Review
Nutrition & Dietetics
Paul J. Nestel, Trevor A. Mori
Summary: This narrative review focuses on the role of diet in reducing LDLc concentrations in polygenic hypercholesterolemia. Statins and ezetimibe are effective drugs that can lower LDLc by more than 20%, providing potential alternatives to strict dieting. PCSK9 plays a significant role in LDL and lipid metabolism, and inhibitory monoclonal antibodies have shown promising results in lowering LDLc. A nutritional approach, such as substituting saturated fats with polyunsaturated fats, along with incorporating specific foods and supplements, has the potential to further reduce LDLc. Industry support and proper guidance from health professionals are necessary for the development and promotion of LDLc-lowering products.
Article
Biochemistry & Molecular Biology
Wenjing Liu, Bing Liang, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Xiaokun Hu, Xufu Wang, Na Han, Chenghui Lu, Jiao Li, Congcong Wang, Huanting Li, Renshuai Zhang, Dongming Xing
Summary: Parthenolide (PTL), a naturally occurring small molecule from Tanacetum parthenium, has shown potential in lowering cholesterol levels by inhibiting cellular uptake of cholesterol. Its interaction with NPC1L1 supports its potential as a therapeutic inhibitor for hypercholesterolemia.
Article
Pharmacology & Pharmacy
Shamuha Bahetibieke, Sakib M. Moinuddin, Asiya Baiyisaiti, Xiaoang Liu, Jie Zhang, Guomin Liu, Qin Shi, Ankang Peng, Jun Tao, Chang Di, Ting Cai, Rong Qi
Summary: Hypercholesterolemia is an independent risk factor for cardiovascular diseases. This study successfully improved the dissolution, oral bioavailability, storage stability, and cholesterol-lowering effects of cholesterol-lowering drugs by preparing a co-amorphous system. The SIM-EZE co-amorphous solids showed improved physical stability and faster dissolution release profiles compared to their physical mixture.
Article
Immunology
Solenne Vigne, Donovan Duc, Benjamin Peter, Jessica Rebeaud, Yannick Yersin, Florian Ruiz, Valentine Bressoud, Tinh-Hai Collet, Caroline Pot
Summary: This study investigated the effect of circulating cholesterol levels on multiple sclerosis (MS) using a mouse model. The results showed that blood cholesterol level does not have a direct role in neuro-inflammatory diseases, and the protective effects of statins in MS are not related to circulating cholesterol.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Homa Nath Sharma, Jonathan Catrett, Ogechi Destiny Nwokeocha, Melissa Boersma, Michael E. Miller, Audrey Napier, Boakai K. Robertson, Daniel A. Abugri
Summary: Toxoplasma gondii (T. gondii) infection is increasing globally with significant socioeconomic and public health challenges. Current treatments for T. gondii infection are limited in effectiveness, safety, and cost. This study aimed to evaluate the effects of a higher fungi extract on T. gondii growth and its mechanism of action. The extract was found to inhibit T. gondii growth and induce oxidative stress and mitochondrial membrane disruption. The findings suggest that the extract holds promise as a potential source of new compounds for anti-Toxoplasma gondii drugs.
