Article
Biochemistry & Molecular Biology
Chunfang Dai, Bin Wu, Yuxin Chen, Xiaohuan Li, Yanrui Bai, Yehong Du, Yayan Pang, Yu Tian Wang, Zhifang Dong
Summary: The study suggests that Aagab may serve as a regulator of NEDD4-1-mediated Pten nuclear translocation to promote functional recovery following HIBD in neonatal rats, providing a new potential therapeutic target for guiding clinical treatment for HIE.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Chemistry, Physical
Zhixiong Deng, Bing Yuan, Kai Yang
Summary: This study used molecular dynamics simulations to uncover the key role of interfacial cardiolipin in regulating the functional dimerization of the membrane protein VsSemi-SWEET. The research identified four binding sites for cardiolipins and observed two types of dimerization modes during the assembly process. The findings provide valuable information on the relationship between lipid binding and functional dimerization, contributing to a better understanding of the molecular mechanism of sugar transporter biological function.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Psychiatry
Bin Wang, Ning Xin, Xuanchen Qian, Lijing Zhai, Zhigang Miao, Yong Yang, Shihua Li, Miao Sun, Xingshun Xu, Xiao-Jiang Li
Summary: Research has shown that AHI1 is a crucial regulator of GR levels, and its deficiency can affect the efficacy of antidepressants and stress responses. Ahi1 interacts with GR to stabilize each other in the cytoplasm, facilitating the nuclear translocation of GR under stress conditions.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Cell Biology
Lilian C. Russo, Pault Y. M. Ferruzo, Fabio L. Forti
Summary: DUSP3 interacts with NPM in the cell nucleus after UV stress, showing high-affinity binding and dephosphorylating specific tyrosines of NPM. This interaction affects HDM2-p53 interaction in the nucleoplasm, leading to increased stability and transcriptional activity of p53, favoring DNA repair and genomic stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Michael D. Tarpey, Adam J. Amorese, Elizabeth R. LaFave, Everett C. Minchew, Kelsey H. Fisher-Wellman, Joseph M. McClung, Eli G. Hvastkovs, Espen E. Spangenburg
Summary: Brca1 is expressed in skeletal muscles and localizes to mitochondria and the nucleus, playing a critical role in maintaining force production and mitochondrial respiration in skeletal muscle.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Article
Biochemical Research Methods
Xiaofang Zheng, Sijia Chang, Yini Liu, Xiaoxia Dai, Changjun You
Summary: The generation of deoxyinosine (dI) in DNA is a significant cause of genetic mutations, which can lead to cancer and other human diseases. Identifying and characterizing dI-binding proteins is crucial for understanding the biological effects of dI. In this study, a mass spectrometry-based proteomics approach was used to identify cellular proteins that interact with dI-bearing DNA. The results revealed that human mitochondrial heat shock protein 60 (HSPD1) can bind to dI in DNA and play a role in DNA damage response and dI regulation in human cells.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Wenyu Hu, Anqi Dong, Kohei Karasaki, Shota Sogabe, Daiki Okamoto, Masato Saigo, Mari Ishida, Masao Yoshizumi, Hiroki Kokubo
Summary: Smad4 plays an essential role in cardiomyocyte differentiation by controlling both transcription and the nuclear localization of Nkx2-5.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zoe N. Loh, Mu-En Wang, Changxin Wan, John M. Asara, Zhicheng Ji, Ming Chen
Summary: PTEN regulates various biological processes including metabolism through distinct molecular targets in different subcellular compartments. While its role in cytosol is well-studied, the metabolic regulation of PTEN in the nucleus is yet unknown. This study reveals that nuclear PTEN contributes to pyrimidine metabolism, specifically de novo thymidylate biosynthesis, through interaction with MTHFD1. The findings provide insight into the nuclear function of PTEN and have potential implications for targeted therapy in nuclear-excluded PTEN prostate cancer cells with antifolate drugs.
Article
Multidisciplinary Sciences
Amanda B. Wass, Benjamin A. Krishna, Laura E. Herring, Thomas S. K. Gilbert, Masatoshi Nukui, Ian J. Groves, Abigail L. Dooley, Katherine H. Kulp, Stephen M. Matthews, Daniel M. Rotroff, Lee M. Graves, Christine M. O'Connor
Summary: This study reveals the crucial role of cellular mitogen-activated protein kinase signaling in the balance between CMV latency and reactivation, and identifies the use of dasatinib as a potential risk factor for CMV-associated diseases.
Article
Immunology
Rui Xu, Shuang-Shuang Yu, Ran-Ran Yao, Rong-Chun Tang, Jia-Wei Liang, Xuewen Pang, Jun Zhang
Summary: LINC02605 is an induced lncRNA by viral infection that plays a positive feedback role in antiviral immune response by modulating the nuclear translocation of IRF3.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinyi Zhou, Lili Gu, Yingying Shi, Ting Huang, Xirui Fan, Xiaowen Bi, Shuai Lu, Juanjuan Liang, Lan Luo, Peng Cao, Zhimin Yin
Summary: The study showed that GSTpi can protect cells from cell death during DNA damage via Ser184 phosphorylation, enhance NBS1 nuclear translocation to activate the ATM-Chk2-p53 signaling pathway, block the cell cycle in the G2/M phase to allow more time for DNA damage repair.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sandra Rayego-Mateos, Jose Luis Morgado-Pascual, Carolina Lavoz, Raul R. Rodrigues-Diez, Laura Marquez-Exposito, Antonio Tejera-Munoz, Lucia Tejedor-Santamaria, Irene Rubio-Soto, Vanessa Marchant, Marta Ruiz-Ortega
Summary: This study aimed to locate the cellular binding sites of CCN2/EGFR in the kidney. The results showed that CCN2 primarily binds to tubular epithelial cells, and the activation of CCN2(IV) can promote the progression of kidney damage.
