Article
Oncology
Catherine M. Nickson, Maria Rita Fabbrizi, Rachel J. Carter, Jonathan R. Hughes, Andrzej Kacperek, Mark A. Hill, Jason L. Parsons
Summary: Ionizing radiation induces DNA damage leading to cell death. The biological effects of high-LET IR are not well understood, but USP9X plays a crucial role in cell survival post high-LET radiation by stabilizing proteins involved in centrosome formation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Soumya Banerjee, Samuel Vernon, Wei Jiao, Ben Jiwon Choi, Evelyne Ruchti, Jamshid Asadzadeh, Olivier Burri, R. Steven Stowers, Brian D. McCabe
Summary: The decline of synaptic structures and functions during ageing can be mitigated by enhancing miniature neurotransmission, which is essential for maintaining and prolonging motor ability in adult organisms.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia, Dengqun Liu
Summary: This study reveals the important role of inducible nitric oxide synthase (iNOS) in the intestinal crypts and its effects on intestinal stem cell (ISC) proliferation and differentiation. iNOS deficiency leads to morphological changes in the intestine and alters gluconeogenesis and the adaptive immune response. These findings highlight the potential of iNOS as a therapeutic target for intestinal disorders.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Linxiang Lan, Theodore Evan, Huafu Li, Aasia Hussain, E. Josue Ruiz, May Zaw Thin, Rute M. M. Ferreira, Hari Ps, Eva M. Riising, Yoh Zen, Jorge Almagro, Kevin W. Ng, Pablo Soro-Barrio, Jessica Nelson, Gabriela Koifman, Joana Carvalho, Emma L. Nye, Yulong He, Changhua Zhang, Anguraj Sadanandam, Axel Behrens
Summary: This study identifies BMP inhibitor GREM1 as a key regulator of cellular heterogeneity in pancreatic cancer. Continuous activity of GREM1 is required to maintain the stability of the epithelial PDAC subpopulations, while high activity of GREM1 can revert the mesenchymal fate of PDAC cells. By inhibiting the expression of epithelial-mesenchymal transition transcription factors, GREM1 restricts the epithelial-mesenchymal plasticity of pancreatic cancer cells.
Article
Biochemistry & Molecular Biology
Monica L. Bomber, Jing Wang, Qi Liu, Kelly R. Barnett, Hillary M. Layden, Emily Hodges, Kristy R. Stengel, Scott W. Hiebert
Summary: Genetic models indicated that SMARCA5 is essential for DNA-templated events and its degradation affects nucleosome repeat length and CTCF binding sites. The rapid degradation of SMARCA5 resulted in increased nucleosome repeat length and disruption of CTCF DNA binding. Our findings suggest that SMARCA5 is continuously required for maintaining nucleosomal spacing and controlling nucleosome repeat length.
Article
Multidisciplinary Sciences
Xiaowei Sun, Jie Shen, Norbert Perrimon, Xue Kong, Dan Wang
Summary: This study demonstrates the role of the Drosophila endoribonuclease CG2145 (Arlr) in regulating lipid metabolism. Arlr affects lipid homeostasis by degrading the mRNAs of lipolysis genes and this phenotype can be rescued by high-fat or high-glucose diet.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Takaaki Yoshikawa, Akihisa Fukuda, Mayuki Omatsu, Mio Namikawa, Makoto Sono, Yuichi Fukunaga, Tomonori Masuda, Osamu Araki, Munemasa Nagao, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Yu Muta, Motoyuki Tsuda, Takahisa Maruno, Yuki Nakanishi, Kenji Kawada, Shigeo Takaishi, Hiroshi Seno
Summary: Brg1 is crucial for intestinal TSCs in mice by inhibiting apoptosis and is critical for cell survival and stem cell features in human CRC cells, representing a new therapeutic target for human CRC.
JOURNAL OF PATHOLOGY
(2021)
Article
Physiology
Carole L. Wilson, Chi F. Hung, Brian M. Burkel, Suzanne M. Ponik, Sina A. Gharib, Lynn M. Schnapp
Summary: Nephronectin (NPNT) is a basement membrane protein that plays a crucial role in kidney morphogenesis. This study found that NPNT is also present in the basement membrane of the lung, and its potential role in pulmonary development was investigated using knockout mouse models. The results suggest that NPNT signaling through integrin a8 is important for maintaining the separation of right lung lobes during embryogenesis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jordan L. Levy, Emily T. Mirek, Esther M. Rodriguez, Brian Zalma, Jeffrey Burns, William O. Jonsson, Harini Sampath, Kirk A. Staschke, Ronald C. Wek, Tracy G. Anthony
Summary: GCN2 activation and amino acid transport support adaptive thermogenesis during acute cold exposure in a sex-independent manner.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cell & Tissue Engineering
Morgan D. Zumbaugh, Ashley E. Geiger, Jing Luo, Zhengxing Shen, Hao Shi, David E. Gerrard
Summary: The study revealed that O-GlcNAcylation plays a critical role in the maintenance of muscle satellite cell health and function. Deficiency of OGT affects the proliferation, self-renewal, and repair capacity of SCs in injured muscle.
Article
Immunology
Tian-Shu Zhao, Li-Wei Xie, Shang Cai, Jia-Yu Xu, Hao Zhou, Lin-Feng Tang, Chao Yang, Shuguang Fang, Ming Li, Ye Tian
Summary: The study found that dysbiosis of gut microbiota occurs in acute radiation-induced intestinal injury, varying with radiation dose and persisting until the recovery stage. Administration of probiotics can improve survival duration, alleviate intestinal epithelial injury, and partially restore gut microbiota diversity in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Benjamin A. W. R. Ralph, Melanie Lehoux, Hanna Ostapska, Brendan D. D. Snarr, Alayna K. K. Caffrey-Carr, Richard Fraser, Maya Saleh, Joshua J. J. Obar, Salman T. T. Qureshi, Donald C. C. Sheppard
Summary: Aspergillus fumigatus airway infections in patients with chronic lung disease are associated with increased hospitalizations and declining lung function. IL-1 cytokines play a critical role in enhancing host resistance to A. fumigatus airway infection by suppressing neutrophil apoptosis at the site of infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Liu Yang, Haiyan Yang, Yunxiang Chu, Yunhao Song, Lidan Ding, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye, Yinyin Wang, Zhijie Chang
Summary: This study reveals the essential role of CREPT in maintaining murine intestinal stem cells, with its deficiency impairing cell proliferation and regeneration. The downregulation of Wnt signaling due to CREPT deletion is identified as a key mechanism affecting ISC function.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Julian Haase, Richard Chen, Wesley M. Parker, Mary Kate Bonner, Lisa M. Jenkins, Alexander E. Kelly
Summary: The TFIIH complex plays a crucial role in maintaining chromosome compaction and condensin enrichment by dynamically altering the chromatin environment to facilitate condensin loading and condensin-dependent loop extrusion.
Article
Chemistry, Multidisciplinary
Hang Li, Shuya Zhao, Mian Jiang, Tong Zhu, Jinjian Liu, Guoxing Feng, Lu Lu, Jiali Dong, Xin Wu, Xin Chen, Yu Zhao, Saijun Fan
Summary: This study found that exosomes derived from mice exposed to total body irradiation can protect recipient mice against radiation-induced gut injury. MiR-142, highly expressed in exosomes, plays a key role in mediating the protective effect against radiation enteritis by improving the intestinal microenvironment. Biomodification of exosomes through enhancing miR-142 expression and intestinal specificity can further improve the protection against radiation enteritis.
Article
Oncology
Cristian Perna, Antonia Navarro, Ignacio Ruz-Caracuel, Tamara Caniego-Casas, Eva Cristobal, Susanna Leskela, Federico Longo, Alejandra Caminoa, Almudena Santon, Reyes Ferreiro, David Pizarro, Maria Luisa Palacios-Berraquero, Jose Palacios
Summary: The study characterized the clinicopathological, immunohistochemical, and molecular features of high grade colorectal carcinomas (HG-CRCs), finding that mismatch repair deficiency (MMRd) was a major contributing factor to intertumor and intratumor molecular heterogeneity in HG-CRCs. MMR status conditioned the frequency and clonality of molecular alterations, with distinct molecular differences observed between MMR deficient and MMR proficient tumors.
Article
Multidisciplinary Sciences
Dominik Pfister, Nicolas Gonzalo Nunez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Mueller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jorn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jorg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rossler, Alexander Siebenhuner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Mueller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kutting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Summary: The study investigated the impact of NASH on immunotherapy response in HCC patients and found that NASH-HCC may be less responsive to immunotherapy. Aberrant T cell activation caused by NASH-related tissue damage led to impaired immune surveillance in HCC patients.
