Article
Biochemistry & Molecular Biology
Mengling Ye, Cheng Wang, Jie Zhu, Mingkai Chen, Shuhong Wang, Mingxuan Li, Yajing Lu, Pingping Xiao, Mengsi Zhou, Xiaoqing Li, Rui Zhou
Summary: The lncRNA PINT has been found to act as an activator of inflammatory responses by regulating the transcription of inflammatory genes, primarily dependent on the NF-kappa B signaling pathway. It selectively regulates the expression of TNF-alpha in both basal and stimulated cells, serving as a modular scaffold for p65 and EZH2 to coordinate localization and specify binding to target genes. High expression of PINT in intestinal mucosal tissues of ulcerative colitis patients highlights its potential as a therapeutic target for infectious and inflammatory diseases.
Article
Cell Biology
Xin Huang, Nazym Bashkenova, Yantao Hong, Cong Lyu, Diana Guallar, Zhe Hu, Vikas Malik, Dan Li, Hailin Wang, Xiaohua Shen, Hongwei Zhou, Jianlong Wang
Summary: This study uncovers a TET1-PSPC1-Neat1 molecular axis that modulates PRC2 binding affinity to chromatin and bivalent gene transcripts, thereby controlling stem cell bivalency.
Article
Multidisciplinary Sciences
Joshua K. Stone, Lana Vukadin, Eun-Young Erin Ahn
Summary: The novel eRNA eNEMAL transcribed from the MALAT1-20 kb enhancer regulates NEAT1 isoform expression in breast cancer cells, suggesting a co-regulation of MALAT1 and NEAT1 in response to hypoxia.
Article
Biochemistry & Molecular Biology
Hiromi Sakaguchi, Hiroyuki Tsuchiya, Yutaka Kitagawa, Tomohiko Tanino, Kenji Yoshida, Nobue Uchida, Goshi Shiota
Summary: The long noncoding RNA NEAT1v1 is involved in the maintenance of cancer stem cells in hepatocellular carcinoma and affects the sensitivity to radiation therapy. NEAT1v1 overexpression enhances autophagy and confers resistance to radiation treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Retraction
Biochemistry & Molecular Biology
Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Qiao Wu, Jun-Hua Tan, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Summary: The research article was retracted due to the discovery that image elements of the experimental data had been published elsewhere in a different scientific context, leading the editors to deem the conclusions invalid.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Xin Chai, Zhengwei Liang, Junshi Zhang, Jing Ding, Qian Zhang, Sha Lv, Yazhu Deng, Rongrui Zhang, Deqin Lu
Summary: Increasing evidence suggests that chlorogenic acid (CGA), a polyphenol with various effects, can protect against myocardial ischemia-reperfusion injury (MIRI). This study explored the cardiac protection mechanism of CGA and found that it could reduce myocardial infarction and NLRP3 inflammasome-mediated pyroptosis by suppressing Lnc Neat1 expression. In vitro experiments further confirmed these findings. Inhibiting Lnc Neat1 expression may be a potential therapeutic strategy for MIRI.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Diana Nitusca, Anca Marcu, Alis Dema, Loredana Balacescu, Ovidiu Balacescu, Razvan Bardan, Alin Adrian Cumpanas, Ioan Ovidiu Sirbu, Bogdan Petrut, Edward Seclaman, Catalin Marian
Summary: This study suggests that NEAT1 could serve as a diagnostic biomarker for PCa with a relatively high diagnostic value. Further studies on larger cohorts are needed to confirm these findings and explore the oncogenic mechanism of NEAT1 in the development of PCa.
Article
Multidisciplinary Sciences
Apple Cortez Vollmers, Sergio Covarrubias, Daisy Kuang, Aaron Shulkin, Justin Iwuagwu, Sol Katzman, Ran Song, Kasthuribai Viswanathan, Christopher Vollmers, Edward Wakeland, Susan Carpenter
Summary: Recent studies have identified a previously unknown function for the lncRNA GAPLINC, which acts as a negative regulator of inflammation in the context of innate immunity, macrophages, and LPS-induced endotoxic shock. Transcriptome analysis in human and mouse macrophages showed that GAPLINC is highly expressed following macrophage differentiation, but rapidly down-regulated upon inflammatory activation. Depletion of GAPLINC leads to enhanced expression of inflammatory genes, while overexpression suppresses this response, ultimately modulating endotoxic shock and multiorgan failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Tao Liu, Hui Wang, Zhibin Fu, Zheng Wang, Jie Wang, Xinxin Gan, Anbang Wang, Linhui Wang
Summary: In renal cell carcinoma (RCC), METTL14 downregulation decreases NEAT1_1 expression, promoting tumor cell proliferation and migration. YTHDF2 accelerates NEAT1_1 degradation by recognizing METTL14-mediated m6A marks, facilitating RCC growth and metastasis.
