Article
Chemistry, Multidisciplinary
Bac Thanh Le, Chau Que Nguyen, Phuong Thi Nguyen, Ha Duc Ninh, Tri Minh Le, Phuong Thi Hoai Nguyen, Duong Duc La
Summary: In this study, a porous FeBDC-PEG material was successfully constructed and tested for its drug delivery properties. The FeBDC-PEG showed a high loading capacity and efficient release of 5-fluorouracil. Additionally, the study demonstrated the safety and stability of FeBDC-PEG in mice.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Cell Biology
Mengping Liu, Lin Wang, Young Lo, Simon Chi-Chin Shiu, Andrew B. Kinghorn, Julian A. Tanner
Summary: The interdisciplinary field of nanomaterials and aptamer science has significant potential for biomedical applications in drug delivery, imaging, and therapy. However, there are challenges to be addressed for their future development.
Review
Biotechnology & Applied Microbiology
Xiujuan Yin, Zhenqiang He, Weiying Ge, Zhenhua Zhao
Summary: Cancer is a major cause of human death worldwide. Traditional cancer treatments have limitations, such as recurrence, poor efficacy, and side effects. Targeted therapy using aptamer-functionalized nanomaterials (AFNs) has become a hot topic, due to the high stability, affinity, and selectivity of aptamers. AFNs have shown promising applications in targeted therapy for various types of tumors.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Chun-Nan Zhu, Zhi-Jia Wang, Xiang-Peng Li, Si-Yi Chen, Dong-Yun Zheng, Chao Liu, Xiao-Jun Liu, Dong-Bing Cheng, Zeng-Ying Qiao
Summary: In this study, a mitochondria-targeting peptide nanotherapeutic was developed to selectively target MDR tumor cells and inhibit their growth. The nanotherapeutic showed great potential for targeted chemotherapy in drug-resistant cancers.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tianyi Wang, Huali Lei, Xiang Li, Nailin Yang, Cheng Ma, Guangqiang Li, Xiang Gao, Jun Ge, Zhuang Liu, Liang Cheng, Gang Chen
Summary: Intracerebral hemorrhage (ICH) is a significant cause of morbidity and mortality worldwide, and surgery remains the most effective way to remove ICH. However, surgery brings potential risks such as brain tissue damage, post-operative infection, and difficulty in removing deep hematoma, which are the main problems in the surgical treatment of ICH.
Review
Biotechnology & Applied Microbiology
Ashish Ranjan Sharma, Yeon-Hee Lee, Altanzul Bat-Ulzii, Manojit Bhattacharya, Chiranjib Chakraborty, Sang-Soo Lee
Summary: Recent efforts in designing nanomaterials for targeted drug delivery, especially for nucleic acids, have revolutionized the next-generation therapy by overcoming traditional pharmaceutical challenges.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xu Zuo, Xiaoping Guo, Yinuo Gu, Haoyu Zheng, Zhengjie Zhou, Xinlei Wang, Shengyu Jiang, Guoqiang Wang, Caina Xu, Fang Wang
Summary: Asthma is a chronic airway inflammatory disease with complex mechanisms. Clinical treatments for asthma are currently based on glucocorticoid-based combination drug therapy, but more effective treatments are needed due to glucocorticoid resistance and multiple side effects. Nanotechnology provides promising solutions for drug delivery, improving targeting and bioavailability. This review discusses the mechanisms and current therapeutic methods of asthma, as well as the design and synthesis of various nanomaterials for asthma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Rashmi Trivedi, Tarun Kumar Upadhyay, Mohd Hasan Mujahid, Fahad Khan, Pratibha Pandey, Amit Baran Sharangi, Khursheed Muzammil, Nazim Nasir, Atiq Hassan, Nadiyah M. Alabdallah, Sadaf Anwar, Samra Siddiqui, Mohd Saeed
Summary: Nanotechnology involves multiple disciplines such as engineering, physics, chemistry, and biology. The utilization of metallic nanoparticles in bio-engineering and bio-medicine has attracted attention. Medical nanotechnology research has significant health benefits for humans. However, there are still unresolved issues in the development of nanomaterials to ensure their safety for living organisms. Nanoparticles have unique value in biology and materials science, with various applications, especially in the development of new materials.
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Materials Science, Multidisciplinary
Abdullah Abdelkawi, Aliyah Slim, Zaineb Zinoune, Yashwant Pathak
Summary: This review focuses on the surface modification of metallic nanoparticles for targeted drug delivery. Various strategies, such as polymer coating, functionalization with specific groups, and bioconjugation with targeting ligands, have been explored to enhance their therapeutic potential. The challenges in clinical translation include scalable fabrication and functionalization of nanoparticles, toxicity concerns, and regulatory hurdles. However, continuous advancements in nanoparticle synthesis and surface modification techniques offer a positive outlook for the future.