SCIENTIFIC REPORTS
(2023)
Review
Peripheral Vascular Disease
Waleed Z. Butt, Jennifer K. Yee
Summary: Non-statin medications for lowering cholesterol are available as adjunctive therapy for children and adolescents, particularly for those with HeFH and HoFH, to help achieve lower LDL-C levels.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Mincheol Kim, Minjee Lee, Min-Goo Kim, Hayoung Kim, Boyoung Choi, Seongsik Kim, Won-Yeong Bang, Yong-Jin Kim, Jungwoo Yang, Hyun-Jae Kang
Summary: This randomized, double-blind, placebo-controlled trial aimed to assess the efficacy of Bifidobacterium breve IDCC 4401 (BBR 4401) in lowering cholesterol levels. The results showed that BBR 4401 significantly reduced LDL-C and apolipoproteinB levels compared to the placebo group, with no significant adverse events.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Qian Xu, Yiming Deng, Jun Xiao, Xiangrui Liu, Min Zhou, Zhong Ren, Juan Peng, Yaling Tang, Zhisheng Jiang, Zhihan Tang, Lushan Liu
Summary: Coronary heart disease (CHD) is closely related to hypercholesterolemia, with lowering serum cholesterol being the most important strategy in reducing CHD. The serum cholesterol level in humans is mainly determined by three metabolic pathways - dietary cholesterol intake, cholesterol synthesis, and cholesterol degradation in vivo. Targeting key molecules in these pathways through intervention is essential in lowering serum lipids.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Food Science & Technology
Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Sunita Nilkhet, Nuntanat Moungkote, Tewarit Sarachana, Alison T. Ung, Seung Joon Baek, Tewin Tencomnao
Summary: The study revealed that Auricularia polytricha extracts have anti-inflammatory and antioxidative effects against BPA-induced neuroinflammation, regulating the occurrence of neuroinflammation through the NF-kappa B signaling pathway.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Adrianna Dec, Aleksandra Niemiec, Eliza Wojciechowska, Mateusz Maliglowka, Lukasz Buldak, Aleksandra Boldys, Boguslaw Okopien
Summary: Hypercholesterolemia is an undertreated and underdiagnosed disease that plays a crucial role in atherosclerosis development. In recent years, novel lipid-lowering therapies such as inclisiran, a small interfering RNA (siRNA), have been introduced to address this issue. Inclisiran increases the number of LDL receptors on hepatic cells, potentially lowering plasma LDL cholesterol level and showing promising efficacy for future hypolipemic therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Bilal Azmi, Fearoz Khan, Uzma Asif, Beenish Khurshid, Abdul Wadood, Shamim Akhtar Qureshi, Syed Danish Haseen Ahmed, Hina Akram Mudassir, Sadia Ikhlaque Sheikh, Nazia Feroz
Summary: In this study, the inhibitory activity of Withania coagulans compounds against Hmgcr of Mus musculus was investigated using computer simulations. The results showed that Withania coagulans compounds have promising binding affinity and potential inhibitory effects against Hmgcr. Further in vitro and in vivo studies are needed to validate their cholesterol-lowering activity.
Review
Biotechnology & Applied Microbiology
Changtian Li, Shuai Xu
Summary: China is one of the largest producers and exporters of wild edible fungi, with mushroom cultivation having a significant impact on poverty alleviation and higher earnings compared to rice and corn. The products are mainly exported to countries like Japan, and there is a rapid market development and increased demand. Researchers focus on logical farm design to reduce agricultural investment costs and promote mushroom consumption through smart production and intelligent factories.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Ok-Kyung Kim, Jeong Moon Yun, Dakyung Kim, Soo-Jeung Park, Chungil Lee, Eun Byeol Go, Jae Sil Kim, Sang Yong Park, Jeongmin Lee
Summary: This study found that krill oil supplementation can reduce cholesterol levels in hypercholesterolemic rats induced by high-cholesterol diet through multiple mechanisms, and it can prevent atherosclerosis.
Review
Food Science & Technology
Panthakarn Rangsinth, Rajasekharan Sharika, Nattaporn Pattarachotanant, Chatrawee Duangjan, Chamaiphron Wongwan, Chanin Sillapachaiyaporn, Sunita Nilkhet, Nichaporn Wongsirojkul, Anchalee Prasansuklab, Tewin Tencomnao, George Pak-Heng Leung, Siriporn Chuchawankul
Summary: Ergosterol, a sterol found in edible mushrooms, is not only a precursor to vitamin D2 but also exhibits various pharmacological effects, such as antimicrobial, antioxidant, anticancer, antidiabetic, and anti-neurodegenerative activities. This review provides an overview of the pharmacological effects of ergosterol, its underlying mechanisms, and potential applications.
Article
Microbiology
Quan Dai, Fa-Lei Zhang, Zheng-Hui Li, Juan He, Tao Feng
Summary: This study identified 23 sesquiterpenoids in the edible mushroom Craterellus ordoratus, including 18 new bergamotane sesquiterpenes and one new victoxinine derivative. Some of the compounds showed inhibitory activity against cell proliferation, particularly against B lymphocyte cells.
