期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 595, 期 -, 页码 161-175出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2015.11.016
关键词
Singlet oxygen; Naphthalene endoperoxide; [O-18]-Labeled compounds; Lipids; Nucleic acids; Proteins
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/12663-1, 2011/10048-5]
- CNPq (Conselho Nacional para o Desenvolvimento Cientifico e Tecnologico) [301307/2013-0, 500591/2012-1, 470293/2008-0, 490440/2013-4]
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
- PRO-CAD/NF) [677/2010]
- PRONEX/FINEP (Programa de Apoio aos Nucleos de Excelencia) [331/97/1997]
- Institut do Milenio-Redoxoma [420011/2005-6]
- INCT Redoxoma (FAPESP/CNPq/CAPES) [573530/2008-4]
- PRPUSP (Pro-Reitoria de Pesquisa da Universidade de Sao Paulo NAP Redoxoma (PRPUSP) [2011.1.9352.1.8]
- CEPID Redoxoma (FAPESP) [2013/07937-8]
- John Simon Guggenheim Memorial Foundation (P.D.M. Fellowship)
Inspired by Helmut Sies we continue the development of suitable chemical generators of O-1(2) based on the thermodissociation of naphthalene endoperoxide derivatives. The present manuscript focuses on how the use of [O-18] -labeled endoperoxides and hydroperoxides can be applied to study mechanistic aspects related to the generation of singlet molecular oxygen and its reactions in biological systems. The peroxidation reactions of the main cellular targets including unsaturated lipids, proteins and nucleic acids have received major attention during the last three decades. Emphasis is placed in this manuscript on the description of the synthesis and the main use of [O-18]-labeled compounds, and especially of peroxides and O-1(2), for tracer elucidation of reaction mechanisms. (C) 2015 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据