Review
Chemistry, Medicinal
Stefano Da Pozzo, Pierluigi Iacono, Alessandro Arrigo, Maurizio Battaglia Parodi
Summary: Central serous chorioretinopathy (CSC) is a contentious disease involving various eye structures, with multiple therapeutic options available. Imaging plays a crucial role in evaluating and guiding treatment, while biomarkers serve as diagnostic and prognostic reference points.
Article
Ophthalmology
Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H. Tezel, Stanley Chang, Tarun Sharma, Janet R. Sparrow
Summary: qAF was correlated with SD-OCT detectable features in CSC patients, while NIR-AF images were helpful in detecting lesions. Elevated qAF levels were associated with specific CSC-related abnormalities, indicating a potential role in disease progression.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Ophthalmology
Zhiqiao Liang, Jinfeng Qu, Lvzhen Huang, Dandan Linghu, Jie Hu, Enzhong Jin, Hui Xu, Hongyan Li, Ye Tao, Xiulan Xu, Guodong Liu, Yan Li, Mingwei Zhao
Summary: The study included 173 cases of CSCR patients and compared the outcomes of cases with or without subfoveal fibrin. The results showed that half-dose verteporfin photodynamic therapy was an effective and safe treatment option, with no significant differences in treatment outcomes and resolution rates of subfoveal fibrin.
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Multidisciplinary Sciences
Junseo Ko, Jinyoung Han, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Kyu Hyung Park, Daniel Duck-Jin Hwang
Summary: This study developed a deep learning-based classification model using multiple spectral domain optical coherence tomography (SD-OCT) images to diagnose central serous chorioretinopathy (CSC). The proposed model achieved high accuracy in cross-validation testing and outperformed other models in distinguishing between acute, chronic, and normal cases. The results suggest that the automated deep learning-based model can serve as a supplementary tool for ophthalmologists in the diagnosis and management of CSC.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Timothy Y. Y. Lai, Ziqi Tang, Adrian C. W. Lai, Simon K. H. Szeto, Ricky Y. K. Lai, Carol Y. Cheung
Summary: The specific form of drusen, known as pachydrusen, is associated with pachychoroid eye diseases, such as central serous chorioretinopathy (CSC) and polypoidal choroidal vasculopathy (PCV). This study found that pachydrusen are more prevalent in PCV than CSC and may be linked to age and more extensive abnormalities in fundus autofluorescence (FAF).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jose Ignacio Fernandez-Vigo, Francisco Javier Moreno-Morillo, Emilio Lopez-Varela, Jorge Novo-Bujan, Marcos Ortega-Hortas, Barbara Burgos-Blasco, Lorenzo Lopez-Guajardo, Juan Donate-Lopez
Summary: This study assessed the repeatability of flow signal voids (FSV) measurements of the choriocapillaris (CC) and choroid (CH) in central serous chorioretinopathy (CSCR) using Swept-Source optical coherence tomography angiography (SS-OCTA). The results showed that SS-OCTA offers good repeatability for quantifying macular FSV in both CSCR eyes and fellow eyes.
Article
Ophthalmology
Dmitrii S. Maltsev, Alexei N. Kulikov, Niroj Kumar Sahoo, Filippo Tatti, Alexander S. Vasiliev, Maria A. Burnasheva, Claudio Iovino, Enrico Peiretti, Jay Chhablani
Summary: This study investigated the interocular asymmetry in distribution of leaks in central serous chorioretinopathy (CSC) and found that the left eye had leaks closer to the optic disk edge and a higher prevalence of leaks within the peripapillary area compared to the right eye.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Geun Woo Lee, Yun Young Kim, Kyung Jun Choi, Se Woong Kang
Summary: This retrospective cross-sectional study aimed to investigate biomarkers associated with visual symptoms and best corrected visual acuity (BCVA) improvement after photodynamic therapy (PDT) for central serous chorioretinopathy. Forty-two consecutive eyes from 42 patients who underwent successful PDT were divided into complete (20 eyes) and incomplete recovery groups (22 eyes) based on improvement in subjective visual complaints. Clinical characteristics, such as central foveal thickness (CFT), foveal avascular zone (FAZ) area, and changes in signal voiding of the choriocapillaris, were compared between the two groups. The study found that CFT and FAZ areas at baseline were significantly different between the groups. Logistic regression analysis showed that greater CFT predicted complete recovery from visual complaints. Reduction or disappearance of signal voiding in the choriocapillaris was more frequent in the complete recovery group. The study also revealed correlations between FAZ area before PDT and BCVA before and after treatment, as well as BCVA improvement during the study period.
Article
Multidisciplinary Sciences
Young Ho Kim, Edward Kang, Jaeryung Oh
Summary: This study used en-face optical coherence tomography to investigate the location of pigment epithelial detachment (PED) in relation to various anatomical landmarks in the eye. The results suggest that the development of complicated PED with choroidal neovascularisation (CNV) can be attributed to both choroidal vascular abnormalities and retinal pigment epithelial insufficiency.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Supriya Arora, Dmitrii S. Maltsev, Niroj Kumar Sahoo, Deepika C. Parameshwarappa, Claudio Iovino, Tarun Arora, Alexei N. Kulikov, Filippo Tatti, Ramesh Vankatesh, Nikitha Gurram Reddy, Ram Snehith Pulipaka, Sumit Randhir Singh, Enrico Peiretti, Jay Chhablani
Summary: The study evaluated the visual acuity and factors influencing it in central serous chorioretinopathy using a new multimodal imaging-based classification. Factors such as foveal involvement and outer retinal atrophy showed strong correlation with visual acuity, while age and duration of the disease also played a significant role. The study suggests that objective parameters of this new classification can help in establishing treatment guidelines for CSCR.