Article
Multidisciplinary Sciences
Hui Miao, Fan Wu, Yu Li, Chenyu Qin, Yongyun Zhao, Mingfeng Xie, Hongyuan Dai, Hong Yao, Haoyang Cai, Qianhong Wang, Xu Song, Ling Li
Summary: This study investigates how lncRNA MALAT1 cooperates with splicing factors in alternative splicing regulation. It is found that MALAT1 stabilizes the interaction between PTBP1 and PSF, forming a functional module that affects alternative splicing events. The functional module has more significance in hepatocellular carcinoma. Additionally, MALAT1 also stabilizes the interaction between PSF and other heterogeneous nuclear ribonucleoparticle proteins.
Article
Multidisciplinary Sciences
Yong-jia Hu, Gui-yua Song, Fan Zhang, Nan Zhang, Fei Wang, Jing-long Wang, Xia Wang, Tao-yang Wang, Yu-feng Li, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu
Summary: The study aimed to investigate the potential role of lncRNA NEAT1, miR-147 and Phosphoinositide Dependent Protein Kinase 1 (PDPK1) interaction in radioprotection by troxerutin (TRT). The findings showed that NEAT1 sponged miR-147, and PDPK1 mRNA was the primary target of miR-147. TRT effectively upregulated NEAT1 to inhibit miR-147 and to upregulate PDPK1, promoting radioprotection.
Article
Medicine, Research & Experimental
Jianming Lu, Chuanfan Zhong, Junqi Luo, Fangpeng Shu, Daojun Lv, Zezhen Liu, Xiao Tan, Shuo Wang, Kaihui Wu, Taowei Yang, Weibo Zhong, Bin Wang, Yanfei Chen, Yuehan Li, Zhenyu Jia, Yaguang Zou, Weide Zhong, Xiangming Mao
Summary: This study demonstrated the biological relevance of circCSPP1 and HnRNP-L in the progression of prostate cancer, indicating that increased circCSPP1 in prostate cancer cells regulated by HnRNP-L can induce autophagy, leading to enhanced proliferation, migration, and invasion. Furthermore, a potential competing endogenous RNA network involving circCSPP1, miR-520h, and EGR1 was revealed in prostate cancer cells, suggesting its significance in prostate cancer progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Virology
Burcu Bayyurt, Mehmet Bakir, Aynur Engin, Caner Oksuz, Serdal Arslan
Summary: The study investigated the expression of NEAT1, IFNG-AS1, and NRIR in CCHF patients, showing that NRIR expression was significantly associated with CCHF cases and important clinical parameters. NEAT1 and IFNG-AS1 were downregulated in the case and fatal groups, suggesting NRIR may be a key player in CCHF pathogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Qi Wang, Daining Zhang, Wenjing Feng, Yidi Guo, Xiaoning Sun, Maolin Zhang, Zhenhong Guan, Ming Duan
Summary: This study found that the host lncRNA TSPOAP1-AS1 is significantly induced by influenza A virus (IAV) infection and is involved in viral replication through the regulation of the nuclear factor-kappa B signaling pathway. Overexpression of TSPOAP1-AS1 enhances viral replication, while inhibition of TSPOAP1-AS1 restricts viral replication. TSPOAP1-AS1 also negatively regulates the expression of interferon-stimulated genes.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Shanshan Wang, Xuewen Xu, Yan Liu, Jianjun Jin, Feng Zhu, Wei Bai, Yubo Guo, Jiali Zhang, Hao Zuo, Zaiyan Xu, Bo Zuo
Summary: The study identified a novel EZH2-binding lincRNA, TCONS-00036665, which promotes pig skeletal satellite cell proliferation and inhibits cell differentiation. Mechanistic studies revealed that TCONS-00036665 interacts with EZH2 to repress target gene expression involved in pig myogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Yonghui Fan, Zhaoyan Lv, Yue Zhang, Liangliang Ma, Boya Qin, Qiuxia Liu, Wenjing Zhang, Shangyu Ma, Chuanxi Ma, Zhenglai Huang
Summary: The study found that applying night warming treatments during the early growth stages of wheat can effectively increase yield. In particular, the night warming treatment from the jointing to the booting stage showed the best improvement in yield, helping to reduce the negative impact of high temperature on grain filling.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Meteorology & Atmospheric Sciences
Huiqing Hao, Yonghong Hao, Yan Liu, Tian-Chyi Jim Yeh, Ming Zhang, Qi Wang, Yonghui Fan
Summary: This study reveals that the mass balance of glaciers is highly dependent on elevation and exhibits vertical heterogeneity. The middle-elevation zone is identified as the sensitive zone for glacier mass balance, with a core region of gain and loss transformation. The cold phases of La Niña and North Atlantic Oscillation have a significant impact on the mass balance, causing loss in certain elevation intervals.
