Article
Cell Biology
Nadine Weinelt, Christos Karathanasis, Sonja Smith, Juliane Medler, Sebastian Malkusch, Simone Fulda, Harald Wajant, Mike Heilemann, Sjoerd J. L. van Wijk
Summary: TNFR1 is a crucial regulator of proinflammatory cell survival and programmed cell death, and deregulation of TNFα and TNFR1 signaling underlies major diseases. Therefore, finding alternative approaches to directly antagonize TNFR1 is beneficial.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Food Science & Technology
Hongbing Fan, Khushwant S. Bhullar, Zihan Wang, Jianping Wu
Summary: This study investigated the protective effects of four chicken muscle-derived peptides on TNF alpha-induced endothelial inflammation and oxidative stress. It was found that V-F treatment significantly reduced inflammation and oxidative stress through the inhibition of TNFR1 signaling. These findings suggest that V-F has the potential to be used as a functional food ingredient or nutraceutical for the prevention and treatment of hypertension and cardiovascular diseases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pediatrics
Chengcheng Huang, Wang Wang, Hongbiao Huang, Jiaqi Jiang, Yueyue Ding, Xuan Li, Jin Ma, Miao Hou, Xiangqiang Pu, Guanghui Qian, Haitao Lv
Summary: USP5 is upregulated in human coronary artery endothelial cells (HCAECs) when incubated with acute KD sera or TNF alpha in vitro. It promotes proinflammatory cytokine expression by sustaining NF-kappa B signaling activation in HCAECs. The USP5 inhibitor vialinin A can suppress the expression levels of proinflammatory cytokines in HCAECs, providing a novel mechanism and intervention strategy in KD therapy.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Cecile Rittore, Deborah Mechin, Elodie Sanchez, Lea Marineche, Vuthy Ea, Stephan Soler, Marion Vereecke, Aude Mallavialle, Eric Richard, Isabelle Duroux-Richard, Florence Apparailly, Isabelle Touitou, Sylvie Grandemange
Summary: A newly discovered TNFR1-d2 protein exhibits different clustering kinetics on the cell surface compared to full-length TNFR1, but does not activate the NF-κB signaling pathway inside the cell.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Maria Mancini, Jyoti C. Patel, Alison H. Affinati, Paul Witkovsky, Margaret E. Rice
Summary: This study found that leptin regulates dopamine release and uptake in the striatum, affecting motor and reward pathways. The results suggest that leptin increases dopamine release by modulating the excitability of cholinergic interneurons through nicotinic acetylcholine receptors. This highlights the important neuroregulatory role of leptin in the brain.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Katie H. Barker, James P. Higham, Luke A. Pattison, Toni S. Taylor, Iain P. Chessell, Fraser Welsh, Ewan St J. Smith, David C. Bulmer
Summary: Visceral pain is a major cause of morbidity in gastrointestinal diseases, and the pro-inflammatory cytokine TNFα is associated with pain in these diseases. TNFα has been shown to sensitize colonic sensory neurons through TNFR1, p38 MAPK, and TRPV1 signaling pathways. Targeting these pathways may provide potential treatments for visceral pain in gastrointestinal diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Immunology
Flavia Batista Ferreira Franca, Murilo Vieira Silva, Mariana Ferreira Silva, Eliezer Lucas Pires Ramos, Vanessa dos Santos Miranda, Caroline Martins Mota, Fernanda Maria Santiago, Jose Roberto Mineo, Tiago Wilson Patriarca Mineo
Summary: This study aimed to evaluate the role of TNF in immune responses during N. caninum infection. The results showed that TNFR1 is required for regular IgG subclass production and antigen recognition, and plays a crucial role in mediating host resistance to N. caninum infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Yuejin Liang, James Fisher, Casey Gonzales, Brandon Trent, Galen Card, Jiaren Sun, Alexei Tumanov, Lynn Soong
Summary: This study demonstrates the importance of TNF-TNFR signaling in protective immunity against scrub typhus infection. Mice lacking TNFR1 and TNFR2 were highly susceptible to infection, with deficiencies in cellular immunity activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rui Li, Lingxing Zeng, Hongzhe Zhao, Junge Deng, Ling Pan, Shaoping Zhang, Guandi Wu, Ying Ye, Jialiang Zhang, Jiachun Su, Yanfen Zheng, Shuang Deng, Ruihong Bai, Lisha Zhuang, Mei Li, Zhixiang Zuo, Dongxin Lin, Jian Zheng, Xudong Huang
Summary: The m(6)A-TNFRSF1A axis plays a critical role in the development of esophageal squamous cell carcinoma (ESCC), and may serve as a potential drug target.