Article
Chemistry, Multidisciplinary
Pradip Das, Silvia Pujals, Lamiaa M. A. Ali, Magali Gary-Bobo, Lorenzo Albertazzi, Jean-Olivier Durand
Summary: In this study, the degradation of biodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) triggered by glutathione and the multivalency of antibody-conjugated nanoPMOs were quantified using direct stochastic optical reconstruction microscopy (dSTORM). The impact of these properties on cancer cell targeting, drug loading and release capability, and anticancer activity were also investigated. The higher spatial resolution of dSTORM imaging enabled the characterization of structural properties of fluorescent and biodegradable nanoPMOs. The quantification of nanoPMOs' biodegradation using dSTORM imaging demonstrated their excellent structure-dependent degradation behavior at a higher glutathione concentration. The surface functionality of anti-M6PR antibody-conjugated nanoPMOs, as quantified by dSTORM imaging, played a key role in prostate cancer cell labeling and the higher biodegradability and cancer cell-targeting properties of nanorods conjugated with oriented antibody effectively delivered the anticancer drug doxorubicin to cancer cells, exhibiting potent anticancer effects.
Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Quan-Bing Chen, Mei-Hua Shen, Xiao-He Ren, Shuai Zhu, Jin-Ting Shang, Wei Liu, Zhao-Wei Zhang, Zhi-Jun Dong, Hua-Zhi Gu, Xian-Zheng Zhang, Qiong Yuan, Tao Zou
Summary: This study utilizes tumor-triggered targeting ammonium bicarbonate liposomes for fluorescence and photothermal imaging-guided chemo/photothermal/photodynamic multimodal therapy, which effectively treats tumors without significant side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Michael J. Siedlik, Zijian Yang, Parnika S. Kadam, James Eberwine, David Issadore
Summary: Cells are complex machines with behaviors derived from the interaction of organelles, complexes, and chemicals. The technological challenge of measuring the large number of small-sized organelles within each cell has limited understanding. The development of micro- and nano-technologies presents opportunities to study subcellular biology on the scale of organelles.
Article
Multidisciplinary Sciences
Yulong Wei, Lesan Yan, Lijun Luo, Tao Gui, Biang Jang, Ahmad Amirshaghaghi, Tianyan You, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: The study found that the enzyme sPLA(2) increases in OA cartilage tissues, and inhibiting its activity could be an effective treatment strategy. By incorporating an sPLA(2) inhibitor into micelles, it improved drug delivery within the joints and showed promising potential as a therapeutic agent for OA.
Article
Biochemical Research Methods
Wendy Yu, Kevin P. Gillespie, Bonirath Chhay, Anne-Sophie Svensson, Per-Ake Nygren, Ian A. Blair, Feifan Yu, Andrew Tsourkas
Summary: ADCs have great therapeutic potential, but the heterogeneous nature of conventional drug conjugation strategies can impact their safety, efficacy, and stability. Site-specific conjugation methods can address these issues without the need for genetic modification or glycan modification.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemical Research Methods
Linghan Mei, Fabiana Zappala, Andrew Tsourkas
Summary: Bispecific antibodies are capable of binding two antigens simultaneously, leading to unique biological effects. Two methods are introduced for rapid assembly of Bispecific antibodies from any two off-the-shelf IgG antibodies, allowing for low-cost, high-throughput production and validation.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Engineering, Biomedical
Tao Gui, Lijun Luo, Bonirath Chhay, Leilei Zhong, Yulong Wei, Lutian Yao, Wei Yu, Jun Li, Charles L. Nelson, Andrew Tsourkas, Ling Qin, Zhiliang Cheng
Summary: Oxidative stress and reactive oxygen species play important roles in the development and progression of osteoarthritis (OA). This study utilized SOD-loaded nanoparticles to deliver antioxidant enzymes to mouse knee joints, demonstrating the accumulation of nanoparticles in the synovium and reduction of oxidative damage. Intra-articular injections of the nanoparticles were effective in attenuating OA initiation and progression, via reduction of reactive oxygen species production and catabolic protease synthesis.
Article
Medicine, Research & Experimental
Alexander Chan, Hejia Henry Wang, Rebecca M. Haley, Cindy Song, David Gonzalez-Martinez, Lukasz Bugaj, Michael J. Mitchell, Andrew Tsourkas
Summary: This study demonstrates the feasibility of using small protein scaffolds with anionic polypeptides to interact with positively charged nonviral lipid-based delivery systems, enabling efficient intracellular delivery. This method can be used to inhibit intracellular proteins that are currently not amenable to small molecule drugs and biologics.
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Fabiana Zappala, Elizabeth Higbee-Dempsey, Bian Jang, Joann Miller, Lesan Yan, Nicholas G. Minutolo, Gabriela T. Rosado Gonzalez, Andrew Tsourkas, Burcin Altun Ozdemir
Summary: Researchers have developed a simple method to attach a T cell-redirecting domain to off-the-shelf human immunoglobulin G (IgG) or native IgG, allowing the generation of T cell-redirecting autoantibodies (TRAAbs) without the need for antibody engineering, cloning, or knowledge of the antibody sequence. These TRAAbs preferentially bind tumor tissue over healthy tissue, indicating a previously unexplored therapeutic window. This approach represents a new paradigm in personalized medicine.
