Article
Obstetrics & Gynecology
Liye Fu, Hongxia Yuan, Hong Cao, Qichang Zhou, Xiaotan Tan, Jun Guo
Summary: This study investigated the correlation between ultrasound indicators in early pregnancy and the outcome of caesarean scar pregnancy (CSP) after pregnancy termination. Ultrasound indicators such as residual myometrium thickness, blood flow around the gestational sac, and types of CSP were found to have a low correlation with postoperative complications.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Surgery
Yi Wu, Bing Peng, Jianhua Liu, Xinmin Yin, Zhijian Tan, Rong Liu, Defei Hong, Wenxing Zhao, Heshui Wu, Rufu Chen, Dewei Li, Heguang Huang, Yi Miao, Yahui Liu, Tingbo Liang, Wei Wang, Jingxiong Yuan, Shizhen Li, Hang Zhang, Min Wang, Renyi Qin
Summary: This study aimed to assess the textbook outcome (TO) following laparoscopic pancreaticoduodenectomy (LPD), identify factors associated with achieving TO, and analyze hospital variations after case-mix adjustment. The study found that less than 70% of LPD patients achieved TO. Dilated pancreatic ducts, advanced age, and concomitant cardiovascular disease were independently associated with achieving TO. No significant hospital variations were observed after case-mix adjustment.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Sandra R. Alouche, Roni Molad, Marika Demers, Mindy F. Levin
Summary: The Comprehensive Coordination Scale (CCS) was developed to assess coordination in adults with neurological injuries. It includes six complementary tests focusing on coordination of different body segments, with experts identifying a gap related to hand/finger coordination assessment. The CCS measures spatial and temporal variables totaling 69 points, with higher scores indicating better performance.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Dentistry, Oral Surgery & Medicine
Anna Simonelli, Roberto Farina, Luigi Minenna, Cristiano Tomasi, Leonardo Trombelli
Summary: This retrospective study evaluated the prognostic value of a composite outcome measure (COM) on clinical attachment level (CAL) change during a 4-year period of supportive periodontal care (SPC). The study found that COM can be used to predict CAL change at sites undergoing SPC following periodontal regenerative surgery.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dermatology
Nour Kibbi, Yulia Khan, David J. Leffell, Sean R. Christensen, Kathleen C. Suozzi
Summary: This study found that outcomes of SIH treatment in the periocular region are significantly impacted by the size of the defect, with larger defects associated with poorer results. Factors such as eyelid margin involvement, age, and follow-up interval were not significant, but defects in the medial canthus were least likely to heal with optimal results.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Brigitte Gerstl, Christina Signorelli, Claire E. Wakefield, Chantelle D'Souza, Rebecca Deans, Tejnei Vaishnav, Karen Johnston, Kristen A. Neville, Richard J. Cohn, Antoinette Anazodo
Summary: The majority of cancer survivors participating in the pilot study found the RS-PROM to be an acceptable, feasible, and useful tool to facilitate discussions about their sexual and reproductive health concerns with their clinical team.
Review
Dermatology
Madelaine Fritsche, Martin Okun, Joslyn S. Kirby
Summary: The purpose of this study was to review outcome measures and instruments used in HS, as well as in other inflammatory and destructive diseases, to gain insight into developing a specific outcome measure for HS damage.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Clinical Neurology
Roni Molad, Sandra R. Alouche, Marika Demers, Mindy F. Levin
Summary: The Comprehensive Coordination Scale (CCS) was developed to assess motor coordination in individuals with neurological injuries, and demonstrated high internal consistency and reliability. It showed no ceiling or floor effects, indicating strong measurement properties for assessing spatial and temporal coordination deficits in chronic stroke survivors.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Oncology
Soha Atallah, Lisa Barbera, Matthew Folwell, Doris Howell, ZhihuiAmy Liu, Jennifer Croke
Summary: The study evaluated the feasibility and acceptability of implementing the EORTC QLQ-CX24 in gynecologic oncology clinics, with positive feedback from patients and oncologists on the use of the questionnaire in clinical encounters.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Behavioral Sciences
Stela P. Petkova, Anna Adhikari, Elizabeth L. Berg, Timothy A. Fenton, Jessica Duis, Jill L. Silverman
Summary: This study investigated motor impairments in a mouse model of Angelman Syndrome (AS), focusing on quantifying various spatial and temporal aspects of gait as a reliable and translatable outcome measure. The findings demonstrated marked global motor deficits in AS mice, as well as nuanced aberrations in quantitative spatial and temporal components of gait. These results highlight the potential of gait as a valuable metric for therapeutic development in AS and other genetic neurodevelopmental syndromes.
