期刊
EPIGENOMICS
卷 11, 期 11, 页码 1267-1282出版社
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0009
关键词
fatty liver; lipid metabolism; m(6)A; translation
资金
- National Key R&D Program of China [2018YFD0500402]
- National Natural Science Foundation of China [31660641]
- Guangxi Science and Technology Base and Talents Project [AD18281085]
- Guangxi Natural Science Foundation [2017GXNSFAA198139]
- State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources [SKLCUSA-a201808]
- Training Project of High-level Professional and Technical Talents of Guangxi University
- Guangxi Hundred-Talent Program
Aim: To assess the m(6)A methylome in mouse fatty liver induced by a high-fat diet (HFD). Materials & methods: MeRIP-seq was performed to identify differences in the m(6)A methylomes between the normal liver and fatty liver induced by an HFD. Results: As compared with the control group, the upmethylated coding genes upon feeding an HFD were primarily enriched in processes associated with lipid metabolism, while genes with downmethylation were enriched in processes associated with metabolism and translation. Furthermore, many RNA-binding proteins that potentially bind to differentially methylated m(6)A sites were mainly annotated in processes of RNA splicing. Conclusion: These findings suggest that differential m(6)A methylation may act on functional genes through RNA-binding proteins to regulate the metabolism of lipids in fatty liver disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据