Article
Nutrition & Dietetics
Lu Huang, Yuqing Ren, He Li, Qibo Zhang, Yong Wang, Jinnuo Cao, Xinqi Liu
Summary: In this study, protein/polysaccharide composite emulsion gel was prepared using soybean protein isolate (SPI), coconut oil, and konjac flour. The addition of 1% SPI in the fat substitute resulted in higher overall acceptability. Increasing protein and konjac content decreased the juiciness of the samples, while increasing konjac content reduced the brightness and increased the yellowness of the compound fat substitutes.
FRONTIERS IN NUTRITION
(2022)
Review
Chemistry, Applied
Lu Li, Yueyue He, Nini Jin, He Li, Xinqi Liu
Summary: This study evaluated the effects of protein supplementation and exercise on muscle strength, mass and physical performance in healthy older adults. The results showed that combining protein supplementation with exercise can increase lower-extremity strength in Asian countries, but has no significant effects on upper-extremity strength, muscle mass and physical performance.
Review
Chemistry, Applied
Xiangquan Zeng, He Li, Weibo Jiang, Qianqian Li, Yu Xi, Xiaomei Wang, Jian Li
Summary: Crabapples are small edible fruits with unique aroma and taste. They are rich in bioactive compounds and possess health-promoting properties such as antioxidant and anticancer activities. Various crabapple-based food products and additives have been developed. Crabapples have great potential in the development of new functional food and drinks.
Review
Food Science & Technology
Yuqing Ren, Lu Huang, Yinxiao Zhang, He Li, Di Zhao, Jinnuo Cao, Xinqi Liu
Summary: This paper discusses the use of emulsion gels as fat substitutes in meat products to maintain sensory quality. Among them, double emulsions are considered a promising method for encapsulating bioactive substances and developing low-fat or functional healthy meat products.
Article
Chemistry, Applied
Yinxiao Zhang, Chi Zhang, Shuya Zhu, Jingyi Wang, He Li, Xinqi Liu
Summary: This study identified and analyzed digested soybean peptides (dPEP) utilized by L. rhamnosus Lra05 after 36 hours. The findings showed that L. rhamnosus Lra05 preferentially utilizes hydrophobic peptides with three to five amino acid residues and hydrophilic peptides with more than five residues. Moreover, they tend to use peptides with proline at penultimate C-terminal position or arginine at ultimate C-terminal position. Fraction 1 (F1) and fraction 7 (F7) obtained from dPEP exhibited the strongest growth and metabolism promoting effects, and their characteristics were similar to dPEP. These results provide a theoretical basis for the application of soybean peptides as potential prebiotics.
Article
Chemistry, Applied
Xuejie Li, Xiangquan Zeng, Huanlu Song, Yu Xi, Yan Li, Bowen Hui, He Li, Jian Li
Summary: GC x GC-O-TOF-MS and GC-IMS have been increasingly used in complex food flavor analysis, but few studies have applied these techniques to identify the aroma components of tomato pastes. This study comprehensively characterized the aroma profiles of cold and hot break tomato pastes using SAFE-GC-O-MS, SAFE-GC x GC-O-TOF-MS, and HS-GC-IMS for the first time. A total of 274 volatile compounds were identified, which is far more than previously reported.
Article
Chemistry, Applied
Haochun Zhou, Bushra Safdar, He Li, Lingyu Yang, Zhiwei Ying, Xinqi Liu
Summary: This study extracted peptides from quinoa protein that can reduce blood glucose levels by inhibiting the activity of alpha-amylase. Among these peptides, MMFPH exhibited the highest inhibitory capability. Molecular docking experiments revealed that MMFPH bound to the active site of alpha-amylase, inhibiting its activity. These findings suggest that the small peptides produced during quinoa protein digestion can quickly bind to alpha-amylase, thus reducing blood glucose levels.
Article
Chemistry, Applied
Zhiwei Ying, Tianyu Zhang, He Li, Xinqi Liu
Summary: A magnetic soybean dreg-based biochar was prepared and used to effectively remove aflatoxin B1 from contaminated oil. The adsorbent demonstrated paramagnetic properties and could be easily separated from the oil using an external magnet. The removal process had minimal impact on the oil quality, and the adsorption behavior followed a pseudo-second-order kinetic and Freundlich model. This study provides a simple and efficient method for removing contaminants from oil.