Article
Surgery
Young-Dong Yu, Kwang-Sig Lee, Jong Man Kim, Je Ho Ryu, Jae-Geun Lee, Kwang-Woong Lee, Bong-Wan Kim, Dong-Sik Kim
Summary: This study compared the performance of traditional statistical models and machine learning approaches in predicting survival following liver transplantation. The results showed that machine learning methods such as random forest performed better than traditional statistical models and previously reported survival scores. The study also identified major predictors associated with survival. This suggests that artificial intelligence has significant potential in aiding clinical decision-making during liver transplantation.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Multidisciplinary Sciences
Wanting Zu, Xuemiao Huang, Tianxin Xu, Lin Du, Yiming Wang, Lisheng Wang, Wenbo Nie
Summary: This review provides a summary of the use of machine learning for predicting the potential benefits of stroke rehabilitation treatments, evaluates the risk of bias in predictive models, and offers recommendations for future models.
Article
Health Care Sciences & Services
Mirjam V. Neumann-Langen, Verena Sontheimer, Gudrun H. Borchert, Kaywan Izadpanah, Hagen Schmal, Eva J. Kubosch
Summary: This study retrospectively reviewed all distal femur fractures treated in a level I trauma center over a decade. The results showed that screw fixation had fewer postoperative complications than plate fixation and was favored for certain types of fractures. Plate fixation remained the superior method for complex fractures, but was associated with higher rates of non-union and leg axis deviation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Masashi Kondo, Masanori Matsuzaki
Summary: The study reveals that the activity of neocortical neurons in mice during classical conditioning is influenced by reward cues and outcome history, with the dorsomedial frontal cortex (dmFrC) playing a crucial role in licking movements.
Article
Clinical Neurology
Brian E. Powers, Son T. Ton, Robert G. Farrer, Suhani Chaudhary, Russ P. Nockels, Gwendolyn L. Kartje, Shih-Yen Tsai
Summary: This study suggests that anti-Nogo-A antibody treatment may improve functional recovery by promoting axonal growth and neuronal plasticity in individuals with traumatic brain injury. The experiments conducted on rats showed significant improvement in motor deficits after receiving the treatment, indicating the potential efficacy of anti-Nogo-A Ab therapy for patients with TBI.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Clinical Neurology
Helge Kasch, Uffe Schou Love, Anette Bach Jonsson, Kaare Eg Severinsen, Marc Possover, Soren Bruno Elmgreen, Axel Forman
Summary: The study design was a 1-year prospective randomized controlled trial comparing the effects of the LION procedure with NMES in SCI patients. The results showed significant improvement in walking ability in the LION group compared to controls on the WISCI-II scale, while no significant changes were observed in the secondary outcome measures.
Article
Clinical Neurology
Soren Krogh, Per Aagaard, Anette Bach Jonsson, Krystian Figlewski, Helge Kasch
Summary: This study investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on lower limb muscle strength and gait function during spinal cord injury (SCI) rehabilitation. Results showed a more prominent increase in muscle strength in the rTMS group, although no clear main effects were observed. High-frequency rTMS may enhance long-term muscle strength recovery following SCI, while the effect on short-term recovery remains unclear.
Article
Clinical Neurology
Mathias Moller Thygesen, Torben Ellegaard Lund, Irene Klaerke Mikkelsen, Helge Kasch, Rikke Beese Dalby, Stig Eric Dyrskog, Michael Pedersen, Mikkel Mylius Rasmussen
Summary: This study aimed to establish a DKI protocol for acute SCI and found a significant correlation between decreasing mean kurtosis values at the injury site of the spinal cord and higher grade of disability in patients.
ACTA NEUROCHIRURGICA
(2022)
Article
Clinical Neurology
Nicolaj J. Holm, Randi Steensgaard, Lone H. Schou, Tom Moller, Helge Kasch, Fin Biering-Sorensen
Summary: The study found that overall BMI remained stable but higher than recommended in people with SCI undergoing rehabilitation at two national centers in Denmark. Participants with AIS D SCI had significantly higher BMI during rehabilitation compared to other groups, and their BMI increased from discharge to follow-up.
Article
Multidisciplinary Sciences
Simple Futarmal Kothari, Peter Preben Eggertsen, Oana Veronica Frederiksen, Mille Moeller Thastum, Susanne Wulff Svendsen, Astrid Tuborgh, Erhard Trillingsgaard Naess-Schmidt, Charlotte Ulrikka Rask, Andreas Schroeder, Helge Kasch, Jorgen Feldbaek Nielsen
Summary: The characteristics of persistent post-traumatic headache (PTH) in young individuals are unclear, leading to difficulties in diagnosis and diverse management approaches. This study found that most young individuals with PTH following mild traumatic brain injury (mTBI) presented with a combination of migraine-like headache and tension-type-like headache, followed by migraine-like headache alone. Preventive headache medication was rarely used, while simple analgesics and bedrest were commonly used for short-term relief of headache.