Article
Environmental Sciences
Wenyang Wang, Yonghui Fan, Kai Li, Xintong Wang, Jintao Kang
Summary: This paper investigates and analyzes spring water resources using the example of the karst area of Jinan. The geological causes of springs and the reasons for spring flow attenuation are analyzed. The necessity and development statuses of rail transit construction are also analyzed based on the current situation of traffic congestion in Jinan. The Jinan spring area is divided into three research regions, and the spring protection problems faced by each region during the construction of urban railways are described, with countermeasures and suggestions presented.
Article
Materials Science, Multidisciplinary
Jun Yang, Jieyun Wang, Chao Luo, Yaxi Ding, Yonghui Fan
Summary: The study investigated the temperature distribution of the sealing hinge layer inside a large UHPC arch seat and proposed a suggestion for the design of a large-volume UHPC layer through thermal field solid finite element analysis. Results show a hydration induction period of 10 h with a peak temperature of 69 degrees C in 20 h, and a maximum temperature difference of 40 degrees C between core and surface. The early temperature field and heat release rate of UHPC are affected by initial temperature, with materials reaching equivalent heat release at 75 h as at 300 h.
FRONTIERS IN MATERIALS
(2022)
Article
Plant Sciences
Shangyu Ma, Junyou Hou, Yanyan Wang, Mengchang Wang, Wenjing Zhang, Yonghui Fan, Zhenglai Huang
Summary: Soil waterlogging is a major limitation for grain yield of winter wheat crops, especially in regions like the middle and lower reaches of the Yangtze River China. Increasing duration of waterlogging decreases leaf physiology and grain development, leading to oxidative damage and reduced final grain yield. Management strategies such as planting time, fertilization, and genotype selection are crucial for areas prone to waterlogging issues.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Yonghui Fan, Zhaoyan Lv, Yuxing Li, Boya Qin, Qingyu Song, Liangliang Ma, Qianqian Wu, Wenjing Zhang, Shangyu Ma, Chuanxi Ma, Zhenglai Huang
Summary: This study found that exogenous salicylic acid (SA) treatment at different stages can improve heat tolerance in wheat during grain filling, resulting in reduced yield loss and improved photosynthetic performance. SA treatment alters dry matter distribution and enhances physiological parameters, leading to an alleviation of heat stress inhibition and ultimately higher productivity.
Article
Plant Sciences
Yonghui Fan, Zhaoyan Lv, Boya Qin, Jinhao Yang, Kaiming Ren, Qiuxia Liu, Fengyi Jiang, Wenjing Zhang, Shangyu Ma, Chuanxi Ma, Zhenglai Huang
Summary: Night warming at different growth stages can improve the photosynthetic efficiency and dry matter accumulation of winter wheat, thereby increasing the yield.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Optics
Dan Li, Jing Li, Wei Huang, Yonghui Fan, Chen Tan, Chuanhao Yu, Shiti Huang, Jia Li, Wanqing Zhao, Yifei Xia, Bing Zhang, Xiaoyan Gui, Li Geng
Summary: We propose and demonstrate an integrated approach for making low-cost, high-speed half-duplex optical transceivers with rapid reconfigurability. By using a single Distributed-Feedback (DFB) diode as the unified E/O-O/E device, which can function as a laser or a photodetector depending on the transmitter or receiver mode. The bias for the DFB and the T/R signal path are provided by a custom-designed reconfigurable CMOS chip, enabling high-speed signal transmission and rapid reconfiguration.
