potential therapeutic approach for the treatment of end-stage liver diseases.
Article
Biochemistry & Molecular Biology
Sen Zhu, Xuan Li, Bingrong Dang, Fen Wu, Chunming Wang, Changjun Lin
Summary: LBP protects skin cells from PM2.5-induced cytotoxicity by regulating the oxidative stress-ER stress-autophagy-apoptosis signaling axis.
Article
Medicine, Research & Experimental
Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Jinzhi Xu, Ningyi Shao, Guokai Chen, Junfeng Zhang, Lei Dong, Chunming Wang
Summary: Nonhealing diabetic wounds can be effectively healed by training macrophages to mimic the reparative functions of tumor-associated macrophages (TAMs), which produce immunosuppressive and proliferative factors. These TAM-educated macrophages (TAMEMs) outperform other macrophage phenotypes in reducing inflammation, promoting angiogenesis, and activating fibroblasts. A nine-factor cocktail has also been developed to train human primary monocytes into TAMEMs, enabling the preparation of safer and autologous cells. This study demonstrates the potential of recapitulating TAMs' reparative activities in non-tumor cells for regenerative medicine.
EMBO MOLECULAR MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Ru Zhang, Cuiwen Liu, Chengmeng Wei, Jingtao Huang, Xiaohui Zou, Yanxian Feng, Song Ang, Suqin Guo, Jinqing Qu, Ning Qing, Chengcheng Tang, Xiaoqing Zhou, Min Chen, Liuyan Tang
Summary: Here, a series of hydrogels (CT-hydrogels) with charge transfer complex are designed and synthesized. These hydrogels have rapid self-healing property, injectability, thermosensitivity, good adhesive strength on skin, and excellent antibacterial performance. They also exhibit high wound healing rate and promote neovascularization in diabetic wound healing.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Biology
Yunqin Wu, Xiaohua Peng, Song Ang, Yue Gao, Yue Chi, Jinling Wang, Chengcheng Tang, Xiaoqing Zhou, Yanxian Feng, Kun Zhang, Qingjian Zou, Min Chen
Summary: In this study, genetically modified neural stem cells (NSCs) were developed to enhance the survival and formation of motor neurons. The modified NSCs exhibited improved resistance to stress and toxicity, and successfully differentiated into motor neurons.
Review
Medicine, Research & Experimental
Zuohao Liu, Chunming Wang, Changjun Lin
Summary: Pyroptosis is a recently discovered programmed cell death mode caused by inflammasomes and Gasdermin family proteins. It leads to the release of inflammatory factors and triggers an inflammatory cascade response. Pyroptosis has different morphological features compared to other cell death modes and can be a potential cancer treatment strategy. However, there is still much unknown about its molecular mechanisms in pathogenicity and therapeutics, requiring further research.
Article
Chemistry, Medicinal
Lingzhi Wang, Catarina Oliveira, Qiu Li, Andreia S. Ferreira, Claudia Nunes, Manuel A. Coimbra, Rui L. Reis, Albino Martins, Chunming Wang, Tiago H. Silva, Yanxian Feng
Summary: This study characterized a pharmaceutical-grade fucoidan extracted from Fucus vesiculosus and investigated its anti-inflammatory potential. The extract contained mainly fucose, followed by uronic acids, galactose, and xylose, with a molecular weight of 70 kDa and a sulfate content of around 10%. In vitro and in vivo experiments demonstrated the ability of the fucoidan extract to modulate cytokine expression and reverse inflammation induced by lipopolysaccharide.
Article
Zoology
Wen Guo, Mengna Wang, Haotian Li, Chunming Wang
Summary: A new species of nematode, Chromadorina communis sp. nov., is described in this study. Its characteristics include: medium-sized body, finely striated cuticle with homogeneous punctations, absence of ocelli, buccal cavity with three equal-sized, solid teeth, four cephalic setae, oval amphidial fovea between cephalic setae, curved spicules with tapered distal ends, simple boat-shaped gubernaculums, five or six cup-shaped precloacal supplements, and conical tail with a very short spinneret.
Article
Chemistry, Multidisciplinary
Xiaoyu Yin, Lintao Wang, Yiming Niu, Daping Xie, Qingwen Zhang, Jian Xiao, Lei Dong, Chunming Wang
Summary: This study discovered an oligosaccharide biomaterial (OG6) that stimulates specific expression of a chemokine in macrophages, leading to hair regeneration without inducing excessive inflammation. This finding opens up new possibilities for designing glycan-based therapeutic tools.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Lijuan Zhao, Lingzhi Wang, Gengrui Chen, Wenxi Li, Hongzhou Ge, Fuqiang Tang, Yating Wen, Yanxian Feng, Haoyi Wu
Summary: The cytotoxicity of graphene quantum dots (GQDs) can be reduced through photocatalysis with TiO2 and ultraviolet light, which removes hydrophilic functional groups of GQDs, causing aggregation of nanoparticles and reduction of water-diffused concentration. This treatment is valuable for the disposal of nano-carbon materials in wastewater.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Engineering, Biomedical
Daping Xie, Jiaxi Chen, Chonghao Chen, Yiming Niu, Lei Dong, Chunming Wang
Summary: The emerging applications of click chemistry have provided new possibilities for understanding cellular processes and designing therapeutic tools. This study focuses on the modification of neutrophils, which are known for short lives but play a crucial role in innate immune responses. A two-step strategy involving lipid fusion and click chemical reaction is studied to engineer neutrophil surfaces with carbohydrates. Among the modified neutrophils, those modified with mannose stimulate macrophage phagocytosis, suggesting a potential approach for anti-inflammatory therapies.
ADVANCED NANOBIOMED RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shuaifei Ji, Mingchen Xiong, Huating Chen, Yiqiong Liu, Laixian Zhou, Yiyue Hong, Mengyang Wang, Chunming Wang, Xiaobing Fu, Xiaoyan Sun
Summary: The ageing process involves the decline from cellular dysfunction to organ degeneration, resulting in increased susceptibility to deteriorated disorders. However, rejuvenation techniques, such as cellular reprogramming and epigenetic regulation, have demonstrated that ageing can be reversed or delayed. This review discusses the factors influencing cell rejuvenation, the core mechanisms involved, and the latest advancements in rejuvenation strategies. These strategies, including cellular reprogramming, removal of senescence cells, metabolic manipulation, and immune rejuvenation, have potential applications in ageing-related disease treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Immunology
Ruoyu Mu, Lei Dong, Chunming Wang
Summary: This article summarizes the latest trends in developing carbohydrate-containing adjuvants and discusses how the physicochemical characteristics of glycans affect their immunostimulatory functions. Additionally, potential technologies for addressing challenges in carbohydrate adjuvant design are explored from a translational perspective.
TRENDS IN IMMUNOLOGY
(2023)