Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical axis in rodents

Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice

(2018) Alexandre A. da Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Acute intraperitoneal administration of taurine decreases the glycemia and reduces food intake in type 1 diabetic rats

(2018) Rosane Gomez et al.   BIOMEDICINE & PHARMACOTHERAPY

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

(2018) Rachel J. Perry et al.   CELL

Intermittent food restriction in female rats induces SREBP high expression in hypothalamus and immediately postfasting hyperphagia

(2018) Mariana Alejandra Rosas Fernández et al.   NUTRITION

Influence of sex and estrous cycle on blood glucose levels, body weight gain, and depressive-like behavior in streptozotocin-induced diabetic rats

(2018) Daniela Rebolledo-Solleiro et al.   PHYSIOLOGY & BEHAVIOR

Genetic identification of leptin neural circuits in energy and glucose homeostases

(2018) Jie Xu et al.   NATURE

Mechanism for leptin’s acute insulin-independent effect to reverse diabetic ketoacidosis

(2017) Rachel J. Perry et al.   JOURNAL OF CLINICAL INVESTIGATION

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling

(2017) Jon M. Resch et al.   NEURON

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

Leptin reverses hyperglycemia and hyperphagia in insulin deficient diabetic rats by pituitary-independent central nervous system actions

(2017) Alexandre A. da Silva et al.   PLoS One

Glucocorticoid Signaling: An Update from a Genomic Perspective

(2016) Maria A. Sacta et al.   Annual Review of Physiology

Euglycemia Restoration by Central Leptin in Type 1 Diabetes Requires STAT3 Signaling but Not Fast-Acting Neurotransmitter Release

(2016) Yuanzhong Xu et al.   DIABETES

Elevated Hypothalamic Glucocorticoid Levels Are Associated With Obesity and Hyperphagia in Male Mice

(2016) Charlotte Sefton et al.   ENDOCRINOLOGY

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet

(2016) Miyuki Shibata et al.   ENDOCRINOLOGY

Biologically Inactive Leptin and Early-Onset Extreme Obesity

(2015) Martin Wabitsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

(2015) Yael Mandelblat-Cerf et al.   eLife

Adrenal insufficiency

(2014) Evangelia Charmandari et al.   LANCET

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans

(2014) Bronwyn S. Berthon et al.   NUTRITION RESEARCH

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

(2012) Tiemin Liu et al.   NEURON

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes

(2011) B. Mittendorfer et al.   DIABETES

Leptin Therapy Reverses Hyperglycemia in Mice With Streptozotocin-Induced Diabetes, Independent of Hepatic Leptin Signaling

(2011) H. C. Denroche et al.   DIABETES

Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice

(2011) M. Naito et al.   DIABETES

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid non-genomic effects of corticosteroids and their role in the central stress response

(2011) Femke L Groeneweg et al.   JOURNAL OF ENDOCRINOLOGY

Involvement of brain ketone bodies and the noradrenergic pathway in diabetic hyperphagia in rats

(2011) Kinuyo Iwata et al.   Journal of Physiological Sciences

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Leptin is an effective treatment for hypothalamic amenorrhea

(2011) S. H. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corticosterone Regulates Synaptic Input Organization of POMC and NPY/AgRP Neurons in Adult Mice

(2010) Erika Gyengesi et al.   ENDOCRINOLOGY

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

(2010) Caitlin S. Wyrwoll et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

(2010) Laurence E. Ring et al.   JOURNAL OF CLINICAL INVESTIGATION

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation of Feeding and Counter-Regulatory Hormone Responses to Intermediate Insulin-Induced Hypoglycaemia in the Ovariectomised Female Rat: Effects of Oestradiol

(2009) K. P. Briski et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons

(2009) A. N. van den Pol et al.   JOURNAL OF NEUROSCIENCE

Effects of intracerebroventricular administration of the NPY-Y1 receptor antagonist, 1229U91, on hyperphagic and glycemic responses to acute and chronic intermediate insulin-induced hypoglycemia in female rats

(2009) T. Prashant Nedungadi et al.   REGULATORY PEPTIDES

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY