Article
Food Science & Technology
Huan-Yu Lin, Jiunn-Wang Liao, Ruo-Shiuan Chen, Chia-Hua Chang, Hui-Wen Chang, Shih-Chieh Chang, Wen-Shen Chu, Chien-Ku Lin, Hsin-Tang Lin
Summary: The 90-day study concludes that commercial GM soybeans are substantially equivalent to non-GM soybeans in rats, showing no adverse biological effects on body weight, organ weight, or histopathological lesions.
Editorial Material
Hematology
Marcela Maus
Summary: Genetically modified immune effector cells (IECs) hold promise as a new type of therapeutic for hematologic malignancies, but their potential to increase the risk of secondary cancers is unclear. This study found no increased risk of secondary cancers in over 1000 patient-years of follow-up across multiple clinical trials of genetically modified IECs for cancer.
Article
Food Science & Technology
Jasper Engel, Hilko van der Voet
Summary: This paper proposes a new equivalence test method, aiming to address issues with the EFSA test. By constructing statistical power and assessing distributions, it solves the problem of being unable to establish equivalence limits with limited genotypic variation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Hossein Azadi, Fatemeh Taheri, Samane Ghazali, Saghi Movahhed Moghaddam, Narges Siamian, Imaneh Goli, Shahla Choobchian, Maryam Pour, Ahsen Isik Ozguven, Kristina Janeckova, Petr Sklenicka, Frank Witlox
Summary: This study investigates the environmental, social, and economic consequences of genetically modified (GM) crops at the farm level in developing countries through a meta-analysis. The results show that genetic modification technology can enhance the socio-economic and environmental efficiency of farmers in developing countries. However, the long-term sustainability of genetic modification production is reduced.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Medicine, General & Internal
Bartley P. Griffith, Corbin E. Goerlich, Avneesh K. Singh, Martine Rothblatt, Christine L. Lau, Aakash Shah, Marc Lorber, Alison Grazioli, Kapil K. Saharia, Susie N. Hong, Susan M. Joseph, David Ayares, Muhammad M. Mohiuddin
Summary: A porcine-to-human heart transplantation was performed on a 57-year-old man with nonischemic cardiomyopathy who was not eligible for standard therapeutics, including traditional allograft. The patient was successfully weaned from ECMO and the xenograft functioned normally until sudden failure on day 49 post-transplantation. Further studies are needed to identify the mechanisms responsible for the changes observed in the xenograft.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Daria Grigorieva, Irina Gorudko, Natalia A. Grudinina, Oleg M. Panasenko, Igor Semak, Alexey Sokolov, Alexander Timoshenko
Summary: LTF can be modified by hypohalous acids, affecting the functional responses of neutrophils. After halogenative modification, LTF lost some of its abilities, but still showed inhibitory effects on certain neutrophil responses like respiratory burst. Halogenative modification of LTF plays a role in regulating neutrophil signaling pathways and pro-inflammatory activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Charles C. Y. Xu, Claire Ramsay, Mitra Cowan, Mehrnoush Dehghani, Paul Lasko, Rowan D. H. Barrett
Summary: The study demonstrates that simple and non-invasive environmental DNA (eDNA) methods can be used to detect transgenes of genetically modified (GM) animals in both terrestrial and aquatic environments. With the rapid advancement of genome-editing technologies like CRISPR, there will be a significant increase in the prevalence and diversity of GM animals, highlighting the importance of sensitive and cost-effective detection methods like eDNA.
Article
Communication
Yuan Wang
Summary: This study reveals that, in a social media context, corrective messages from expert sources and receiving high social endorsements can enhance the effectiveness of misinformation correction and counteract the influence of misinformation. Participants tend to evaluate information in a biased way that aligns with their preexisting beliefs about GM food safety, but their initial misperceptions can be reduced when they receive corrective messages.
SCIENCE COMMUNICATION
(2021)
Article
Food Science & Technology
Marie Deckers, Marc De Loose, Nina Papazova, Dieter Deforce, Marie-Alice Fraiture, Nancy H. C. Roosens
Summary: Several methods have been developed to detect genetically modified bacteria in fermentation products, leading to the identification of bacterial GM strains and confirming their presence through various detection techniques.
Article
Nanoscience & Nanotechnology
Sheng Xu, Huanhuan Tan, Qianqian Yang, Riyuan Wang, Chi Tian, Yanting Ji, Ping Zhao, Qingyou Xia, Feng Wang
Summary: The study provides a useful strategy by fabricating a silk sericin hydrogel system delivering recombinant human lactoferrin (SSH-rhLF) to alleviate chemotherapy-caused immune organ damage, successfully overcoming the challenges of lactoferrin resource scarcity and low delivery efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Environmental Sciences
Dong Won Jeon, Jae-Ryoung Park, Yoon-Hee Jang, Eun-Gyeong Kim, Taehun Ryu, Kyung-Min Kim
Summary: The research found that GM rice and non-GM rice showed no significant differences in all major agricultural traits, except for newly assigned characteristics, and there was no gene mobility. Therefore, GM rice can be a potential solution to food insecurity in response to the unpredictable era of climate change in the future.
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Review
Agriculture, Multidisciplinary
Bara Krizkovska, Jitka Viktorova, Jan Lipov
Summary: Potatoes, one of the most important crops worldwide, face threats to their production and nutrient content from biotic and abiotic stresses. Genetic engineering offers a promising solution to reduce economic losses, decrease the use of insecticides, and improve the nutritional properties of potatoes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Agriculture, Multidisciplinary
Bara Krizkovska, Jitka Viktorova, Jan Lipov
Summary: Potatoes are a globally important crop, but their production and nutrient content are threatened by various stresses. Genetic engineering has been shown to be a valuable tool for improving pest resistance, reducing economic losses, and enhancing the nutritional properties of potatoes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Environmental Sciences
Chen Shen, Xiang-Chang Yin, Bo-Yang Jiao, Jing Li, Peng Jia, Xiao-Wen Zhang, Xue-Hao Cheng, Jian-Xin Ren, Hui-Di Lan, Wen-Bin Hou, Min Fang, Xun Li, Yu-Tong Fei, Nicola Robinson, Jian-Ping Liu
Summary: A systematic review on the safety of genetically modified (GM) food consumption found serious adverse events in some animal studies, and only minor illnesses in a human trial. There were no significant differences in adverse event reporting rates between different funding sources, suggesting the need for more human clinical trials and long-term cohort studies in this area.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Food Science & Technology
Vittorio Silano, Jose Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Alicja Mortensen, Gilles Riviere, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Jaime Aguilera, Giulio Di Piazza, Rita Ferreira de Sousa, Yi Liu, Andrew Chesson
Summary: The genetically modified Aspergillus niger strain is used to produce the food enzyme chymosin, which has been evaluated to be safe for use in milk processing. The enzyme is free from viable cells and DNA of the production organism. The dietary exposure to the enzyme in European populations is estimated to be below 0.09 mg/kg bw per day. The enzyme has been tested for genotoxicity and systemic toxicity, and the results indicate that it does not raise safety concerns. The likelihood of allergic reactions from dietary exposure is considered low, although some similarity to respiratory allergens was found. Overall, the data provided support the conclusion that this food enzyme is safe under the intended conditions of use.
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)