Article
Plant Sciences
Wenjing Zhang, Anmin Zhang, Qirui Zhou, Ranran Fang, Yan Zhao, Zihong Li, Jiawen Zhao, Mengting Zhao, Shangyu Ma, Yonghui Fan, Zhenglai Huang
Summary: With the increase in frequency of low-temperature stress (LTS) due to global climate change, wheat yield decline has been greatly affected. The effects of LTS at booting stage on grain starch synthesis and yield were investigated in two wheat varieties with different low-temperature sensitivities. LTS caused a significant reduction in photosynthetic characteristics, starch synthesis enzymes activity, and starch content, resulting in decreased grain number and weight.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Construction & Building Technology
Zengwu Liu, Yuexing Wu, Chengwei Wang, Yonghui Fan, Chao Luo, Shaorui Wang
Summary: This study investigates the reasonable range of inclination angles for arch ribs in a CFST arch bridge with a span of 360m. It is found that an inclination angle ranging from 8° to 10° increases the natural frequencies of the bridge, improving lateral and torsional stiffness while ensuring optimal stability.
Article
Agronomy
Yonghui Fan, Liangliang Ma, Jinhao Yang, Wenjin Ding, Wei He, Yu Tang, Guoji Cui, Wenjing Zhang, Shangyu Ma, Chuanxi Ma, Zhenglai Huang
Summary: This study aimed to evaluate the effects of night warming during different growth stages on wheat grain yield, dry matter accumulation and distribution, photosynthetic characteristics, and enzymes related to sucrose metabolism. The results showed that early vegetative night warming improved the photosynthetic capacity of the flag leaves during the grain-filling stage, promoted post-anthesis accumulation of dry matter, and enhanced the transfer of dry matter to the grains, ultimately benefiting the yield.
EUROPEAN JOURNAL OF AGRONOMY
(2023)
Article
Chemistry, Analytical
Yonghui Fan, Chao Luo, Yin Zhou, Ligui Yang, Xinglin Li, Jinlong Liao
Summary: A 1:10 scale model experiment was conducted to study the stress evolution on the ring and segment interfaces during the construction of the concrete encapsulation of the main arch ring in a rigid-frame arch bridge. The experiment showed significant stress disparities in the concrete cross-section after the closure of the encapsulation, with different stress levels in different parts of the cross-section. The non-uniformity of stress distribution in the concrete sheath can lead to reductions in the ultimate bearing capacity of the arch ring.
Article
Construction & Building Technology
Yonghui Fan, Jianting Zhou, Chao Luo, Jun Yang, Jingzhou Xin, Shaorui Wang
Summary: A self-balancing pulley-group loading system was designed based on a 1:10 scale model test of the world's largest spanning arch bridge. An optimization algorithm for loading points at different construction stages was proposed. The results showed that the loading scheme can provide reference for the design of loading systems with the same type of scale model test.
Article
Optics
Dan Li, Jing Li, Wei Huang, Yonghui Fan, Chen Tan, Chuanhao Yu, Shiti Huang, Jia Li, Wanqing Zhao, Yifei Xia, Bing Zhang, Xiaoyan Gui, Li Geng
Summary: We present and demonstrate an integrated approach to make low-cost high-speed half-duplex optical transceiver with rapid reconfigurability. This approach utilizes a single DFB diode as the unified E/O-O/E device and includes a custom-designed reconfigurable CMOS chip that provides the biasing and signal path for the DFB diode. The transceiver front-end operates up to 5 Gb/s and has a reconfiguration time of less than 131 ns, making it suitable for the future fiber-to-everything paradigm shift.
Proceedings Paper
Computer Science, Artificial Intelligence
Yonghui Fan, Yalin Wang
Summary: This paper proposes a hierarchical Bayesian learning model for feature aggregation on 3D manifold-valued vision data. By introducing a kernel with geometry-awareness and intra-kernel convolution properties, and combining Gaussian process regression and hierarchical Bayesian network, geometric features from irregular inputs are effectively aggregated. Experimental results demonstrate the superiority of this method on manifolds and investigate the potential of combining neural networks with Bayesian networks.
2022 IEEE WINTER CONFERENCE ON APPLICATIONS OF COMPUTER VISION (WACV 2022)
(2022)