Article
Veterinary Sciences
Selena Tinga, Natalie Hughes, Stephen C. Jones, Brian Park, Lindsey Palm, Sasank S. Desaraju, Scott A. Banks, Sandra L. MacArthur, Daniel D. Lewis
Summary: The purpose of this study was to evaluate the three-dimensional limb motion in dogs with CCL-I treated with CBLO, and to assess the treatment effect through force plate gait analysis. The results showed that CBLO reduced craniocaudal motion and substantially improved lameness.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Karol Sevcik, Viera Karaffova, Marian Hluchy, Marieta Sevcikova, Zuzana Sevcikova, Valent Ledecky
Summary: This study evaluated the possible relationship between inflammatory markers in the synovial fluid and peripheral blood of dogs with cranial cruciate ligament rupture, and found a possible association with both local and systemic inflammation processes during osteoarthritis progression.
Article
Veterinary Sciences
Thomas Giansetto, Pierre P. Picavet, Michael Lefebvre, Marc Balligand
Summary: The study found significant differences in the knee angle during mid-stance phase among different dog breeds, highlighting the importance of measuring the required tibial tuberosity advancement to reduce the incidence of post-operative meniscal lesions.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Karolina Engdahl, Gudrun Seeberg Boge, Jessica Ingman, Veronica Naslund, Charles J. Ley
Summary: The degree of osteophyte formation seen on radiographs is associated with CCLD-related euthanasia in dogs, with increased osteophyte formation indicating a higher risk of euthanasia.
Article
Agriculture, Dairy & Animal Science
Brunella Restucci, Mariafrancesca Sgadari, Gerardo Fatone, Giovanni Della Valle, Federica Aragosa, Chiara' Caterino, Gianmarco Ferrara, Gert W. Niebauer
Summary: Spontaneous cranial cruciate ligament rupture is a common joint disease in dogs, but its cause is still unknown. This study found strong expression of relaxin and its receptors in intra-articular target tissues, suggesting their involvement in collagen degradation and ligament rupture. The findings have important implications for early treatment and modeling of human diseases.
Article
Veterinary Sciences
Karolina S. Engdahl, Gudrun S. Boge, Annika F. Bergstrom, Elena R. Moldal, Odd Hoglund
Summary: A study on 255 dogs treated surgically for CCLD found that while TPLO had the highest occurrence of severe postoperative complications, the hazard was lower than LFS after adjusting for body weight and age. This highlights the importance of considering potential effect-modifiers when comparing postoperative complications after CCLD surgery.
PREVENTIVE VETERINARY MEDICINE
(2021)
Review
Veterinary Sciences
GiuseppeY Spinella, Giulia Arcamone, Simona Valentini
Summary: Cranial cruciate ligament (CrCL) rupture is a common orthopaedic condition in veterinary medicine, impacting the stability and biomechanics of the femoral-tibio-patellar joint in dogs. Treatment options include conservative and surgical approaches, with decisions influenced by factors such as patient age, health, and cost. Physiotherapy is essential for restoring proper limb functionality and enabling a return to normal activities.
VETERINARY SCIENCES
(2021)
Article
Veterinary Sciences
Mitsuhiro Isaka, Wataru Konno, Daiki Kokubo, Hiromu Udagawa, Sho Hizuka, Toshikazu Sakai, Shushi Yamamoto, Shidow Torisu, Hiroshi Ueno
Summary: Cranial cruciate ligament (CCL) rupture is a common orthopedic disease in dogs, and it is usually treated with tibial plateau leveling osteotomy (TPLO) or extracapsular lateral suture (ECLS). This study aimed to investigate the changes in serum OSTN concentrations before and after stifle surgery in dogs and compare the concentrations between TPLO and ECLS. The results showed that serum OSTN concentrations decreased significantly after TPLO surgery, while no significant differences were observed in the ECLS group.
RESEARCH IN VETERINARY SCIENCE
(2023)
Review
Veterinary Sciences
Annika Christina Wemmers, Marios Charalambous, Oliver Harms, Holger Andreas Volk
Summary: Tibial Plateau Leveling Osteotomy (TPLO) and Tibial Tuberosity Advancement (TTA) are common surgical techniques for treating cranial cruciate ligament (CCL) rupture in dogs. However, the existing studies lack sufficient high-quality evidence to determine which technique is superior. Further research with high-level evidence is urgently needed.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Annika Christina Wemmers, Szymon Pawlak, Nikola Medl, Jan Bokemeyer, Rolf Wagels, Oliver Harms, Holger Andreas Volk
Summary: Rupture of the cranial cruciate ligament in dogs is a common condition, and surgical treatment options such as TPLO and TTA have shown good clinical outcomes. However, the high cost of these procedures poses a financial burden for patients' owners. This study compares prices and costs of TPLO and TTA, and questions whether the more expensive procedure provides greater profitability. Future research should consider economic factors and cost-effectiveness analysis in evaluating surgical treatment options.
Article
Veterinary Sciences
Alison A. Cain, Garrett J. Davis, Spencer Davis, Richard P. Bastian, Veronica Marquez, Hollyn Probasco, Emma Desantis
Summary: This study found that infrared thermography is not reliable for diagnosing canine CCL disease.
CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE
(2023)
Article
Veterinary Sciences
Dylan N. Clements, John M. Ryan, Ian G. Handel, Adam G. Gow, Susan Campbell, Emma Hurst, Richard J. Mellanby
Summary: The study found that the vitamin D status of dogs with a CCLR was not significantly different from healthy dogs, and pre-operative serum 25(OH)D concentrations were not correlated with either pre-surgical disease severity or post-operative clinical outcomes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Karolina Engdahl, Annika Bergstrom, Odd Hoglund, Elena R. Moldal, Ulf Emanuelson, Gudrun S. Boge
Summary: This study evaluated the long-term outcome of 71 dogs with cranial cruciate ligament disease (CCLD) treated with different methods. The results showed an increased risk of stiffness and lameness in dogs treated with TPLO or TTA compared to LFS. The limitations of the study include the lack of follow-up veterinary examination and the possibility of referral bias from only two university animal hospitals.
Review
Immunology
Kun Zhao, Jiaqi Ruan, Liuyan Nie, Xiangming Ye, Juebao Li
Summary: Osteoarthritis is a common degenerative disease in mammals, but its pathogenesis is still unclear. Studies suggest that it is not only an aging process but also an inflammation-related disease. Synovitis is closely associated with the progression of osteoarthritis, and synovial macrophages play a crucial role in synovitis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Gert W. Niebauer, Brunella Restucci
Summary: The spontaneous rupture of the cranial cruciate ligament in dogs is a common veterinary orthopedic problem. The causes of this disease are largely unknown, making prevention and treatment challenging. Recent research has revealed a systemic, metabolic multifactorial disease background behind the disease, and it also showed an association between this disease in dogs and humans. Therefore, unraveling the enigma of spontaneous cruciate ligament disease is of great importance for the treatment of degenerative joint disease in both dogs and humans.
Article
Veterinary Sciences
Constance G. Fazio, Peter Muir, Susan L. Schaefer, Kenneth R. Waller
VETERINARY RADIOLOGY & ULTRASOUND
(2018)
Article
Genetics & Heredity
Lauren A. Baker, Guilherme J. M. Rosa, Zhengling Hao, Alexander Piazza, Christopher Hoffman, Emily E. Binversie, Susannah J. Sample, Peter Muir
Article
Multidisciplinary Sciences
Jason A. Bleedorn, Troy A. Hornberger, Craig A. Goodman, Zhengling Hao, Susannah J. Sample, Ermias Amene, Mark D. Markel, Mary Behan, Peter Muir
Article
Veterinary Sciences
A. E. Ashour, C. L. Hoffman, P. Muir
AUSTRALIAN VETERINARY JOURNAL
(2019)
Article
Veterinary Sciences
M. A. Hayes, S. Jemilo, P. Muir, R. Sullivan, J. A. Bleedorn
AUSTRALIAN VETERINARY JOURNAL
(2020)
Article
Veterinary Sciences
Hannah M. Terhaar, Peter Muir, Lauren A. Baker, Emily E. Binversie, Jacqueline Chi, Susannah J. Sample
VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY
(2020)
Editorial Material
Veterinary Sciences
Victoria A. Colgate, Celia M. Marr
EQUINE VETERINARY JOURNAL
(2020)
Article
Genetics & Heredity
Lauren A. Baker, Mehdi Momen, Kore Chan, Nathan Bollig, Fernando Brito Lopes, Guilherme J. M. Rosa, Rory J. Todhunter, Emily E. Binversie, Susannah J. Sample, Peter Muir
G3-GENES GENOMES GENETICS
(2020)
Article
Multidisciplinary Sciences
Emily E. Binversie, Lauren A. Baker, Corinne D. Engelman, Zhengling Hao, John J. Moran, Alexander M. Piazza, Susannah J. Sample, Peter Muir
Article
Genetics & Heredity
Lauren A. Baker, Mehdi Momen, Rachel McNally, Mark E. Berres, Emily E. Binversie, Susannah J. Sample, Peter Muir
Summary: ACL rupture is a common condition that affects young people, with genetic and environmental risk factors. Leveraging a canine model, researchers identified novel genetic variants associated with ACL rupture and found unique selection signatures in cases compared to controls. The study's genetic associations mirror those found in human beings, laying the groundwork for potential disease-modifying therapies.
FRONTIERS IN GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Timothy L. L. Menghini, Georgia Shriwise, Peter Muir
Summary: This study found that implant failure is common in small animal orthopedics and is associated with abnormal fracture healing. Among the cases studied, 23% experienced implant failure, which was significantly associated with delayed union, malunion, or non-union.
Review
Veterinary Sciences
Lauren Baker, Peter Muir, Susannah J. Sample
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2019)
Article
Veterinary Sciences
Christopher L. Hoffman, Nicola J. Volstad, Eric C. Hans, Brett W. Nemke, Peter Muir
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2018)
Meeting Abstract
Clinical Neurology
Susannah Sample, Shahriar Salamat, Xiao-Jun Wu, Zhengling Hao, Lauren Baker, Emily Binversie, Peter Muir, John Svaren
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)