Review
Immunology
Nikolaos Skartsis, Leonardo M. R. Ferreira, Qizhi Tang
Summary: TNFa blocking agents, the first-in-class biologic drugs used for treating autoimmune diseases, have shown paradoxical exacerbation of autoimmunity in some patients. The complex signaling pathways of TNFa might explain the controversial findings of previous studies. Targeted manipulation of TNFa-TNF receptor signaling on select CD4(+) T cell subsets may offer specific therapeutic interventions for autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Roza Izgilov, Alex Naftaly, Dafna Benayahu
Summary: Adipose tissue metabolism under hyperglycemia leads to Type II diabetes (T2D). In this study, adipocytes were cultured with glycation-induced advanced glycation end products (AGEs), which increased cell and niche stiffness and altered cell signaling. The formation of AGEs coincided with changes in protein structure and reduced adipogenesis, leading to impairment of insulin signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Optics
Cooper Doyle, Wei-Wei Zhang, Michelle Wang, Bryn A. Bell, Stephen D. Bartlett, Andrea Blanco-Redondo
Summary: In this study, we achieved entanglement between different topological spatial modes in a bipartite array of silicon waveguides, demonstrating topology as an additional degree of freedom for entanglement and opening new avenues for investigating information teleportation.
Article
Immunology
Iwona Niemietz, Kelly L. Brown
Summary: This study found that hyaluronan (HA) can prime neutrophils to produce a stronger oxidative burst in response to different stimuli, when combined with TNF alpha. Additionally, HA can enhance intracellular reactive oxygen species (ROS) production induced by TNF alpha, as well as activate p38 MAPK and apoptosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Georgii B. Telegin, Aleksandr S. Chernov, Vitaly A. Kazakov, Elena A. Romanova, Tatiana N. Sharapova, Denis Yashin, Alexander G. Gabibov, Lidia P. Sashchenko
Summary: The novel peptide 17.1A derived from PGLYRP1/Tag7 protein inhibits TNF receptor 1 (TNFR1) activation, showing anti-inflammatory and protective effects in a mouse model of arthritis. This peptide has potential as a therapeutic agent for autoimmune arthritis and other diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maximilian Ochs, Luka Zurak, Enno Krauss, Jessica Meier, Monika Emmerling, Rene Kullock, Bert Hecht
Summary: This study demonstrates the selective electrical excitation of symmetric and antisymmetric plasmonic modes in a two-wire transmission line. Mode selectivity is achieved by precisely positioning nanoscale excitation sources. The resulting device represents the smallest electrically driven light source with directly switchable polarization states.
Article
Oncology
Claudia Owczarek, Elena Ortiz-Zapater, Jana Kim, Efthymia Papaevangelou, George Santis, Maddy Parsons
Summary: The coxsackie and adenovirus receptor (CAR) is highly expressed in lung cancer and may promote tumor growth and regulate epithelial mesenchymal transition (EMT). Our study demonstrates that CAR contributes to lung cancer metastasis through promoting cell-matrix adhesion, providing new insights into the cooperation between cell-cell and cell-matrix proteins in tumorigenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
J. M. Vicencio, R. Evans, R. Green, Z. An, J. Deng, C. Treacy, R. Mustapha, J. Monypenny, C. Costoya, K. Lawler, K. Ng, K. De-Souza, O. Coban, V Gomez, J. Clancy, S. H. Chen, A. Chalk, F. Wong, P. Gordon, C. Savage, C. Gomes, T. Pan, G. Alfano, L. Dolcetti, J. N. E. Chan, F. Flores-Borja, P. R. Barber, G. Weitsman, D. Sosnowska, E. Capone, S. Iacobelli, D. Hochhauser, J. A. Hartley, M. Parsons, J. N. Arnold, S. Ameer-Beg, S. A. Quezada, Y. Yarden, G. Sala, T. Ng
Summary: In this study, the combination of osimertinib and anti-HER3 monoclonal antibodies was explored, and it was found that the immune system played a role in eliminating lung cancer cells by regulating the cGAS-STING pathway and innate immunity.