SCIENTIFIC REPORTS
(2022)
Review
Health Care Sciences & Services
Carrie Ritchie, Tonny Elmose Andersen, Sophie Lykkegaard Ravn, Anne Soderlund, Michele Sterling, CATWAD
Summary: This study aimed to assess the measurement properties of patient-reported outcome measures (PROMs) for anxiety, depression, fear of movement, pain catastrophizing, post-traumatic stress, self-efficacy, and stress in people with whiplash-associated disorders. The results showed that only PSEQ, PCS, and PFActS-C had reliable internal structures among these PROMs, while the original structures of the other measures were not confirmed in whiplash patients.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Editorial Material
Anesthesiology
Lars Arendt-Nielsen, Kristian Kjaer-Staal Pedersen, Lene Dreyer, Salome Kristensen, Sten Rasmussen, Bo Biering-Sorensen, Helge Kasch, Andrew Rice
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Michele Sterling, Tonny Andersen, Linda Carroll, Luke Connelly, Pierre Cote, Michele Curatolo, Genevieve Grant, Gwendolen Jull, Helge Kasch, Sophie Lykkegaard Ravn, Joy Macdermid, Eva-Maj Malmstrom, Trudy Rebbeck, Anne Soderlund, Julia Treleaven, David M. Walton, Hans Westergren
Summary: This study evaluated patient-reported outcome measures for whiplash associated disorders and recommended a core outcome set consisting of 6 domains: Physical Functioning, Perceived Recovery, Psychological Functioning, Quality of Life, Pain, and Work and Social Functioning. The recommendations were based on systematic reviews and consensus from an International Steering Committee.
Article
Chemistry, Medicinal
Julie Schjodtz Hansen, Stefan Gustavsen, Homayoun Roshanisefat, Matthias Kant, Fin Biering-Sorensen, Claus Andersen, Anna Olsson, Helene Hojsgaard Chow, Nasrin Asgari, Julie Richter Hansen, Helle Hvilsted Nielsen, Rikke Middelhede Hansen, Thor Petersen, Annette Bang Oturai, Finn Sellebjerg, Eva Aggerholm Saedder, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Kristina Bacher Svendsen
Summary: This study investigated the effect of cannabis-based medicine (CBM) on central neuropathic pain (NP) and spasticity in patients with multiple sclerosis (MS) and spinal cord injury (SCI). The results showed that THC, CBD, or their combination did not have a significant effect on pain and spasticity. The study was limited by a smaller sample size due to COVID-19 and recruitment challenges.
Article
Clinical Neurology
Thea Overgaard Wichmann, Helge Kasch, Stig Dyrskog, Kristian Hoy, Bjarne Kuno Moller, Jan Krog, Hans Jurgen Hoffmann, Claus Vinter Bodker Hviid, Mikkel Mylius Rasmussen
Summary: This study compares the feasibility of using cerebrospinal fluid (CSF) and peripheral blood (PB) as sample media for measuring biomarkers in traumatic spinal cord injury (TSCI). The results suggest that GFAP is a potential diagnostic biomarker that can be measured in both CSF and PB.
ACTA NEUROCHIRURGICA
(2023)
Review
Rehabilitation
Soren Krogh, Anette B. Jonsson, Per Aagaard, Helge Kasch
Summary: This study aimed to determine the efficacy of repetitive transcranial magnetic stimulation (rTMS) compared to sham stimulation in improving lower-limb functional outcomes in individuals with neurological disorders. The study included randomized clinical trials with parallel-group design and individuals with neurological disorders. The results showed that rTMS had an overall effect on gait and muscle strength, particularly in patients with stroke, Parkinson's disease, and spinal cord injury. However, no significant effect was found on mobility and balance. Further research is needed to confirm these findings.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Review
Anesthesiology
Shirin Modarresi, Michael J. Lukacs, Maryam Ghodrati, Shahan Salim, Joy C. MacDermid, David M. Walton
Summary: This study conducted a systematic review of the measurement properties of the Numeric Pain Rating Scale (NPRS) and the Visual Analog Scale (VAS) as patient-reported outcome measures in neck pain research. The results showed that the NPRS and VAS have good-to-excellent test-retest reliability, clinically important differences, and moderate associations with the Neck Disability Index. However, further research is needed to determine the extent to which these measures reflect outcomes that are important to patients.
CLINICAL JOURNAL OF PAIN
(2022)