Article
Neurosciences
Lili Sun, Rui Han Jiang, Wen Jing Ye, Michael Rosbash, Fang Guo
Summary: A novel self-reinforcing loop within the circadian network and a new sleep-promoting neuropile have been identified in the fruit fly, which are both essential for maintaining normal sleep. These findings provide new insights into sleep research.
Article
Cell Biology
Dong Yun Kim, Yu Jin Sub, Hye-Youn Kim, Kyeong Jee Cho, Won Il Choi, Yo Jun Choi, Min Goo Lee, Friedhelm Hildebrandt, Heon Yung Gee
Summary: LRRC6 functions as an assembly factor for dynein arms in motile ciliated cells. We investigated its role in the active nuclear translocation of FOXJ1, a master regulator for cilia-associated gene transcription. Knockout of LRRC6 hindered the assembly of cilia components and resulted in decreased expression of cilia-related proteins and transcripts.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Mukul Prasad, Joanna Brzostek, Namrata Gautam, Renu Balyan, Vasily Rybakin, Nicholas R. J. Gascoigne
Summary: Themis-deficient CD4(+) T cells exhibit poor proliferative responses, reduced cytokine production, and weaker inflammatory potential, suggesting impaired effector functions. This defect is likely caused by inefficient TCR signal transduction leading to defective metabolic reprogramming, as evidenced by the inability to upregulate key metabolic pathways and NFAT translocation upon TCR stimulation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Plant Sciences
Shuaiming Zhu, Fengxia Ren, Zhe Guo, Jianghua Liu, Xingzhong Liu, Gang Liu, Yongsheng Che
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Medicine, Research & Experimental
Quan Gao, Bolin Hou, Huaiyi Yang, Xuejun Jiang
Article
Plant Sciences
Jinyu Zhang, Yumei Li, Fengxia Ren, Yang Zhang, Xingzhong Liu, Ling Liu, Yongsheng Che
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Chemistry, Multidisciplinary
Qibin Chen, Jie Gao, Cooper Jamieson, Jiawang Liu, Masao Ohashi, Jian Bai, Daojian Yan, Bingyu Liu, Yongsheng Che, Yanan Wang, K. N. Houk, Youcai Hu
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Biochemistry & Molecular Biology
Longfang Guo, Caining Zhang, Quan Gao, Bolin Hou, Ling Liu, Huaiyi Yang, Xuejun Jiang
CHEMISTRY & BIODIVERSITY
(2020)
Article
Plant Sciences
Erwei Li, Bolin Hou, Quan Gao, Yang Xu, Caining Zhang, Xingzhong Liu, Xuejun Jiang, Yongsheng Che
JOURNAL OF NATURAL PRODUCTS
(2020)
Correction
Biochemistry & Molecular Biology
Yuanyuan Pan, Ling Liu, Feifei Guan, Erwei Li, Jin Jin, Jinyang Li, Yongsheng Che, Gang Liu
ACS CHEMICAL BIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Youwei Xu, Shanmeng Lin, Rongkun He, Yichuan Zhang, Quan Gao, Dennis K. P. Ng, Jin Geng
Summary: The research presents a photoactivation system that cleaves unsaturated bonds using visible light, allowing for the release of aldehydes in live cells. It also demonstrates the targeting of specific cells using a mannose-functionalized photocage.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jin Geng, Yichuan Zhang, Quan Gao, Kevin Neumann, Hua Dong, Hamish Porter, Mark Potter, Hua Ren, David Argyle, Mark Bradley
Summary: The article introduces a chemistry-based strategy for simultaneous chemo-radiotherapy by activating cancer prodrugs through irradiation, enabling site-directed chemotherapy instead of systemic chemotherapy, which opens up a new era in targeted and directed chemotherapy.
Article
Plant Sciences
Chuan Li, Yang Xu, Peinan Fu, Liangdong Guo, Yongsheng Che
Summary: Four new diphenyl ether derivatives were isolated from cultures of the plant endophytic fungus, and their structures were determined by NMR experiments. Two of the compounds exhibited modest cytotoxicity against HepG2 cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Yang Zhang, Peinan Fu, Yiqing Zhang, Yang Xu, Chunyan Zhang, Xingzhong Liu, Yongsheng Che
Summary: In this study, two new xanthone derivatives, Cladoxanthones A and B, as well as a known compound, mangrovamide J, were isolated from the culture of Cladosporium sp. The structures and absolute configurations were determined using NMR and X-ray crystallography. These compounds exhibited weak cytotoxic effects.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Yichuan Zhang, Quan Gao, Weishuo Li, Rongkun He, Liwei Zhu, Qianjin Lian, Liang Wang, Yang Li, Mark Bradley, Jin Geng
Summary: In this study, a photoactivatable prodrug system based on PET-RAFT polymerization was developed for the synthesis of structure-predictable polymers in living cells. The generated polymers showed inhibitory effects on cancer cell growth and migration.
Article
Chemistry, Multidisciplinary
Rongkun He, Yichuan Zhang, Suresh Madhu, Quan Gao, Qianjin Lian, Sriram Srinivasa Raghavan, Jin Geng
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Organic
Ying Wang, Jinwei Ren, Honghua Li, Yuanyuan Pan, Xingzhong Liu, Yongsheng Che, Gang Liu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)