CELL DEATH & DISEASE
(2022)
Article
Developmental Biology
Gabriela D'Amico, Isabelle Fernandez, Jesus Gomez-Escudero, Hyojin Kim, Eleni Maniati, Muhammad Syahmi Azman, Faraz K. Mardakheh, Bryan Serrels, Alan Serrels, Maddy Parsons, Anthony Squire, Graeme M. Birdsey, Anna M. Randi, Alfonso Bolado-Carrancio, Rathi Gangeswaran, Louise E. Reynolds, Natalia Bodrug, Yaohe Wang, Jun Wang, Pascal Meier, Kairbaan M. Hodivala-Dilke
Summary: Precise vascular patterning is dependent on the regulation of ERG transcription factor and DLL4/Notch signaling pathway. This study reveals that endothelial cell-specific focal adhesion kinase (FAK) controls ERG protein degradation, which in turn affects vascular development.
Article
Multidisciplinary Sciences
Elena Ortiz-Zapater, Dustin C. Bagley, Virginia Llopis Hernandez, Luke B. Roberts, Thomas J. A. Maguire, Felizia Voss, Philipp Mertins, Marieluise Kirchner, Isabel Peset-Martin, Grzegorz Woszczek, Jody Rosenblatt, Michael Gotthardt, George Santis, Maddy Parsons
Summary: This study demonstrates the important role of epithelial protein CAR in regulating lung inflammation and remodelling. Deletion of CAR leads to reduced house dust mite-induced lung inflammation, decreased neutrophil accumulation and alterations in airway remodelling.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Campbell D. Lawson, Samantha Peel, Asier Jayo, Adam Corrigan, Preeti Iyer, Mabel Baxter Dalrymple, Richard J. Marsh, Susan Cox, Isabel Van Audenhove, Jan Gettemans, Maddy Parsons
Summary: Fascin is an important regulator of F-actin bundling in tumor cells. It has been found that Fascin bundles F-actin within the nucleus, supporting chromatin organization and efficient DNA damage response. Increased nuclear accumulation of Fascin leads to sustained nuclear F-actin bundling, resulting in reduced invasion, viability, and apoptosis of cancer cells.
Article
Microscopy
Thomas A. A. Phillips, Valeria Caprettini, Nandini Aggarwal, Stefania Marcotti, Rob Tetley, Yanlan Mao, Tanya Shaw, Ciro Chiappini, Maddy Parsons, Susan Cox
Summary: Multicellular tumour cell spheroids embedded within 3D hydrogels or extracellular matrices are used as cancer models. UV photolithography is used to create PDMS stamps for generating well-like structures for precise positioning of spheroids. This method allows for reproducible high-/super-resolution live imaging.
JOURNAL OF MICROSCOPY
(2023)
Article
Dermatology
Chuin Y. Ung, Alasdair Warwick, Alexandros Onoufriadis, Jonathan N. Barker, Maddy Parsons, John A. McGrath, Tanya J. Shaw, Nick Dand
Summary: This study evaluated established comorbidities of excessive scarring in European individuals and identified novel comorbidities using a phenome-wide association study. The results showed associations between excessive scarring and hypertension and atopic eczema. This study validated common comorbidities of excessive scarring and provided a reference for future studies on underlying pathophysiological mechanisms.