Article
Chemistry, Multidisciplinary
Min Jun Oh, Alaa Babeer, Yuan Liu, Zhi Ren, Jingyu Wu, David A. Issadore, Kathleen J. Stebe, Daeyeon Lee, Edward Steager, Hyun Koo
Summary: Scientists have developed a magnetic field-directed self-assembling robotic superstructure called STARS, which can adapt to irregular surface topography and be used for precise removal of biofilms and diagnostic sampling. These superstructures have multiaxis motion and adjustable shape, length, and stiffness, allowing them to scrub adherent biofilms, produce antibacterial reagents, and capture pathogens and matrix components for diagnostic analysis.
Article
Endocrinology & Metabolism
Tao Gui, Yulong Wei, Lijun Luo, Jun Li, Leilei Zhong, Lutian Yao, Frank Beier, Charles L. Nelson, Andrew Tsourkas, X. Sherry Liu, Motomi Enomoto-Iwamoto, Feifan Yu, Zhiliang Cheng, Ling Qin
Summary: This study demonstrates the importance of EGFR signaling in maintaining articular cartilage during PTOA development and explores the development of novel nanomedicines for PTOA treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Andrew A. A. Lin, Zhimin Jiang, Stephanie S. S. Yee, Erica L. L. Carpenter, James H. H. Pikul, David Issadore
Summary: Extracellular vesicles (EVs) are nanoscale membranous particles that have potential as biomarkers. Researchers have developed a novel approach to isolate sparse EVs from clinical samples by incorporating billions of nanomagnetic sorters that act in parallel at high flow rates. This method increases the yield and purity of EVs and has the potential to enable rapid, sensitive, and specific isolation of EV subpopulations from clinical samples.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Jingyu Wu, David A. Issadore, Daeyeon Lee
Summary: Controlling surface wetting properties of microfluidic channels is essential for reliable performance. Current patterning methods have limited spatial resolution, making them impractical. In this study, a replica mold fabrication technique inspired by soft lithography was developed to transfer channel geometry and surface wettability from a silicon wafer mold to a co-polymer network replica. This technique was successfully demonstrated in the fabrication of a PFPE-PEG-based microfluidic chip with patterned microchannels for double emulsion generation.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Rebecca M. Haley, Alexander Chan, Margaret M. Billingsley, Ningqiang Gong, Marshall S. Padilla, Emily H. Kim, Hejia Wang, Dingzi Yin, Kirk J. Wangensteen, Andrew Tsourkas, Michael J. Mitchell
Summary: This study demonstrates the successful delivery of DARPin protein K27-D30 to the cytosol of liver cancer cells using a lipid nanoparticle platform, inhibiting RAS-driven tumor growth and highlighting the potential of K27 as a new cancer therapeutic.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Ahmad Amirshaghaghi, Wen-Chi Chang, Bonirath Chhay, Ariane R. Bartolomeu, Margie L. Clapper, Zhiliang Cheng, Andrew Tsourkas
Summary: The current standard of care for colon cancer surveillance, white light endoscopy, often misses dysplastic lesions that are not visible to the naked eye. Dye-based chromoendoscopy shows promise but lacks accuracy in differentiating tumor tissues from healthy tissues. This study aimed to improve tumor tissue visualization using various phthalocyanine (PC) dye-loaded micelles administered intravenously. Zinc PC (tetra-tert-butyl)-loaded micelles were identified as the optimal formulation, turning tumors dark blue for easy identification. These micelles were also effective in turning colorectal adenomas in mice a dark blue color, aiding in their detection and removal.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemical Research Methods
Vasant Iyer, David A. Issadore, Firooz Aflatouni
Summary: Since its inception, microfluidic pioneers have made significant progress in realizing complete lab-on-chip systems for sophisticated sample analysis and processing. By integrating microelectronics, particularly with the use of integrated circuits (ICs), microfluidic-IC hybrid chips have gone beyond miniaturization to enable high-performance applications. This review highlights recent examples of labs-on-chip that utilize high-resolution, high-speed, and multifunctional electronic and photonic chips to enhance conventional sample analysis capabilities. It also discusses advancements in IC technology, including on-chip data processing and integrated photonics, that can further advance microfluidic-IC hybrid chips.
Review
Biochemical Research Methods
Vasant Iyer, Zijian Yang, Jina Ko, Ralph Weissleder, David Issadore
Summary: Microfluidic diagnostic (mu DX) technologies miniaturize sensors and actuators to interact with cells and detect biomarkers at the micro and nanometer scales. This field has made steady progress over the years, with recent advancements in machine learning, micro/nano devices, and sample processing. However, there are challenges in commercializing these technologies and navigating regulatory requirements.