Review
Biology
Karla Santos-de-Frutos, Nabil Djouder
Summary: This review article discusses the implication of dormant cancer cells in tumor relapse and the roles that quiescent and senescent cells may play in this process.
COMMUNICATIONS BIOLOGY
(2021)
Correction
Biochemistry & Molecular Biology
Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, Cesar Nombela-Arrieta, Anahita Rafiei, Martina Hinterleitner, Marcel Rall, Florian Baku, Oliver Borst, Caroline L. Wilson, Jack Leslie, Tracy O'Connor, Christopher J. Weston, Abhishek Chauhan, David H. Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte N. Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J. Withers, Jerry Ware, Derek A. Mann, Hellmut G. Augustin, Alexandros Vegiopoulos, Michael D. Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Matthias Matter, Nabil Djouder, Paul Kubes, Percy A. Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber, Mathias Heikenwalder
Article
Immunology
Almudena Chaves-Perez, Karla Santos-de-Frutos, Sergio de la Rosa, Irene Herranz-Montoya, Cristian Perna, Nabil Djouder
Summary: This study reveals the important role of transit-amplifying cells in controlling inflammatory signals and R-spondin production, which are essential for maintaining intestinal stem cell proliferation and tissue regeneration.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Letter
Dermatology
Emilio Berna-Rico, Cristian Perna, Carlos Azcarraga-Llobet, Emilio Garcia-Mouronte, Belen de Nicolas-Ruanes, Maria Rosa Melendez-Gispert, Maria J. Vivancos, Laura Martinez-Garcia, Pablo Fernandez-Gonzalez
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Tatiana P. Grazioso, Nabil Djouder
Summary: In their latest article, Seki and colleagues investigate the potential role of cold exposure in treating various cancer types, including untreatable ones like pancreatic cancer. They suggest that cold exposure may suppress tumor growth by activating brown adipose tissue (BAT), which dissipates heat through non-shivering thermogenesis. This leads to decreased circulating blood glucose, limiting tumor glucose uptake and favoring BAT uptake for thermogenesis.
Review
Biochemistry & Molecular Biology
Carlos Martinez-Garay, Nabil Djouder
Summary: In recent years, dietary interventions have shown promise in cancer treatment by influencing metabolism, tumor growth, development, and therapeutic response. However, due to a lack of understanding in the mechanisms behind dietary therapeutics, they are often overlooked as a potential line of cancer treatment. This review aims to provide a comprehensive overview of the anticancer effects of various diets and their development for clinical use, with the goal of establishing nutritional interventions as a standard treatment.
TRENDS IN MOLECULAR MEDICINE
(2023)
Review
Multidisciplinary Sciences
Tatiana P. Grazioso, Nabil Djouder
Summary: Cold therapy, a powerful therapeutic approach that has been used for centuries, has been largely forgotten in modern medicine. This review explores its history and potential application in treating various diseases, including cancer, through techniques like cryoablation, cryotherapy, cryoimmunotherapy, cryothalectomy, and cryogen agent delivery. Although clinical trials are limited, recent research shows promising results in experimental animal cancer models, highlighting the significance of further investigation.
Review
Oncology
Maria del Mar Rigual, Paula Sanchez Sanchez, Nabil Djouder
Summary: The liver, as the largest organ in mammals, has the ability to fully regenerate for tissue homeostasis. However, stress signals can impair liver regeneration and contribute to the development of hepatocellular carcinoma (HCC), a highly aggressive liver cancer. This review discusses the mechanisms of hepatic regeneration and their potential role in HCC development.
Article
Biochemical Research Methods
Raul Torres-Ruiz, Tatiana P. Grazioso, Marta Brandt, Marta Martinez-Lage, Sandra Rodriguez-Perales, Nabil Djouder
Summary: Chromosomal instability (CIN) is a type of genomic instability that is associated with the progression of various diseases, including cancer. An optimized molecular cytogenetic protocol has been developed to detect and analyze CIN, providing a useful tool for cancer diagnosis and treatment.
Article
Endocrinology & Metabolism
Ana Teijeiro, Amanda Garrido, Anna Ferre, Cristian Perna, Nabil Djouder
Summary: The study demonstrates that inhibiting the IL-17A axis can suppress diet-induced obesity and metabolic disorders, while promoting adipose tissue browning, thermogenesis, and energy expenditure. IL-17A also induces pathological changes in adipocytes, leading to obesity and metabolic syndrome.