Review
Biochemistry & Molecular Biology
Claudia Owczarek, Yassmin Elmasry, Maddy Parsons
Summary: Coxsackievirus and adenovirus receptor (CAR) is a crucial cell-cell adhesion receptor that plays a key role in maintaining epithelial barrier integrity and mediating immune cell transmigration across epithelial tissues. CAR is emerging as a potential mediator of tumorigenesis and a target for viral therapy delivery on cancer cells, but its function is tightly regulated and the contributions to disease progression are likely to be context specific.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2023)
Article
Dermatology
Sofia Endzhievskaya, Chao-Kai Hsu, Hsing-San Yang, Hsin-Yu Huang, Yu-Chen Lin, Yi-Kai Hong, John Y. W. Lee, Alexandros Onoufriadis, Takuya Takeichi, Julia Yu-Yun Lee, Tanya J. Shaw, John A. McGrath, Maddy Parsons
Summary: Dermatofibromas (DFs) are common, benign fibrous skin tumors that can occur at any skin site. In some cases, DFs are multiple and familial, but the mechanisms leading to these lesions are currently unclear. This study identified a variant in the RND3 gene that encodes the small GTPase RhoE, and loss of RhoE function was found to enhance collagen activation and integrin activation, resulting in a disorganized extracellular matrix and contributing to the development of DF.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Lena Bruecker, Stefanie Kornelia Becker, Vanessa Maissl, Gregory Harms, Maddy Parsons, Helen Louise May-Simera
Summary: Primary cilia are important for cellular communication and defects in cilia development or function are associated with genetic disorders. Recent research suggests that ciliary proteins are involved in actin regulation, but the exact nature of their interconnection is not fully understood.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Frederic Li Mow Chee, Bruno Beernaert, Billie G. C. Griffith, Alexander E. P. Loftus, Yatendra Kumar, Jimi C. Wills, Martin Lee, Jessica Valli, Ann P. Wheeler, J. Douglas Armstrong, Maddy Parsons, Irene M. Leigh, Charlotte M. Proby, Alex von Kriegsheim, Wendy A. Bickmore, Margaret C. Frame, Adam Byron
Summary: In this study, the authors discovered that the integrin adhesome undergoes systems-level changes in cutaneous squamous cell carcinoma cells. They also found that the actin regulator Mena plays an important role in force transmission at the nuclear envelope, regulating nuclear architecture, chromatin organization, and gene expression.
NATURE COMMUNICATIONS
(2023)
Correction
Multidisciplinary Sciences
Tanguy Lechertier, Louise E. Reynolds, Hyojin Kim, Ana Rita Pedrosa, Jesus Gomez-Escudero, Jose M. Munoz-Felix, Silvia Batista, Matthew Dukinfield, Fevzi Demircioglu, Ping Pui Wong, Kylie P. Matchett, Neil C. Henderson, Gabriela D'Amico, Maddy Parsons, Catherine Harwood, Pascal Meier, Kairbaan M. Hodivala-Dilke
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Salwa Alhamad, Yassmin Elmasry, Isabel Uwagboe, Elena Chekmeneva, Caroline Sands, Benjamin W. Cooper, Stephane Camuzeaux, Ash Salam, Maddy Parsons
Summary: B7-H3 is a protein associated with lung cancer and is involved in the metabolic signaling of cancer cells. It forms a complex with the enzyme IMPDH2, protecting cancer cells from oxidative stress and apoptosis triggered by chemotherapy. However, its loss promotes tumor growth in 3D models. These findings provide insights into the function of B7-H3 in lung cancer cells and caution against the use of anti-B7-H3 therapies in certain clinical settings.
Article
Cell Biology
Jennifer Rynne, Elena Ortiz-Zapater, Dustin C. Bagley, Onofrio Zanin, George Doherty, Varsha Kanabar, Jon Ward, David J. Jackson, Maddy Parsons, Jody Rosenblatt, Ian M. Adcock, Rocio T. Martinez-Nunez
Summary: The article discusses the importance of asthma as the most common chronic inflammatory disease of the airways. It focuses on the expression and potential role of the TTP family of RNA binding proteins in asthma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)