Review
Chemistry, Applied
Xiangquan Zeng, Weibo Jiang, He Li, Qianqian Li, Jozef L. Kokini, Zhenjiao Du, Yu Xi, Jian Li
Summary: Nowadays, food hydrogels are widely used in food processing to deliver functional components. Mesona chinensis Benth polysaccharides (MCBP), the main compounds of Mesona chinensis Benth, have been developed as stabilizers, coagulants, and binders in the food industry. However, MCBP needs to interact with other biomacromolecules to form hydrogels due to the insufficient viscosity of single MCBP solution. Researchers have prepared novel composite hydrogels by interacting MCBP with different polysaccharides. The addition of these polysaccharides significantly affects the properties of MCBP, such as pasting, gelling, textural, rheological, thermal, retrogradation, color, optical, and in vitro digestible properties. The physicochemical properties of composite hydrogels are greatly influenced by treatments like heat, urea, alkali, and salt ions, which affect the interactions between two polysaccharides. Overall, MCBP shows great potential for the development of novel functional hydrogels in the future.
FOOD HYDROCOLLOIDS
(2023)
Review
Food Science & Technology
Lingyu Yang, Tianyu Zhang, He Li, Tianpeng Chen, Xinqi Liu
Summary: The development of plant-based meat analogs is hindered by the beany flavor from raw soybean protein and extrusion processing. Understanding its formation and control is crucial for obtaining ideal flavor and maximizing food quality. This study examines the formation and influence of beany flavor during extrusion, discusses control methods, and proposes future research directions.
Review
Food Science & Technology
Tianyu Zhang, Wenhui Li, He Li, Xinqi Liu
Summary: Soybean, as a staple crop, has broad prospects in the food industry and other fields due to its high-quality protein content. This review discusses common soybean protein products, their safety, biological activity, and processing characteristics. It also introduces soybean peptides and compares traditional and novel techniques for processing soybean protein isolate and peptides. The analysis and innovative concepts proposed in this work aim to promote the healthy development of the soybean protein industry chain.
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xinwei Chen, Wanlu Liu, Jian Zhang, He Li, Xinqi Liu
Summary: This study purified selenium-enriched soybean peptides (SePPs) and identified 19 selenium-enriched peptides, among which Sep-1 and Sep-2 showed preventive effects on heat stress-induced damage to intestinal epithelial cells. Sep-1 and Sep-2 reduced intracellular reactive oxygen species generation, prevented tight junction protein disruption, and decreased paracellular permeability. The molecular docking and dynamics simulations revealed the binding and stability of Sep-1 and Sep-2 with key signaling proteins.
Article
Biochemistry & Molecular Biology
Wenhui Li, Xiaohang Fu, Tianyu Zhang, He Li, Tianpeng Chen, Xinqi Liu
Summary: In this study, the researchers compared the alpha-glucosidase inhibitory activity of extruded soybean protein (ESPro) with different extrusion parameters. They found that ESPro1 (160 degrees C, 30 rpm) had the highest inhibitory activity. Further experiments showed that ESPro1 had a superior hypoglycemic effect in vitro and in vivo, and may have a beneficial impact on the treatment of type 2 diabetes mellitus (T2DM). In addition, ESPro1 also improved lipid profiles and alleviated liver and pancreatic injury in T2DM mice.
Article
Polymer Science
Yihao Zhang, Ruijia Liu, He Li, You Li, Xinqi Liu
Summary: This study investigated the interaction between 0.1 wt% soybean trypsin inhibitor (STI) and different concentrations of chitosan (CS) in aqueous solutions under different pH conditions. The formation of soluble/insoluble complexes between STI and CS was observed through hydrophobic or electrostatic interactions. The study also discussed the protective effect of the complexes on STI stability in simulated gastric juice. The results provide theoretical references for the development of supramolecular-structured carrier substances based on CS and STI.
Review
Biochemistry & Molecular Biology
Lu Li, Nini Jin, Kexin Ji, Yueyue He, He Li, Xinqi Liu
Summary: This systematic review and meta-analysis evaluated the effects of chronic orange juice consumption on cardiovascular disease risk factors in overweight and obese adults. The results showed that long-term orange juice consumption has a beneficial effect on blood pressure and HDL-C levels, but does not significantly affect other lipid, glycemic, and inflammatory markers.
